DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tep4 and c3a.2

DIOPT Version :9

Sequence 1:NP_001260590.1 Gene:Tep4 / 35248 FlyBaseID:FBgn0041180 Length:1498 Species:Drosophila melanogaster
Sequence 2:NP_571318.1 Gene:c3a.2 / 30491 ZFINID:ZDB-GENE-990415-36 Length:1651 Species:Danio rerio


Alignment Length:1699 Identity:373/1699 - (21%)
Similarity:662/1699 - (38%) Gaps:416/1699 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 FAVSLCVILALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAV-AVHQTKEPVTLKVGI------- 63
            |..::.:..|||...:|:     |.::.|..:......||.| |...:.||:.:|:.:       
Zfish     7 FLSAVLLSSALLTLCDPL-----YVLMAPNLLRVGSSENVFVEAQDYSGEPLRVKISVKNFPAKN 66

  Fly    64 ----------TGPSYNKTETVELATAGEF------KQITFKLPPLEAGEYNLTAEGVKGLEFKNS 112
                      ||..|.....:|:.....|      ||..:    |:|...::|.|.|..:.|::.
Zfish    67 VEMMQKTVTLTGEKYQILTDIEIPDDKNFFSDDEKKQYVY----LQAHFPSVTLEKVVMVSFQSG 127

  Fly   113 TKLNWENFKPYIKIQTDKGKYKPGDTINYRVIFLDENLRP--------DTAKDEVVVWFEDSKRN 169
                      |:.:||||..|.||..:.||:..:..||:|        |....:.:....|:   
Zfish   128 ----------YLFVQTDKPIYTPGSNVQYRIFSMTPNLKPLSQPGITVDIMNPQGITVASDA--- 179

  Fly   170 RIKQEKHIKTTGGVYTGKFELSEFATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDE 234
             ||.||      ||.:..:.:.:..:||.|.:..:..:.         ..|.|            
Zfish   180 -IKAEK------GVKSSIYNIPDVTSLGMWKVVTRYTNT---------PLKTF------------ 216

  Fly   235 LVNFEVEKYVLPKYSVKMDAT---------QQVSVRDGEFNVVLKANYTYGKPVNGKVLVNVHLD 290
            ...|||::||||.:.||:..:         :|.:..:....|.::|.|.:||.::|...|...: 
Zfish   217 TAEFEVKEYVLPTFEVKLTPSSFFYYVGDNKQENDEEDSLTVDIEAKYLFGKKMDGNAFVVFGV- 280

  Fly   291 STSSWENVDG--KTVQTDYPGHSVVGTADMVG-----GKAKLTMDL--KDFASYLPHKTSSSYAQ 346
                   :||  ||        |:|.:...|.     |.|:||.::  |.|.:.......|.|..
Zfish   281 -------MDGAAKT--------SIVNSLQKVPVVNGVGTAELTREMITKTFKNIKDLVGKSIYVS 330

  Fly   347 ITATVEEDFTGVKLNETGGVQLY--PYRYEMSCTDYSSCFSFKPDKEHELNFKITY--------V 401
            :....|.....|:. |..|:|:.  ||......|   |.| |||.....::..:|.        |
Zfish   331 VNLLTESGSEMVEA-EKRGIQIVTSPYTIHYKRT---SQF-FKPGMPLGVSVYVTNPDETPAKDV 390

  Fly   402 DGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELPTIEKKTFVFESHLNASGVAPFKVVLP 466
            :..::.|.|..|..|..:                                    :|:|..||..|
Zfish   391 EVEVLVDGKGGVSGKTRD------------------------------------NGIAKVKVNTP 419

  Fly   467 DLPDIANFTRYYSIELEFVDEKRDL--YTTYPYREPKQIENPSSEEEKEWFRAEVQRPKDVWNLK 529
            ........|. .:...|:..|::.:  .|...|:        :..:.|.:....::..:    .:
Zfish   420 GGASTLKITA-KTKNTEYTSEQQAVKTMTAQAYK--------TKHDSKNYLHINIESAE----FE 471

