Protein Alignment Tep4 and c3a.6

DIOPT Version :10

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: NP_001008582.4
• Gene: c3a.6 / 494039
• ZFINID: ZDB-GENE-041212-2
• Length: 1642
• Species: Danio rerio
• Alignment Length: 1695
• Identity: 375/1695 - (22%)
• Similarity: 659/1695 - (38%)
• Gaps: 420/1695 - (24%)

  Fly     7 FAVSLCVILALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAV-AVHQTKEPVTLKVGITG-PSYN 69
            |..::.:..|||...:|:     |.:..|..:......||.| |...:...:.:|:.:.. |..|
Zfish     7 FLSAVLLSSALLTLCDPL-----YVLSAPNLLRVGSSENVFVEAQDYSGGSLIVKISVKNHPRKN 66

  Fly    70 ---KTETVELATAGEFKQIT-FKLP---------PLEAGEYNL-------TAEGVKGLEFKNSTK 114
               .::||.|.....|:.:. .|:|         |||.....|       |.|.|..|.|::.
Zfish    67 LEILSKTVTLTDENNFQILADIKIPSDRDYFSDDPLEKQYVYLQAQFPTHTLEKVVMLSFQSG-- 129

  Fly   115 LNWENFKPYIKIQTDKGKYKPGDTINYRVIFLDENLRP-DTAKDEVVVWFEDSKRNRIKQEKHIK 178
                    ||.:||||..|.||..:.||:..|...|:| :.|...|.:.   ..:......:.|.
Zfish   130 --------YIFVQTDKPIYTPGSNVQYRIFSLTSGLKPLENAGVSVEIM---DPQGITTMRETIF 183

  Fly   179 TTGGVYTGKFELSEFATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKY 243
            ...|:.:||:.:.:.|:.|.|.:..:           |....|          .:...:|||:.|
Zfish   184 PKQGIRSGKYMVPQPASPGIWKVVTR-----------FTNTPQ----------KNYTADFEVKDY 227

  Fly   244 VLPKYSVKMDATQQ-VSVRDGEFNVVLKANYTYGKPVNGK--VLVNVHLDS-----TSSWENV-- 298
            |||.|.|.:..::. .||:|....|.::|.|.:|..|||.  |:..|..|.     .||.:.|
Zfish   228 VLPTYEVTLSPSKSFFSVKDDSLTVSIEARYLHGNNVNGHAFVVFGVMEDDRKTSIPSSLQRVQI 292

  Fly   299 -DGKTVQTDYPGHSVVGTADMVGGKAKLTMD--LKDFASYLPHKTSSSYAQITATVEEDFTGVKL 360
             ||:                   |.||||..  |:.|.........|.|..::...:   :|.:|
Zfish   293 SDGE-------------------GNAKLTKQTILQTFPDISQLVGRSIYISVSVLTD---SGSEL 335

  Fly   361 NET--GGVQLY--PYRYEMSCTDYSSCFSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGI 421
            .|.  .|:|:.  ||......|..    .|||.....::..||
Zfish   336 VEAQRRGIQIVTSPYTINFQKTPQ----FFKPGMPFSVSVYIT---------------------- 374

  Fly   422 RRNYAFYAFGTDHQEP-ELPTIEKKTFV----FESHLNASGVAPFKVVLPDLPDIANFTRYYSIE 481
                          :| ::|....:..|    .:....::|:|...|              .|||
Zfish   375 --------------DPNQMPAENVEVLVNPGGVKGQTKSNGIAKLTV--------------NSIE 411

  Fly   482 ----LEFVDEKRDLYTTYPYREPKQIENPSSEEEKEWFRAEVQRPK--------------DVWNL 528
                ||...:.:|               |..:::::..:..|.:..              |....
Zfish   412 GSSALEITVQTKD---------------PKFDDDQQALKKMVPQAYKTKGSSQNYLHIGIDAAEF 461

