Protein Alignment Tep4 and A2ml1

DIOPT Version :10

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: NP_001418713.1
• Gene: A2ml1 / 362442
• RGDID: 1565709
• Length: 1458
• Species: Rattus norvegicus
• Alignment Length: 1652
• Identity: 392/1652 - (23%)
• Similarity: 648/1652 - (39%)
• Gaps: 377/1652 - (22%)

  Fly     9 VSLCVILAL-LQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGITGPSYNKTE 72
            |...|:.|| |.....|.:|.:|.:.....:.........:.:....|||:|.|.:.....|.|.
  Rat     2 VPTIVLSALVLHLTNVVASEPRYLLWVSAVVQRFSSEKACLHLVNLNEPVSLSVILEYAGVNTTI 66

  Fly    73 TVELATAGEF-------------KQITF-----KLPPLEAGEYNLTAEGVKGLEFKNSTKLNWEN 119
            ..:....|.|             :|:.|     :...|...|....|...:    :|:|
  Rat    67 FDQRVKEGNFYACANFKVSHVSPEQLAFVTLLVQQNTLIISERRAVAVAAE----ENAT------ 121

  Fly   120 FKPYIKIQTDKGKYKPGDTINYRVIFLDENLRPDTAKDEV--VVWFEDSKRNRIKQEKHIKTTGG 182
                 .:|||...:|||||:::||:.|:..|:|   .||:  ::..::.:.|.|.|..::.|...
  Rat   122 -----FVQTDTPVHKPGDTVHFRVVTLNTWLKP---VDELYPLITVQNPQGNVIFQWINVTTFRN 178

  Fly   183 VYTGKFELSEFATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPK 247
            :....|:|:....||.:.:.:               :||.|        ...:.:|.|.:.|||:
  Rat   179 ITQLSFQLTPEPVLGDYMIVI---------------KKQSG--------MTVVDHFTVNQDVLPR 220

  Fly   248 YSVKMDATQQVSVRDGEFNVVLKANYTYGKPVNGKVLVNVHLDSTSSWENVDGKTVQTDYPGHSV 312
            :.|::.|.:.:::.|.:|.||:.|.|.||:||.||..:.|..:..|              ||:..
  Rat   221 FEVELTAPETITIADNQFPVVMCAKYIYGQPVRGKAQIKVCRELFS--------------PGYCE 271

  Fly   313 VGTADMVGGKAKLTMDLKD-FASYLPH-KTSSSY-------AQITATVEEDFTGVKLNETGGVQL 368
            ....::.   .:.|:.||| .|||:.: |....|       ..|...:.|..|||::::|..|.:
  Rat   272 SNENEIC---EQFTLQLKDGCASYIVNTKVFQLYRSGLFMTLNINGVITESGTGVQISKTHSVFI 333

  Fly   369 YPYRYEMSCTDYSSCFSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTD 433
                     |......||:       |....|                     ||...::.
  Rat   334 ---------TSVLGTVSFE-------NMDSFY---------------------RRGIPYFG---- 357

  Fly   434 HQEPELPTIEKKTFVFESHLNASGVAPFKVVLPDLPDIANFT------RYYSIEL-EFVDEKRDL 491
                        |..|....|...|.....:..|...:.|:|      ..:||.. |..:.:..|
  Rat   358 ------------TLKFSGPNNTPMVNKLLQLELDGKPLGNYTTDEKGEAQFSINTSEIFEAQMSL 410

  Fly   492 YTTYPYREPKQIENPSSEEEKEWFRAE---------------------VQRPKDVWNLKIGQEYQ 535
            ..||        ..|.|.....|...|                     :..||.   |...||..
  Rat   411 KATY--------VRPRSCHRSSWLDPEYLDAYFSASRFYSQTSSFMKIILEPKP---LPCDQEKM 464

  Fly   536 V-ILNSSRPLKY-------FVYNIVGRGNILETKRVDLAEPQTTVNVTIK------PTFLT---T 583
            | :|.|..|..|       |.|.::.||:|       |...||.|.|..:      |..:|   .
  Rat   465 VSVLYSLNPEVYKEASKVTFFYLVMVRGSI-------LLSGQTEVKVQAQNGNFSFPIIVTADLA 522

  Fly   584 PYGRVYFYYVDETGEFRYTEETFSVEVELQNQIEIKAPAEVK-PGADVALEIKTSPKSFVGLLAV 647
            |...::.|.:..:||..........|...:|::.||...|.. ||::.:|.::.:|.||..|.||
  Rat   523 PAADLFVYTLHPSGEIVADSVKLQTEKCFKNKVSIKFSKEQDLPGSNTSLHLQAAPGSFCALRAV 587

  Fly   648 DQSVLLLGSNNDLNKES----------FNWRLNGY-------DTSTP----WQGGYSYYP----- 686
            |:|.|||....::..||          :.:..||.       |...|    :..|..|.|
  Rat   588 DKSALLLNHGQEMTPESVYNMLPYVHQYGYFYNGLNLDDERADPCIPQKDLFHNGLYYKPTSNVW 652

  Fly   687 -GERTGVVTMTNAYFFYN------------------RTAPDYNILTEGFGGSSFAMRKTTVAHDS 732
             |:.:.:|.......|.|                  ||..|.|.....:||
  Rat   653 DGDLSNLVRNMALKIFTNIRYRKPEVCSSQENQPLLRTFNDPNERIMMYGG-------------- 703

