DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tep4 and c3a.3

DIOPT Version :9

Sequence 1:NP_001260590.1 Gene:Tep4 / 35248 FlyBaseID:FBgn0041180 Length:1498 Species:Drosophila melanogaster
Sequence 2:NP_001032313.2 Gene:c3a.3 / 565074 ZFINID:ZDB-GENE-990415-37 Length:1651 Species:Danio rerio


Alignment Length:1705 Identity:374/1705 - (21%)
Similarity:662/1705 - (38%) Gaps:428/1705 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 FAVSLCVILALLQTMEPVKAEGKYTIVGPGTIH---------SHRDY-----NVAVAVH----QT 53
            |..::.:..|||...:|:     |.:..|..:.         ..:||     ||.::|.    :.
Zfish     7 FLSAVLLSSALLTLCDPL-----YVLSAPNLLRVGSSENVFVEAQDYSGGPLNVRISVKNFPAKN 66

  Fly    54 KEPVTLKVGITGPSYNKTETVELA------TAGEFKQITFKLPPLEAGEYNLTAEGVKGLEFKNS 112
            .|.:...|.:||..|.....:::.      :..|.||..:    |:|...::|.|.|..:.|::.
Zfish    67 VEMMQKTVTLTGAKYQSLTDIQIPGDRNYFSDDEKKQYVY----LQAHFPSVTLEKVVMVSFQSG 127

  Fly   113 TKLNWENFKPYIKIQTDKGKYKPGDTINYRVIFLDENLRP--------DTAKDEVVVWFEDSKRN 169
                      |:.:||||..|.||..::||:..:..||:|        |....:.:....|:   
Zfish   128 ----------YLFVQTDKPIYTPGSNVHYRIFSMTPNLKPFSKPGITVDITNPQGITVASDT--- 179

  Fly   170 RIKQEKHIKTTGGVYTGKFELSEFATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDE 234
             |..||      ||.:..:.:.|..:||.|.:..:..:.         .:|.|            
Zfish   180 -IFAEK------GVKSSIYNIPEVTSLGMWKVVTRYANT---------PQKTF------------ 216

  Fly   235 LVNFEVEKYVLPKYSVKMDATQQV---------SVRDGEFNVVLKANYTYGKPVNGKVLVNVHLD 290
            ...|||::||||.:.||:..::..         :..|....|.::|.|.:||.::|...|...: 
Zfish   217 TAEFEVKEYVLPTFEVKLKTSKSFYYVGDSKPKNNEDDSLTVDMEAKYLFGKKMDGNAFVVFGV- 280

  Fly   291 STSSWENVDG--KTVQTDYPGHSVVGTADMVG-----GKAKLTMDL--KDFASYLPHKTSSSYAQ 346
                   :||  ||        |:|.:...|.     |.|:||.::  |.|.:.......|.|..
Zfish   281 -------MDGAMKT--------SIVNSLQKVQVFNGVGTAELTREMITKTFKNIKDLVGKSIYVS 330

  Fly   347 ITATVEEDFTGVKLNETGGVQLY--PYRYEMSCTDYSSCFSFKPDKEHELNFKITYVD------- 402
            :....|.....|:. |..|:|:.  ||......|   |.| |||.....::..:|..|       
Zfish   331 VNLLTESGSEMVEA-EKRGIQIVTSPYTIHYKRT---SQF-FKPGMPLGVSVYVTNPDETPAEDV 390

  Fly   403 ---------GSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELPTIEK--KTFVFESHLNAS 456
                     |.:.:.||:...||.|...:...:........::|||...::  ||.:.:::....
Zfish   391 EVEVLVDGVGGVNSKTKANGIAKVTVNTKAGVSTLKITATTRDPELANEQQADKTMIAQAYKTNL 455

  Fly   457 GVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTTYPYREPKQIENPSSEEEKEWFRAEVQR 521
            |                ...|..|.:|                       |:|.|          
Zfish   456 G----------------SKNYLHINIE-----------------------SAEFE---------- 471