  Fly   529 KIGQEYQVILNSSRPL----KYFVYNIVGRGNILETKRVDLAEPQTTVNVTIKPTFLTTPYGRVY 589
            :||.:.:|.||..:..    :.|.|.|:.:|.|::..|.. .:.|..|.:::..|....|..|..
Zfish   462 EIGDQMKVNLNLGKSPGVRDQDFTYMILSKGQIVQADRFK-RQGQALVTLSLPVTKEMVPSFRFV 525

  Fly   590 FYYVDETGEFRYTEETFSVEVELQN------QIEIKAPAEV-KPGADVALEIKTSPKSFVGLLAV 647
            .||  ..|......:  ||.|::::      ::::|.|..: :||.:.:|.|...|.:.|||:||
Zfish   526 AYY--HVGSSEVVSD--SVWVDVKDTCMGTLKVQVKEPRPIYQPGEEFSLLITGDPGAKVGLVAV 586

  Fly   648 DQSVLLLGSNNDLNKESFNWRL-NGYDTSTPWQGGYSYYPGERTGVVTMTNAYFFY--------- 702
            |::|  .|.|.:...::..|.: ..:||.....||       |..:....:|...:
Zfish   587 DKAV--HGLNQNRLTQTKIWDIVEKHDTGCTAGGG-------RDSMGVFIDAGLMFESHTAGGTE 642

  Fly   703 NRTAPD--------------YNILTEGFGGSSFAMRKTTV--AHDSHVFHS-------------- 737
            :||.|:              ..|.|...|..|..:||..|  ..|:.:.::
Zfish   643 SRTVPECVIPSKRRRRAESLQKITTILAGQYSGDLRKCCVDGMRDNKLGYTCERRATYVSDGVEC 707

  Fly   738 ----------------GAGGPTQAVGFSAESASASAAPVV--RKNFAETWIFAD----IESTEEE 780
                            .||.....:..|.||....:...:  |..|.|:|::::    :.|....
Zfish   708 VRAFLHCCNDVVSRSLEAGEEEMILARSEESDYYESFEEITSRTQFPESWLWSEEILPVCSATTS 772

  Fly   781 VFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALV 845
            |.|....:.::||.|.:...||....|:.|. |...:..::.||:.:::|:|..|.|.:.|.|::
Zfish   773 VTKSRIYLKESITTWQIFAVSLSKTHGICVA-DPHEMIVYKMFFIDLKVPFSAVRNEQLQVRAIL 836

  Fly   846 FNYLPKTLDVELTLDNEDQEYDFVDASNEVIGDQKRTQNIRVGANEAAGASFLIRPKVIGN--IL 908
            .||..|  .::..|:.::.::....|||:  |..:  ..:.|.:..:.....:|.|..:||  |.
Zfish   837 HNYTKK--KIKARLEFKETKHICSSASNK--GSYQ--TEVEVESMSSRTIPHVIIPLELGNHWIE 895

  Fly   909 LKFKAISPLAGDAIHKPLKVVPEGI-TQYQNRAFFINLKDTGEFKNTFELEV----PEDVVPD-- 966
            :|..|...:..|.:.|.||||.||: |..|.....:|....|..:   |:.|    |:..||:
Zfish   896 VKAAAFDSVYSDGVKKILKVVSEGVLTMVQETNVELNPAKIGGLQ---EVSVRSGKPDTRVPNTP 957

  Fly   967 ------------SERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKK 1019
                        |:.:|..:.|::       ::..:..|.|.||:.|..:....:...||    .
Zfish   958 ANTYISVTGKDFSKTIEQPIGGEV-------MKQFIVQPRGTGEENMIYMTFPVIATHYL----D 1011

  Fly  1020 LTPALDT--RIKRN-----LQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRS 1077
            :|...||  ..:||     ::.|||..|.:|..||||::...|.         .||||||||.:.
Zfish  1012 ITNQWDTVGMNRRNEAINHIKTGYQRQLTFRKPDGSFAALMTTP---------SSTWLTAYVAKV 1067

