DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep4 and TEP8

DIOPT Version :9

Sequence 1:	NP_001260590.1	Gene:	Tep4 / 35248	FlyBaseID:	FBgn0041180	Length:	1498	Species:	Drosophila melanogaster
Sequence 2:	XP_309878.3	Gene:	TEP8 / 3291179	VectorBaseID:	AGAP010831	Length:	936	Species:	Anopheles gambiae

Alignment Length:	1060	Identity:	285/1060 - (26%)
Similarity:	484/1060 - (45%)	Gaps:	180/1060 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   479 SIELEFVDEKRDLYTTYPYREPKQIENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQVILNSSRP 543
            |:.|:|  :..|.:..|        |:.:..|...:.:.|::.|     :|:.:.....:..:..
Mosquito    15 SVLLQF--DAVDAFLFY--------EDVNKVETDAFIKLELKSP-----IKLNKLMHFTVTCTER 64

  Fly   544 LKYFVYNIVGRGNILETKRVDLAEPQTTVNVTIKPT---------FLTTPYGRVYFY-YVDETGE 598
            :.:|||.:|.:.||::...: ||..:||..:.:..|         .:.|..||...| |::.  :
Mosquito    65 MSFFVYYVVSKSNIIDAGFM-LANKETTFLLQLNATENMIPKAKILIITVAGRTVMYDYINL--D 126

  Fly   599 FRYTEETFSVEVELQNQIEIKAPAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKE 663
            |:.....|.:.|:.|         |:|||..:.|.:...|.::|||.|.|:::||...|:||..|
Mosquito   127 FQELRNNFDLSVDEQ---------EIKPGRQIELSMSGRPGAYVGLAAYDKALLLFNKNHDLFWE 182

  Fly   664 SFNWRLNGYDTSTPWQGGYSYYPGE-----RTGVVTMTNAYFFYNRTAPDYNILTEGFGGSSFAM 723
            .|   |..:|      |.:||...|     ..|:...|...||    ..:||..:|..|..   |
Mosquito   183 DF---LKVFD------GFHSYDTNEFDLFHTMGLFARTLDDFF----VQNYNHKSERNGQQ---M 231

  Fly   724 RKTTVAHDSHVFHSGAGGPTQAVGFSAESASASAAPVVRKNFAETWIFADIESTEEEVFKWVKTI 788
            .:|                                 ||||.|.|:|::.::........|..:.:
Mosquito   232 EQT---------------------------------VVRKQFVESWLWKNVTIGSSGSLKLTEVV 263

  Fly   789 PDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTL 853
            |||.|:|.:||||:.|..|||:........|.||||:...||||:||||.|.:..::.:.|....
Mosquito   264 PDTTTSWYLTGFSIDPVVGLGIIKKPIEFTTVQPFFILESLPYSIKRGEAIEIQFILISNLQGEH 328

  Fly   854 DVELTLDNEDQEYDFVDASNEVIGDQKRTQNIRVGANEAAGASFLIRPKVIGNILLKFKA--ISP 916
            .|::||.||:.|.:|:..|   |.:...|:::.|........|||::.|.:|.::::.||  .:.
Mosquito   329 TVDVTLYNENNEMEFIGRS---IANASYTKSVSVLPKWGKPISFLVKAKKLGEMMVRVKASIANG 390

  Fly   917 LAGDAIHKPLKVVPEGITQ------------YQNRAFFINLKDTGEFKNTFELEVPEDVVPDSER 969
            ||.||:.|.::|.||.:.|            |||:.|.:       |.|     :|::....|..
Mosquito   391 LATDALEKVIRVTPESLEQSRVESFGIFFDEYQNQTFSV-------FPN-----IPKNADNGSVE 443

  Fly   970 VEFGLVGDLLGPVVKNLENLLRLPSGCGEQ---TMSKLVPNYLVRDYLKSIKKLTPALDTRIKRN 1031
            :|..:..:||..|.:||.::....|.|.:.   |::..|.||||            |:.:..:.:
Mosquito   444 IELRVNPNLLITVKENLNDIRTDWSECSKGIRFTLNFAVHNYLV------------AIGSSDQIS 496

