DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep4 and c3b.2

DIOPT Version :9

Sequence 1:	NP_001260590.1	Gene:	Tep4 / 35248	FlyBaseID:	FBgn0041180	Length:	1498	Species:	Drosophila melanogaster
Sequence 2:	XP_009294666.1	Gene:	c3b.2 / 566347	ZFINID:	ZDB-GENE-030131-3063	Length:	1769	Species:	Danio rerio

Alignment Length:	1771	Identity:	384/1771 - (21%)
Similarity:	657/1771 - (37%)	Gaps:	504/1771 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LQTMEPVK-AEGKYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGI------------------ 63
            ::.:|||| ....::::.|..|......|:.|..|...:.|.:.|.:
Zfish    34 MRQIEPVKDPSPSFSLLAPAKIRPGTKQNILVEGHNLAKVVKVTVVVYDYPNSQTALSRGSVSLN 98

  Fly    64 TGPSYNKTETVE-----LATAGEFKQITFKLPPLEAGEYNLTAEGVKGLEFKNSTKLNWENFKPY 123
            :..:|:..:|:|     |...|:.|.:  ||....:..|.  ||.|..:.|::.          :
Zfish    99 SDNNYSVLQTLEINPNLLLPDGKKKYV--KLVAQFSNIYR--AEKVMAVSFRSG----------H 149

  Fly   124 IKIQTDKGKYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGKF 188
            |.|||||..|.|||.:.:|....|...|  :::..:.:..::.....:.....:|...||::..|
Zfish   150 IFIQTDKPIYNPGDKVRFRAFVSDLEFR--SSERTISLEIQNPDGIAVHGIGRVKAIDGVFSDIF 212

  Fly   189 ELSEFATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKM- 252
            .||.....|.|.: |...||        |....|..            .|||:|||||.::|.:
Zfish   213 SLSTVVKEGRWKV-VAKFDQ--------GKENVFSR------------EFEVKKYVLPAFNVTLT 256

  Fly   253 DATQQVSVRDGEFNVVLKANYTYGKPVNG--KVLVNVHLDS----TSSWENVDGKTVQTDYPGHS 311
            ..|..:|:...:..|.:.|.|.||..|.|  .||..:.::.    .:|.:.:|
Zfish   257 PKTSHLSLDAEKLEVEITARYLYGAQVKGVAYVLFGIEINGEKKRLTSMKQID------------ 309

  Fly   312 VVGTADMVGGKAKLTMD-----LKDFASYLPHKTSSSYAQITAT----VEEDFTGVKLNETGGVQ 367
                 |:.||...|||:     ..|..|.|........:.:|::    ||.:.:|:|:..:
Zfish   310 -----DLNGGSVSLTMEEIKRAYPDINSLLGSTVYVKASVLTSSGSDLVEAEKSGIKIVNS---- 365

  Fly   368 LYPYRYEMSCT-DYSSCFSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFG 431
              ||...:..| .|     :||.....:...::..|||
Zfish   366 --PYMLTIKDTPKY-----YKPGLPLAMTVIVSNHDGS--------------------------- 396

  Fly   432 TDHQEPELPTIEKKTFVFESHLNASGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTTYP 496
               ..|.:|.  |.||:.......||.....:.:|                    :||     .|
Zfish   397 ---PTPNIPV--KVTFLKRPISVHSGTINIHINMP--------------------KKR-----IP 431

  Fly   497 YREPKQIE----NPSSEEEKEWFRAEVQRPKDVW-------NLKIGQ---------EYQVILNSS 541
            |...:.::    :||.:.|::..:....:|...:       ::.:|.         ..||.:.||
Zfish   432 YGNSQMLKVETVDPSLKPEQQAIQEVYVKPYSTFRSHGNYLHVSVGASRVVVGGSISVQVYIKSS 496

  Fly   542 RP-----LKYFVYNIVGRGNILETKRVDL-AEPQTTVNVTIKPTFLTTPYGRVYFYYVDETGEFR 600
            .|     :::..|.::.:|.|::..||:: .:..|:|::.|....|  |..|...||| ...:.|
Zfish   497 LPNHRALVEHLTYIVLNKGKIIQAGRVNVKGQDVTSVHLLITSEML--PAFRFVAYYV-LPWQHR 558

