Protein Alignment Tep4 and C5

DIOPT Version :10

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: NP_444179.1
• Gene: C5 / 362119
• RGDID: 2237
• Length: 1688
• Species: Rattus norvegicus
• Alignment Length: 1666
• Identity: 374/1666 - (22%)
• Similarity: 657/1666 - (39%)
• Gaps: 323/1666 - (19%)

  Fly    11 LCVILALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGITGPSY-NKTET- 73
            ||:::.|.:|.   ..|..|.|..|.........||.:..|...|.....:.:  .|| :|..|
  Rat    12 LCLLIFLDKTW---GQEQTYVISAPKIFRVGSSENVVIQAHGYTEAFDATISL--KSYPDKKVTY 71

  Fly    74 ----VELATAGEFK-QITFKLPPLE-AGEYNLTAE---GVKGLEFKNSTKLNWENFKPYIKIQTD 129
                |.|:...:|: .....|||.: ..:.|..:.   .|..:.|..|.|:.......::.|.||
  Rat    72 SSGYVNLSPENKFQNSALLTLPPKQFPRDENPVSHVYLEVVSMHFSKSKKIPITYDNGFLFIHTD 136

  Fly   130 KGKYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFA 194
            |..|.|..::..||..|.::|:|  ||.|.|:.|.|.:...:...:....||.:....|::....
  Rat   137 KPVYTPDQSVKIRVYSLSDDLKP--AKRETVLTFVDPEGTEVDIVEENDYTGIISFPDFKIPSNP 199

  Fly   195 TLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQQ-V 258
            ..|.|::..:.             :|.|...|..:        |||::||||::||.::.... :
  Rat   200 KYGVWTIKAKY-------------KKDFTTTGTAY--------FEVKEYVLPRFSVSIEPESNFI 243

  Fly   259 SVRD-GEFNVVLKANYTYGKPV-NGKVLVNVHLDSTSSWENV--DGKTVQTDYPGHSVVGTADMV 319
            ..:: ..|.:.:||.|.|.|.| :.:|.:...|.     |::  |.|.:.     |..:..|.:|
  Rat   244 GYKNFKNFEITVKARYFYNKMVPDAEVYIFFGLR-----EDIKEDEKQMM-----HKAMQAATLV 298

  Fly   320 GGKAKLTMDLKDFASYLPHKT----SSSYAQITATVEEDFTGVKLN-ETGGVQ--LYPYRYEMSC 377
            .|.|:::.|.:.....|.:::    ::.|..|..||.|...|.... |..|::  |.||...:..
  Rat   299 NGVAQISFDSETAVKELSYESLEDLNNKYLYIAVTVTESSGGFSEEAEIPGIKYVLSPYTLNLVA 363

  Fly   378 TDY----SSCFSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPE 438
            |..    ...||.|...:..|...:..|..:|:..|.:|                       ..|
  Rat   364 TPLFLKPGIPFSIKVQVKDSLEQLVGGVPVTLMAQTVNV-----------------------NQE 405

  Fly   439 LPTIEKKTFVFESHLNASGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTTYPYREPKQI 503
            ...:|.|..:..|   |.|||.|.|.||        :...|::.|...:..:|        |:
  Rat   406 TSDLEPKRSITHS---ADGVASFVVNLP--------SEVTSLKFEVKTDAPEL--------PE-- 449

  Fly   504 ENPSSEEEKE--------------WFRAEVQRPKDVWNLKIGQEYQVILNSSRP----LKYFVYN 550
            ||.:|:|.:.              |  .|..:|     :.:|:...:|:....|    :.::.|.
  Rat   450 ENQASKEYEAVTYSSLSQSYIYIGW--TENYKP-----MLVGEYLNIIVTPKSPYIDKITHYNYL 507