  Fly  1078 FSKIKDIIDLDEQILAKGYEFL-LTRQAENGSFTEHGEYFYSSQRSLL-------TLTANSLLAL 1134
            .:...|:..:||.::....::| ..:|..:|.|.|.....:...:..:       :|||..|:|:
Zfish  1068 LTIASDLTVVDESVICSALQWLAANKQLSDGMFKEDSHILHEEMQGAVRGKDADASLTAFVLIAM 1132

  Fly  1135 LE------EEKPN-QAAIDKAVAYLS--ANTAESIELLPKSIAIYALQKAKAPEAAKQVASLKSL 1190
            .|      :...| |::::|||.||:  .:|..|    |.::||.:...|.|.:..|.:  ||..
Zfish  1133 QEGSQICAKSVQNLQSSMNKAVGYLTLRIHTLTS----PYAVAISSYALAHAGKLEKGI--LKRH 1191

  Fly  1191 AKHEDDRTWWTEDLDKLRASKNCGRWWCWIWSQDVEITSYALLSLL-DSDQETADSVLNTVRWLI 1254
            :...|..::|... ..|..|              :|.|.||:|:|: :.|.::|.|   .||||.
Zfish  1192 STQNDAGSFWRVP-GALHLS--------------LEATGYAVLALVKEQDFQSAGS---AVRWLR 1238

  Fly  1255 AQRNGFGGFASSQDTVVGLTALIKFAEKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQT- 1318
            |||..:|...::|.:::...|:.::...:..:....::.:|.:| |:...|...|..|..:.::
Zfish  1239 AQRAAYGAHGTTQASLIVFQAVAEYRTGAKKQDVNLDIQLSVEG-RKTQNKWTFSRSNSHVTRSD 1302

  Fly  1319 -VEFPQGTKSLEFEAKGTGAAMVQI-SYQYNLVEKEPKPSFKIQTTV-----LPESSPANLE--- 1373
             |:..||   ....|.|.|.|.:.: |..|.|.|:........:.:|     |..|.|..:|
Zfish  1303 KVQLAQG---FNVTAHGNGLATLSVYSLYYALPEERENDCKVFELSVQMDKQLEVSHPGAIESYL 1364

  Fly  1374 LSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSFADI-----RNIERVRL-VETKNGDSVVVI 1432
            |::...:  ....:::.|::|:|.|.:|:..|:...:.:     |.|:|..: .|..:.:|:|:|
Zfish  1365 LTIETHF--RSSERDAAMSVLDVGLLTGFKVDDGDLSKLAKGKDRYIDRFEMNKELSDRESLVII 1427

  Fly  1433 YFENLAKNEEKCIRIEAYRTHAVANQ----KPSSVVLYDYYDTNKKATEYY------SIKSKLC- 1486
                |.|...|.....|:|.|.| |:    :|:.|.:|:|...:.:..::|      ...::||
Zfish  1428 ----LNKVSHKVRDRVAFRVHKV-NEVGMLQPAGVTVYEYNTPDDRCVKFYHPHKRDGALNRLCH 1487

  Fly  1487 -DICE 1490
             |:|:
Zfish  1488 EDLCQ 1492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	YfaS	<76..1411	CDD:441940	335/1522 (22%)
		A2M_2	982..1279	CDD:239227	84/321 (26%)
		A2M_recep	1387..1480	CDD:462226	26/108 (24%)
c3a.6	NP_001008582.4	MG1	22..125	CDD:465508	23/107 (21%)
		MG2	130..224	CDD:426464	26/117 (22%)
		MG3	227..306	CDD:465509	29/97 (30%)
		MG4	352..442	CDD:465507	20/158 (13%)
		A2M_BRD	452..593	CDD:462235	37/147 (25%)
		ANATO	669..733	CDD:237984	8/63 (13%)
		A2M	756..850	CDD:459711	24/96 (25%)
		complement_C3_C4_C5	979..1263	CDD:239226	85/327 (26%)
		A2M_recep	1376..1474	CDD:462226	25/102 (25%)
		NTR_complement_C3	1493..1640	CDD:239638	375/1695 (22%)