Protein Alignment Tep4 and a2m3e

DIOPT Version :10

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: NP_001188334.2
• Gene: a2m3e / 562067
• ZFINID: ZDB-GENE-030131-9306
• Length: 1482
• Species: Danio rerio
• Alignment Length: 1607
• Identity: 410/1607 - (25%)
• Similarity: 653/1607 - (40%)
• Gaps: 339/1607 - (21%)

  Fly    22 EPVKAEGK-YTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGITGPSYNKTETVELATAGEFKQ- 84
            |||...|. :.::.|..|.|..|..:.|::.:.:..:|:.:.:......:|:.|:..:..:..:
Zfish    64 EPVIVNGPIFMVMFPSLIESGSDAKLCVSLLKPEGSLTMTISLVDDKNTETQLVQQTSQRKLHRC 128

  Fly    85 ITFKLPPLEAGEYNLTAEGVKG--LEFKNSTKLNWENFKPYIKIQTDKGKYKPGDTINYRVIFLD 147
            ..|:.|.:...........|:|  :......|:.:.::.|...|||||..|.||.|:|:||:.:.
Zfish   129 FNFQAPQVSGDSVQTVRVVVQGPSITMTEERKVMFRSYLPLTFIQTDKPLYNPGQTVNFRVVTMS 193

  Fly   148 ENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFATLGSWSLHVQNGDQHHDG 212
            :.|.|......:|| .||.:..||.|..::.:|..:.....:|...:.:|.::|..
Zfish   194 DKLVPLDQMYNLVV-LEDFRNIRINQWTNVSSTNWILELSHDLIPESPVGKYTLRA--------- 248

  Fly   213 GIYFGGRKQFGGFGHRWHRSDELV--NFEVEKYVLPKYSVKMDATQQVSVRDGEFNVVLKANYTY 275
              |.|               |.::  :|:|:||||||:.|.::..|..||.|....|.....||:
Zfish   249 --YIG---------------DRIISQSFDVKKYVLPKFDVTLNTPQTYSVADVGLKVEACGKYTF 296

  Fly   276 GKPVNGKVLVNVHLDS---------TSSWENVDGKTVQTDYPGHSVVGTADMVGGKAKLTMDLK- 330
            |:||.|:|.|.|....         ||.......||..|               |.|.|.:...
Zfish   297 GQPVPGQVFVEVCRQPVTYVQDPKVTSVCLKKSTKTTDT---------------GCASLALSTSV 346

  Fly   331 DFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPYRYEMSCTDYSSCFSFKPDKEHELN 395
            .|.:...:...:|:. |...:.|:.|||.::::..|.:   .:|:.
Zfish   347 FFGTSFENNLQNSFV-INVNITEEGTGVVMSKSTTVSI---TFEVG------------------- 388

  Fly   396 FKITYVDGSLITDTKSVVKAK-----FTEGIRRNYAFYAFGTDHQEPELPTIEKKTFVFESHLNA 455
             |:.:||.....:..|.|..|     |......|...|...:. |.|.       ..:|....|.
Zfish   389 -KVKFVDLPKFYNYGSTVNGKISASDFNGNPINNKVVYLLDSS-QWPH-------KMLFNLTTNK 444

  Fly   456 SGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDL--------YTTYPYREP-----------K 501
            :|.|.|.:.....|                  |.||        .:.|.|..|           .
Zfish   445 NGFAEFSLWTTSFP------------------KADLNLVASATPQSYYGYNSPYFTTDSQVVRLS 491

  Fly   502 QIENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQVILNSSRPLKYFV-----------YNIVGRG 555
            :...|.:....:....::::|     ||.|..|.|.:..|     ||           |.::.||
Zfish   492 RTAAPDTPTFSDLSIVKLEQP-----LKCGTTYPVTVTYS-----FVGETGDYSADIIYMVMSRG 546

  Fly   556 NILETKRVDL----AEPQTTVNVTIKPTFLT--TPYGRVYFYYV-----DETGEFRY-TEETFSV 608
            .|:....:.:    ::..|...||...:.:.  .|..::..|.|     ..||...: ||:.||.
Zfish   547 VIILHGFISVQALASDTLTKGTVTFDLSIVAKMAPVVQILVYSVLPSQTVVTGSASFDTEKCFSN 611

  Fly   609 EVELQNQIEIKAPAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKES-FNWRLNGY 672
            :|.||     .:||...||....|.:.....|..||.|:|||||::.|...|:.|: ||
Zfish   612 QVSLQ-----FSPATAVPGEGSILTVSAQAGSLCGLSAIDQSVLIMQSGGRLSAEAVFN------ 665

  Fly   673 DTSTPWQGGYSYYPGERTGVVTMTNAYFFYNRTAPDYNILTEGFGGSSFAMRKTT---------V 728
              ..|.|...:|.||..    ...|.::..:|.|...|.....|  .|..::..|         :
Zfish   666 --LLPLQSLSNYPPGAE----DQQNCFYVRSRRAVPTNQAYNTF--KSVGIKIATNLPVRAPPCM 722

  Fly   729 AHDSHVFHSGAGG--PTQAVGFS-----------AESASASAAPV-VRKNFAETWIF-----ADI 774
            .:...::.....|  |.|...|:           ||.|.:|:..| :|..|.||||:     .|.
Zfish   723 TYKDVIYFPNFRGVVPLQEAVFAMAREAPAPIAKAEVAGSSSVDVTIRTYFPETWIWQLAHVGDS 787

