Protein Alignment Tep4 and c5

DIOPT Version :10

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: XP_001919226.4
• Gene: c5 / 565774
• ZFINID: ZDB-GENE-120510-2
• Length: 1704
• Species: Danio rerio
• Alignment Length: 1660
• Identity: 373/1660 - (22%)
• Similarity: 633/1660 - (38%)
• Gaps: 366/1660 - (22%)

  Fly    37 TIHSHRDYNVAVAVHQTKEPVTLKVGITGPSYNKTETVELATAGEFKQITFKLPPLEAGEYNLTA 101
            |:|.|....:||. ::..:..:||:.... :|..:.|:.: .|.:|       |..:...|..|.
Zfish    51 TVHLHLKNTLAVG-NKEYDYQSLKLNAAN-NYQASATLRI-LAKDF-------PKEDTSVYLQTI 105

  Fly   102 EGVKGLEFKNSTKLNWENFKPYIKIQTDKGKYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDS 166
            ...    |.::.|:.......::.|||||..|.|...:..||..|:|.||....  .|.:.|:|.
Zfish   106 SSA----FTDNVKIPVTTVNGFLFIQTDKPLYTPEQEVQVRVYSLNEELRKSAR--TVTLTFQDP 164

  Fly   167 KRNRIKQEKHIKTTGG-VYTGKFELSEFATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWH 230
            :..:::........|. .....|::......|.|.:.....|.                     .
Zfish   165 RGVKVEIIDMTDINGAKPLLPPFKIPLKPIYGIWKIVATYADN---------------------F 208

  Fly   231 RSDELVNFEVEKYVLPKYSVKMD-ATQQVSVRDGE-FNVVLKANYTYGKPVNGKVLVNVHLD--- 290
            .:.....|||::||||..||::: .|..:|..:.: |.:.:.|.|..|.||..   .|:.|.
Zfish   209 ETTATAEFEVKEYVLPSISVQIEPETNYISEENFDTFKLKISAKYVQGMPVKS---ANILLKFGY 270

  Fly   291 STSSWENVDGKTVQTDYPGHSVVGTADMVGGKAKLTMDLK-------DFASYLPHKTSSSYAQIT 348
            ||.. |.|   .:.:.|..:.      :..||.::.:|::       |...:|.....:::..:.
Zfish   271 STPE-ETV---IIPSTYRSYM------LYNGKMEVDLDIRSALSSKPDAPQFLNAMKENTFLYVE 325

  Fly   349 ATVEEDFTG---------VKLNETGGVQLYPYRYEMSCTDYSSCFSFKPDKEHELNFKITYVDGS 404
            ..::|...|         ||..||      |:...:..|..    ..||...:.:...:....|.
Zfish   326 VLLQESTGGLSQEAVLSHVKFVET------PFTLSIIATPP----FIKPGLPYAMRVLVKDPLGE 380

  Fly   405 LITDTKSVVKAKFT--EGIRRNYAFYAFGTDHQEP-ELPTIEKKTFVFESHLNASGVAPFKVVLP 466
            .:.|....::|..|  :.:..|..|..    ||:. .:|:            :..|||.|...:|
Zfish   381 PVKDVSVTMRATATTVDNLSDNLKFLG----HQDSVTVPS------------SKDGVAYFTCNIP 429

  Fly   467 DLPDIANFTRYYSIELEFVDEKRDLYTTYPYREPKQIENPSSEEEKEWFRAE-----VQRPKDVW 526
                 ||..     ..||..|..|...:         :.|.:.:.:.:....     :..|.:..
Zfish   430 -----ANVK-----NAEFTFETEDASWS---------QGPLTLKAESYVSVNHRYLYIDLPPESS 475

  Fly   527 NLKIGQEYQV-ILNSSR---PLKYFVYNIVGRGNILE---TKRVDLAEPQTTVNVTIKPTFLTTP 584
            ..::||...: ::.|.|   .|..|.|.|:.:|.:::   .|||  :|...::|:.|.|..:  |
Zfish   476 VFEVGQYVDISVVFSYRDYLSLDTFSYQIISKGKVVKYDTVKRV--SEKSQSLNIKITPDMV--P 536

