Protein Alignment Tep4 and Pzp

DIOPT Version :10

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: NP_665722.2
• Gene: Pzp / 252922
• RGDID: 628643
• Length: 1500
• Species: Rattus norvegicus
• Alignment Length: 1654
• Identity: 451/1654 - (27%)
• Similarity: 712/1654 - (43%)
• Gaps: 340/1654 - (20%)

  Fly     1 MRRADAFAVSLCVILALLQTMEPVKAEGK--YTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGI 63
            ||| :...:.:.::|.||...:...|.||  |.::.|..:::.....|.|.::...|.|||.|.:
  Rat     1 MRR-NQLPIPVFLLLLLLLPRDATAATGKPRYVVLVPSELYAGVPEKVCVHLNHLNETVTLNVTL 64

  Fly    64 T-GPSYNK---TETVELATAGEFKQITFKLPPLEAGEYNLTAEGVKGLEFKNST------KLNW- 117
            . |..|:.   .:.|: ..:......|...|        |:...:..:|.|..|      |..|
  Rat    65 EYGVQYSNLLIDQAVD-KDSSYCSSFTISRP--------LSPSALIAVEIKGPTHHFIKKKSMWI 120

  Fly   118 ENFKPYIKIQTDKGKYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGG 182
            ...:..:.:||||..||||.|:.:||:.:|.:.|| ..:...||:.|:.|||||.|.:::...||
  Rat   121 TKAESPVFVQTDKPIYKPGQTVKFRVVSVDISFRP-VNETFPVVYIENPKRNRIFQWQNVDLPGG 184

  Fly   183 VYTGKFELSEFATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPK 247
            ::...|.||....||.:.:.||..          .|:|    ..|         :|||::|||||
  Rat   185 LHQLSFPLSVEPALGIYKVVVQKD----------SGKK----IEH---------SFEVKEYVLPK 226

  Fly   248 YSVKMDATQQVSVRDGEFNVVLKANYTYGKPVNGKVLVNVHLDSTSSWENVDGK---------TV 303
            :.|::...:.::..:.|..|.....|||||||.|.|.:.|....|.|:.|..|:         :.
  Rat   227 FEVQVKMPKTMAFLEEELVVTACGLYTYGKPVPGLVTMKVCRKYTQSYSNCHGQHSKSICEEFSK 291

  Fly   304 QTDYPG--HSVVGTADMVGGKAKLTMDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGV 366
            |.|..|  ..||.|  .|....:...|:|              .::.|.::||.||::|..||
  Rat   292 QADEKGCFRQVVKT--KVFQPRQKGYDMK--------------IEVEAKIKEDGTGIELTGTG-- 338

  Fly   367 QLYPYRYEMSCTDYSSCFSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYA-- 429
                     ||.                           |.:|.|  |.|||:.    ..||.
  Rat   339 ---------SCE---------------------------IANTLS--KLKFTKA----NTFYRPG 361

  Fly   430 ---FG----TDHQEPELP----TIE------KKTFVFESHLNASGVAPFKVVLPDLPDIANFT-R 476
               ||    .|.:...:|    |::      :.||..:.|    |:|..      |.|..||| .
  Rat   362 LPFFGQVLLVDEKGQPIPNKNLTVQVNSVRSQFTFTTDEH----GLANI------LIDTTNFTFS 416

  Fly   477 YYSIELEF-----------VDEKRDLYTTYPYREPKQIENPSSEEEKEWFRAEVQRPKDVWNLKI 530
            :..|.:.:           |||    |.|.......:|.:||        |:.:|....:..|..
  Rat   417 FMGIRVIYKQNNICFDNWWVDE----YHTQADHSAARIFSPS--------RSYIQLELVLGTLAC 469

  Fly   531 GQEYQV---------ILNSSRPLKYFVYNIVGRGNILETKRVDLAEPQTTVN------VTIKPTF 580
            ||..::         .|..::.|.:: |.|..||:|..:....|...|..|.      :.::|..
  Rat   470 GQTQEIRIHFLLNEDALKDAKDLTFY-YLIKARGSIFNSGSHVLPLEQGKVKGVVSFPIRVEPGM 533

  Fly   581 LTTPYGRVYFYYVDETGEFRYTEETFSVEVELQNQIEIKAP-AEVKPGADVALEIKTSPKSFVGL 644
              .|..::..|.:....|.....:.|.:|....|.:.:..| |:..|.:|..|.:|.:|.|...|
  Rat   534 --APVAKLIVYTILPNEELIADVQKFDIEKCFANTVNLSFPSAQSLPASDTHLTVKATPLSLCAL 596

  Fly   645 LAVDQSVLLLGSNNDLNKESFNWRL------NGYDTSTPWQGG---------------------- 681
            .|||||||||.....|:.:|....|      ..|....|::||
  Rat   597 TAVDQSVLLLKPEAKLSPQSIYNLLPQKAEQGAYLGPLPYKGGENCIKAEDITHNGIVYTPKQDL 661