  Fly   775 ESTEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVI 839
            .|:...:     |:|||||.|....|.| ...|.|:.. ...:.:|||||:.:.||||:.|||..
Zfish   788 GSSSVPL-----TVPDTITTWDTEAFCL-SSSGFGLAL-PVLLTSFQPFFLELTLPYSIIRGEFF 845

  Fly   840 NVPALVFNYLPKTLDVELT-----------LDNEDQEYDFVDASNEVIGDQKRTQNIRVGANEAA 893
            .:.|.|||||.:.:.|::|           ||::|..                    .:.||...
Zfish   846 ELKATVFNYLSQCIKVQVTPTPSSNFTLKSLDDQDSS--------------------TISANGRK 890

  Fly   894 GASFLIRPKVIG--NILLKFKAISP---LAG------------DAIHKPLKVVPEGITQYQNRAF 941
            ...:.:...|||  |:.:..:| ||   |.|            |.:.:.|.|:.||:.:...|::
Zfish   891 TFKWALTASVIGTLNVTVSGEA-SPSQELCGNQDVTVPSRGRIDIVTRSLLVLAEGVERTFIRSW 954

  Fly   942 FINLKDTGEFKNTFELEVPEDVVPDSERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSKLVP 1006
            .:..|.| ......::..|.:|:..|.:....::||::|..:|||:||||:|||||||.|..|.|
Zfish   955 LLCPKGT-TLSEVVKITFPTNVIQGSAKCSVSVIGDIMGRALKNLDNLLRMPSGCGEQNMIILAP 1018

  Fly  1007 NYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLT 1071
            |..:..||....:|||.:.......||.|||..|:|||.|||||:||      .||   .:||||
Zfish  1019 NIYILRYLTVTAQLTPVIRDTATGYLQIGYQGELNYRHTDGSFSTFG------YDP---SNTWLT 1074

  Fly  1072 AYVLRSFSKIKDIIDLDEQILAKGYEFLLTRQAENGSFTEHGEYFYSSQR----SLLTLTANSLL 1132
            |:|:|:|...:....:|..:|....::|::.|..:|.|.:.|..::...:    ..:|:|...:|
Zfish  1075 AFVMRTFGLARSFTYIDPNVLKSAKDWLISTQGSDGGFVQQGTLYHKDMKGGVGDNVTMTGYIVL 1139

  Fly  1133 ALLEEEKP-NQAAIDKAVAYLSANTAESIELLPKSIAIYALQKA-KAPEAAKQVASLKSLAKHED 1195
            :|||...| ....|.||:::|.............::..|....| :....|:.:.||::.|..|.
Zfish  1140 SLLEIGVPVTDPVITKALSFLRPLVGNLGNTYVTALLAYTFSLAGETSTRAQLLHSLRNTAISEG 1204

  Fly  1196 DRTWWTEDL--DKLRASKNCGRWWCWIWSQDVEITSYALLSLLDSDQET------ADSVLNTVRW 1252
            ....|::..  |.|.                |||::|.||::|.....|      |:.::|   |
Zfish  1205 TTLHWSQTTSGDTLA----------------VEISAYVLLAVLTVHPVTTANLGYANRIVN---W 1250

  Fly  1253 LIAQRNGFGGFASSQDTVVGLTALIKFAEKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQ 1317
            |:||:|.:|||.|:|||||.|.||..:|.:.........|||.:............:..|.||.|
Zfish  1251 LVAQQNPYGGFTSTQDTVVALQALALYAAQVFSPGGSSTVTVQSSVPAGDVFNFAVTPNNRLLYQ 1315

  Fly  1318 --TVEFPQGTKSLEFEAKGTGAAMVQISYQYNLVEKEPKP-------SFKIQTTVLPESSPANLE 1373
              ::....||.|:  .|:|:..|.||:|..||:    |.|       |...:.|...:::|.||.
Zfish  1316 RNSLNNVPGTYSV--VARGSACASVQVSCFYNI----PTPITVSKTLSVVAKVTGNCQAAPVNLM 1374

  Fly  1374 LSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSFADIRN----IERVRLVETKNGDSVVVIYF 1434
            |:..|.|.  |....:||.::::.:.||:|||........|    ::||.    .:||.|:| |.
Zfish  1375 LTFTVKYT--GPKPTTNMVLVDIKVLSGFTADTSLLGSPPNFTPFVQRVE----SDGDHVLV-YL 1432

  Fly  1435 ENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKK-ATEYYS 1480
            :.:.|.......|:..:..||.|.||:.:.:||||..|.| .|.|.|
Zfish  1433 QEVPKGVPVTFSIQLTQAVAVQNLKPAVIYIYDYYQRNDKFETTYKS 1479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	YfaS	<76..1411	CDD:441940	374/1476 (25%)
		A2M_2	982..1279	CDD:239227	104/310 (34%)
		A2M_recep	1387..1480	CDD:462226	30/97 (31%)
a2m3e	NP_001188334.2	YfaS	<171..1268	CDD:441940	325/1274 (26%)
		A2M_2	994..1269	CDD:239227	99/302 (33%)
		A2M_recep	1386..1477	CDD:462226	29/95 (31%)