  Fly   585 YGRVYFYYV---DETGEFRYTEETFSVEVELQNQIE-----IKAPAEVKPGADVALEIKTSPK-- 639
            ..|:..|||   :|..|.........|:.:....:.     :|...:.||  ...||||.|.:
Zfish   537 SARLLVYYVLYGEEKAELVADSTWIDVKAKCVKNLNLELSTLKLQDDYKP--KDKLEIKVSSRSK 599

  Fly   640 --SFVGLLAVDQSVLLLGSNNDLNKESFNWRLNGYDTSTPWQGGYSYYP-GERTGVVTMTNAYFF 701
              |.|...|||.::..|.:|.....:.....:...|......||.:... .:|.|::.:|||
Zfish   600 GESLVAFSAVDTALFNLRTNKKDPLKKILQHVEKSDLGCGKGGGKNNADVFDRAGLMFITNA--- 661

  Fly   702 YNRTAPDYNILTEGFGGS-SFAMR-KTTV--------------AHDSHVFHSGAGGPT------- 743
                    |......||: |..:| |.:|              |...:........||
Zfish   662 --------NAKASSAGGTCSDTLRPKRSVDLKKKFEDKAQKYGAFREYCLSGTRSSPTLETCKDR 718

  Fly   744 --------------------------QAVGF-------SAESASASAAPV----------VRKNF 765
                                      |...|       :||:...|.|.:          ||..|
Zfish   719 ANRVTLPNKKTRRDYEKEKYCRLAFEQCCVFAKDLRKENAENIILSRAAIDFLMDAPLSQVRSYF 783

  Fly   766 AETWIFADIESTEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTND-----QTNIKTFQPFFV 825
            .|:|::.:..|....| ...||:||:||.|.:        |.:||.|:     ...|...|..:|
Zfish   784 PESWLWEEHLSKSGSV-SISKTLPDSITTWEL--------KAVGVFNEGICVSDKRIPVSQDIWV 839

  Fly   826 SVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDF-------VDASNEVIGDQKRTQ 883
            .|.||||:.|||.|.:...|:|.....:...:||........|       .|.:||..|
Zfish   840 DVPLPYSMVRGEQILLKGSVYNQRSSGIKFTVTLTASSAVCVFHGAQQGKPDKTNENSG------ 898

  Fly   884 NIRVGANEAAGASFLIRPKVIGNILLKFKAISPLAGDAIHKPLKVVPEGITQYQ--------NRA 940
              :|.....|..||.|.....|...|.|...:....:::.|.|:||||||...:        |..
Zfish   899 --QVAGGSVAMVSFYIMALEAGTHTLTFTLTTDWITESVVKKLRVVPEGIRMEEYIGKRIDPNGV 961

  Fly   941 FFINLKDTGEFKNTFELEVPEDVVPDS--ERVEFGLVGDLLGPVVKNLEN------LLRLPSGCG 997
            |...::.. ||||.    :|..:||.|  :|: ..:.|::||.::..|.|      |..||.|..
Zfish   962 FGTPMRKL-EFKNV----IPPKIVPKSSVDRI-ITVNGEVLGDILSILNNPEGIKMLTNLPRGSA 1020

  Fly   998 EQTMSKLVPNYLVRDYLKSIKKL------TPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTK 1056
            |..:..|:|.|.|..||...:|.      ..|.:..:||.:|.|...::.::..:|...|.
Zfish  1021 ELELMSLLPVYYVYHYLDKTEKWNILGKEAAASEKELKRKMQAGITSIMSFQLKNGEAFSM---- 1081

