Protein Alignment Tep4 and Mug6

DIOPT Version :10

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: XP_038963368.1
• Gene: Mug6 / 297572
• RGDID: 1566313
• Length: 1493
• Species: Rattus norvegicus
• Alignment Length: 1632
• Identity: 427/1632 - (26%)
• Similarity: 704/1632 - (43%)
• Gaps: 326/1632 - (19%)

  Fly    11 LC---VILALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGITGPSYNKTE 72
            ||   |:||||.:........||.::.|..:::.....:.:.::...|.||:...:......:..
  Rat     9 LCLFSVLLALLPSASSFNGNSKYMVLVPSQLYTDTPEKICLHLYHLNETVTVTASLISQRGTRKL 73

  Fly    73 TVELATAGE-FKQITFKLPPLEAGE----YNLTAEGVKGLEFKNSTKLNWENFKPYIKIQTDKGK 132
            ..||....: |..::|.:|.|.:.|    .::..||.|. :|.....:..:|.:..:.:||||..
  Rat    74 FDELVVDKDLFHCLSFTIPRLPSSEEEESLDINIEGAKH-KFSKRRVVLVKNKESVVFVQTDKPV 137

  Fly   133 YKPGDTINYRVIFLDENLRPDTAKDEV--VVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFAT 195
            ||||.::.:|::.:|:||.|   .:|:  :.:.||.|.|||.|.:.|||..|:....|.||....
  Rat   138 YKPGQSVKFRIVSMDKNLHP---LNELFPLAYIEDPKINRIMQWQDIKTENGLKQLSFSLSAEPI 199

  Fly   196 LGSWSLHV--QNG--DQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQ 256
            .|.:.:.:  |:|  ::|                           :|.|.::|||::.|.:....
  Rat   200 QGPYKIVILKQSGVKEEH---------------------------SFTVMEFVLPRFGVDVKVPN 237

  Fly   257 QVSVRDGEFNVVLKANYTYGKPVNGKVLVNV-------HLDSTSSWENVDGKTVQTDYPGHSVVG 314
            .:||.|...:|...|.|||||||.|:|.:::       ...:.|:.:..|.   :.|..|.|.
  Rat   238 AISVYDEIISVTACATYTYGKPVPGRVKISLCHGNPSFRSQTKSACKEEDS---ELDNNGCST-- 297

  Fly   315 TADMVGGKAKLT-MDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPYRYEMSCT 378
                  .:..:| ..||:  :||  |...:: .:.|||.|:.||.:.:.:|.:::...|.:....
  Rat   298 ------QEVNITEFRLKE--NYL--KVRQAF-HVNATVTEEGTGSEFSGSGRIEVKRTRNKFLFL 351

  Fly   379 DYSSCFSFKPDKEHELNF----KITYVDGSLITDTKSVVKAK---FTEGIRRNYAFYAFGTDHQE 436
            ...|.|      .|.:.|    ::..:.|..|.:.:..:||:   ||.         |..||..
  Rat   352 KADSHF------RHGIPFFVKVRLVNIKGDPIPNQQVFIKAQGAGFTN---------ATTTDQH- 400

  Fly   437 PELPTIEKKTFVFESHLNASGVAPFKVVLPDLPDIANFTRY-YSIELEFVDEKRDLYT------- 493
                                |:|.|.:      |.:..:|| .:|::...:|...:::
  Rat   401 --------------------GLAKFSI------DTSGISRYILNIKVYHKEENSCIHSSCTAERH 439

  Fly   494 ---------------TYPYREPKQIENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQVILNSSRP 543
                           :|.|.:.:....|.::..      .||..   :.|| ||...|:     |
  Rat   440 AEAHHTAYAVYSLSKSYIYLDTEAGVLPCNQSH------TVQAH---FILK-GQVLGVL-----P 489

  Fly   544 LKYFVYNIVGRGNILET-KRVDLAEP-----QTTVNVTIKPTFLTTPYGRVYFYYVDETGEFRYT 602
            ...|.|.::.:|:||:| ......||     |....:.|...|...|..::..|.:...||....
  Rat   490 QIVFHYLVMAQGSILQTGNHTHQVEPGESPVQGNFALEIPVEFSMVPMAKMLIYTILPDGEVIAD 554

  Fly   603 EETFSVEVELQNQIEIK-APAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKESFN 666
            ...|.||..|::::.:. :|::..|.:...:.:..||:|..||.|||||||||....:|: .|..
  Rat   555 SVKFQVEKCLRHEVHLSFSPSQSLPASQTHMRVTASPQSLCGLRAVDQSVLLLKPEAELS-PSLI 618

  Fly   667 WRLNGYDTST-------PWQ-------------GGYSY---YPGER--------TGVVTMTN--- 697
            :.|.|...|.       |::             |..:|   |..|:        ||:..:||
  Rat   619 YDLPGMQESKFIPRSHYPFEDEDGCVIYRPRVIGKLTYSVPYGREKDVFRYMRDTGLTALTNLKL 683

  Fly   698 -AYFFYNRTAPDYNILTEGFGGSSFAMRKTTVAHDSHVFHSGAGGPTQAVGFSAESASASAAP-- 759
             .:.|      ||:::.          .....|..|.:|:|...|..::.  ..:|.....||
  Rat   684 RTFCF------DYDMVP----------LAVPAARSSDLFNSDGYGSWRSA--RVKSLPPKKAPHK 730

