Protein Alignment Tep4 and C4b

DIOPT Version :9

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: NP_001002805.1
• Gene: C4b / 406161
• RGDID: 1591983
• Length: 1737
• Species: Rattus norvegicus
• Alignment Length: 1718
• Identity: 403/1718 - (23%)
• Similarity: 672/1718 - (39%)
• Gaps: 441/1718 - (25%)

  Fly    47 AVAVHQTKEPVTLKVGITGPSYNKTETVELATAGEFKQITFKLPPLE----AGEYNL-TAEGVKG 106
            |.|..:.|..|.|:...:||...|.: .:|::..:|..:..:: |||    .|.::| .|..::.
  Rat    46 APAGQEVKGSVYLRNPTSGPCSPKKD-FKLSSGNDFVLLRLEV-PLEDVRNCGLFDLRRAPHIQL 108

  Fly   107 LEF----KNS---------TKLNWENFKPYIKIQTDKGKYKPGDTINYRVIFLDENLRPDTAKDE 158
            :.:    ||:         ..|.:.:.:.:|.:|||:..|.||..:.|||..||:.:||.|  |.
  Rat   109 VAYSPWLKNTAPKATETQGVNLLFSSRRGHIFVQTDQPIYNPGQRVRYRVFALDQKMRPST--DT 171

  Fly   159 VVVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFATLGSWSLHVQNGDQHHDGGIYFGGRKQFG 223
            :.|..|:|...|:: :|.:.....::|..|.:.:.:..|:|.:..:..|     |:
  Rat   172 LTVTVENSHGLRVR-KKVVFAPTSIFTDDFVIPDISEPGTWKISARFSD-----GL--------- 221

  Fly   224 GFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQQV-----SVRDGEFNVVLKANYTYGKPVNGKV 283
                   .|:...:|||:|||||.:.||:...:..     |.|: |..:.::|.|.|||||.|..
  Rat   222 -------ESNRSTHFEVKKYVLPNFEVKLTPWKPYILTVPSYRE-EIQLDIQARYVYGKPVQGVA 278

  Fly   284 LVNVHL-DSTSSWENVDGKTVQTDYPGHSVVGTADMVGGKAKLTMDLKDFASYLPHKTSSSYAQI 347
            .....| |.......:.|...||           .:|.|:..:::....|.:.|        .::
  Rat   279 YTRFALMDEQGKKTFLRGLETQT-----------KLVEGQTHISISRDQFQAAL--------GKV 324

  Fly   348 TATVEEDFTGVKLN------ETGGVQLYPYRYEMSCTDY---SSCFS--FKPDKEH-------EL 394
            ...: .|..|::|.      |:.|.::    .|...|.:   ||.||  ....|:|       .|
  Rat   325 NTEI-GDLEGLRLYAAVAVIESPGGEM----EEAELTSWPFVSSAFSLDLSHTKQHLVPGAPFLL 384

  Fly   395 NFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELPTIEKKTFVFESHLNASGVA 459
            ...:..:.||..:|....|.|....|                     .:.|...|:.:.|..|..
  Rat   385 QALVREMSGSEASDVPVKVSATLLSG---------------------SDSKVLDFQQNTNGIGQV 428

  Fly   460 PFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTTY--------PYREP--KQIENPSSEEEKEW 514
            .|.:.:|  |.|.        ||..:.....||...        |.|.|  ..||
  Rat   429 SFSIHVP--PTIT--------ELRLLVSAGSLYPAVAKLTVQAPPSRGPGFLSIE---------- 473

  Fly   515 FRAEVQRPKDVWNLKIGQEYQVILNSSR------PLKYFVYNIVGRGNILETKRVDLAEPQTT-- 571
                   |.|:.:.::|..:  |||...      ...::.|.|:.||.|:...|    ||:||
  Rat   474 -------PLDLRSPRVGDTF--ILNLRTVGIPVPTFSHYYYMIISRGQIMAMSR----EPRTTLT 525

