DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep4 and c3a.6

DIOPT Version :9

Sequence 1:	NP_001260590.1	Gene:	Tep4 / 35248	FlyBaseID:	FBgn0041180	Length:	1498	Species:	Drosophila melanogaster
Sequence 2:	NP_001008582.4	Gene:	c3a.6 / 494039	ZFINID:	ZDB-GENE-041212-2	Length:	1642	Species:	Danio rerio

Alignment Length:	1695	Identity:	375/1695 - (22%)
Similarity:	659/1695 - (38%)	Gaps:	420/1695 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FAVSLCVILALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAV-AVHQTKEPVTLKVGITG-PSYN 69
            |..::.:..|||...:|:     |.:..|..:......||.| |...:...:.:|:.:.. |..|
Zfish     7 FLSAVLLSSALLTLCDPL-----YVLSAPNLLRVGSSENVFVEAQDYSGGSLIVKISVKNHPRKN 66

  Fly    70 ---KTETVELATAGEFKQIT-FKLP---------PLEAGEYNL-------TAEGVKGLEFKNSTK 114
               .::||.|.....|:.:. .|:|         |||.....|       |.|.|..|.|::.
Zfish    67 LEILSKTVTLTDENNFQILADIKIPSDRDYFSDDPLEKQYVYLQAQFPTHTLEKVVMLSFQSG-- 129

  Fly   115 LNWENFKPYIKIQTDKGKYKPGDTINYRVIFLDENLRP-DTAKDEVVVWFEDSKRNRIKQEKHIK 178
                    ||.:||||..|.||..:.||:..|...|:| :.|...|.:.   ..:......:.|.
Zfish   130 --------YIFVQTDKPIYTPGSNVQYRIFSLTSGLKPLENAGVSVEIM---DPQGITTMRETIF 183

  Fly   179 TTGGVYTGKFELSEFATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKY 243
            ...|:.:||:.:.:.|:.|.|.:..:           |....|          .:...:|||:.|
Zfish   184 PKQGIRSGKYMVPQPASPGIWKVVTR-----------FTNTPQ----------KNYTADFEVKDY 227

  Fly   244 VLPKYSVKMDATQQ-VSVRDGEFNVVLKANYTYGKPVNGK--VLVNVHLDS-----TSSWENV-- 298
            |||.|.|.:..::. .||:|....|.::|.|.:|..|||.  |:..|..|.     .||.:.|
Zfish   228 VLPTYEVTLSPSKSFFSVKDDSLTVSIEARYLHGNNVNGHAFVVFGVMEDDRKTSIPSSLQRVQI 292

  Fly   299 -DGKTVQTDYPGHSVVGTADMVGGKAKLTMD--LKDFASYLPHKTSSSYAQITATVEEDFTGVKL 360
             ||:                   |.||||..  |:.|.........|.|..::...:   :|.:|
Zfish   293 SDGE-------------------GNAKLTKQTILQTFPDISQLVGRSIYISVSVLTD---SGSEL 335

  Fly   361 NET--GGVQLY--PYRYEMSCTDYSSCFSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGI 421
            .|.  .|:|:.  ||......|..    .|||.....::..||
Zfish   336 VEAQRRGIQIVTSPYTINFQKTPQ----FFKPGMPFSVSVYIT---------------------- 374

  Fly   422 RRNYAFYAFGTDHQEP-ELPTIEKKTFV----FESHLNASGVAPFKVVLPDLPDIANFTRYYSIE 481
                          :| ::|....:..|    .:....::|:|...|              .|||
Zfish   375 --------------DPNQMPAENVEVLVNPGGVKGQTKSNGIAKLTV--------------NSIE 411

  Fly   482 ----LEFVDEKRDLYTTYPYREPKQIENPSSEEEKEWFRAEVQRPK--------------DVWNL 528
                ||...:.:|               |..:::::..:..|.:..              |....
Zfish   412 GSSALEITVQTKD---------------PKFDDDQQALKKMVPQAYKTKGSSQNYLHIGIDAAEF 461

