DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep4 and LOC297568

DIOPT Version :9

Sequence 1:	NP_001260590.1	Gene:	Tep4 / 35248	FlyBaseID:	FBgn0041180	Length:	1498	Species:	Drosophila melanogaster
Sequence 2:	XP_038963365.1	Gene:	LOC297568 / 297568	RGDID:	1584999	Length:	1484	Species:	Rattus norvegicus

Alignment Length:	1603	Identity:	418/1603 - (26%)
Similarity:	707/1603 - (44%)	Gaps:	277/1603 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LCV---ILALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGITGPSYNKTE 72
            ||:   :||.|.....:....||.::.|..:::.....:.:.::...|.||:...:......:..
  Rat     9 LCLFSALLAFLPFASLLNGNSKYMVLVPSQLYTETPEKICLHLYHLNETVTVTASLISQRGTRKL 73

  Fly    73 TVELATAGE-FKQITFKLPPLEAGE----YNLTAEGVKGLEFKNSTKLNWENFKPYIKIQTDKGK 132
            ..||....: |..::|.:|.|.:.|    .::..||.|. :|.....:..:|.:..:.:||||..
  Rat    74 FDELVVDKDLFHCVSFTIPRLPSSEEEESLDINIEGAKH-KFSERRVVLVKNKESVVFVQTDKPM 137

  Fly   133 YKPGDTINYRVIFLDENLRPDTAKDEV--VVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFAT 195
            ||||.::.:||:.:|:||.|   .:|:  :.:.||.|.|||.|.:.:||..|:....|.||....
  Rat   138 YKPGQSVKFRVVSMDKNLHP---LNELFPLAYIEDPKMNRIMQWQDVKTENGLKQLSFSLSAEPI 199

  Fly   196 LGSWSLHV--QNG--DQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQ 256
            .|.:.:.:  |:|  ::|                           :|.|.::|||::.|.:....
  Rat   200 QGPYKIVILKQSGVKEEH---------------------------SFTVMEFVLPRFGVDVKVPN 237

  Fly   257 QVSVRDGEFNVVLKANYTYGKPVNGKVLVNV-HLDSTSSWENVDGKTVQTDYPGHSVVGTADMVG 320
            .:||.|...||...|.|||||||.|.|.::: |.:.|.|.|.......:.....::...|.::
  Rat   238 AISVYDEIINVTACATYTYGKPVPGHVKISLCHGNPTFSSETKSACKEEDSRLDNNGCSTQEV-- 300

  Fly   321 GKAKLT-MDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPYRYEMSCTDYSSCF 384
               .:| ..||:  :||  |...:: .:.|||.|:.||.:.:.:|.:::...|.:.......|.|
  Rat   301 ---NITEFQLKE--NYL--KMHQAF-HVNATVTEEGTGSEFSGSGRIEVERTRNKFLFLKADSHF 357

  Fly   385 SFKPDKEHELNF--KITYVD--GSLITDTKSVVKAK---FTEGIRRNYAFYAFGTDHQEPELPTI 442
                  .|.:.|  |:..||  |..|.:.:.::||:   :|.         |..||..
  Rat   358 ------RHGIPFFVKVRLVDIKGDPIPNEQVLIKARDAGYTN---------ATTTDQH------- 400

  Fly   443 EKKTFVFESHLNASGVAPFKVVLPDLPDIA-NFTRYYSIELEFVDEK----------------RD 490
                          |:|.|.:....:.|.: |...|:..|...:...                ..
  Rat   401 --------------GLAKFSIDTSGISDYSLNIKVYHKEESSCIHSSCTAERHAEAHHTAYAVYS 451

  Fly   491 LYTTYPYREPKQIENPSSEEEKEWFRAEVQRPKDVWNLK---IGQEYQVILNSSRPLKYFVYNIV 552
            |..:|.|.:.:....|.:         ::...:..:.||   :|...|::         |.|.::
  Rat   452 LSKSYIYLDTEAGVLPCN---------QIHTVQAHFILKGQVLGVLQQIV---------FHYLVM 498

  Fly   553 GRGNILE----TKRVDLAEPQTTVN--VTIKPTFLTTPYGRVYFYYVDETGEFRYTEETFSVEVE 611
            .:|:||:    |.:|:..|.|...|  :.|...|...|..::..|.:...||.......|.||..
  Rat   499 AQGSILQTGNHTHQVEPGESQVQGNFALEIPVEFSMVPVAKMLIYTILPDGEVIADSVKFQVEKC 563

  Fly   612 LQNQIEIK-APAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKESFNWRLNGYDTS 675
            |:|::::. :|::..|.:...:.:..||:|..||.||||||||.....:|: .|..:.|.|...|
  Rat   564 LRNKVQLSFSPSQSLPASQTHMRVTASPQSLCGLRAVDQSVLLQKPEAELS-PSLIYDLPGMQDS 627

  Fly   676 T-------PWQGG---YSYYPGER----------TGVVTMTNAYF---FYNRTAPDYNILTEGFG 717
            .       |::..   ..|.|..|          ||::..||...   .|..|  ||:::
  Rat   628 NFIASSNDPFEDEDYCLMYQPIAREKDVYRYVRETGLMAFTNLKIKLPTYCNT--DYDMV----- 685

  Fly   718 GSSFAMRKTTVAHDSHVFHSGAGGPTQAVGFSAESASASAAP-------------VVRKNFAETW 769
                .:....||.||    |...|..:::...|..:.....|             .:|..|.|||
  Rat   686 ----PLAVPAVALDS----STDRGMYESLPVVAVKSPLPQEPPRKDPPPKDPVIETIRNYFPETW 742

