DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep4 and Cd109

DIOPT Version :9

Sequence 1:	NP_001260590.1	Gene:	Tep4 / 35248	FlyBaseID:	FBgn0041180	Length:	1498	Species:	Drosophila melanogaster
Sequence 2:	NP_001102241.2	Gene:	Cd109 / 363104	RGDID:	1311287	Length:	1442	Species:	Rattus norvegicus

Alignment Length:	1559	Identity:	421/1559 - (27%)
Similarity:	698/1559 - (44%)	Gaps:	222/1559 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AFAVSLCVILALLQTMEPVKAEG-KYTIVGPGTIHSHRDYNVAVAVHQTKEP-VTLKVGITGPSY 68
            |..:|:||:        .|.|.| ::.:..||.|....:..:.|.:.|...| |.:|..:...:.
  Rat    10 AHLLSVCVV--------AVAAHGSRFLVTVPGIIRPGANMTIGVELLQNSPPQVLVKARVLKIAS 66

  Fly    69 NKTETVELATAGEFKQITF------KLPPLEAGE-YNLTAEGVKGLE--FKNSTKLNWENFKPYI 124
            |::.|| |...|.|.:..|      .||..:|.: |.|...|....|  |.|.|:|.:::.:..:
  Rat    67 NRSTTV-LEAEGVFNRGHFGILVLPALPLHKANKIYELHISGKSETEIVFSNRTRLTFDSKRISV 130

  Fly   125 KIQTDKGKYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGKFE 189
            .|||||..|||...:.:||:.|..:|:|  .|..|.::.:|.|.|.|:|....:...||.:..|:
  Rat   131 FIQTDKVIYKPKQEVKFRVLTLFSDLKP--YKTPVDIYIKDPKSNLIQQWLSQEGELGVVSKTFQ 193

  Fly   190 LSEFATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDA 254
            ||....||.||:.||..||     :|:                   .:|:|..|||||:.|.:..
  Rat   194 LSSHPILGDWSIQVQVIDQ-----LYY-------------------QSFQVLDYVLPKFEVTLQT 234

  Fly   255 TQQVSVRDGEFNVVLKANYTYGKPVNGKV-LVNVHLDSTSSWENVDGKTVQTDYPGH-SVVGTAD 317
            ....|::.......:.|.|||||||.|.: |..:.|   |.|......|...:..|. :....||
  Rat   235 PLYCSLKAKYLRGNVTAKYTYGKPVKGSLSLTFIPL---SFWGKKKNITKNFEINGFTNFAFDAD 296

  Fly   318 MVGGKAKLTMDLKDFASYLPHKTSSSYAQ----------ITATVEEDFTGVKLNETGGVQLYPYR 372
                :.|..|:||.....    :..:|.|          |.|||.|..||.....:..|....:.
  Rat   297 ----EMKKVMNLKKATEI----SDGNYDQVDPVFPGPVEIVATVTESLTGTSRKASTNVFFKQHD 353

  Fly   373 YEMSCTDYSSCFSFKPDKEHELNFKITYVDGSLIT------DTKSVVKAKFTEGIRRNYAFYAFG 431
            |.:...||::.  .||........||:..||..:|      |..:||..|..:...|.   .|.|
  Rat   354 YVIEIFDYTTV--LKPTLNFTATVKISRSDGKQLTPEEMENDLVTVVTQKKNDNPTRE---KAQG 413

  Fly   432 TDHQEPELPTIEKKTFVFESHLNASGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTTYP 496
            ||:.:           :.|..:..:||.  ||..|.:.|.:..    .::..|:|....:.....
  Rat   414 TDYIQ-----------MTEYSVPHNGVV--KVEFPIMSDSSEL----QLKASFLDSASSVAVHSV 461