  Fly   529 KIGQEYQVILNSSRPL----KYFVYNIVGRGNILETKRVDLAEPQTTVNVTIKPTFLTTPYGRVY 589
            :||.:.:|.||..:..    :.|.|.|:.:|.|::..|.. .:.|..|.:::..|....|..|..
Zfish   462 EIGDQMKVNLNLGKSPGVRDQDFTYMILSKGQIVQADRFK-RQGQALVTLSLPVTKEMVPSFRFV 525

  Fly   590 FYYVDETGEFRYTEETFSVEVELQN------QIEIKAPAEV-KPGADVALEIKTSPKSFVGLLAV 647
            .||  ..|......:  ||.|::::      ::::|.|..: :||.:.:|.|...|.:.|||:||
Zfish   526 AYY--HVGSSEVVSD--SVWVDVKDTCMGTLKVQVKEPRPIYQPGEEFSLLITGDPGAKVGLVAV 586

  Fly   648 DQSVLLLGSNNDLNKESFNWRL-NGYDTSTPWQGGYSYYPGERTGVVTMTNAYFFY--------- 702
            |::|  .|.|.:...::..|.: ..:||.....||       |..:....:|...:
Zfish   587 DKAV--HGLNQNRLTQTKIWDIVEKHDTGCTAGGG-------RDSMGVFIDAGLMFESHTAGGTE 642

  Fly   703 NRTAPD--------------YNILTEGFGGSSFAMRKTTV--AHDSHVFHS-------------- 737
            :||.|:              ..|.|...|..|..:||..|  ..|:.:.::
Zfish   643 SRTVPECVIPSKRRRRAESLQKITTILAGQYSGDLRKCCVDGMRDNKLGYTCERRATYVSDGVEC 707

  Fly   738 ----------------GAGGPTQAVGFSAESASASAAPVV--RKNFAETWIFAD----IESTEEE 780
                            .||.....:..|.||....:...:  |..|.|:|::::    :.|....
Zfish   708 VRAFLHCCNDVVSRSLEAGEEEMILARSEESDYYESFEEITSRTQFPESWLWSEEILPVCSATTS 772

  Fly   781 VFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALV 845
            |.|....:.::||.|.:...||....|:.|. |...:..::.||:.:::|:|..|.|.:.|.|::
Zfish   773 VTKSRIYLKESITTWQIFAVSLSKTHGICVA-DPHEMIVYKMFFIDLKVPFSAVRNEQLQVRAIL 836

  Fly   846 FNYLPKTLDVELTLDNEDQEYDFVDASNEVIGDQKRTQNIRVGANEAAGASFLIRPKVIGN--IL 908
            .||..|  .::..|:.::.::....|||:  |..:  ..:.|.:..:.....:|.|..:||  |.
Zfish   837 HNYTKK--KIKARLEFKETKHICSSASNK--GSYQ--TEVEVESMSSRTIPHVIIPLELGNHWIE 895

  Fly   909 LKFKAISPLAGDAIHKPLKVVPEGI-TQYQNRAFFINLKDTGEFKNTFELEV----PEDVVPD-- 966
            :|..|...:..|.:.|.||||.||: |..|.....:|....|..:   |:.|    |:..||:
Zfish   896 VKAAAFDSVYSDGVKKILKVVSEGVLTMVQETNVELNPAKIGGLQ---EVSVRSGKPDTRVPNTP 957

  Fly   967 ------------SERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKK 1019
                        |:.:|..:.|::       ::..:..|.|.||:.|..:....:...||    .
Zfish   958 ANTYISVTGKDFSKTIEQPIGGEV-------MKQFIVQPRGTGEENMIYMTFPVIATHYL----D 1011

  Fly  1020 LTPALDT--RIKRN-----LQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRS 1077
            :|...||  ..:||     ::.|||..|.:|..||||::...|.         .||||||||.:.
Zfish  1012 ITNQWDTVGMNRRNEAINHIKTGYQRQLTFRKPDGSFAALMTTP---------SSTWLTAYVAKV 1067

