Protein Alignment Tep4 and Mcr

DIOPT Version :9

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Alignment Length: 1752
• Identity: 414/1752 - (23%)
• Similarity: 693/1752 - (39%)
• Gaps: 428/1752 - (24%)

  Fly    15 LALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLK-------VGITGPSYNKTE 72
            |..|.:.||........:|.||.|     |.|:|::.|.:.|:|:.       |.|:|.|.:..|
  Fly   122 LESLHSREPTYFIVASRMVRPGLI-----YQVSVSILQAQYPITVHASIACDGVQISGDSKDVKE 181

  Fly    73 TVELATAGEFKQITFKLPPLE-AGEYNLTAEG-----VKGLEFKNSTKLNWENFKPYIKIQTDKG 131
            .:.       :.:..::||.. .|.|.|..||     ..||.|.|.|:|::......|.:||||.
  Fly   182 GIP-------ETLLMRIPPTSVTGSYKLRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQTDKP 239

  Fly   132 KYKPGDTINYRVIFLDENLRP-DTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFAT 195
            .|..|:|:.:|.|.:...|:. |...|   |:..|..|:.:|:....::..|..:.:::||:..|
  Fly   240 LYMQGETVRFRTIPITTELKGFDNPVD---VYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQPT 301

  Fly   196 LGSWSLHV-QNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQQVS 259
            .|.|::.| ..|.|                         |..:|.||:|...::.|.:.......
  Fly   302 FGEWTIRVIAQGQQ-------------------------EESHFTVEEYYQTRFEVNVTMPAYFF 341

  Fly   260 VRDGEFNVVLKANYTYGKPVNGKVLVNV----------------------HLDSTS----SWE-N 297
            ..|......:.||:|.|.||.|.:.:..                      .|:.|:    .|. |
  Fly   342 TTDPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYN 406

  Fly   298 VDGKTVQTDYPGHSVVGTADMVGGKAKLTMDLKDFASYL-----------------PHKTSSSYA 345
            ...:..|..|   :|.|.....|  |.|:.|:.....|:                 |....|||.
  Fly   407 NPNQNPQVQY---NVPGQLPQDG--ADLSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYE 466

  Fly   346 QITATVEEDFTGVKLNETGGVQLYPY-RYEMSCTDYSSCFSFK-PDKEHEL---NFKITYVDGSL 405
            ..:.|..:..              || ||      ::..|.|| |.:|.||   |...:.|   |
  Fly   467 AWSGTYRKTL--------------PYLRY------FNGTFDFKWPLRELELLVPNLANSEV---L 508

  Fly   406 ITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELPTIEKKTFVFESHLNA--SGVAPFKVVLPDL 468
            ||.|   |..||.:.|...|:.                  ..|:.|.|..  .|.:| :|..|.:
  Fly   509 ITAT---VGEKFYDEIISGYSV------------------ARVYNSSLRVVFLGDSP-QVFKPAM 551

  Fly   469 PDIANFTRYYSIELE-------------------FVDEKRDLYTTYP-YREPKQIENPSSEEEKE 513
            |    ||.|.::|..                   ||:.:......:| .|.|...::....|.|.
  Fly   552 P----FTTYLAVEYHDGSPIDPNLLRQGLMEVSGFVESRNGGRRDWPAQRLPMSQQSDGIWEVKI 612

  Fly   514 WFRAEV---QRPK------DVWNLKI-------------------------GQEYQVILNSSRP- 543
            ..|.::   .||:      .|.|:::                         .|..:|..::.:|
  Fly   613 DIRNDLNLDDRPQARDFLNGVQNMRLQANFVDPRGERIQTELLLVSHYSPRNQHIKVTTSTEKPV 677

  Fly   544 --------------LKYFVYNIVGRGNILETKRVDLAEPQTTVNVTIKPTFLTTPYGRVYFYYVD 594
                          |:.|.|.|:.:|.||...|..:.|...|:.|.:....  .|...:..:.::
  Fly   678 VGEYIIFHIRTNFYLEEFNYLIMSKGVILVNDRETITEGIKTIAVVLSSEM--APVATIVVWKIN 740

  Fly   595 ETGEFRYTEETFSVEVELQNQIEI-----KAPAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLL 654
            :.|:......||.|....:|...:     ||    :.|..|.:.|...|.|:|||..:|.:...:
  Fly   741 QQGQVVADSLTFPVNGISRNNFTVYINNRKA----RTGEKVEVAIFGEPGSYVGLSGIDSAFYTM 801

  Fly   655 GSNNDLNKESFNWRLNGYDTSTPWQGGYS--------------YYPG-----------ERTGVVT 694
            .:.|:|.......:::.:|..|  .|.|.              |:|.           |.:|::.
  Fly   802 QAGNELTYAKIITKMSNFDEQT--NGTYKHIWYSHEGNPDELVYFPASSFGVDANRTFEYSGLIV 864

  Fly   695 MTNAYF-----FYNRTAPDYNILTEGFG----GSSFAMRKT----------TVAHDSHVFHSGAG 740
            .|:.|.     ..|||.        |||    |..:.:.|.          |...:.|     |.
  Fly   865 FTDGYVPRRQDTCNRTL--------GFGECLSGRCYRLEKQCDGLFDCDDGTDEINCH-----AR 916

  Fly   741 GPTQAVGFSAESASASAAPVVRKNFAETWIFADIESTEEEVFKWVKTIPDTITNWVVTGFSLHPQ 805
            ..|:.:.:.....:.     |.:::...|::.|:.......:.:...:||....|:|:.||:.|.
  Fly   917 NDTELLNYRKYRFNR-----VLRHYENVWLWKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPS 976