  Fly   770 IFADIESTEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVK 834
            |:..:......|.:...|:|||||.|......|....|||::: ..:.:.||||||.:.:||||.
  Rat   743 IWDLVTVNSSGVTELEMTVPDTITEWKAGALCLSNDTGLGLSS-VASFQAFQPFFVELTMPYSVI 806

  Fly   835 RGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVDASNEVIGDQKRTQNIRVGANEAAGASFLI 899
            |||...:.|.|.||||.:|.:.:.|:...   ||.     .:..:....:..:|||....:|:|:
  Rat   807 RGEAFTLKATVLNYLPTSLPMAVLLEASP---DFT-----AVPVENNQDSYCLGANGRHTSSWLV 863

  Fly   900 RPKVIGNILLKFKAIS--------------PLAG--DAIHKPLKVVPEGITQYQNRAFFINLKDT 948
            .||.:||:.....|.:              |..|  |.:.|.|.|.||||.:....:..:...|
  Rat   864 TPKSLGNVNFSVSAEARQSPGPCGSEVATVPETGRKDTVVKVLIVEPEGIKKEHTFSSLLCASD- 927

  Fly   949 GEFKNTFELEVPEDVVPDSERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRDY 1013
            .|...|..|.:|..||.||.|..|.::||:|...:||.:||:::|.|||||.|....||..|..|
  Rat   928 AELSETLSLLLPPTVVKDSARAHFSVMGDILSSAIKNTQNLIQMPYGCGEQNMVLFAPNIYVLKY 992

  Fly  1014 LKSIKKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSF 1078
            |...::||..:.::....|:.|||..|:|:|.|||:|:||....:.:     |:|||||:||:||
  Rat   993 LNETQQLTEKIKSKALGYLRAGYQRELNYKHKDGSYSAFGDHNGQGQ-----GNTWLTAFVLKSF 1052

  Fly  1079 SKIKDIIDLDEQILAKGYEFLLTRQAENGSFTEHGEYFYSSQR----SLLTLTANSLLALLEEEK 1139
            ::.:..|.:||..:...:.:|..:|.::|.|...|....::.:    ..:||:|...:||||...
  Rat  1053 AQARAFIFIDESHITDAFTWLSKQQKDSGCFRSSGSLLNNAMKGGVDDEITLSAYITMALLESSL 1117

  Fly  1140 PN-QAAIDKAVAYLSANTAESIE-------LLPKSIAIYALQKAKAPEAAKQVASLKSLAKH--- 1193
            |: ...:.||::.|.::. |:||       :..|::..||...|...|...::  ||||.|.
  Rat  1118 PDTDPVVSKALSCLESSW-ENIEQGGNGSFVYTKALMAYAFALAGNQEKRNEI--LKSLDKEAIK 1179

  Fly  1194 EDDRTWWTEDLDKLRASKNCGRWWCWIW-----SQDVEITSYALLSLL-----DSDQETADSVLN 1248
            ||:...|..   ..:.:|:.|    :::     |.:||:::|.:|:.|     .|.::.|.| :.
  Rat  1180 EDNSIHWER---PQKPTKSEG----YLYTPQASSAEVEMSAYVVLARLTAQPAPSPEDLALS-MG 1236

  Fly  1249 TVRWLIAQRNGFGGFASSQDTVVGLTALIKFAEKSGYEAAKW-EVTVSNKGKREKTEKLNTSEEN 1312
            |::||..|:|.:|||:|:|||||.|.||.|:...:..::.|. .|||.:.|  ..::|....:.|
  Rat  1237 TIKWLTKQQNSYGGFSSTQDTVVALDALSKYGAATFSKSQKTPSVTVQSSG--SFSQKFQVDKSN 1299

  Fly  1313 DLLLQTVEFPQGTKSLEFEAKGTGAAMVQISYQYNLVEKEPKPSF--KIQTTVLPESSPA---NL 1372
            .||||.|..|....:......|.|....|.:.:||:..::.:|:|  |:||..|..::|.   :.
  Rat  1300 RLLLQQVSLPYIPGNYTVSVSGEGCVYAQTTLRYNVPLEKQQPAFALKVQTVPLTCNNPKGQNSF 1364

  Fly  1373 ELSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSFADIRNIERVRLVETKNGDSVVVIYFENL 1437
            ::|:.:.|.  |....|||.|.:|.:.||:...:.:...:..:..|...|....:  |::|.:.:
  Rat  1365 QISLEISYT--GSRPASNMVIADVKMLSGFIPLKPTVKKLERLGHVSRTEVTTNN--VLLYLDQV 1425

  Fly  1438 AKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKKATEYYS 1480
            . |:.........:...|.|.:|:.|.:||||:|::.|...||
  Rat  1426 T-NQTLSFSFIIQQDIPVKNLQPAIVKVYDYYETDEVAFAEYS 1467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081	32/98 (33%)
		A2M_N_2	528..653	CDD:285005	38/134 (28%)
		A2M	768..859	CDD:278630	35/90 (39%)
		A2M_2	982..1279	CDD:239227	104/321 (32%)
		A2M_comp	1035..1281	CDD:284982	86/270 (32%)
		A2M_recep	1389..1479	CDD:284981	22/89 (25%)
LOC297568	XP_038963365.1	A2M_N	129..221	CDD:396416	33/121 (27%)
		MG3	223..309	CDD:407663	26/90 (29%)
		MG4	348..443	CDD:407661	22/130 (17%)
		A2M_N_2	457..606	CDD:400170	40/166 (24%)
		A2M	741..831	CDD:395153	35/90 (39%)
		A2M_2	961..1267	CDD:239227	104/321 (32%)
		A2M_recep	1379..1466	CDD:400149	22/89 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I8631
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X292
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720