  Fly   530 IGQEYQVIL-----NSSRPLKYFVYNIVGRGNILETKRVDLAEPQTTVNVTIKPTFLTTPYGRVY 589
            ||.:..|.|     :..|...| .|.|:.:|.|:..:|.. .:.||.|.:::..|....|..|..
Zfish   472 IGDQMTVNLITGQSSGDRDQDY-TYMILSKGQIVLAERFK-RQGQTLVTLSLTITKEMVPSFRFV 534

  Fly   590 FYYVDETGEFRYTEETFSVEVELQNQIEIKAPAEVK-------PGADVALEIKTSPKSFVGLLAV 647
            .||  ..|:.....:  ||.|::::....|...|||       .|.||.|.|...|.:.|||:.|
Zfish   535 AYY--HVGKDEVVSD--SVWVDVKDTCMGKLNVEVKEKKNTYETGNDVNLHITGDPGARVGLVVV 595

  Fly   648 DQSVLLLGSNNDLNKESFNWR-LNGYDTSTPWQGGYSYYPGERTGVVTMTNAYFFYN-------R 704
            |::|.:|..|.  ..:|..|. :..:||.....||     .:..||.:.....|..|       |
Zfish   596 DKAVQVLNKNR--LTQSKVWDVIEKHDTGCTGGGG-----KDSMGVFSDAGLIFESNTAGGTDTR 653

  Fly   705 TAPD-------------YNILTEGFGGSSFAMRKTTVAHDSHVFHSGAGGPTQAVGFSAESASAS 756
            |.|:             ...:|....| .:..:.....:|        |.....:|::.|   ..
Zfish   654 TVPECPAPLKRKRRSESLQTITTTLAG-QYTEKIRPCCYD--------GMRNNRIGYTCE---RR 706

  Fly   757 AAPVV--------------------------------------------------RKNFAETWIF 771
            |:.|:                                                  |..|.|:|::
Zfish   707 ASYVIDGEECVKAFLHCCKEVKNHKEKETEEEELILARSDEDEEGDYKDYDDITSRTQFPESWLW 771

  Fly   772 ADIE--------STEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVR 828
            .:.:        |.::.::     :.|:||.|.:...||.|..|:.|...: .|..|:.||:.::
Zfish   772 EEFDLCDKCSKPSKDKVIY-----LKDSITTWQILAISLSPTHGICVAEPE-EIVVFKSFFIDLK 830

  Fly   829 LPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVDASNEVIGDQKRTQ---NIRVGAN 890
            :|||..|||.:.:.|::.||.||.|        :....:|::.:.......|:.:   .:.|..:
Zfish   831 VPYSAVRGEQVEIKAIIHNYTPKHL--------KKVRVEFLETAGVCSAASKKGKYRTTVNVDKD 887

  Fly   891 EAAGASFLIRPKVIGNILLKFKAISPLAGDAIHKPLKVVPEGI-TQYQNRAFFINLKDTGEFKNT 954
            .:...||:|.|..:.:..::.||......|.:.|.||||.||: |:::.....:|....||....
Zfish   888 SSVAVSFVIVPMTLESQHIEVKASISDYEDGVRKTLKVVSEGVLTKFRTEKLELNPGKKGEKPLV 952

  Fly   955 FELEVPEDVVPD--------------SERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSKLV 1005
            ....:|.|.||.              |:.:|..:.|..:|       .|:..|.|||||.|..:.
Zfish   953 LRSGIPADQVPGTPVNSYITVTGEEISQSIEQAINGSFMG-------ELIIQPHGCGEQNMVTMT 1010

  Fly  1006 PNYLVRDYLKSIKKLT-PALDTR--IKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGS 1067
            ..::...||.:..:.. ..:|.|  ...:::.||:..|.:|..|||::     .|.:.|    .|
Zfish  1011 LPFIATHYLDNTNQWEYVGIDRRKVAINHIKTGYEGQLKFRKQDGSYA-----LWIETD----SS 1066

  Fly  1068 TWLTAYVLRSFSKIKDIIDLDEQILAKGYEFL-LTRQAENGSFTEHGEYFY-------SSQRSLL 1124
            |||||||.:.|:....:|.::|.::....::| :.:|..:|||.|....::       ..|.:.:
Zfish  1067 TWLTAYVAKVFAMASKLIAIEENVICSALKWLVMHKQLPDGSFKEDKPVYHREIMGGIEGQNTDV 1131