  Fly   551 IVGRGNILE--TKRVDLAEPQTTVNVTIKPTFLTTPYGRVYFYYV---DETGEFRYTEETFSVEV 610
            |:.:|.|::  ||...|......:|:.:....:  |..|:..||:   ::|.|........::|.
  Rat   508 ILSKGKIVQYGTKEKLLYSSYQNINIPVTQDMV--PSARLLVYYIVTGEQTAELVADAVWINIEE 570

  Fly   611 ELQNQIEIKAPAE---VKPGADVALEIKTSPKSFVGLLAVDQSVL-LLGSNNDLNKESFNWRLNG 671
            :..||:::....:   ..||..|:|::.|...|:|.|.|||.:|. :.|......:..|....:.
  Rat   571 KCGNQLQVHLSPDKDVYSPGQTVSLDMVTEADSWVALSAVDSAVYGVRGKAKRAMQRVFQAFDDK 635

  Fly   672 YDTSTPWQGGYSYYPGERTGVVTMTNAYFFYNRTAPD--YN------ILT--------------- 713
            .|......||     .:...|..:....|..|..|.|  |:      ||.
  Rat   636 SDLGCGAGGG-----RDNVDVFHLAGLTFLTNANADDSQYHDDSCKEILRPKRDLQLLHQKVEEQ 695

  Fly   714 --------------EGFGGSSFAMRKTTVAH-----------------------DSHVFHSGAGG 741
                          :|...:.:...:..||.                       :||  |.|.
  Rat   696 AAKYKHRVPKKCCYDGARENKYETCEQRVARVTIGPHCIRAFNECCTIADKIRKESH--HKGM-- 756

  Fly   742 PTQAVGFSAESASASAAPV----VRKNFAETWIFADIESTEEEVFKWVK------TIPDTITNWV 796
                  ........:..||    :|..|.|:|::        ||.:..|      .:||::|.|.
  Rat   757 ------LLGRIQIKALLPVMKAEIRSYFPESWLW--------EVHRVPKRNQLQVALPDSLTTWE 807

  Fly   797 VTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDN 861
            :.|..: ...|:.|. |....|.|:..|:.:.:||||.|||.|.:...|:||  :|......:..
  Rat   808 IQGIGI-SDNGICVA-DTLKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNY--RTSGTMFCVKM 868

  Fly   862 EDQEYDFVDASNEVIGDQKRTQNI---RVGANEAAGASFLIRPKVIGNILLKFKAISPLAGDAIH 923
            ...|......|:.......|:...   |:..:.:...:|.:.|..||...:.|...:....:.:.
  Rat   869 SAVEGICTPGSSAASPQTSRSSRCVRQRIEGSSSHLVTFSLLPLEIGLHSINFSLETSFGKEILV 933

  Fly   924 KPLKVVPEGITQYQNRAFFINLKDTGEF-----KNTFELEVPEDVVPDSE-----RVEFGLVGDL 978
            |.|:||||||.:.....  :.|...|.:     :..|...:|.|:||.:.     .|:..|:|:.
  Rat   934 KTLRVVPEGIKRESYAG--VTLDPRGVYGIVNRRKEFPYRIPLDLVPKTNVKRILSVKGLLIGEF 996

  Fly   979 LGPVV--KNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKS------IKKLTPALDTRIKRNLQDG 1035
            |..|:  :.::.|..||.|..|..:..:||.:.|..||::      ....|.|....:::.:::|
  Rat   997 LSTVLSKEGIDILTHLPKGSAEAELMSIVPVFYVFHYLEAGNHWNIFHPDTLARKQSLQKKIKEG 1061

  Fly  1036 YQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSFSKIKDIIDLDEQILAKGYEFLL 1100
            ...::.||:.|.|:|     .|:.    .:.|.||||:.||...::...:..|:..:.....:|:
  Rat  1062 LVSVMSYRNADYSYS-----MWKG----ASSSAWLTAFALRVLGQVNKYVKQDQYSICNSLLWLI 1117

