Protein Alignment Tep4 and c3a.3

DIOPT Version :10

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: NP_001032313.2
• Gene: c3a.3 / 565074
• ZFINID: ZDB-GENE-990415-37
• Length: 1651
• Species: Danio rerio
• Alignment Length: 1705
• Identity: 374/1705 - (21%)
• Similarity: 662/1705 - (38%)
• Gaps: 428/1705 - (25%)

  Fly     7 FAVSLCVILALLQTMEPVKAEGKYTIVGPGTIH---------SHRDY-----NVAVAVH----QT 53
            |..::.:..|||...:|:     |.:..|..:.         ..:||     ||.::|.    :.
Zfish     7 FLSAVLLSSALLTLCDPL-----YVLSAPNLLRVGSSENVFVEAQDYSGGPLNVRISVKNFPAKN 66

  Fly    54 KEPVTLKVGITGPSYNKTETVELA------TAGEFKQITFKLPPLEAGEYNLTAEGVKGLEFKNS 112
            .|.:...|.:||..|.....:::.      :..|.||..:    |:|...::|.|.|..:.|::.
Zfish    67 VEMMQKTVTLTGAKYQSLTDIQIPGDRNYFSDDEKKQYVY----LQAHFPSVTLEKVVMVSFQSG 127

  Fly   113 TKLNWENFKPYIKIQTDKGKYKPGDTINYRVIFLDENLRP--------DTAKDEVVVWFEDSKRN 169
                      |:.:||||..|.||..::||:..:..||:|        |....:.:....|:
Zfish   128 ----------YLFVQTDKPIYTPGSNVHYRIFSMTPNLKPFSKPGITVDITNPQGITVASDT--- 179

  Fly   170 RIKQEKHIKTTGGVYTGKFELSEFATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDE 234
             |..||      ||.:..:.:.|..:||.|.:..:..:.         .:|.|
Zfish   180 -IFAEK------GVKSSIYNIPEVTSLGMWKVVTRYANT---------PQKTF------------ 216

  Fly   235 LVNFEVEKYVLPKYSVKMDATQQV---------SVRDGEFNVVLKANYTYGKPVNGKVLVNVHLD 290
            ...|||::||||.:.||:..::..         :..|....|.::|.|.:||.::|...|...:
Zfish   217 TAEFEVKEYVLPTFEVKLKTSKSFYYVGDSKPKNNEDDSLTVDMEAKYLFGKKMDGNAFVVFGV- 280

  Fly   291 STSSWENVDG--KTVQTDYPGHSVVGTADMVG-----GKAKLTMDL--KDFASYLPHKTSSSYAQ 346
                   :||  ||        |:|.:...|.     |.|:||.::  |.|.:.......|.|..
Zfish   281 -------MDGAMKT--------SIVNSLQKVQVFNGVGTAELTREMITKTFKNIKDLVGKSIYVS 330

  Fly   347 ITATVEEDFTGVKLNETGGVQLY--PYRYEMSCTDYSSCFSFKPDKEHELNFKITYVD------- 402
            :....|.....|:. |..|:|:.  ||......|   |.| |||.....::..:|..|
Zfish   331 VNLLTESGSEMVEA-EKRGIQIVTSPYTIHYKRT---SQF-FKPGMPLGVSVYVTNPDETPAEDV 390

  Fly   403 ---------GSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELPTIEK--KTFVFESHLNAS 456
                     |.:.:.||:...||.|...:...:........::|||...::  ||.:.:::....
Zfish   391 EVEVLVDGVGGVNSKTKANGIAKVTVNTKAGVSTLKITATTRDPELANEQQADKTMIAQAYKTNL 455

  Fly   457 GVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTTYPYREPKQIENPSSEEEKEWFRAEVQR 521
            |                ...|..|.:|                       |:|.|
Zfish   456 G----------------SKNYLHINIE-----------------------SAEFE---------- 471

