Protein Alignment Tep4 and TEP1

DIOPT Version :9

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: XP_024667078.1
• Gene: TEP1 / 36518491
• VectorBaseID: AGAP010815
• Length: 1028
• Species: Anopheles gambiae
• Alignment Length: 1188
• Identity: 331/1188 - (27%)
• Similarity: 539/1188 - (45%)
• Gaps: 208/1188 - (17%)

  Fly   356 TGVKLNETGGVQLYPYRYEMSCTDYSSCFSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEG 420
            |.||.::   :.:|.|.|.:.....|.  .|:|....:...:.|:.||:         .||...|
Mosquito     2 TVVKQSQ---ITVYRYAYRVELIKESP--QFRPGLPFKCALQFTHHDGT---------PAKGISG 52

  Fly   421 IRRNYAFYAFGTDHQEPELPTIEKKTFVFESHLNASGVAPFKVVLPDLPDIANFTRYYSIELEFV 485
                                .:|.....||:...:......|:.|..    :..|...||....|
Mosquito    53 --------------------KVEVSDVRFETTTTSDNDGLIKLELQP----SEGTEQLSIHFNAV 93

  Fly   486 DEKRDLYTTYPYREPKQIENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQVILNSSRPLKYFVYN 550
            |      ..:.|.:..::|..:.    .:.:.|::.|     :|..:..:.::..:..:.:|||.
Mosquito    94 D------GFFFYEDVNKVETVTD----AYIKLELKSP-----IKRNKLMRFMVTCTERMTFFVYY 143

  Fly   551 IVGRGNILETKRVDLAEPQ------TTVNVTIK-----PTFLTTPYGRVYFY-YVDETGEFRYTE 603
            ::.:|||::   .....|.      ..:|.|.|     ...:.|..||...| :.|.  :|:...
Mosquito   144 VMSKGNIID---AGFMRPNKQPKYLLQLNATEKMIPRAKILIATVAGRTVVYDFADL--DFQELR 203

  Fly   604 ETFSVEVELQNQIEIKAPAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKESFNWR 668
            ..|.:.::.|         |:|||..:.|.:...|.::|||.|.|:::||...|:||..|
Mosquito   204 NNFDLSIDEQ---------EIKPGRQIELSMSGRPGAYVGLAAYDKALLLFNKNHDLFWE----- 254

  Fly   669 LNGYDTSTPWQGGYSYYPGERTGVVTMTNAYFFYNRTAPDYNILTEGFGGSSFAMRKTTVAHDSH 733
                |....:.|.::....|    ..:.::...:.||..|  ||.:.      |..||
Mosquito   255 ----DIGQVFDGFHAINENE----FDIFHSLGLFARTLDD--ILFDS------ANEKT------- 296

  Fly   734 VFHSGAGGPTQAVGFSAESASASAAPV-----VRKNFAETWIFADIESTEEEVFKWVKTIPDTIT 793
                            ..:|..|..|:     .|.||.|:|::.::........|.::.:|||.|
Mosquito   297 ----------------GRNALQSGKPIGKLVSYRTNFQESWLWKNVSIGRSGSRKLIEVVPDTTT 345

  Fly   794 NWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELT 858
            :|.:||||:.|..|||:........|.|||::...||||:||||.:.:...:||.|......::|
Mosquito   346 SWYLTGFSIDPVYGLGIIKKPIQFTTVQPFYIVENLPYSIKRGEAVVLQFTLFNNLGAEYIADVT 410

  Fly   859 LDNEDQEYDFVDASNEVIGDQKRTQNIRVGANEAAGASFLIRPKVIGNILLKFKAISPLAG---D 920
            |.|...:.:||...|.   |...|:::.|........||||:.:.:|.:.::.|| |.:.|   |
Mosquito   411 LYNVANQTEFVGRPNT---DLSYTKSVSVPPKVGVPISFLIKARKLGEMAVRVKA-SIMLGHETD 471

  Fly   921 AIHKPLKVVPEGITQ------------YQNRAFFINLKDTGEFKNTFELEVPEDVVPDSERVEFG 973
            |:.|.::|:||.:.|            ::|:.|.||            |::.:.....|.::||.
Mosquito   472 ALEKVIRVMPESLVQPRMDTRFFCFDDHKNQTFPIN------------LDINKKADSGSTKIEFR 524