  Fly   601 YTEETFSVEVELQNQ---------IEIKAPAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLLGS 656
            ......||.|:::::         ::.:..:...||:....::|....:.|.|:|||.::.||..
Zfish   559 AEVVADSVFVDVEDRCVGSLNVGPVDGEIVSSYSPGSSFKFQVKGDVGAKVSLVAVDNAIFLLSK 623

  Fly   657 NNDLNKESFNWRL-----------NGYD-------------TSTPWQGG---------------- 681
            |....|:.  |.:           .|.|             :||   ||
Zfish   624 NRLTQKKV--WEVVDQADMGCTAGGGKDNMGVFSDAGLMFHSST---GGSTDSKEDCSSKTKRRR 683

  Fly   682 -----------------------------------YS-----------------------YYPGE 688
                                               ||                       .|.||
Zfish   684 RSAAKLQLRDQLEKAYSDELLQRCCVDGMKEIPMPYSCYRRSLYITEDWSCVLAFLRCCAEYRGE 748

  Fly   689 RTGVVTMTNAYFFYNRTAP--------------DYNILTE--------------------GFGGS 719
            ..||:|..........|||              :|:.:.|                    ..|..
Zfish   749 ELGVITRPPTTTAPPTTAPPTTSLPTLFDLPYLEYDYMEEKVILRARMIEPMPKLYARANDVGVR 813

  Fly   720 SFAMRKTTVAHDSHVFHSGAGGPTQAVGFSAESASASAAPVVRKNFAETWIFADIE--STEEE-- 780
            ..:.|:..|..:..         ..|..|..:..|......||..|.|:|::.||.  ||.:.
Zfish   814 QDSYREVVVEEEEE---------EAASVFEEDDLSDLEDIYVRSKFFESWLWTDIRLPSTAKSDG 869

  Fly   781 --VFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPA 843
              ||.....:||:||.|.....|..|:||:.|. :..|::.::|||:.:|||:||.|.|.:.:.|
Zfish   870 LAVFPVDTVLPDSITQWGFLAVSASPEKGVCVA-EPYNVRVWKPFFIDLRLPHSVSRNEQVEIKA 933

  Fly   844 LVFNYLPKTLDVELTLDNEDQEYDFVDASNEVIGDQKRTQNIRVGANEAAGASFLIRPKVIGNIL 908
            ::.||...||:|.:.|:..:      |..:.....|.| |.:.|.|..:...::.|.|...|.:.
Zfish   934 VIHNYKNSTLEVMVILEKTE------DMCSVAYTGQHR-QQVTVAAGSSKLITYTIIPLKTGELP 991

  Fly   909 LKFKAI--SPLAGDAIHKPLKVVPEGITQYQNRAFFINLKDTGEFKNTFELEVP----EDVVPDS 967
            |:..|:  |.:..||:.|.|:||.|||...:.|:|.:|..:.|.......::|.    :.|||.|
Zfish   992 LQVTAVAASFMGQDAVKKNLRVVVEGIQTLKVRSFVLNPSEKGGSAGQQLIQVKKLQLDAVVPKS 1056

  Fly   968 ERVEF-GLVGDLLGPVVKN------LENLLRLPSGCGEQTMSKLVPNYLVRDYLK--------SI 1017
            ....| .:.||||...:.|      |..|:|:|.||.||.::::....:...||.        .|
Zfish  1057 VPETFVNVRGDLLADSIDNSIKEDSLAALIRMPGGCVEQNLARITLPLIAAHYLDRSADWEIVGI 1121

  Fly  1018 KKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSFSKIK 1082
            .:...|:     :.:|.||::.|:|:..|.|:..:..         ...|||:||||::.||...
Zfish  1122 SRREEAI-----KYIQKGYENQLNYKKSDDSYPPYAN---------EGTSTWITAYVVKVFSMAH 1172