  Fly   572 -----VNVTIKPTFLTTPYGRVYFYYVDETGEFRYTEETFSVEV---ELQNQIEIKAPA--EVKP 626
                 |:..:.|:|    |...|||:     :......:..:.|   :.:.::|:|...  |.:.
  Rat   526 SISVLVDHHLAPSF----YFVAYFYH-----QGLPVANSLLINVQPGDCEGKLELKVDGAKEYRN 581

  Fly   627 GADVALEIKTSPKSFVGLLAVDQSVLLLGSNN----DLNK-----ESFNWRL---NGYDTSTPWQ 679
            |..:.|:::|..::.|.|.|||.::..:|..:    |::|     .|:|...   .|.|....:|
  Rat   582 GESMKLQLQTDSEALVALGAVDTALYAVGGRSHKPLDMSKVFEVMNSYNLGCGPGGGDDALQVFQ 646

  Fly   680 -GGYSYYPGERTGVVTMT----------------NAYF-------FYNRTAPDYNILTEGFGGSS 720
             .|.::..|:|   :|.|                |..|       ....::||.....:. |.:.
  Rat   647 TAGLAFSDGDR---LTQTKEDLSCPKEKISRQKRNVNFQKAISEKLGQYSSPDTKRCCQD-GMTK 707

  Fly   721 FAMRKTTVAHDSHVFHSGAGGPTQAVGFSAE---------SASASAAP--------------VVR 762
            ..|.:|.....:.|.......|..:....||         .|..:.|.              :||
  Rat   708 LPMARTCEQRAARVPQPACREPFLSCCKFAEDLRRNQTRSQAGLARAQNVMQEEDLIDEDDILVR 772

  Fly   763 KNFAETWIFADIESTEEE--VFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFV 825
            ..|.|.|:: .:|..:..  :..|   :||::|.|.:.|.||...|||.|.. .|.::.|:.|.:
  Rat   773 SFFPENWLW-KVEPVDRSKLLTVW---LPDSLTTWEIHGVSLSKSKGLCVAK-PTRVRVFREFHL 832

  Fly   826 SVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVDASNEVIGDQKRTQNIRVGAN 890
            .:|||.||:|.|.:.:..:::|||.:.:.|.:.:...:        ...:.|.....|.:.|.|.
  Rat   833 HLRLPISVRRFEQLELRPVLYNYLSEDVTVSVHVSPVE--------GLCLAGGGLLAQQVSVPAG 889

  Fly   891 EAAGASFLIRPKVIGNILLKFKAISPL-AGDAIHKPLKVVPEGITQYQNRAFFIN-LKDTGEFKN 953
            .|...:|.:.|....::.||..|.... .|||:.|.|::..||....:...:.:: |.:.|.
  Rat   890 SARPVAFSVVPTAAASMPLKVVARGSFDIGDAVSKILQIEKEGAIHREEIVYNLDPLNNLGR--- 951

  Fly   954 TFELEVP----EDVVPD-----------SERVE-FGLVGDLLGPVVKNLENLLRLPSGCGEQTMS 1002
              .||:|    .:|:||           ||.:| .|..| .|.|  ..:.:||:||:||.||||.
  Rat   952 --SLEIPGSSDPNVIPDGDFSSFVRVTASEPLETLGSEG-ALSP--GGVASLLKLPTGCAEQTMV 1011

  Fly  1003 KLVPNYLVRDYL---KSIKKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVR 1064
            .|.|......||   :...||.|.........:|.|:..:..:|..||||.:     |..    |
  Rat  1012 LLAPTLTASRYLDRTEQWSKLPPETKDHAVDLIQKGHMRIQQFRKKDGSFGA-----WLD----R 1067

  Fly  1065 NGSTWLTAYVLRSFSKIKDIIDLDEQILAKGYEFLLTRQAENGSFTE---------HGEYFYSSQ 1120
            :.||||||:||:..|..::.|....:.|.:...:||.:|.::|||.:         .|....:.:
  Rat  1068 DSSTWLTAFVLKILSLAQEQIGDSPEKLQETAGWLLGQQLDDGSFHDPCPVIQRGMQGGLVGTDE 1132