  Fly   522 PKDVWNLKIGQEYQVILNSSRPL----KYFVYNIVGRGNILETKRVDLAEPQTTVNVTIKPTFLT 582
                    ||.:..|.||:....    :.|.|.|:.:|.|:..:|.. .:.||.|::::..|...
Zfish   472 --------IGDQMTVYLNTGESPGVKDQDFTYMILSKGQIVLAERFK-RQGQTLVSLSLPVTKDM 527

  Fly   583 TPYGRVYFYYVDETGEFRYTEETFSVEVELQNQIEIKAPAEV-------KPGADVALEIKTSPKS 640
            .|..|...||  ..|:.....:  ||.|::::....|...||       :.|.:|.|:|.....:
Zfish   528 VPSFRFVAYY--HVGKDEVVSD--SVWVDVKDTCMGKLKVEVTEKQKFYETGNEVNLQISGDFGA 588

  Fly   641 FVGLLAVDQSVLLLGSNNDLNKESFNWR-LNGYDTSTPWQGGYSYYPGERTGVVTMTNAYF---- 700
            .|||:.||::|.:|..|.  ..:|..|. :..:||.....||     .:..||.:.....|
Zfish   589 RVGLVVVDKAVQVLNKNR--LTQSKIWDVIEKHDTGCTGGGG-----KDSMGVFSDAGLMFESDP 646

  Fly   701 ---FYNRTAP-------------DYNILTEGFGGSSFAMRKTTVAHDSHVFHSGAGGPTQAVGFS 749
               ...||.|             ....:|....| .:..:.....:|        |.....:|::
Zfish   647 AGGTNTRTEPKCPAPPKRKRRSESLQTITTTLAG-QYTEKIRPCCYD--------GMRNNRIGYT 702

  Fly   750 AESASASAAPVV--------------------------------------------------RKN 764
            .|   ..|:.|:                                                  ||.
Zfish   703 CE---RRASYVIDGEECVKAFLHCCKEVKNHKETEEEELILARKDDEETYEEDYEDYDDITSRKQ 764

  Fly   765 FAETWIFADI---ESTEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVS 826
            |.|:|::.:.   :...:.....|..:.|:||.|.:...||.|..|:.|...: .|..|:.||:.
Zfish   765 FPESWLWEEFDLCDKCSKPSKNKVTYLKDSITTWQILAISLSPTHGICVAEPE-EIVVFKSFFID 828

  Fly   827 VRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVDASNEVIGDQKRTQ---NIRVG 888
            :::|||..|||.:.:.|::.||.||.|        :....:|::.:.......|:.:   .:.|.
Zfish   829 LKVPYSAVRGEQVEIKAIIHNYTPKHL--------KKVRVEFLETAGVCSAASKKGKYRATVNVD 885

  Fly   889 ANEAAGASFLIRPKVIGNILLKFKAISPLAGDAIHKPLKVVPEGI-TQYQNRAFFINLKDTGEFK 952
            .:.:...||:|.|..:.:..::.||......|.:.|.||||.||: |::|::...:|....||..
Zfish   886 KDSSIAVSFVIVPMTLESQHIEVKASILDYTDGVRKTLKVVSEGVLTKFQSQKLELNPAKKGEQP 950

  Fly   953 NTFELEVPEDVVPD--------------SERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSK 1003
            ......:|.|.||.              |:.:|..:.|..:|.::|.       |.|||||.|:|
Zfish   951 LLLRAGIPGDQVPGTPVHSYITVTGEEISQSIEHAINGSFMGELIKR-------PGGCGEQNMAK 1008

  Fly  1004 LVPNYLVRDYLKSIKKL-TPALDTR--IKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRN 1065
            :....:...||.:..:. :..:|.|  ...:::.||...|.||..|||::.:..|.
Zfish  1009 MTLPVVATHYLDNTNQWESVGIDRRKVAINHIKTGYDGQLKYRKPDGSYAIWINTP--------- 1064