  Fly   733 HVFHSGAGGPTQAVGFSAESASASAAPV-----VRKNFAETWIF--ADIESTEEEVFKWVKTIPD 790
                .|.||...|..|.....|.|.|.|     ||.||.:||::  ..::|:......::  :||
  Rat   704 ----GGGGGAPAASAFHDAPDSISHAKVAIKETVRTNFPKTWLWNLISVDSSGSTNVSFL--VPD 762

  Fly   791 TITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDV 855
            |||.|..:.|.::...|.|: :.:.:::..||||:.|..|:||.|.|..::...||||  :|..|
  Rat   763 TITQWQASTFCVNGNAGFGI-SPKVSLQISQPFFMEVTSPFSVVRSEQSDLIVTVFNY--RTTCV 824

  Fly   856 ELTLDNEDQEYDFVDASNEVIGDQKRTQNIRVGANEAAGASFLIRPKVIGNILLKFKAISPLAG- 919
            |:::..|..|.  .:||   |..|..|.:..:.|.|.....:.:.||.:|.:.:...|.|..:.
  Rat   825 EISVQLEASEN--YEAS---INTQSNTDSEVLPAGEQKTYVWTVTPKTLGKVNITVVATSKQSSA 884

  Fly   920 --------------DAIHKPLKVVPEGITQYQNRAFFINLKDTGEFKNTFELEVPEDVVPDSERV 970
                          |.:.|.|.|.||||.:...::|.|..|.|...|. ..||:|.|||..|.|.
  Rat   885 CPNDAHEEQDVNWKDTVVKTLLVEPEGIEKESTQSFLICPKGTKASKQ-ITLELPNDVVEGSARS 948

  Fly   971 EFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDG 1035
            ....|||:||..::|||:||:.|.|||||.:::|..:..:.|||.:.|:||..:.::....|..|
  Rat   949 FVTFVGDILGVAMQNLESLLQTPYGCGEQNIAQLAADIYILDYLNATKQLTEEVRSKALLLLSKG 1013

  Fly  1036 YQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSFSKIKDIIDLDEQILAKGYEFLL 1100
            ||..|.:::.|||:..|....       :.||.||:|...::|.|:|:.|.::|.:..:...:|:
  Rat  1014 YQKHLSFKNYDGSYDVFCHNN-------QEGSVWLSALSFKTFEKMKEYIFIEETVPKQTLIWLV 1071

  Fly  1101 TRQAENGSFTEHGEYFYSSQRSLLTLTANSLLALLEEEKPNQAAIDKAV--AYLSANTAESIELL 1163
            .:|..||.|.::.....::|               |:...:..|:...|  |:|......|...|
  Rat  1072 KKQKSNGCFRKNENLVNNAQ---------------EDSDEDDIALTAYVVGAFLEGGLNSSFPAL 1121

  Fly  1164 PKSIAIYALQKAKAPEAA------------------KQVASLKSLAKHEDDRT----WWTEDLDK 1206
            ..  .:|.|::|.:....                  :||.||..:......:|    :|.:| :|
  Rat  1122 RN--GLYCLEEAFSSSVTDDHTQAIMAYVFTLAGKQQQVKSLLPILDRSATKTNNMIYWEKD-EK 1183

  Fly  1207 LRASKNCGRWWCWI---WSQDVEITSYALLSLLDSDQETADSVLNTVRWLIAQRNGFGGFASSQD 1268
            .:|..:..    :|   .|.:.|.|.|.||::|..|....|.....|:||..:.|..|||::.||
  Rat  1184 PKADSSPS----FIPSALSGETEKTCYVLLAVLSQDTPDLDYASKIVQWLAQRMNSHGGFSAVQD 1244

  Fly  1269 TVVGLTALIKFAEKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQTVEFPQGTKSLEFEAK 1333
            |.|.|.||.::.:.:|..... .:|:|.:   |..|..:.:.:|.||:|..:..:|.:....:.:
  Rat  1245 TTVCLLALTRYMKLTGSNPQN-TITLSTE---ESEEVFHINRDNRLLVQHSKVSEGHRRYTVDVE 1305

  Fly  1334 GTGAAMVQISYQYNLVEKEPKP------SFKIQTTVLPESSPANLELSVCVDYVEEGESKESNMA 1392
            |.|.:..|.:.:||:    |.|      |..::|.....|.....:..:.|.....|..:.|...
  Rat  1306 GDGCSFTQATLRYNV----PLPKEASGFSLSVKTRKSNSSDELQTKFDLMVTLTYTGAHESSGTV 1366

  Fly  1393 ILEVSLPSGYTADEDSFADIRNIERVRLVETKNGDSVVVIYFENLAKNEEK-CIRIEAYRTHAVA 1456
            :::|.:.||:|....|..:::...:....:.|||.  |:.|.:|:.|.... ...||  :|:.|.
  Rat  1367 LVDVRMLSGFTPVFSSIEELKFNGQAMKTDIKNGH--VLFYLKNVPKAATSFTFSIE--QTNLVV 1427

  Fly  1457 NQKPSSVVLYDYYDTNKKATEYYSIKS 1483
            |.:|:.|.::. |:.::.|.:.|:|.|
  Rat  1428 NIQPAPVTVHS-YEKDEYAFDSYNINS 1453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	YfaS	<76..1411	CDD:441940	358/1509 (24%)
		A2M_2	982..1279	CDD:239227	86/323 (27%)
		A2M_recep	1387..1480	CDD:462226	22/93 (24%)
A2ml1	NP_001418713.1	A2M_2	960..1255	CDD:239227	86/323 (27%)
		A2M_recep	1361..1450	CDD:462226	22/93 (24%)
		YfaS	<122..1379	CDD:441940	348/1436 (24%)