  Fly  1121 RSLLT----LTANSLLALLEEEKPNQ------AAIDKAVAYLSANTAESIELL---PKSIAIYAL 1172
            ...||    :..:..||:.::|...|      |:|.||.::|....  |..||   ..:|..|||
  Rat  1133 TVALTAFVVIALHHGLAVFQDENSQQLKKRVEASIMKANSFLGQKA--SAGLLGAHASAITAYAL 1195

  Fly  1173 QKAKAPEAAKQVA--SLKSLAKHEDDRTWW-----TED--LDKLRASKNCGR--------WWCWI 1220
            ...||.|..:.||  ||.::|:...:..:|     ::|  :....|.:|...        |
  Rat  1196 TLTKASEDLRNVAHNSLMAMAEETGENLYWGLAIGSQDNVVSSTAAPRNPSEPVPQAPALW---- 1256

  Fly  1221 WSQDVEITSYALLSLL--DSDQETADSVLNTVRWLIAQRNGFGGFASSQDTVVGLTALIKFAEKS 1283
                :|.|:|.||.||  :...|.||   ....||..|.:..|||.|:|||||.|.||      |
  Rat  1257 ----IETTAYGLLHLLLREGKGEMAD---KAATWLTHQGSFQGGFRSTQDTVVALDAL------S 1308

  Fly  1284 GY-------EAAKWEVTVSNKGK---REKTEKLNTSEENDLLLQTVEFPQGTKSLEFEAKGTGAA 1338
            .|       |.....||:|:.|:   :....:||..:... |.:.::|..|: ::..:..|....
  Rat  1309 AYWIASHTTEEKALNVTLSSMGRNGYKSHLLQLNNHQVKG-LEEELKFSLGS-TINVKVGGNSKG 1371

  Fly  1339 MVQISYQYNLVEKEPK--PSFKIQTTV-------------------LP-------ESSP------ 1369
            .::|...||:::.:..  ...:|:.|:                   :|       .|.|
  Rat  1372 TLKILRTYNVLDMKNTTCQDLRIEVTITGYVEYTREANEDYEYDYDMPAADDPSVHSQPVTPLQL 1436

  Fly  1370 --------------------ANLELSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSFADIRN 1414
                                :.::.:||:  ...|....|.|||.:::|.||:.|..   ||:..
  Rat  1437 FEGRRSRRRREAPKAADEQESRVQYTVCI--WRNGNLGLSGMAIADITLLSGFQALR---ADLEK 1496

  Fly  1415 IERV--RLVETKNGDSV-VVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKKAT 1476
            :..:  |.|.....|.. |::||:::....| |:...|.:..||...:|:|.||||||..:.|.:
  Rat  1497 LTSLSDRYVSHFETDGPHVLLYFDSVPTTRE-CVGFGALQEVAVGLVQPASAVLYDYYSPDHKCS 1560

  Fly  1477 EYYS--IKSKLCD-ICEGDDC---KSKC 1498
            .:|:  .||||.. :|..|.|   :.||
  Rat  1561 VFYAGPTKSKLLSTLCSADVCQCAEGKC 1588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081	26/92 (28%)
		A2M_N_2	528..653	CDD:285005	33/142 (23%)
		A2M	768..859	CDD:278630	28/92 (30%)
		A2M_2	982..1279	CDD:239227	100/340 (29%)
		A2M_comp	1035..1281	CDD:284982	82/286 (29%)
		A2M_recep	1389..1479	CDD:284981	30/92 (33%)
C4b	NP_001002805.1	A2M_N	139..231	CDD:280081	29/115 (25%)
		A2M_N_2	475..608	CDD:285005	34/147 (23%)
		ANATO	684..752	CDD:237984	10/68 (15%)
		A2M	779..866	CDD:278630	28/91 (31%)
		complement_C3_C4_C5	991..1310	CDD:239226	102/348 (29%)
		A2M_comp	1046..1312	CDD:284982	84/293 (29%)
		A2M_recep	1474..1563	CDD:284981	30/92 (33%)
		NTR_complement_C4	1581..1735	CDD:239639	3/8 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343873
Domainoid	1	1.000	50	1.000	Domainoid score	I11352
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.810