  Fly  1078 FSKIKDIIDLDEQILAKGYEFL-LTRQAENGSFTEHGEYFYSSQRSLL-------TLTANSLLAL 1134
            .:...|:..:||.::....::| ..:|..:|.|.|.....:...:..:       :|||..|:|:
Zfish  1068 LTIASDLTVVDESVICSALQWLAANKQLSDGMFKEDSHILHEEMQGAVRGKDADASLTAFVLIAM 1132

  Fly  1135 LE------EEKPN-QAAIDKAVAYLS--ANTAESIELLPKSIAIYALQKAKAPEAAKQVASLKSL 1190
            .|      :...| |::::|||.||:  .:|..|    |.::||.:...|.|.:..|.:  ||..
Zfish  1133 QEGSQICAKSVQNLQSSMNKAVGYLTLRIHTLTS----PYAVAISSYALAHAGKLEKGI--LKRH 1191

  Fly  1191 AKHEDDRTWWTEDLDKLRASKNCGRWWCWIWSQDVEITSYALLSLL-DSDQETADSVLNTVRWLI 1254
            :...|..::|... ..|..|              :|.|.||:|:|: :.|.::|.|   .||||.
Zfish  1192 STQNDAGSFWRVP-GALHLS--------------LEATGYAVLALVKEQDFQSAGS---AVRWLR 1238

  Fly  1255 AQRNGFGGFASSQDTVVGLTALIKFAEKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQT- 1318
            |||..:|...::|.:::...|:.::...:..:....::.:|.:| |:...|...|..|..:.::
Zfish  1239 AQRAAYGAHGTTQASLIVFQAVAEYRTGAKKQDVNLDIQLSVEG-RKTQNKWTFSRSNSHVTRSD 1302

  Fly  1319 -VEFPQGTKSLEFEAKGTGAAMVQI-SYQYNLVEKEPKPSFKIQTTV-----LPESSPANLE--- 1373
             |:..||   ....|.|.|.|.:.: |..|.|.|:........:.:|     |..|.|..:|
Zfish  1303 KVQLAQG---FNVTAHGNGLATLSVYSLYYALPEERENDCKVFELSVQMDKQLEVSHPGAIESYL 1364

  Fly  1374 LSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSFADI-----RNIERVRL-VETKNGDSVVVI 1432
            |::...:  ....:::.|::|:|.|.:|:..|:...:.:     |.|:|..: .|..:.:|:|:|
Zfish  1365 LTIETHF--RSSERDAAMSVLDVGLLTGFKVDDGDLSKLAKGKDRYIDRFEMNKELSDRESLVII 1427

  Fly  1433 YFENLAKNEEKCIRIEAYRTHAVANQ----KPSSVVLYDYYDTNKKATEYY------SIKSKLC- 1486
                |.|...|.....|:|.|.| |:    :|:.|.:|:|...:.:..::|      ...::||
Zfish  1428 ----LNKVSHKVRDRVAFRVHKV-NEVGMLQPAGVTVYEYNTPDDRCVKFYHPHKRDGALNRLCH 1487

  Fly  1487 -DICE 1490
             |:|:
Zfish  1488 EDLCQ 1492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081	22/93 (24%)
		A2M_N_2	528..653	CDD:285005	36/135 (27%)
		A2M	768..859	CDD:278630	23/94 (24%)
		A2M_2	982..1279	CDD:239227	84/321 (26%)
		A2M_comp	1035..1281	CDD:284982	72/263 (27%)
		A2M_recep	1389..1479	CDD:284981	25/99 (25%)
c3a.6	NP_001008582.4	A2M_N	130..224	CDD:280081	26/117 (22%)
		A2M_N_2	454..590	CDD:285005	36/140 (26%)
		ANATO	669..733	CDD:237984	8/63 (13%)
		A2M	756..849	CDD:278630	23/95 (24%)
		complement_C3_C4_C5	979..1263	CDD:239226	85/327 (26%)
		A2M_comp	1033..1263	CDD:284982	72/262 (27%)
		A2M_recep	1380..1473	CDD:284981	25/97 (26%)
		NTR_complement_C3	1493..1640	CDD:239638	375/1695 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584191
Domainoid	1	1.000	48	1.000	Domainoid score	I11904
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.940