DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep4 and c3a.1

DIOPT Version :9

Sequence 1:	NP_001260590.1	Gene:	Tep4 / 35248	FlyBaseID:	FBgn0041180	Length:	1498	Species:	Drosophila melanogaster
Sequence 2:	NP_571317.1	Gene:	c3a.1 / 321046	ZFINID:	ZDB-GENE-990415-35	Length:	1643	Species:	Danio rerio

Alignment Length:	1708	Identity:	372/1708 - (21%)
Similarity:	655/1708 - (38%)	Gaps:	439/1708 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FAVSLCVILALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAV-AVHQTKEPVTLKVGITG-PSYN 69
            |..::.:..|||...:|:     |.:..|..:......||.| |...:|....:|:.:.. |..:
Zfish     6 FLSAVLLSSALLTLCDPL-----YVLSAPNLLRVGSSENVFVEAQDYSKNAFEVKITVKNHPKKD 65

  Fly    70 K---TETVELATAGEFKQIT-FKLP---------PLEAGEYNL-------TAEGVKGLEFKNSTK 114
            |   |::|.|.....|:.:| .|:|         |||.....|       |.|.|..|.|::.
Zfish    66 KQILTKSVNLNAQNNFQILTDIKIPDDQNLFSDDPLEKQYVYLQAIFPDHTLEKVVLLSFQSG-- 128

  Fly   115 LNWENFKPYIKIQTDKGKYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKT 179
                    ||.:||||..|.|..|:.||.:.|..||:| .::..:.|...:.:...:..:| :..
Zfish   129 --------YIFVQTDKPIYTPSSTVQYRTLSLTPNLKP-LSQTGITVEIMNPQNITVSSDK-VYP 183

  Fly   180 TGGVYTGKFELSEFATLGSWSL--HVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEK 242
            ..|:.:||:.:.|.|:||.|.:  ...|..|           |.|            ...|||::
Zfish   184 VKGMKSGKYAIPEVASLGIWKVVTRFANTPQ-----------KTF------------TAEFEVKE 225

  Fly   243 YVLPKYSVKMDATQQ-VSVRDGEFNVVLKANYTYGKPVNGKVLVNVHLDSTSSWENVDGKTVQTD 306
            ||||.:.||:..::. ..|.|....|.::|.|.:||.|.|...|...:        :||:|..
Zfish   226 YVLPTFEVKLQPSKLFYYVGDESLTVDIEAKYLFGKQVEGNAFVMFGV--------MDGETKT-- 280

  Fly   307 YPGHSVVGTADMVG-----GKAKLTMD-LKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGG 365
                .:.|:...:.     |.|:||.. ::.:.|.......|.|..::...|.....|:. |..|
Zfish   281 ----GITGSLQKIQILKGVGTAELTKQMIETYKSIDKLVGQSIYVSVSLLTESGSEMVEA-ERRG 340

  Fly   366 VQLY--PYRYEMSCTDYSSCFSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFY 428
            :::.  ||......|    ...|||....:::..:|..|.   |..::|:......|:|
Zfish   341 IRIVTSPYTINFKKT----AQFFKPGMPFDVSIYVTNPDE---TPAQNVIVEVNPGGVR------ 392

  Fly   429 AFGTDHQEPELPTIEKKTFVFESHLNASGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYT 493
                                  ....|:|:|  ||.                    |:.:.::.|
Zfish   393 ----------------------GQTKANGIA--KVT--------------------VNTQGNVLT 413

  Fly   494 TYPYREPKQIENPSSEEEKEWFRAEVQRPK-----------DVWNLKIGQEYQVILNSSRPL--- 544
            .....:.|..:....|:..:...|....||           |...|:||.:.:|.||:.:..
Zfish   414 QEITAQTKDPDITDEEQAVKKMTAHAYVPKGGSKNYLHIGIDAAELEIGDQMKVNLNTGQSPGVK 478