  Fly   497 YREPKQ--IENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQVILNSSRPLKYFVYNIVGRGNILE 559
            :..|..  |:..:.:|                ::.:|..:.:.::.::..|...|.::.:|.::.
  Rat   462 FTSPSNTYIQLKTRDE----------------HITVGSPFNLTVSGNQKFKEISYMVISKGQLVA 510

  Fly   560 TKRVDLAEPQTTVNVTIKPTFLTTPYGRVYFYYVDETGEFRYTEETFSVEVELQNQIEIK-APAE 623
            ..:      |::...::.|.....|...:..||:::.||.........|:::.:|:|::. :...
  Rat   511 VGK------QSSRTFSLTPEASWAPKACIIVYYIEQDGEVISDILKIPVQLDFKNKIKLSWSKPR 569

  Fly   624 VKPGADVALEIK-TSPKSFVGLLAVDQSVLLLGSNNDLNKESFNWRLNGYDTSTPWQGGYSYYPG 687
            |||...|:|.|. |...|.||::|||:||.|:|::||:..|:....|..|:|        .||.|
  Rat   570 VKPSDKVSLRISVTQSYSLVGIVAVDKSVKLIGNSNDITMENVVHELELYNT--------EYYLG 626

  Fly   688 ---------ERTGVVTMTNAYFFYNRTAPDYNILTEGFGGSSFAMRKTTVAHDSHVFHSGAGGPT 743
                     :..|:..:|:|           |::.:..          ...:|:..:........
  Rat   627 MFLNSFAVFQECGLWVLTDA-----------NLVRDNI----------DEVYDTQEYSERFAEEN 670

  Fly   744 QAVGFSAESASASAAPVVRKNFAETWIFADIESTEEEVFKWVKTIPDTITNWVVTGFSLHPQKGL 808
            :|.....|..|:::...|||:|.|:||:.|.....:...::..|:||:||:||.:.|.:....|.
  Rat   671 EANLVDFEDTSSASNSHVRKHFPESWIWLDFYMGSKNHEEYEVTVPDSITSWVASAFVISEDLGF 735

  Fly   809 GVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVDASN 873
            |:|.....:..|||||:|:.|||||.|||...:...:.|||..|..|.:.::..| .:|.:..||
  Rat   736 GLTATPAELHAFQPFFISLNLPYSVIRGEEFALEVSIVNYLKDTTKVVVLIEESD-SFDILMFSN 799

  Fly   874 EVIGDQKRTQNIRVGANEAAGASFLIRPKVIGNILLKFKAISPLAGDAIHKPLKVVPEGITQYQN 938
            ::.....| :...|....:....|.|:|..:||:.:...|.||.:.|.:.:.:.|.|||:.:..:
  Rat   800 DINNTIYR-KTALVPRENSVTLVFPIKPTHLGNVPITVTAASPTSSDVVTRTIVVKPEGVAKSYS 863

  Fly   939 RAFFINLKDTGE--FKNTFELEVPEDVVPDSERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTM 1001
            ::..:.|.|..:  ...:.....|.|.:..|||::...:||:||..:..|.:|:|||.|||||.|
  Rat   864 QSVLLELIDKKQQTEPKSLSFSFPPDTISGSERIQITAIGDILGSSINGLSSLIRLPYGCGEQNM 928

  Fly  1002 SKLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNG 1066
            ..|.||..:.|||...|:||..|..:....::.|||..|.|:.:|||||:||.:.       .:|
  Rat   929 VYLAPNVYILDYLTKQKQLTVNLKEKALSFMRQGYQRELLYQREDGSFSAFGNSD-------SSG 986

  Fly  1067 STWLTAYVLRSFSKIKDIIDLDEQILAKGYEFLLTRQAENGSFTEHGEYFY----SSQRSLLTLT 1127
            ||||:|:|||.|.:....||:|:.:|.:.|.:|...:..||.|.|.|...:    ...:|.:|||
  Rat   987 STWLSAFVLRCFMEAAQYIDIDQDVLHRTYSWLEAHKKTNGEFWEPGRVIHIELQGGNKSPITLT 1051