  Fly   522 PKDVWNLKIGQEYQVILNSSRPL----KYFVYNIVGRGNILETKRVDLAEPQTTVNVTIKPTFLT 582
                    ||.:..|.||:....    :.|.|.|:.:|.|:..:|.. .:.||.|::::..|...
Zfish   472 --------IGDQMTVYLNTGESPGVKDQDFTYMILSKGQIVLAERFK-RQGQTLVSLSLPVTKDM 527

  Fly   583 TPYGRVYFYYVDETGEFRYTEETFSVEVELQNQIEIKAPAEV-------KPGADVALEIKTSPKS 640
            .|..|...||  ..|:.....:  ||.|::::....|...||       :.|.:|.|:|.....:
Zfish   528 VPSFRFVAYY--HVGKDEVVSD--SVWVDVKDTCMGKLKVEVTEKQKFYETGNEVNLQISGDFGA 588

  Fly   641 FVGLLAVDQSVLLLGSNNDLNKESFNWR-LNGYDTSTPWQGGYSYYPGERTGVVTMTNAYF---- 700
            .|||:.||::|.:|..|.  ..:|..|. :..:||.....||     .:..||.:.....|    
Zfish   589 RVGLVVVDKAVQVLNKNR--LTQSKIWDVIEKHDTGCTGGGG-----KDSMGVFSDAGLMFESDP 646

  Fly   701 ---FYNRTAP-------------DYNILTEGFGGSSFAMRKTTVAHDSHVFHSGAGGPTQAVGFS 749
               ...||.|             ....:|....| .:..:.....:|        |.....:|::
Zfish   647 AGGTNTRTEPKCPAPPKRKRRSESLQTITTTLAG-QYTEKIRPCCYD--------GMRNNRIGYT 702

  Fly   750 AESASASAAPVV--------------------------------------------------RKN 764
            .|   ..|:.|:                                                  ||.
Zfish   703 CE---RRASYVIDGEECVKAFLHCCKEVKNHKETEEEELILARKDDEETYEEDYEDYDDITSRKQ 764

  Fly   765 FAETWIFADI---ESTEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVS 826
            |.|:|::.:.   :...:.....|..:.|:||.|.:...||.|..|:.|...: .|..|:.||:.
Zfish   765 FPESWLWEEFDLCDKCSKPSKNKVTYLKDSITTWQILAISLSPTHGICVAEPE-EIVVFKSFFID 828

  Fly   827 VRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVDASNEVIGDQKRTQ---NIRVG 888
            :::|||..|||.:.:.|::.||.||.|        :....:|::.:.......|:.:   .:.|.
Zfish   829 LKVPYSAVRGEQVEIKAIIHNYTPKHL--------KKVRVEFLETAGVCSAASKKGKYRATVNVD 885

  Fly   889 ANEAAGASFLIRPKVIGNILLKFKAISPLAGDAIHKPLKVVPEGI-TQYQNRAFFINLKDTGEFK 952
            .:.:...||:|.|..:.:..::.||......|.:.|.||||.||: |::|::...:|....||..
Zfish   886 KDSSIAVSFVIVPMTLESQHIEVKASILDYTDGVRKTLKVVSEGVLTKFQSQKLELNPAKKGEQP 950

  Fly   953 NTFELEVPEDVVPD--------------SERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSK 1003
            ......:|.|.||.              |:.:|..:.|..:|.::|.       |.|||||.|:|
Zfish   951 LLLRAGIPGDQVPGTPVHSYITVTGEEISQSIEHAINGSFMGELIKR-------PGGCGEQNMAK 1008

  Fly  1004 LVPNYLVRDYLKSIKKL-TPALDTR--IKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRN 1065
            :....:...||.:..:. :..:|.|  ...:::.||...|.||..|||::.:..|.         
Zfish  1009 MTLPVVATHYLDNTNQWESVGIDRRKVAINHIKTGYDGQLKYRKPDGSYAIWINTP--------- 1064