  Fly   545 -KYFVYNIVGRGNILETKR--------VDLAEPQTTVNVTIKPTFLTTPYGRVYFYYVDETGEFR 600
             :.:.:.|:.:|.|::..|        :.|::|.|...|   |:|      |...||  ..|...
Zfish   479 DQDYTFMILSKGQIVKIDRFKRQGQALITLSQPVTKEMV---PSF------RFVAYY--HVGANE 532

  Fly   601 YTEETFSVEVELQNQIEIKAPAEVK-------PGADVALEIKTSPKSFVGLLAVDQSVLLLGSNN 658
            ...:  ||.|::::....|...:||       .|.:|.|:|...|.:.|||:.||::|.:|..|.
Zfish   533 VVSD--SVWVDVKDTCMGKLKLQVKNKQNNYNTGEEVKLQISGDPGARVGLVVVDKAVHVLNKNR 595

  Fly   659 DLNKESFNWRLNGYDTSTPWQGGYSYYPGERTGVVTMTNA-YFFYNRTAPDYNILTEGFGGSSFA 722
             |.:......:..:||.....||       |..:...::| ..|.:.||          ||:...
Zfish   596 -LTQTKIWDVIEKHDTGCTAGGG-------RDVMGVFSDAGLMFESNTA----------GGTDTR 642

  Fly   723 M-----------RKTTVAHDSHVFHSG-----AGGPTQA---------VGFSAESASA------- 755
            :           |:.|.:.:.....:.     |.|..|.         :|::.|..:.
Zfish   643 LNPECPDPPKRRRRRTESENLRTITATLAGQYADGQRQCCIDGMKDNKLGYTCERRATYIGDGPE 707

  Fly   756 ---------------------------------------SAAPVVRKNFAETWIFADIE------ 775
                                                   |...|.|..|.|:|::.:|:
Zfish   708 CVKAFLHCCDEMKKRKNIKTEEEEMILARSDDDDDYYTDSEEIVSRTQFPESWLWEEIDLCDNCP 772

  Fly   776 --STEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEV 838
              :.|:.::     :.|:||.|.|...|:.|..|:.|...: .|..|:..|:.:::|||..|||.
Zfish   773 ASAMEKAMY-----LKDSITTWQVLAVSMSPTLGICVAEPE-EIVVFKSLFIDLKMPYSAVRGEQ 831

  Fly   839 INVPALVFNYLPKTLDVELTLDNEDQEYDFVDASNEVIGDQKRTQ---NIRVGANEAAGASFLIR 900
            :.:.|::.||.|         |......:|:::::......|:.:   .:.:....:....::|.
Zfish   832 LEIKAIIHNYTP---------DKRKVRVEFMESADVCSLASKKGKYRTTVTIPKESSLSVPYVII 887

  Fly   901 PKVIGNILLKFKAIS--PLAGDAIHKPLKVVPEGIT-QYQNRAFFINLKDTGEFKNTFELEVPED 962
            |..:||.:::.||.:  .:..|.:.|.||||.||:. ..|.....:|....|:.......::|.|
Zfish   888 PMTLGNHMIEVKAAAYDAVYTDGVRKGLKVVSEGVLFPLQRPNVELNPVKNGDSPIIVRADIPAD 952

  Fly   963 VVPD--------------SERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRDY 1013
            .||.              |:.||..:.|..:|       .|:..|.|||||.|..:....:...|
Zfish   953 RVPGTPAHTHISITGEEISQTVEQAISGSFMG-------QLIVQPHGCGEQNMIFMTLPVIATHY 1010

  Fly  1014 LKS--------IKKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWL 1070
            |.|        :|:...|:.     :::.||.....||..|||:::     |..    |..||||
Zfish  1011 LDSTNQWEAIGMKRRDEAIG-----HIKTGYNRQQAYRKPDGSYAA-----WID----RPSSTWL 1061

  Fly  1071 TAYVLRSFSKIKDIIDLDEQILAKGYEFL-LTRQAENGSFTE-----HGEYF--YSSQRSLLTLT 1127
            ||||.:.|:...|:|.::||:|....::| |.||..:|||.|     |||..  ...:.:..:||
Zfish  1062 TAYVAKIFAMANDLITIEEQVLCSALKWLVLNRQLPDGSFEEKAAVVHGEMVGDVQGRDAEASLT 1126

