Protein Alignment Tep4 and LOC36518491

DIOPT Version :10

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: XP_024667078.2
• Gene: LOC36518491 / 36518491
• VectorBaseID: AGAMI1_007003
• Length: 1340
• Species: Anopheles gambiae
• Alignment Length: 1526
• Identity: 416/1526 - (27%)
• Similarity: 678/1526 - (44%)
• Gaps: 270/1526 - (17%)

  Fly    32 IVGPGTIHSHRDYNVAVAVHQTK-EPVTLKVGITGPSYNKTETVELATAGEFKQ-----ITFKLP 90
            :|||..|.::::|.:.::...:: ..|.|.:.:.|.:.|....:.:....:.::     |.|.:|
Mosquito    24 VVGPKFIRANQEYTLVISNFNSQLSKVDLLLKLEGETDNGLSVLNVTKMVDVRRNMNRMINFNMP 88

  Fly    91 -PLEAGEYNLTAEGVKGLEFKNSTKLNWENFKPYIKIQTDKGKYKPGDTINYRVIFLDENLRPDT 154
             .|.||.|.:|.:|.:|..|....:|.:.:......||.||..:|||||:|:|||.||..|:|..
Mosquito    89 EDLTAGNYKITIDGQRGFSFHKEAELVYLSKSISGLIQVDKPVFKPGDTVNFRVIVLDTELKPPA 153

  Fly   155 AKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFATLGSWSLHVQNGDQHHDGGIYFGGR 219
            ....|.|...|.:||.|::....|...||:....:::....||.|::.|:
Mosquito   154 RVKSVYVTIRDPQRNVIRKWSTAKLYAGVFESDLQIAPTPMLGVWNISVE--------------- 203

  Fly   220 KQFGGFGHRWHRSDELVN--FEVEKYVLPKYSVK-------MDATQQVSVRDGEFNVVLKANYTY 275
                      ...:|||:  |||::|||..:.|:       ::..|.|       |:.::|||.:
Mosquito   204 ----------VEGEELVSKTFEVKEYVLSTFDVQVMPSVIPLEEHQAV-------NLTIEANYHF 251

  Fly   276 GKPVNGKVLVNVHLDSTSSWENVDGKTVQTDYPGHSVVGTADMVGGKAKLTMDLKDFASYLPHKT 340
            ||||.|...|.::||.    :.::.|...|.|             ||.::.:...:||.    ..
Mosquito   252 GKPVQGVAKVELYLDD----DKLNQKKELTVY-------------GKGQVELRFDNFAM----DA 295

  Fly   341 SSSYAQITATVEEDFTGVKLNETGGVQLYPYRYEMSCTDYSSCFSFKPDKEHELNFKITYVDGSL 405
            .....::..:..|.:|...:.:...:.:|.|.|.:.....|.  .|:|....:...:.|:.||
Mosquito   296 DQQDVRVKVSFIEQYTNRTVVKQSQITVYRYAYRVELIKESP--QFRPGLPFKCALQFTHHDG-- 356

  Fly   406 ITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELPTIEKKTFVFESHLNASGVAPFKVVLPDLPD 470
             |..|.:.                          ..:|.....||:...:......|:.|..
Mosquito   357 -TPAKGIT--------------------------GKVEVSDVGFETTTTSDNDGLIKLELQP--- 391

  Fly   471 IANFTRYYSIELEFVDEKRDLYTTYPYREPKQIENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQ 535
             :..|....|....||      ..:.|.:..::|..:.    .:.:.|::.|     :|..:..:
Mosquito   392 -SEGTEQLGINFNAVD------GFFFYEDVNKVETVTD----AYIKLELKSP-----IKRNKLMR 440

  Fly   536 VILNSSRPLKYFVYNIVGRGNILETKRVDLAEP--QT----TVNVTIK-----PTFLTTPYGRVY 589
            .::..:..:.:|||.::.:|||::   .....|  ||    .:|.|.|     ...:.|..||..
Mosquito   441 FMVTCTERMTFFVYYVMSKGNIID---AGFMRPNKQTKYLLQLNATEKMIPKAKILIATVAGRTV 502

  Fly   590 FY-YVDETGEFRYTEETFSVEVELQNQIEIKAPAEVKPGADVALEIKTSPKSFVGLLAVDQSVLL 653
            .| |.|.  :|:.....|.:.::.|         |:|||..:.|.:...|.::|||.|.|:::||
Mosquito   503 VYDYADL--DFQELRNNFDLSIDEQ---------EIKPGRQIELSMSGRPGAYVGLAAYDKALLL 556

  Fly   654 LGSNNDLNKESFNWRLNGYDTSTPWQGGYSYYPGERTGVVTMTNAYFFYNRTAPDYNILTEGFGG 718
            ...|:||..|         |....:.|.::....|    ..:.::...:.||..|  ||.:.
Mosquito   557 FNKNHDLFWE---------DIGQVFDGFHAINENE----FDIFHSLGLFARTLDD--ILFDS--- 603

  Fly   719 SSFAMRKTTVAHDSHVFHSGAGGPTQAVGFSAESASASAAPV-----VRKNFAETWIFADIESTE 778
               |..||                       ..:|..|..|:     .|.||.|:|::.::....
Mosquito   604 ---ANEKT-----------------------GRNALQSGKPIGKLVSYRTNFQESWLWKNVSIGR 642