  Fly   806 KGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVD 870
            ||.|:.|........||||::|.:|.:.::||.:.:...||||:...::..:.| ::..:|.||.
  Fly   977 KGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVL-HDSPDYKFVH 1040

  Fly   871 ASNEVIGDQKRTQNIRVGAN--------EAAGASFL---IRPKVIGNILLKFKAISPLAGDAIHK 924
            ...:.|   .|:.|.|....        ||.|.:.:   :.|:.:||:.:.....:.|..|.|.:
  Fly  1041 VEEDGI---VRSYNPRTSFGEHQFFIYLEAQGTTVVYVPVVPQRLGNVDVTLHVATLLGTDTITR 1102

  Fly   925 PLKVVPEGITQYQNRAFFINLKDTG---EFKN---TFELEVPEDV----VPDSERVEFGLVGDLL 979
            .|.|..:|:.||::::..::|.:..   |:.:   |...|:|..|    |..|.:....:|||::
  Fly  1103 TLHVESDGLPQYRHQSVLLDLSNRAYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKARISVVGDVV 1167

  Fly   980 GPVVK----NLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHML 1040
            ||:..    |..:||.||...|||.......|.....|::.|.:....|:.....::..|||..|
  Fly  1168 GPIFPTMPVNASSLLSLPMESGEQNAFSFAANLYTIMYMRLINQRNKTLEKNAFYHMNIGYQRQL 1232

  Fly  1041 HYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLR-----SFSKIKDIIDLDEQILAKGYEFLL 1100
            .:...|||||.| .:.|...|    .|.|||:|.||     ||.:.::.|.:|..|:.|...:||
  Fly  1233 SFMRPDGSFSLF-RSDWNNSD----SSVWLTSYCLRVFQEASFYEWENFIWIDATIIEKNMRWLL 1292

  Fly  1101 TRQAENGSFTEHGEYFYSSQRSL--------LTLTANSLLALLEEEKPN-------QAAIDKAVA 1150
            ..|...|||.   |..:...|.:        :|||::.|:.|...:..:       ..|..:|:|
  Fly  1293 QHQTPQGSFF---EVTWLPDRKMNRTNFDKNITLTSHVLITLATVKDISGTLGSRVALATQRALA 1354

  Fly  1151 YLSANTAESIELL-----PKSIAI--YALQKAKAPEAAKQVASLKSLAKHEDDRTWW-TEDLD-- 1205
            |:..|    ::.|     |..:||  ||||...:|.|.:..|.|:..|:...|..:| .:::.
  Fly  1355 YIERN----MDFLRHQAQPFDVAITAYALQLCNSPIAEEVFAILRRQARTIGDFMYWGNQEIPQP 1415

  Fly  1206 --KLRASKNCGRWWCWIW-----------SQDVEITSYALLSLLDSDQETADSVLNTVRWLIAQR 1257
              ||...|         |           |.::|.|:||||..:...:...|.:   ||||.:||
  Fly  1416 PRKLENQK---------WFSLPRLPYEYDSLNIETTAYALLVYVARREFFVDPI---VRWLNSQR 1468

  Fly  1258 NGFGGFASSQDTVVGLTALIKFAEKSGY-EAAKWEVTVSNKGKREKTEKLNTSEENDLLLQTVEF 1321
            ...||:||:|||...|.||:::..:|.. |.:...|.:....:..||:.|...:.|...||::|.
  Fly  1469 LNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEASSQGGKTQTLYIDDTNLAKLQSIEI 1533

  Fly  1322 PQGTKSLEFEAKGTGAAMVQISYQYNL-VE----KEPKPSFKIQT-TVLPESSPANLELSVCVDY 1380
            |....:::.:|||.|.|::|:..|||: :|    |.|.|:|.:.| .:....:.:::....|.::
  Fly  1534 PDAWGTIKVQAKGAGYAILQMHVQYNVDIEKFQTKPPVPAFGLHTKAIFHGRNQSHISYVACQNW 1598

  Fly  1381 VEEGESKESNMAILEVSLPSGYTADE---DSFA---DIRNIERVRLVETKNGDSVVVIYFENLAK 1439
            :.:.||:.|.||:|:|::|:||...:   |::.   .:||:.|.|.:|.|     :|.||:.| .
  Fly  1599 INQNESERSGMAVLDVAIPTGYWIQQQKLDTYVLSNRVRNLRRARYLERK-----IVFYFDYL-D 1657

  Fly  1440 NEEKCIRIEAYRTHAVAN-QKPSSVVLYDYYDTNK------KATEYYSIKSKLCDICEGDDC 1494
            :|:.|:.....|.:.||| .:...|.:||||...:      .|...|.:  .:|::|....|
  Fly  1658 HEDICVNFTIERWYPVANMSRYLPVRIYDYYAPERFNESIFDALPTYLL--NICEVCGSSQC 1717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081	25/94 (27%)
		A2M_N_2	528..653	CDD:285005	31/169 (18%)
		A2M	768..859	CDD:278630	25/90 (28%)
		A2M_2	982..1279	CDD:239227	98/343 (29%)
		A2M_comp	1035..1281	CDD:284982	86/288 (30%)
		A2M_recep	1389..1479	CDD:284981	31/102 (30%)
Mcr	NP_524688.1	A2M_N	232..332	CDD:280081	31/127 (24%)
		A2M_N_2	669..799	CDD:285005	30/135 (22%)
		LDLa	886..913	CDD:238060	3/26 (12%)
		A2M	940..1030	CDD:278630	25/89 (28%)
		ISOPREN_C2_like	1177..1490	CDD:298658	98/336 (29%)
		A2M_comp	1226..1492	CDD:284982	86/289 (30%)
		A2M_recep	1607..1695	CDD:284981	30/93 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2373
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	76	1.000	Inparanoid score	I382
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10215at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.970