  Fly  1066 GSTWLTAYVLRSFSKIKDIIDLDEQILAKGYEFL-LTRQAENGSFTEHGEYFYSS-------QRS 1122
            .||||||||.:.|:...|...::|.::....::| :.:|..:|||.|....:..|       |.:
Zfish  1065 SSTWLTAYVAKVFAMANDFFAIEENVICSALKWLVMHKQLPDGSFKEDAPVYDKSIMGGIEGQNT 1129

  Fly  1123 LLTLTANSLLALLEEEK-------PNQAAIDKAVAYLSANTAESIELLPK-----SIAIYALQKA 1175
            .::|||..|:|:.|.::       ....::.||||:|.       :.|||     ::|:.:...|
Zfish  1130 DVSLTAFVLIAMQEGKEICGGTVGSLHESMRKAVAFLK-------DQLPKLTNPYAVALTSYALA 1187

  Fly  1176 KAPEAAKQVASLKSLAKHEDDRTWWTEDLDKLRASKNCGRWWCWIWSQDVEITSYALLSLLDS-D 1239
            .|....|.:..:.| .|..|:|.|...:..                ...:|.|:||:|:|:.: |
Zfish  1188 NADSLNKAILMMHS-TKVNDERFWNVPERQ----------------YYSIEATAYAVLALVKAKD 1235

  Fly  1240 QETADSVLNTVRWLIAQRNGFGGFASSQDTVVGLTALIKF-AEKSGYEAAKWEVTVSNKGKREKT 1303
            .:||.   ..|.||..|::..||:.::|.|::...|:.:: |:..........|.:...|:| ||
Zfish  1236 YDTAG---EAVHWLAKQKSSHGGYDTTQVTIMVFQAVAEYHAQTQDLNNFDLNVELVVPGRR-KT 1296

  Fly  1304 EKLNTSEENDLLLQT--VEFPQGTKSLEFEAKGTGAAMVQI--SYQYNLVEKEPKPSF---KIQT 1361
            ::......|..|.::  |:.   .|.....|||||:|::.:  .|.....||:...:|   .::.
Zfish  1297 DRWTIQRSNVHLARSGNVDL---NKDFTVIAKGTGSAILSVLTLYYARPFEKKTDCTFFDLSVKL 1358

  Fly  1362 TVLPESSP-ANLELSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSFADIRNIE--RVRLVET 1423
            ..:||:.| .|...:..:|:..:.:..::.|.||::.||:|:..||   ||::.:.  :.|.::.
Zfish  1359 DKIPETKPGTNGTYNFILDFFYKNKKNDATMTILDIGLPTGFDIDE---ADLKQLSTGKERYIQK 1420

  Fly  1424 KNGDSV------VVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKKATEYYSIK 1482
            ...:.|      ::||...::....:.:....::|..||..:|:||.:|:||..:.:..:||..:
Zfish  1421 YEKNKVLSERGSLIIYLNKVSHEVSEKLVFRMHKTFNVALLQPASVTIYEYYSPDARCKKYYHPE 1485

  Fly  1483 ---SKLCDICEGDDC 1494
               |.|..:|:||.|
Zfish  1486 REDSALYRLCKGDLC 1500

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep4NP_001260590.1 A2M_N 126..219 CDD:280081 23/100 (23%)
A2M_N_2 528..653 CDD:285005 36/135 (27%)
A2M 768..859 CDD:278630 27/93 (29%)
A2M_2 982..1279 CDD:239227 82/320 (26%)
A2M_comp 1035..1281 CDD:284982 69/267 (26%)
A2M_recep 1389..1479 CDD:284981 23/97 (24%)
c3a.3NP_001032313.2 A2M_N 128..222 CDD:280081 27/124 (22%)
A2M_N_2 463..599 CDD:285005 40/181 (22%)
ANATO 674..737 CDD:237984 8/74 (11%)
A2M 768..861 CDD:278630 27/101 (27%)
complement_C3_C4_C5 987..1272 CDD:239226 84/327 (26%)
A2M_comp 1042..1272 CDD:284982 69/265 (26%)
A2M_recep 1387..1482 CDD:284981 23/97 (24%)
NTR_complement_C3 1502..1649 CDD:239638
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170584187
Domainoid 1 1.000 48 1.000 Domainoid score I11904
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
65.800

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