  Fly  1032 LQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSF-SKIKDIIDLDEQILAKG 1095
            ..|......||...:..|:|.|  .||.:       .:.||:::.:. :.:|.:...|::.|.|.
Mosquito   497 SDDNATLSKHYIRLEKCFNSNG--SWRNK-------VFDTAFLVNALHNAMKYVSWKDKRKLEKA 552

  Fly  1096 YEFLLTRQAENGSFTE-HGEYFYSSQRSLLTLTANSLLALLEEEK---PNQAAIDKAVAYLSANT 1156
            :::|.::|..:|||.| ..:..|  :||.:.||:..|..:||.|.   .:...|:|.:::|| :.
Mosquito   553 FDWLASQQHHSGSFKETESDLHY--KRSDVALTSYVLAVMLENESAKVEHAVVIEKGMSFLS-DQ 614

  Fly  1157 AESIELLPKSIAIYALQKAKAPEAAKQVASLKSLAKHEDDRTWWTEDLDKLRASKNCGRWWCWIW 1221
            .|||              ..|.:.|....::.|......|..:  |.|..:....|.|....|..
Mosquito   615 LESI--------------TSANDLAIVTYAMMSYGHRLRDAAF--EKLIYMSTITNNGAERYWNP 663

  Fly  1222 SQDVEITSYALLSLLDSDQETADSVLNTVRWLIAQRNGFGGFASSQDTVVGLTALIKFAEKSGYE 1286
            |..||.||:||||.:.:::  ....|..:|||:..|:.....:..|:|.:...||...|:|....
Mosquito   664 SNSVEATSFALLSHVVANK--LQGALPIMRWLVNHRSELNSVSGQQNTYLRFKALSSIAKKIALS 726

  Fly  1287 AAKWEVTVSNKGKREKTEKL--NTSEENDLLLQTVEFPQGTKSLEFEAKGTGAAMVQISYQYNLV 1349
            ...::|.:    |...:.||  .||.::|  .|.:...|..:.||....|.||.::|:.|:|||.
Mosquito   727 RNDYDVRI----KYRLSRKLFRFTSYDSD--TQHMLITQNVRKLEIHVGGIGAGLLQVFYRYNLN 785

  Fly  1350 EKEPKPSFKIQTTVLPESSPANLELSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSFADIRN 1414
            ....:..||:.......:....|:|:||.:|:.......||||::||:|||||..|.:..::...
Mosquito   786 LMNFEHRFKLDLQKQITNFDQELKLNVCANYIPTVSESRSNMALVEVTLPSGYVVDHNPISEQTT 850

  Fly  1415 IERVRLVETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKKATEYY 1479
            :..::.:|.:.|.:.||:|:.::. :|..|..:.|||...||.::|:.||:|||||||..|.:.|
Mosquito   851 VNPIQRIEIRYGGTSVVLYYYSMG-SERNCFTVSAYRRFKVALKRPAYVVVYDYYDTNLNAIKVY 914

  Fly  1480 SI-KSKLCDICEGDDCKSKC 1498
            .: |..:|:|||.:||:::|
Mosquito   915 EVDKQNVCEICEEEDCRAEC 934

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081
		A2M_N_2	528..653	CDD:285005	32/134 (24%)
		A2M	768..859	CDD:278630	31/90 (34%)
		A2M_2	982..1279	CDD:239227	75/304 (25%)
		A2M_comp	1035..1281	CDD:284982	62/250 (25%)
		A2M_recep	1389..1479	CDD:284981	35/89 (39%)
TEP8	XP_309878.3	A2M_N_2	41..172	CDD:285005	34/147 (23%)
		A2M	243..334	CDD:278630	31/90 (34%)
		ISOPREN_C2_like	<527..717	CDD:298658	54/210 (26%)
		A2M_recep	825..914	CDD:284981	35/89 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880