  Fly   974 LVGDLLGPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQH 1038
            |..:||..|:|||::||.:|:|||||.|.|.|||.||.|||.:|......|..:....|:.|||:
Mosquito   525 LNPNLLTTVIKNLDHLLGVPTGCGEQNMVKFVPNILVLDYLHAIGSKEQHLIDKATNLLRQGYQN 589

  Fly  1039 MLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSF-SKIKDIIDLDEQILAKGYEFLLTR 1102
            .:.||..||||..:..|         |||.:|||:|..|. :.:|.|.|:|..::.|..::|.::
Mosquito   590 QMRYRQTDGSFGLWETT---------NGSVFLTAFVGTSMQTAVKYISDIDAAMVEKALDWLASK 645

  Fly  1103 QAENGSFTEHG-EYFYSSQ---RSLLTLTANSLLALLEEE--KPNQA-AIDKAVAYLSANTAESI 1160
            |..:|.|.:.| ||....|   |:.:.||:..|:||||.:  |...| .|.|.:.|||.......
Mosquito   646 QHFSGRFDKAGAEYHKEMQGGLRNGVALTSYVLMALLENDIAKAKHAEVIQKGMTYLSNQFGSIN 710

  Fly  1161 ELLPKSIAIYALQ---KAKAPEAAKQVASLKSLAKHEDDRTWWTEDLDKLRASKNCGRWWCWIWS 1222
            .....|||.||:.   .....||..::..:..:...:::|.|.|                    :
Mosquito   711 NAYDLSIATYAMMLNGHTMKEEALNKLIDMSFIDADKNERFWNT--------------------T 755

  Fly  1223 QDVEITSYALLSLLDSDQETADSVLNTVRWLIAQRNGFGGFASSQDTVVGLTALIKFAEKSGYEA 1287
            ..:|.|:|||||.:.:::.| |.: ..:.||:.||...|.|.|:|||.|||.||.|.|||  ...
Mosquito   756 NPIETTAYALLSFVMAEKYT-DGI-PVMNWLVNQRYVTGSFPSTQDTFVGLKALTKMAEK--ISP 816

  Fly  1288 AKWEVTVSNKGKRE-KTEKLNTSEENDLLLQTVEFPQGTKSLEFEAKGTGAAMVQISYQYNLVEK 1351
            ::.:.||..|.|:. |..|:| ||:.| :...|:.|:.||.||....|.|..::::.||:||...
Mosquito   817 SRNDYTVQLKYKKSAKYFKIN-SEQID-VENFVDIPEDTKKLEINVGGIGFGLLEVVYQFNLNLV 879

  Fly  1352 EPKPSFKIQTTVLPESSPANLELSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSFADIRNIE 1416
            ..:..|::........|...|.|.||..|:.:...:.||||::||:|||||..|.:..::...:.
Mosquito   880 NFENRFQLDLEKQNTGSDYELRLKVCASYIPQLTDRRSNMALIEVTLPSGYVVDRNPISEQTKVN 944

  Fly  1417 RVRLVETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKKATEYYSI 1481
            .::..|.:.|.:.||:|::|:. :|..|..:.|||...||.::|:.||:||||:||..|.:.|.:
Mosquito   945 PIQKTEIRYGGTSVVLYYDNMG-SERNCFTLTAYRRFKVALKRPAYVVVYDYYNTNLNAIKVYEV 1008

  Fly  1482 -KSKLCDICEGDDCKSKC 1498
             |..||:||:.:||.::|
Mosquito  1009 DKQNLCEICDEEDCPAEC 1026

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081
		A2M_N_2	528..653	CDD:285005	30/136 (22%)
		A2M	768..859	CDD:278630	30/90 (33%)
		A2M_2	982..1279	CDD:239227	105/307 (34%)
		A2M_comp	1035..1281	CDD:284982	81/256 (32%)
		A2M_recep	1389..1479	CDD:284981	35/89 (39%)
TEP1	XP_024667078.1	A2M_N_2	127..244	CDD:311575	29/130 (22%)
		A2M	320..411	CDD:306673	30/90 (33%)
		A2M_2	533..809	CDD:239227	105/306 (34%)
		A2M_recep	917..1006	CDD:311553	35/89 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	51	1.000	Domainoid score	I18731
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.880