Protein Alignment Tep4 and a2m3d

DIOPT Version :10

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: XP_073799915.1
• Gene: a2m3d / 566238
• ZFINID: ZDB-GENE-070720-13
• Length: 1455
• Species: Danio rerio
• Alignment Length: 1618
• Identity: 413/1618 - (25%)
• Similarity: 660/1618 - (40%)
• Gaps: 331/1618 - (20%)

  Fly    11 LCVILAL-------LQTMEPVKAEG--KYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGITGP 66
            ||.|:.:       ::..:|:..:.  .:.:..|..|.|..:..:..::.:.|..||:.:.:...
Zfish    18 LCFIVGVKISDTLAVEVPKPMGPDSGPLFLVTFPSLIESDTEAKLCASLLKPKGSVTMTISLVDE 82

  Fly    67 SYNKTETVELATAGEFKQ-ITFKLPPLEAGEYNLTAEGVKGLEFK--NSTKLNWENFKPYIKIQT 128
            ...:.:.|:..:..:|.: ..|:.|.:...........::|..||  ..:|:.:.::.|...|||
Zfish    83 KSTEIQLVQQTSGRKFHRCFHFQAPQVSGDSVQTVRVVIQGQSFKMTEESKVMFRSYLPLTFIQT 147

  Fly   129 DKGKYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEF 193
            ||..|.||..:|:||:.:.:...|......:|| .||:.:.||:|...|.:|..:......|.:.
Zfish   148 DKPLYNPGQRVNFRVLTMSDTFVPQDQMYSLVV-VEDNNKIRIRQWTDISSTNWILELSHVLDKE 211

  Fly   194 ATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQQV 258
            |.:|:::|....||:...                        .:|:|:||||||:.:.::..|..
Zfish   212 AQVGTYTLKAYIGDRTIS------------------------QSFDVKKYVLPKFDMTLNTPQTY 252

  Fly   259 SVRDGEFNVVLKANYTYGKPVNGKVLVN---------------VHLDSTSSWENVDGKTVQTDYP 308
            :|.|....|...|.||||:||.|:|.||               :.|:.|:..::.
Zfish   253 NVADVGLKVEACAKYTYGQPVPGQVSVNLCRQHFTFIQDPKVTICLNETALMDDT---------- 307

  Fly   309 GHSVVGTADMVGGKAKLTMDLKD-FASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPYR 372
                        |...||..... |.:.|.....:|:. :...:.|..|.|.::::..|.:   .
Zfish   308 ------------GCTSLTFSTSTFFGTSLESSLQNSFV-VNVNITEQGTDVVMSKSATVSI---T 356

  Fly   373 YEMSCTDYSSCFSFKPDKEHELNFKITYVDGSLITDTKSVVKAK-----FTEGIRRNYAFYAFGT 432
            ||:.                    |:|:||.....|..|.:.||     |......|...|....
Zfish   357 YEVG--------------------KVTFVDLPKFYDYGSTINAKISVSDFNGNAISNKVVYLLDR 401

  Fly   433 DHQEPELPTIEKKTFVFESHLNASGVAPFKVVLPDLPDIANFTRYYSI--ELEFVDEKRDLYTTY 495
            ....|::        :|....:.||:|.|.:...:.|. ||.....|:  :|.|.|......|..
Zfish   402 GQWRPKV--------LFNVTTDESGLAEFSLNTTNFPK-ANLYLVASVIPQLWFNDNSPHFTTDS 457

  Fly   496 PYREPKQIENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQVILNSSRPLKY------------FV 548
            ...:..|...|.:....:.....:|:|     ||.|..|.|      .:||            .:
Zfish   458 QVVQLSQTAAPDNPTYSDLSIVSLQQP-----LKCGTTYPV------TVKYTFVGETGDYSADII 511

  Fly   549 YNIVGRGNIL----ETKRVDLAEPQTTVNVT--------IKP-----TFLTTPYGRVYFYYVDET 596
            |.::.||.|:    :|.:...::..||..||        :.|     .|...|...|.      |
Zfish   512 YMVMSRGVIVLHGFKTVQAWASDTLTTGTVTFDLPVHAKMAPMVQILVFSVLPSETVV------T 570

  Fly   597 GEFRY-TEETFSVEVELQNQIEIKAPAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDL 660
            |...: ||:.||.:|.||     .:||...||....|.:.....|..||.|:|||||::.|...|
Zfish   571 GSASFDTEKCFSNQVSLQ-----FSPATAVPGEGSILTVSAQAGSLCGLSAIDQSVLIMQSGGRL 630

  Fly   661 NKES-FNW----RLNGYD---------------TSTPWQGGYSYYPGERTGVVTMTNAYFFYNRT 705
            :.|: ||.    .|:.|.               ...|....|:.:.|  .|:.|.||...   |.
Zfish   631 SAEAMFNLLPVRSLSDYPPGVEDQQNCLNVRPLRDVPTDQAYNTFKG--VGIKTATNLPV---RE 690

  Fly   706 APDYNILTEGFGGSSFAMRKTTVAH---DSHVFHSGAGGPTQAVGFSAESASASAAPVVRKNFAE 767
            .|   .||  :.|.|:......|.:   :|......|..|.: :|......|.|.|..:|..|.|
Zfish   691 PP---CLT--YRGLSYYRNFPGVLYSPVESSDLVLNAPVPVE-LGELVRGDSGSPAVTIRTYFPE 749