  Fly   760 ----------VVRKNFAETWIFADIESTEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQ 814
                      .:|..|.|||::..:........:...|:|||||.|......|....|||:::..
  Rat   731 DPPPKDPVIETIRNYFPETWVWDLVTVNSSGAAELEMTVPDTITEWKAGALCLSNDTGLGLSSVA 795

  Fly   815 TNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVDASNEVIGDQ 879
            | ::.||||||.:.:||||.|||...:.|.|.||||.:|.:.:.|: ...::..|...|    ||
  Rat   796 T-LQAFQPFFVELTMPYSVIRGEAFTLKATVMNYLPTSLPMAVQLE-ASPDFTAVPVGN----DQ 854

  Fly   880 KRTQNIRVGANEAAGASFLIRPKVIGNILLKFKAIS--------------PLAG--DAIHKPLKV 928
               .:..:|||....:|:|:.||.:||:.....|.:              |..|  |.:.|.|.|
  Rat   855 ---DSYCLGANGRHTSSWLVTPKSLGNVNFSVSAEAQQSPEPCGSEVATVPETGRKDTVVKVLIV 916

  Fly   929 VPEGITQYQNRAFFINLKDTGEFKNTFELEVPEDVVPDSERVEFGLVGDLLGPVVKNLENLLRLP 993
            .||||.:....:..:...| .|...|..|.:|..||.||.|..|.::||:|...:||.:||:::|
  Rat   917 EPEGIKREHTFSSLLCASD-AELSETLSLLLPPTVVKDSARAHFSVMGDILSSAIKNTQNLIQMP 980

  Fly   994 SGCGEQTMSKLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWR 1058
            .|||||.|....|:..|..||...::||..:.::....|:.|||..|:|:|.|||:|:||
  Rat   981 YGCGEQNMVLFAPSIYVLKYLNETQQLTEKIKSKALGYLRAGYQRELNYKHKDGSYSAFG----- 1040

  Fly  1059 QEDPVRNGSTWLTAYVLRSFSKIKDIIDLDEQILAKGYEFLLTRQAENGSFTEHGEYFYSSQR-- 1121
            ..|....|:|||||:||:|||:.:..|.:||..:...:.:|..:|.::|.|...|..|.::.:
  Rat  1041 DHDGKGQGNTWLTAFVLKSFSQAQAFIFIDESHITDAFTWLSHQQKDSGCFRSSGSLFNNAMKGG 1105

  Fly  1122 --SLLTLTANSLLALLEEEKPN--QAAIDKAVAYLSANTAESIE-------LLPKSIAIYALQKA 1175
              ..:||:|...:||||...|:  ...:.||::.|.::. |:||       :..|::..||...|
  Rat  1106 VDDEITLSAYITVALLESLPPDTEHPVVSKALSCLESSW-ENIEQGGNGSFVYTKALMAYAFALA 1169

  Fly  1176 KAPEAAKQVASLKSLAKH---EDDRTWW---------TEDLDKLRASKNCGRWWCWIWSQDVEIT 1228
            ...|...::  ||||.|.   ||:...|         ...|.|.:||           |.:||:.
  Rat  1170 GNQEKRNEI--LKSLDKEAIKEDNSIHWERPQKPMKSARSLYKPQAS-----------SAEVEMN 1221

  Fly  1229 SYALLSLLDSDQETADSV---------LNTVRWLIAQRNGFGGFASSQDTVVGLTALIKFAEKSG 1284
            :|.:|:.|     ||.|.         :.|::||..|:|..|||:|:|||||.|.||.|:...:.
  Rat  1222 AYVILARL-----TAQSAPSPKDLALSMGTIKWLTKQQNSRGGFSSTQDTVVALDALSKYGAATF 1281

  Fly  1285 YEAAKW-EVTVSNKGKREKTEKLNTSEENDLLLQTVEFPQGTKSLEFEAKGTGAAMVQISYQYNL 1348
            .::.|. .|||.:.|  ...:|......|.||||.|..|....:......|.|....|...:|||
  Rat  1282 SKSQKTPSVTVQSSG--SFFQKFQVDNSNRLLLQQVSLPDIPGNYTVSVSGEGCVYAQTMLRYNL 1344

  Fly  1349 VEKEPKPSF--KIQTTVLPESSPA---NLELSVCVDYVEEGESKESNMAILEVSLPSGYTADEDS 1408
            ..::.:|:|  |:||..|..::|.   :.::|:.:.|.  |....|||.|.:|.:.||:...:.:
  Rat  1345 PLEKQQPAFALKVQTVPLTCNNPKGQNSFQISLEISYT--GSRPASNMVIADVKMLSGFIPLKPT 1407

  Fly  1409 FADIRNIERVRLVETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNK 1473
            ...:..:|.|...|....:  |::|.:.:. |:.........:...|.|.:|:.|.:||||:|::
  Rat  1408 VKKLERLEHVSRTEVTTNN--VLLYLDQVT-NQTLSFSFIIQQDIPVKNLQPAIVKVYDYYETDE 1469

  Fly  1474 KATEYYS 1480
            .|...||
  Rat  1470 VAFAEYS 1476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	YfaS	<76..1411	CDD:441940	395/1493 (26%)
		A2M_2	982..1279	CDD:239227	108/330 (33%)
		A2M_recep	1387..1480	CDD:462226	23/92 (25%)
Mug6	XP_038963368.1	YfaS	<129..1352	CDD:441940	367/1380 (27%)
		A2M	749..839	CDD:459711	34/90 (38%)
		A2M_2	969..1276	CDD:239227	108/330 (33%)
		A2M_recep	1386..1476	CDD:462226	23/92 (25%)