  Fly  1083 DIIDLDEQILAKGYEFLL-TRQAENGSFTEHGEYFYSSQRSLL-------TLTANSLLALLE--- 1136
            ..|.::|:.|.....:|| .:|..:|:|.|....:.:|....:       :|||..|:||.|
Zfish  1173 SFITVNEKHLCGPLLYLLKNKQGYDGTFQEDNPVYDTSMTGAMRGSEYKASLTAFVLIALAEAQD 1237

  Fly  1137 -----------EEKPNQAAIDKAVAYLSANTAESIELLPKSIAIYALQKAKAPEAAKQVASLKS- 1189
                       .:|..|||     .||:.:.:........:||.|||       |....|.:||
Zfish  1238 KVTCQDQEVNIRDKSRQAA-----GYLTEHFSRLTRPYTAAIACYAL-------AVSNNACVKSM 1290

  Fly  1190 -LAKHEDDRTWWTEDLDKLRASKNCGRWWCWIWSQDVEITSYALLSLLDS-DQETADSVLNTVRW 1252
             |.....|.:.|.:       |.|        :...:|.|.||||:|:.| ..|.|::   ..||
Zfish  1291 LLKFASPDHSHWPD-------SNN--------YFFTLEATGYALLALIKSGHMEEAEA---PFRW 1337

  Fly  1253 LIAQRNGFGGFASSQDTVVGLTALIKFAEK---------------SGYEAAKWEVTVSNKGKREK 1302
            |...|...||:.|:|.|:|.|.||.::..|               .|....:|... .|.....:
Zfish  1338 LNEHRGIGGGYGSTQSTMVVLQALSEYLVKRPPPSDLNLLVQLSVPGRSDVRWTFN-PNLAYVAR 1401

  Fly  1303 TEKLNTSEENDLLLQTVEFPQGTKSLEFEAKGTGAAMVQISYQY----NLVEKEPKPSFKIQTTV 1363
            :.::...:|                ....|.|.|..::::...|    ::.|......|::..::
Zfish  1402 SSRVPLDQE----------------FSVAASGNGKGVLEVVTVYHQLPDVYENSTCNGFQLDVSI 1450

  Fly  1364 LP--ESSPANLE----LSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSFADIRN-----IER 1417
            ..  |.:.:::|    |:|.|..:||   ::..|.||::.||:|:..:......:.|     |..
Zfish  1451 AETNEKTSSDVEKSFRLNVNVRALEE---RQVRMVILDIGLPTGFEPENSDLELLTNSVDRYINN 1512

  Fly  1418 VRLVETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKKATEYYS-- 1480
            .::|:..:....::|:...::..|.:.|.....:...|...:||:|.:|.||:.:|..:.:||
Zfish  1513 FQVVDNLSDRGSLIIHLFKVSNKEAEIISFRLNQRFKVGLLQPSTVKVYQYYNKDKSCSRFYSPP 1577

  Fly  1481 -IKSKLCDICEGDDCK 1495
             .|.:|..|||||.|:
Zfish  1578 EDKQQLDQICEGDVCR 1593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081	24/92 (26%)
		A2M_N_2	528..653	CDD:285005	32/148 (22%)
		A2M	768..859	CDD:278630	34/96 (35%)
		A2M_2	982..1279	CDD:239227	89/335 (27%)
		A2M_comp	1035..1281	CDD:284982	75/270 (28%)
		A2M_recep	1389..1479	CDD:284981	20/94 (21%)
c3b.2	XP_009294666.1	A2M_N	150..243	CDD:280081	27/115 (23%)
		A2M_N_2	489..620	CDD:285005	31/133 (23%)
		ANATO	692..748	CDD:237984	3/55 (5%)
		A2M	853..949	CDD:278630	34/96 (35%)
		TRAPPC10	<940..>992	CDD:289361	13/58 (22%)
		complement_C3_C4_C5	1080..1364	CDD:239226	88/327 (27%)
		A2M_comp	1133..1364	CDD:284982	75/269 (28%)
		A2M_recep	1481..1574	CDD:284981	20/92 (22%)
		NTR_like	1594..1767	CDD:295338	384/1771 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584199
Domainoid	1	1.000	48	1.000	Domainoid score	I11904
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.800