  Fly  1125 TLTANSLLALLEEEK-------PNQAAIDKAVAYLSANTAESIELLPKSIAIYALQKAKAPEAAK 1182
            :|||..|:|:.|.::       ....:|.|:||:|.....:.......::..|||  |.|....|
Zfish  1132 SLTAFVLIAMQEGKEICGGAVGSLHESIRKSVAFLKNQLTKLTNPYAAALTSYAL--ANADSLDK 1194

  Fly  1183 QVASLKSLAKHEDDRTWWTEDLDKLRASKNCGRWW---CWIWSQDVEITSYALLSLLDS-DQETA 1243
            ::     |.||.              ...|.||:|   .|.: ..:|.|:||:|:|:.: |.:||
Zfish  1195 EI-----LMKHS--------------TKGNDGRFWNVPGWHY-HSIEATAYAVLALVKAKDYDTA 1239

  Fly  1244 DSVLNTVRWLIAQRNGFGGFASSQDTVVGLTALIKF-AEKSGYEAAKWEVTVSNKGKREKTEKLN 1307
            .   ..|.||..|::..||:.::|.|::...|:.:: |:....:.....|.:...|:| ||::..
Zfish  1240 G---EAVHWLAKQKSSHGGYDTTQVTIMVFQAVAEYRAQVQDLKNFDLNVELVVPGRR-KTDRWT 1300

  Fly  1308 TSEENDLLLQTVEFPQGTKSLEFEAKGTGAAMVQI--SYQYNLVEKEPKPSF---KIQTTVLPES 1367
            ....|..|.::..... .|.....|||||:|::.:  .|.....||:...:|   .::...:||:
Zfish  1301 IQRSNVHLTRSGSVDM-NKDFTVIAKGTGSAILSVLTLYYARPFEKKTDCTFFDLSVKLDKIPET 1364

  Fly  1368 SP-ANLELSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSFADIRNIE--RVRLVETKNGDSV 1429
            .| .|...:..:|:..:.::.::.|.||::.||:|:..||   ||::.:.  :.|.::....:.|
Zfish  1365 KPGTNGTYNFILDFFYKNKTNDATMTILDIGLPTGFDIDE---ADLKQLSTGKERYIQKYEKNKV 1426

  Fly  1430 ------VVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKKATEYYSIK---SKL 1485
                  ::||...::..|.:.:....::|..|...:|:||.:|:||..:.:..:||..:   |.|
Zfish  1427 LSERGSLIIYLNKVSHKESETLVFRMHKTFNVGLLQPASVTIYEYYSPDARCKKYYHPEREDSAL 1491

  Fly  1486 CDICEGDDC 1494
            ..:|:||.|
Zfish  1492 YRLCKGDLC 1500

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep4NP_001260590.1 A2M_N 126..219 CDD:280081 23/100 (23%)
A2M_N_2 528..653 CDD:285005 39/136 (29%)
A2M 768..859 CDD:278630 27/98 (28%)
A2M_2 982..1279 CDD:239227 82/318 (26%)
A2M_comp 1035..1281 CDD:284982 70/265 (26%)
A2M_recep 1389..1479 CDD:284981 23/97 (24%)
c3a.2NP_571318.1 A2M_N 128..222 CDD:280081 27/124 (22%)
EMA 388..>469 CDD:280624 16/125 (13%)
A2M_N_2 463..599 CDD:285005 38/145 (26%)
ANATO 674..729 CDD:237984 8/66 (12%)
A2M 768..861 CDD:278630 27/106 (25%)
complement_C3_C4_C5 987..1272 CDD:239226 84/325 (26%)
A2M_comp 1042..1272 CDD:284982 70/263 (27%)
A2M_recep 1387..1482 CDD:284981 23/97 (24%)
NTR_complement_C3 1502..1649 CDD:239638
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170584179
Domainoid 1 1.000 48 1.000 Domainoid score I11904
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
65.800

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