  Fly   779 EEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPA 843
            ....|.::.:|||.|:|.:||||:.|..|||:........|.|||::...||||:||||.:.:..
Mosquito   643 SGSRKLIEVVPDTTTSWYLTGFSIDPVYGLGIIKKPIQFTTVQPFYIVENLPYSIKRGEAVVLQF 707

  Fly   844 LVFNYLPKTLDVELTLDNEDQEYDFVDASNEVIGDQKRTQNIRVGANEAAGASFLIRPKVIGNIL 908
            .:||.|......::||.|...:.:||...:.   |...|:::.|........||||:.:.:|.:.
Mosquito   708 TLFNNLGAEYIADVTLYNVANQTEFVGRPDT---DLSYTKSVSVPPKVGVPISFLIKARKLGEMA 769

  Fly   909 LKFKAISPLAG---DAIHKPLKVVPEGITQYQNRAFFINLKDTGEFKN---TFELEVPEDVVPDS 967
            ::.|| |.:.|   ||:.|.::|:||.:.|.:....|....|   :||   .|.|::.:.....|
Mosquito   770 VRVKA-SIMLGHETDALEKVIRVMPESLAQPKMDTSFFCFDD---YKNQTFPFNLDINKKADNGS 830

  Fly   968 ERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKKLTPALDTRIKRNL 1032
            :::||.|..:||..|:|||:|||.:|:|||||.|.|.|||.||.|||.:.......|..:....|
Mosquito   831 KKIEFRLNPNLLTMVIKNLDNLLAVPTGCGEQNMVKFVPNILVLDYLYATGSKEQHLIDKATNLL 895

  Fly  1033 QDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSF-SKIKDIIDLDEQILAKGY 1096
            :.|||:.:.||..||||.     .|.:.    ..|.:|||:|..|. :..|.:.|:|..::.|..
Mosquito   896 RQGYQNQMRYRQTDGSFG-----VWEKS----GSSVFLTAFVATSMQTASKYMNDIDAAMVEKAL 951

  Fly  1097 EFLLTRQAENGSFTEHGEYFYSSQ----RSLLTLTANSLLALLEEE--KPNQA-AIDKAVAYLSA 1154
            ::|.::|..:|.|.|.|:.::...    |:.:.||:..|.||||.:  |...| .|...:.|||.
Mosquito   952 DWLASKQHSSGRFDETGKVWHKDMQGGLRNGVALTSYVLTALLENDIAKVKHAVVIQNGMNYLSN 1016

  Fly  1155 NTAESIELLPKSIAIYALQKAKAPEAAKQVASLKSLAKHEDDRTWWTEDLDKL------RASKNC 1213
            ..|........|||.||:.                |..|    |...|.||||      .|.||
Mosquito  1017 QLAFINNAYDLSIATYAMM----------------LNGH----TMKKEALDKLIDMSFIDADKN- 1060

  Fly  1214 GRWWCWIWSQDVEITSYALLSLLDSDQETADSVLN---TVRWLIAQRNGFGGFASSQDTVVGLTA 1275
            .|:  |..:..:|.|:|||||.:     .|:..|:   .:.||:.||...|.|..:|||.|||.|
Mosquito  1061 ERF--WNTTNPIETTAYALLSFV-----MAEKYLDGIPVMNWLVNQRYVTGSFPRTQDTFVGLKA 1118

  Fly  1276 LIKFAEKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQTVEFPQGTKSLEFEAKGTGAAMV 1340
            |.|.|||  ...::.:.||..|.|: .|:..|.:.|...:...:|.|:.||.||....|.|..::
Mosquito  1119 LTKLAEK--ISPSRNDYTVQLKYKK-STKYFNINSEQIDVQNFLEIPEDTKKLEINVGGIGFGLL 1180

  Fly  1341 QISYQY--NLVEKEPKPSFKIQTTVLPESSPANLELSVCVDYVEEGESKESNMAILEVSLPSGYT 1403
            ::.||:  |||..|.:  ||:........|...|.|.||.:|:.|....:||||::||:|||||.
Mosquito  1181 EVIYQFDLNLVNFEHR--FKLDLEKQNTGSDYELRLRVCANYIPELTDSQSNMALIEVTLPSGYV 1243

  Fly  1404 ADEDSFADIRNIERVRLVETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDY 1468
            .|.:..::...:..::.:|.:.|.:.||:|:.|:. .|..|..:.|||...||.::|:.||:|||
Mosquito  1244 VDRNPISEQTTVNPIQNMEIRYGGTSVVLYYYNMG-TERNCFTVTAYRRFKVALKRPAYVVVYDY 1307

  Fly  1469 YDTNKKATEYYSI-KSKLCDICEGDDCKSKC 1498
            |:||..|.:.|.: |..:|:|||.:||.::|
Mosquito  1308 YNTNLNAIKVYEVDKQNVCEICEEEDCPAEC 1338

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	YfaS	<76..1411	CDD:441940	375/1391 (27%)
		A2M_2	982..1279	CDD:239227	107/313 (34%)
		A2M_recep	1387..1480	CDD:462226	35/92 (38%)
LOC36518491	XP_024667078.2	None