  Fly  1101 TR-QAENGSFTEHGEYF---------YSSQRSLLTLTANSLLALLE------EEKPNQAAIDKAV 1149
            .: |.|||||.|:.:|.         ..:|.:.|.|||.|::.:.:      .|| ...|:.||.
  Rat  1118 EKCQLENGSFKENSQYLPIKLQGTLPAEAQENTLYLTAFSVIGIRKAIGICPTEK-IYTALAKAD 1181

  Fly  1150 AYLSANTAESIELLPKSIAIYALQKAKA--PEAAKQVASLKSLAKHEDD---RTWWTEDLDKLRA 1209
            ::|...|..|......:|..|||.....  |:....|::||..|..:.|   ..:|.:.|.:..:
  Rat  1182 SFLLERTLPSKSTFTLAIVAYALSLGDRTHPKFRSIVSALKREALVKGDPPIYRFWRDTLQRPDS 1246

  Fly  1210 S-KNCGRWWCWIWSQDVEITSYALLSLLDSDQETADSVLN-TVRWLIAQRNGFGGFASSQDTVVG 1272
            | .|.|.      :..||.|:||||:.|:. :||  |.:| .::||..::...|||.|:|||:..
  Rat  1247 SAPNSGT------AGMVETTAYALLTSLNL-KET--SYVNPIIKWLSEEQRYGGGFYSTQDTINA 1302

  Fly  1273 LTALIKFAEKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQTVEFPQGTKSLEFEAKGTGA 1337
            :..|.:::..........::.||.|.|.:..:...|  |.:.|.:.||.|.....:......:|.
  Rat  1303 IEGLTEYSLLVKQLHLDMDINVSYKHKGDFYQYKVT--EKNFLGRPVEVPLNDDLIVTTGYSSGL 1365

  Fly  1338 AMVQIS---YQYNLVEKEPKPSFKIQT------TVLPESSPANLELSVCVDY--VEEGESKESNM 1391
            |.|.:.   ::.::.|:......||.|      :.|..|...:..:..|..|  .:|..:..|:.
  Rat  1366 ATVYVKTVVHKTSVAEEFCSFYLKIDTQEVEASSYLSYSDSGHKRIIACASYKPSKEESASGSSH 1430

  Fly  1392 AILEVSLPSGYTAD-EDSFADIRNIERVRLVETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAV 1455
            |::::.||:|..|: ||..|.:..:::: |.:.:..||.|::...::...:..|:|...:....|
  Rat  1431 AVMDILLPTGIGANQEDLRALVEGVDQL-LTDYQIKDSHVILQLNSIPSRDFLCVRFRIFELFQV 1494

  Fly  1456 ANQKPSSVVLYDYYDTNKKATEYYSIK-SKLCDICEGDDCK 1495
            ....|::..:|:|:..:|:.|..||.. :.|..:|||..||
  Rat  1495 GFLNPATFTVYEYHRPDKQCTMIYSTSDTNLQRVCEGAACK 1535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	YfaS	<76..1411	CDD:441940	336/1508 (22%)
		A2M_2	982..1279	CDD:239227	88/327 (27%)
		A2M_recep	1387..1480	CDD:462226	21/93 (23%)
C5	NP_444179.1	MG1	25..125	CDD:465508	23/101 (23%)
		MG2	131..224	CDD:426464	26/115 (23%)
		MG3	226..310	CDD:465509	24/93 (26%)
		MG4	359..462	CDD:465507	29/146 (20%)
		A2M_BRD	475..615	CDD:462235	33/146 (23%)
		ANATO	691..759	CDD:237984	7/77 (9%)
		A2M	781..868	CDD:459711	27/98 (28%)
		complement_C3_C4_C5	1004..1309	CDD:239226	87/323 (27%)
		A2M_recep	1428..1519	CDD:462226	21/91 (23%)
		NTR_like	1536..1685	CDD:470599	374/1666 (22%)