DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep4 and TEP2

DIOPT Version :9

Sequence 1:	NP_001260590.1	Gene:	Tep4 / 35248	FlyBaseID:	FBgn0041180	Length:	1498	Species:	Drosophila melanogaster
Sequence 2:	XP_555086.4	Gene:	TEP2 / 3291704	VectorBaseID:	AGAP008366	Length:	1388	Species:	Anopheles gambiae

Alignment Length:	1485	Identity:	482/1485 - (32%)
Similarity:	770/1485 - (51%)	Gaps:	154/1485 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 EGKYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGITGPSYN-KTETVELATAGEFKQITFKLP 90
            :|.|:|:|...:..:..|...|:...||..:..::.|...... .||.:.| .:.|.:.|:|.:.
Mosquito    26 DGHYSIIGARILRPNSVYRCVVSTFDTKSAIVFRISIAAKDKPIATEEITL-NSNESRLISFTID 89

  Fly    91 PLEAGEYNLTAEGVKGLEFKNSTKLNWENFKPYIKIQTDKGKYKPGDTINYRVIFLDENLRPDTA 155
            .:...||.|.|||:.|||||..::|:::|....:.|||||..||||||:.|||:.||.:::...|
Mosquito    90 SIPEEEYELVAEGLSGLEFKTKSRLDFDNKFCSVLIQTDKSVYKPGDTVRYRVLVLDRSMKLLPA 154

  Fly   156 KDE-VVVWFEDSKRNRIKQEKHIKTTG--GVYTGKFELSEFATLGSWSLHVQNGDQHHDGGIYFG 217
            .|. ::|:..|.|.|||||..: .:.|  ||:..:..||....||.|:::|:           ..
Mosquito   155 GDSGMMVYIRDGKGNRIKQWSN-ASLGECGVFQAELTLSTEPVLGEWTINVE-----------VV 207

  Fly   218 GRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQQVSVRDGEFNVVLKANYTYGKPVNGK 282
            |.|             |...|:|::||||.|.|.:::.....:.|....||:.:.|||||||.|:
Mosquito   208 GLK-------------ESKTFDVDEYVLPTYEVTVESPGYTFLDDELLKVVVNSKYTYGKPVAGE 259

  Fly   283 VLVNVHLDSTSSWENVDGKTVQTDYPGHSVVGTADMVGGKAKLTMDLKDFASYLPHKTSSSYAQI 347
            :.|:|.|.|:..:.....:|        |:......:.||..:..:||:.   |..||......|
Mosquito   260 LTVSVKLASSMCFRREPTET--------SICQKVLPIDGKTDVEFNLKEI---LSSKTYIRELTI 313

  Fly   348 TATVEEDFTGVKLNETGGVQLYPYRYEMSCTDYSSCFSFKPDKEHELNFKITYVDGSLITDTKSV 412
            .|.|.|..||.....:..|||:..||::...:.||.|   |...:....::|.:|||.:.|
Mosquito   314 EAEVCETLTGRTQKGSTTVQLHDERYQVRMIEESSYF---PGLPYNAWIQVTNLDGSPVQD---- 371

  Fly   413 VKAKFTEGIRRNYAFYAFGTDHQEPELPTIEKKTFVFESHLNASGVAPFKVVLPDLPDIANFTRY 477
             .||..|.:.|||..             .:.|::    |.|:..|:|...|.|.:|    :|. |
Mosquito   372 -GAKEVEIVLRNYNI-------------DLHKQS----STLDDKGMAQLNVKLDEL----DFD-Y 413

  Fly   478 YSIELEFVDEKRDLYTTYPYREPKQIENPSSEEEKEW-FRAEVQRPKDVWNLKIGQEYQVILNSS 541
            .|:|:::  ..:|.|.       :.|..|...||... .|...:.|      ..|::....:..:
Mosquito   414 VSVEVKY--RGKDYYV-------QGITKPRDYEEALMRVRLSEKEP------TAGKDLTFDVACT 463

  Fly   542 RPLKYFVYNIVGRGNILETKRVDLAEPQTTVNVTIKPTFLTTPYGRVYFYYVDETGEFRYTEETF 606
            :||:...|:::.||.:|....|..:|..||:::||..||...|..::..:|:...|....:.:|.
Mosquito   464 KPLQCVSYSLLARGELLAGGAVKGSEASTTISITIPSTFAMVPRAKLLVHYISSAGYIVSSYDTV 528

  Fly   607 SVEVELQNQIEIK-APAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKESFNWRLN 670
            ..:...:|||::. :..|:||...:.::|:|...|||||||||||||||.|.||::::....:|.
Mosquito   529 EFKRVFENQIQLTLSKDELKPVETLDIDIRTEKDSFVGLLAVDQSVLLLKSGNDISRDEVVQQLE 593

  Fly   671 GYDTSTPWQ-GGYSYYPGERTGVVTMTNAYFFYNRTAPDYNIL-----TEGFGGSSFAMRKTTVA 729
            .|:::..:. ..||....:..|.|.::|. |......|...:.     ..|||.:
Mosquito   594 MYESAQNYHWDAYSTSDCQSVGAVLLSNR-FIPRDIFPQARLFACSTSAGGFGAA---------- 647

  Fly   730 HDSHVFHSGAGGPTQAV----GFSAESASASA---APVVRKNFAETWIFADIESTEE-EVFKWVK 786
                        |..|.    |...||..|:|   .|.||..|.||||:..|...:| |..:  |
Mosquito   648 ------------PMMAACKMKGVIMESEMATAPVNEPTVRSKFPETWIWESISKCKEMESIR--K 698