  Fly  1057 WRQEDPVRNGSTWLTAYVLRSFSKIKDIIDLDEQILAKGYEFLLTR-QAENGSFTE------H-- 1112
            |.|:|  :..|||:||.::::.|.|.:.:.:|..:||....:|:.. |.|:|||:|      |
Zfish  1082 WAQKD--KTPSTWVTALIIKTLSDIHEYVYVDTDVLANAIHWLIKNCQNEDGSFSELAKTNPHKL 1144

  Fly  1113 -GEYFYSSQRSLLTLTANSLLALLEEEK-PN------QAAIDKAVAYL------SANTAESIELL 1163
             |.....:::|:. ||:..::.:....| ||      :.|:|:.:.||      |::..||  |.
Zfish  1145 MGAGVGVTEKSVY-LTSYVMIGIKNALKIPNLKLQVFKDALDRGMQYLISRFRKSSHKIES--LY 1206

  Fly  1164 PKSIAIYALQKAKAPE--AAKQVASLKSLAKHEDDR---TWWTE---DLDKLRASKNCGRWWCWI 1220
            .::||.||:..|...:  |.....::|..||.:.:.   .:|.|   ::|.|:.|.        :
Zfish  1207 VRAIASYAMTVADIDDGTAVNVYENIKKKAKIDGNPPRVCFWQESDTNIDPLKPSS--------V 1263

  Fly  1221 WSQDVEITSYALLSLLD-SDQETADSVLNTVRWLIAQRNGFGGFASSQDTVVGLTALIKFAEKSG 1284
            .::.||.|.|.||:.|. .:.|.|..:||   ||...:...||..|:|||::.|.||..::.|:.
Zfish  1264 TAKSVETTVYVLLNTLTRGETEYAKPILN---WLTQDQRYGGGVYSTQDTILTLEALTMYSIKAR 1325

  Fly  1285 YEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQTVEFPQGTKSLEFEAKGTGAAMVQISYQYNLV 1349
            .......|.:..|.:.|:..::..:::.. :.:.:|..|....:...|..||.:.|::...| .|
Zfish  1326 EANLNMVVDIEYKTRGERISRIQLTQQKP-VAKPIEVTQNDDVIVKTAMSTGVSFVKLKTVY-YV 1388

  Fly  1350 EKEPKPSFKIQTTVLPESSPANLE--------LSVCVDY--VEEGESKESNMAILEVSLPSGYT- 1403
            ..|...|....||:....|..|.:        :..|..:  .|.....||.:.::|::||:|.|
Zfish  1389 MTESNKSCLFDTTIDIHDSDQNSDDPMLLSQRIVACAKFKPPENSLETESALTVMEINLPTGVTP 1453

  Fly  1404 --ADEDSFAD-----IRNIERVRLVETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQKPS 1461
              .|.|.:.:     |.|.|.:       ||. ||:..:::..:...|:.............|.|
Zfish  1454 VLEDLDEYQNGLESRISNYEVI-------GDK-VVLQIDSIPSDNFYCVGFRILEEFETGMTKAS 1510

  Fly  1462 SVVLYDYYDTNKKATEYYSIKS-KLCDICEGDDCK 1495
            ...:|:|.....|.|:.|..:: ||..:||.|.|:
Zfish  1511 EFTVYEYQAPAFKCTKLYQKQTRKLLRLCEEDHCQ 1545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	YfaS	<76..1411	CDD:441940	343/1529 (22%)
		A2M_2	982..1279	CDD:239227	93/340 (27%)
		A2M_recep	1387..1480	CDD:462226	23/100 (23%)
c5	XP_001919226.4	MG1	20..118	CDD:465508	16/80 (20%)
		YfaS	<120..1387	CDD:441940	318/1409 (23%)
		A2M_BRD	468..616	CDD:462235	38/153 (25%)
		ANATO	687..756	CDD:237984	5/68 (7%)
		ISOPREN_C2_like	1005..1320	CDD:415487	92/334 (28%)
		A2M_recep	1436..1529	CDD:462226	23/100 (23%)
		NTR_like	1546..1698	CDD:470599	373/1660 (22%)