  Fly  1128 ANSLLALLEEEK--PNQAAIDKAVAYLSANTAESI-ELLPKSIAIYALQKAKAPEAAKQVASLKS 1189
            |..:.:||..:|  || ..|..::.:|.......| :....::..|||....:|:|.:.:..|..
  Rat  1052 AYVVTSLLGYKKYQPN-IEIQDSIKFLENEFNRGISDNYTLALVTYALSAVGSPKAEEALTMLTQ 1115

  Fly  1190 LAKHEDDRTWWTEDLDKLRASKNCGRWWCWIWSQDVEITSYALLSLLDSDQETADSVLNTVRWLI 1254
            .|:.|.|..:|      |.::......|..: |..:||.:||||:   ..|......:..::|||
  Rat  1116 QAEKEGDTQFW------LSSTSESSESWQSL-SAQIEIAAYALLA---HTQHHVPEGIPIMKWLI 1170

  Fly  1255 AQRNGFGGFASSQDTVVGLTALIKFAEKSGYEAAKWEVTVSNKGKR-EKTEKLNTSEENDLLLQT 1318
            .|||..|||.|:||||:.|.||.:|:.....|....:||:  ||.. .|..:.....:|...|..
  Rat  1171 KQRNSLGGFVSTQDTVMALKALSEFSALVYKENRDMQVTI--KGPNVPKPIRFWIDSQNLFKLHK 1233

  Fly  1319 VEF-PQGTKSLEFEAKGTGAAMVQISYQYNLVEKEPKPSFK------------IQTTVLPESSPA 1370
            .|. |....::...|.|:|.|:.|::..||:   :...|||            :...|..|....
  Rat  1234 EELAPLDPIAVNVSAHGSGFAICQLNVDYNV---KASSSFKRRRSMENPIGFDLDVDVNDEHDLR 1295

  Fly  1371 NLELSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSFADIRNIERVRLVETKNGDSVVVIYFE 1435
            .::|:||..::..|   .:.||:|||:|.||:||..||   |...|.::.||.:.|.  :.:|.:
  Rat  1296 YMKLNVCTSHLGPG---RTGMALLEVNLLSGFTATSDS---IPLSEILKKVEYEPGK--LNLYLD 1352

  Fly  1436 NLAKNEEK-CIRIEAYRTHAVANQKPSSVVLYDYYDTNKKATEYYSIKSKL--CDICEGDDCKS 1496
            ::  ||.: |::|...|...|:|.:...|.:.|||:.:::|...|:.:.||  |.:....:|:|
  Rat  1353 HV--NETQFCVKIPTVRDFKVSNIRDGLVSIVDYYEPSRQAVRSYNTQMKLSSCYLSADPNCRS 1414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081	34/92 (37%)
		A2M_N_2	528..653	CDD:285005	29/126 (23%)
		A2M	768..859	CDD:278630	33/90 (37%)
		A2M_2	982..1279	CDD:239227	104/303 (34%)
		A2M_comp	1035..1281	CDD:284982	84/252 (33%)
		A2M_recep	1389..1479	CDD:284981	30/90 (33%)
Cd109	NP_001102241.2	YfaS	<122..>1019	CDD:225248	269/1015 (27%)
		A2M_N_2	470..601	CDD:400170	31/152 (20%)
		A2M	695..784	CDD:395153	33/88 (38%)
		A2M_2	909..1195	CDD:239227	104/303 (34%)
		A2M_recep	1311..1395	CDD:400149	30/90 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343853
Domainoid	1	1.000	77	1.000	Domainoid score	I8631
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	570	1.000	Inparanoid score	I1022
OMA	1	1.010	-	-		QHG45959
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	1	1.000	-	-		FOG0002157
OrthoInspector	1	1.000	-	-		otm44434
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.910