  Fly  1128 ANSLLALLEEEKPNQA-------AIDKAVAYLSANTAESIELLPKSIAIYALQKAKAPEAAKQVA 1185
            |...:|:.|..:...|       :|.|||::|.....:...  |.::|:.:...|.|.:..|.|
Zfish  1127 AFVTIAMQEGRELCGAIVGSLPESIRKAVSFLEGKLNKLTN--PYAVALTSYAMAGADKLNKAV- 1188

  Fly  1186 SLKSLAKHEDDRTWWTEDLDKLRASKNCGRWWCWIWSQ--DVEITSYALLSLLDSDQETADSVLN 1248
                              |.|.......|.:|.....|  ..|.||||:|:|:.:....|..  .
Zfish  1189 ------------------LMKFSTKGEAGTYWNVPGQQYHTREATSYAVLALVKARDFNAAG--E 1233

  Fly  1249 TVRWLIAQRNGFGGFASSQDTVVGLTAL------IKFAEKSGYEAAKWEVTVSNKGK------RE 1301
            .|.||.:|...:||..::|.|::...|:      :|.::....|.   |:.|..:.|      :.
Zfish  1234 AVHWLGSQHYSYGGSGTTQATIMVFQAVAEYRTQVKDSQNFNLEV---ELAVEGRSKPSRYTIKR 1295

  Fly  1302 KTEKLNTSEENDLLLQTVEFPQGTKSLEFEAKGTGAAMVQISYQYNLVEKEPKP-------SFKI 1359
            ....::.|::.|:          .|.....|||||.|.:.:...|.....|.|.       |.||
Zfish  1296 DNRHVSRSDKVDI----------NKDFNVTAKGTGKATLSVLTLYYARPVEKKSDCTLFDLSVKI 1350

  Fly  1360 QTTVLPESSPANL--ELSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSFADI-----RNIER 1417
            ...  ||:..|:.  ...:.:|:..:.....:.|.||::.:|:|:|.:.:...::     :.:|:
Zfish  1351 DKD--PETKHADAIETFKLTMDFFYKNPKSPATMTILDIGIPTGFTVEYNDLEELTRGKEKYLEK 1413

  Fly  1418 VRLVETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVAN---QKPSSVVLYDYYDTNKKATEYY 1479
            ..:.:..:....:::|.:.::..|.:.|   |:|.|.:.|   .:|::|.:|:||..|.:.|:|:
Zfish  1414 FEMDKALSDRGSLILYLKMVSNKESERI---AFRMHKMLNVGLLQPAAVTIYEYYSPNARCTKYF 1475

  Fly  1480 SIKSK--LCDICEGDDCK 1495
            ..:.:  :..:|:||.|:
Zfish  1476 HPEREGVIYRLCKGDMCQ 1493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081	25/94 (27%)
		A2M_N_2	528..653	CDD:285005	37/143 (26%)
		A2M	768..859	CDD:278630	25/98 (26%)
		A2M_2	982..1279	CDD:239227	86/327 (26%)
		A2M_comp	1035..1281	CDD:284982	74/268 (28%)
		A2M_recep	1389..1479	CDD:284981	21/97 (22%)
c3a.1	NP_571317.1	A2M_N	129..223	CDD:280081	30/118 (25%)
		A2M_N_2	452..588	CDD:285005	37/148 (25%)
		ANATO	666..735	CDD:237984	5/68 (7%)
		A2M	759..851	CDD:278630	26/106 (25%)
		complement_C3_C4_C5	979..1264	CDD:239226	88/328 (27%)
		A2M_comp	1034..1264	CDD:284982	73/261 (28%)
		A2M_recep	1380..1475	CDD:284981	21/97 (22%)
		NTR_complement_C3	1494..1641	CDD:239638	372/1708 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584203
Domainoid	1	1.000	48	1.000	Domainoid score	I11904
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.800