  Fly  1066 GSTWLTAYVLRSFSKIKDIIDLDEQILAKGYEFL-LTRQAENGSFTEHGEYFYSS-------QRS 1122
            .||||||||.:.|:...|...::|.::....::| :.:|..:|||.|....:..|       |.:
Zfish  1065 SSTWLTAYVAKVFAMANDFFAIEENVICSALKWLVMHKQLPDGSFKEDAPVYDKSIMGGIEGQNT 1129

  Fly  1123 LLTLTANSLLALLEEEK-------PNQAAIDKAVAYLSANTAESIELLPK-----SIAIYALQKA 1175
            .::|||..|:|:.|.::       ....::.||||:|.       :.|||     ::|:.:...|
Zfish  1130 DVSLTAFVLIAMQEGKEICGGTVGSLHESMRKAVAFLK-------DQLPKLTNPYAVALTSYALA 1187

  Fly  1176 KAPEAAKQVASLKSLAKHEDDRTWWTEDLDKLRASKNCGRWWCWIWSQDVEITSYALLSLLDS-D 1239
            .|....|.:..:.| .|..|:|.|...:..                ...:|.|:||:|:|:.: |
Zfish  1188 NADSLNKAILMMHS-TKVNDERFWNVPERQ----------------YYSIEATAYAVLALVKAKD 1235

  Fly  1240 QETADSVLNTVRWLIAQRNGFGGFASSQDTVVGLTALIKF-AEKSGYEAAKWEVTVSNKGKREKT 1303
            .:||.   ..|.||..|::..||:.::|.|::...|:.:: |:..........|.:...|:| ||
Zfish  1236 YDTAG---EAVHWLAKQKSSHGGYDTTQVTIMVFQAVAEYHAQTQDLNNFDLNVELVVPGRR-KT 1296

  Fly  1304 EKLNTSEENDLLLQT--VEFPQGTKSLEFEAKGTGAAMVQI--SYQYNLVEKEPKPSF---KIQT 1361
            ::......|..|.::  |:.   .|.....|||||:|::.:  .|.....||:...:|   .::.
Zfish  1297 DRWTIQRSNVHLARSGNVDL---NKDFTVIAKGTGSAILSVLTLYYARPFEKKTDCTFFDLSVKL 1358

  Fly  1362 TVLPESSP-ANLELSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSFADIRNIE--RVRLVET 1423
            ..:||:.| .|...:..:|:..:.:..::.|.||::.||:|:..||   ||::.:.  :.|.::.
Zfish  1359 DKIPETKPGTNGTYNFILDFFYKNKKNDATMTILDIGLPTGFDIDE---ADLKQLSTGKERYIQK 1420

  Fly  1424 KNGDSV------VVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKKATEYYSIK 1482
            ...:.|      ::||...::....:.:....::|..||..:|:||.:|:||..:.:..:||..:
Zfish  1421 YEKNKVLSERGSLIIYLNKVSHEVSEKLVFRMHKTFNVALLQPASVTIYEYYSPDARCKKYYHPE 1485

  Fly  1483 ---SKLCDICEGDDC 1494
               |.|..:|:||.|
Zfish  1486 REDSALYRLCKGDLC 1500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	YfaS	<76..1411	CDD:441940	334/1522 (22%)
		A2M_2	982..1279	CDD:239227	82/320 (26%)
		A2M_recep	1387..1480	CDD:462226	24/100 (24%)
c3a.3	NP_001032313.2	MG1	22..123	CDD:465508	21/109 (19%)
		YfaS	<127..1339	CDD:441940	308/1410 (22%)
		A2M	768..862	CDD:459711	27/102 (26%)
		complement_C3_C4_C5	987..1272	CDD:239226	84/327 (26%)
		A2M_recep	1385..1483	CDD:462226	24/100 (24%)
		NTR_complement_C3	1502..1649	CDD:239638