  Fly   787 TIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPK 851
            .:|||||:|::|||||....|||:.::.:.:..|.|||:|:.||||||.||.|.:|.:||||:.:
Mosquito   699 IVPDTITSWIITGFSLSKSHGLGLVDNPSKVNVFMPFFLSIDLPYSVKLGETIRIPVVVFNYMDE 763

  Fly   852 TLDVELTLDNEDQEYDFVDASNEVIGDQK---RTQNIRVGANEAAGASFLIRPKVIGNILLKFKA 913
            ....::...|.|.|::||..:.    |||   |.:.|.|........:|:::|..:|::.||..|
Mosquito   764 DQLADVIFYNNDDEFEFVSDTK----DQKEKHRQEQITVPRGTGKTLTFVLKPTKVGHVTLKITA 824

  Fly   914 ISPLAGDAIHKPLKVVPEGITQYQNRAFFINLKDTGEFKNTFELEVPEDVVPDSERVEFGLVGDL 978
            ...||||.|.:.|.|.|||:.||.|:|..::|:...|.|..||:|:|.|.||||..||..::||:
Mosquito   825 KCALAGDGIERQLLVEPEGLPQYINKALLVDLRLVKEIKQPFEVEIPVDAVPDSTNVEVSVIGDV 889

  Fly   979 LGPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHMLHYR 1043
            ||..::||::|:|:|.|||||.|...||..:|.||||:.|:||..::::.||.::.|||..|.|:
Mosquito   890 LGSSIENLDSLIRMPFGCGEQNMLNFVPCIVVLDYLKACKRLTVEIESKAKRCMEIGYQRELTYK 954

  Fly  1044 HDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSFSKIKDIIDLDEQILAKGYEFLLTRQAENGS 1108
            |.|||||:||.:.       ::|||||||:|.:||.:....:.::|.::.....:|...|..:|:
Mosquito   955 HQDGSFSAFGESD-------KSGSTWLTAFVAKSFQQAAKHMTIEEDVIDSALGWLSKVQTADGA 1012

  Fly  1109 FTEHGEYFYSSQR----SLLTLTANSLLALLEEEKPNQ---AAIDKAVAYLSANTAESIELLPKS 1166
            |.|.|...:...:    |.:.|||.:::|.||..|..:   |::|||:.|:..:.:|..::...:
Mosquito  1013 FPEVGTICHKDMQGGAGSGMALTAYTVIAFLENPKLGEKYKASVDKALTYVKEHISELDDVYAHA 1077

  Fly  1167 IAIYALQKAKAPEAAKQVASLKSLAKHEDDRTWWTEDLDKLRASKNCGRWWCWIWSQDVEITSYA 1231
            :|.||||.|..|...:..|||.|.:..:.|..||::::.:...|..|  ||....|.:||:::|.
Mosquito  1078 LAAYALQIADHPLKNEVYASLLSKSNKQGDIQWWSKEIPEKNDSNCC--WWYRPCSVNVEMSAYG 1140

  Fly  1232 LLSLLDSDQETADSVLNTVRWLIAQRNGFGGFASSQDTVVGLTALIKFAEKSGYEAAKWEVTVSN 1296
            ||:.|::.....:. |..::||::|||..|||.|:|||||||.||.|.|.:.....|...:.|..
Mosquito  1141 LLATLEASSAGLEG-LPIMKWLVSQRNDKGGFESTQDTVVGLQALSKMAAQLSSSEADMSLKVII 1204

  Fly  1297 KGKREKTEKLNTSEENDLLLQTVEFPQGTKSLEFEAKGTGAAMVQISYQYNLVEKEPKPSFKIQT 1361
            .|::||..::|..  |.|:||..|....|:.||..|.|||.|:.|:||:||:.:.:..|.|.::.
Mosquito  1205 TGEQEKCLQVNGG--NILVLQKHELAANTRKLEMIATGTGCALFQLSYKYNIKDVDNSPRFTLKP 1267

  Fly  1362 TVLPESSPANLELSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSFADIRNIERVRLVETKNG 1426
            .....|..:.::||:...::.:.:...||||::||.:|||:..:.|:...::..|.|:.||||..
Mosquito  1268 EAKQGSIKSCIDLSITTSFIPKEDQAVSNMAVMEVDMPSGFIVESDTLKQLKQHEMVKKVETKRS 1332

  Fly  1427 DSVVVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKKATEYYSI 1481
            |:.||:||:|:.: |...:::.|::.|.|.|.||::|::|||||..:.|..:|.|
Mosquito  1333 DTTVVLYFDNIGE-EAVHLQMSAFQKHEVENAKPANVIIYDYYDNTRCARSFYEI 1386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081	35/95 (37%)
		A2M_N_2	528..653	CDD:285005	39/125 (31%)
		A2M	768..859	CDD:278630	40/91 (44%)
		A2M_2	982..1279	CDD:239227	111/303 (37%)
		A2M_comp	1035..1281	CDD:284982	89/252 (35%)
		A2M_recep	1389..1479	CDD:284981	36/89 (40%)
TEP2	XP_555086.4	A2M_N	122..217	CDD:280081	39/119 (33%)
		YfaS	<123..>1006	CDD:225248	322/999 (32%)
		A2M_N_2	443..576	CDD:285005	41/138 (30%)
		A2M	681..769	CDD:278630	40/89 (45%)
		A2M_2	893..1186	CDD:239227	111/302 (37%)
		A2M_comp	945..1189	CDD:284982	89/253 (35%)
		A2M_recep	1295..1384	CDD:284981	36/89 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	71	1.000	Domainoid score	I16385
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45959
OrthoDB	1	1.010	-	-		D10215at33392
OrthoFinder	1	1.000	-	-		FOG0002157
OrthoInspector	1	1.000	-	-		mtm9735
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.890