  Fly   768 TWIF-----ADIESTEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSV 827
            |||:     .|..||...:     |:|||||.|....|.| ...|.|:. ....:.:|||||:.:
Zfish   750 TWIWQLVTVGDSGSTSVPL-----TVPDTITAWDTEAFCL-ASSGFGLA-PPVLLTSFQPFFLEI 807

  Fly   828 RLPYSVKRGEVINVPALVFNYLPKTLDVELT------------------LDNEDQEYDFVDASNE 874
            .||||:.|||::|:.|.||||||:.:.|::|                  |....::....|.:..
Zfish   808 TLPYSIIRGEILNLKATVFNYLPQCIKVQVTPTPSSNFTLKSIGHYSSHLSANGRKTFKWDLTAS 872

  Fly   875 VIGDQKRTQNIRVGANEAAGASFLIRPKVIGNILLKFKAISPLAG--DAIHKPLKVVPEGITQYQ 937
            |||    |.|:.:.| :|:.:..|...:::         ..|..|  |.:.:.|.|:.||:
Zfish   873 VIG----TINVTISA-QASPSEQLCDNQLV---------TVPSRGHTDIVTRSLLVLAEGV---- 919

  Fly   938 NRAFFIN--LKDTGE-FKNTFELEVPEDVVPDSERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQ 999
            .|.|..|  |...|. .....::..|..|:..|.|.....:||::|..:|||.|||::|.|||||
Zfish   920 ERTFIRNWLLCPKGSILSENVKITFPTKVIQGSARCSVSAIGDIMGRALKNLANLLQMPYGCGEQ 984

  Fly  1000 TMSKLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVR 1064
            .|..|.||.....|||...:||||:.......|..|||..|:|||.|||||:|         |..
Zfish   985 NMIILAPNIYTLQYLKVTAQLTPAIQDTATSYLLSGYQRELNYRHSDGSFSTF---------PYS 1040

  Fly  1065 NGSTWLTAYVLRSFSKIKDIIDLDEQILAKGYEFLLTRQAENGSFTEHGEYFYSSQR----SLLT 1125
            ..:||||.:|:|:|...::...:|..:|....::|:..|..:|.|.:.|..::...:    ..:|
Zfish  1041 PSNTWLTTFVMRTFGLARNFTYIDPNVLQSAKDWLIGTQGSDGCFVQQGTLYHKDMKGGVDDNVT 1105

  Fly  1126 LTANSLLALLEEEKP-NQAAIDKAVAYLSANTAESIELLPKSIAIYALQKA-KAPEAAKQVASLK 1188
            :|...:.::||...| ....|.||:::|.............::..|....| :....|:.:.||:
Zfish  1106 MTGYIVASMLEIGVPVTDPVITKALSFLRPLVGNLGNTYVTALLAYTFSLAGETSTRAQLLNSLR 1170

  Fly  1189 SLAKHEDDRTWWTEDL--DKLRASKNCGRWWCWIWSQDVEITSYALLSLLDSDQET------ADS 1245
            :.|..|.....|::..  |.|.                |||::|.||::|.....|      |:.
Zfish  1171 NTAISEGTTLHWSQTTSGDTLA----------------VEISAYVLLAVLTVQPVTTANLGYANR 1219

  Fly  1246 VLNTVRWLIAQRNGFGGFASSQDTVVGLTALIKFAEKSGYEAAKWEVTVSNKGKREKTEKLNTSE 1310
            ::|   ||:||:|.:|||:|:|||||.|.||..:|.:.........|||.:..........:.:.
Zfish  1220 IVN---WLVAQQNPYGGFSSTQDTVVALQALSMYAAQVFSSGGSSTVTVQSSVPAGDVFNFDVTP 1281

  Fly  1311 ENDLLLQTV---EFPQGTKSLEFEAKGTGAAMVQISYQYNLVEKEPKPSFKIQTTVLP------- 1365
            .|.||.|..   .|| ||.|:  .|.|...|.||:...||:    |.| .::..|:..
Zfish  1282 NNRLLYQESPLNNFP-GTYSV--VAAGAACASVQVLCFYNI----PTP-VRVSKTLSVVAKVSGN 1338

  Fly  1366 -ESSPANLELSVCVDYVEEGESKESNMAILEVSLPSGYTADED------SFADIRNIERVRLVET 1423
             :::|.||.|:....|.  |....:||.::::.|.||:|||..      :||.:  ::||    .
Zfish  1339 CQATPVNLMLTFTAKYT--GPKPTTNMVLVDIKLLSGFTADTSLLGSPPNFAPL--VQRV----D 1395

  Fly  1424 KNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYD-TNKKATEYYS 1480
            ..||. |:||.:.:.|.......|:..:|.||.|.||:.:.:||||. ::...|.|.|
Zfish  1396 SEGDH-VLIYLQEVPKGVPVTFSIQLTQTVAVQNLKPAVINIYDYYQRSDSFETAYKS 1452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	YfaS	<76..1411	CDD:441940	379/1472 (26%)
		A2M_2	982..1279	CDD:239227	98/310 (32%)
		A2M_recep	1387..1480	CDD:462226	31/99 (31%)
a2m3d	XP_073799915.1	None