  Fly   682 -----YSYYPGERTGVVTMTNAYFFYNRTAPDYNILTE-GFGGSSFAMRKTTVAHDSHVFHSGAG 740
                 ||.:  :..|:...||......|..|.|..... .:.|...|:..:.:        .|||
  Rat   662 NDNDAYSVF--QSIGLKIFTNTRVHKPRYCPMYQAYPPLPYVGEPQALAMSAI--------PGAG 716

  Fly   741 --------GPTQAVGFSAESASASAAPVVRKNFAETWIF----ADIESTEEEVFKWVKTIPDTIT 793
                    .....:|.|..:........|||.|.||||:    .|:....|...|    :|||||
  Rat   717 YRSSNIRTSSMMMMGASEVAQEVEVRETVRKYFPETWIWDMVPLDLSGDGELPVK----VPDTIT 777

  Fly   794 NWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELT 858
            .|..:.|.|....|||:::..:: |.|||||:.:.|||||.|||...:.|.|.||:|..:.:.::
  Rat   778 EWKASAFCLSGTTGLGLSSTISH-KVFQPFFLELTLPYSVVRGEAFILKATVLNYMPHCIRIHVS 841

  Fly   859 LDNEDQEYDFV-------DASNEVIGDQKRTQNIRV------GANEAAGASFLIRPKVIGNILLK 910
            |   :...||:       :.|:.:.|::::|.:..|      ..|..|.|..|..|::.||.:.:
  Rat   842 L---EMSPDFLAVPVGSHEDSHCICGNERKTVSWAVTPKSLGEVNFTATAEALQSPELCGNKVAE 903

  Fly   911 FKAISPLAGDAIHKPLKVVPEGITQYQNRAFFINLKDTGEFKNTFELEVPEDVVPDSERVEFGLV 975
            ..|:  :..|.:.||:.|.||||.:.|.....:..:| .|.:..:.|::|.:||..|.|....::
  Rat   904 VPAL--VQKDTVVKPVIVEPEGIEKEQTYNTLLCPQD-AELQENWTLDLPANVVEGSARATQSVL 965

  Fly   976 GDLLGPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHML 1040
            ||:||..::||:|||::|.|||||.|...|||..|.:||...::||.|:.::....|..|||..|
  Rat   966 GDILGSAMQNLQNLLQMPYGCGEQNMVLFVPNIYVLEYLNETQQLTEAIKSKAISYLISGYQRQL 1030

  Fly  1041 HYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSFSKIKDIIDLDEQILAKGYEFLLTRQAE 1105
            :|:|.|||:|:||....|..    .|:|||||:||::|::.:..|.:::..:...:.:|..:|.|
  Rat  1031 NYQHSDGSYSTFGDRGMRHS----QGNTWLTAFVLKAFAQAQSYIYIEKTHITNAFNWLSMKQRE 1091

  Fly  1106 NGSFTEHGEYFYSSQR----SLLTLTANSLLALLEEEKP-NQAAIDKAV-----AYLSANTAESI 1160
            ||.|.:.|....::.:    ..:||:|...:||||...| ..:.:..|:     |:.|.:.::..
  Rat  1092 NGCFQQSGSLLNNAMKGGVDDEVTLSAYITIALLEMPLPVTHSVVRNALFCLETAWASISNSQES 1156

  Fly  1161 ELLPKSIAIYALQKAKAPEAAKQVASLKSLAK---HEDDRTWW------TEDLDKLRASKNCGRW 1216
            .:..|::..||.  |.|...||:...|:||.|   :|::...|      .|::.::|:.....|
  Rat  1157 HVYTKALLAYAF--ALAGNRAKRSEVLESLNKDAVNEEESVHWQRPKNVEENVREMRSFSYKPR- 1218

  Fly  1217 WCWIWSQDVEITSYALLSLL------------DSDQETADSVLNTVRWLIAQRNGFGGFASSQDT 1269
               ..|.:||:|:|.||:.|            .||..||..:   |:|:..|:|..|||:|:|||
  Rat  1219 ---APSAEVEMTAYVLLAYLTSASSRPTRDLSSSDLTTASKI---VKWISKQQNSHGGFSSTQDT 1277

  Fly  1270 VVGLTALIKFA----EKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQTVEFPQGTKSLEF 1330
            ||.|.||.|:.    .||..|.:   ||:.:.|....|  |:.:..|.||||.|.......:...
  Rat  1278 VVALQALSKYGAATFTKSNKEVS---VTIESSGTVSGT--LHVNNGNRLLLQEVRLADLPGNYIT 1337

  Fly  1331 EAKGTGAAMVQISYQYNLV-EKEPKPSFKIQTTVLP-----ESSPANLELSVCVDYVEEGESKES 1389
            :..|:|...:|.|.:||:: |.|.:..|.::...||     .......::.:.|.|:  ||...|
  Rat  1338 KVSGSGCVYLQTSLKYNILPEAEGEAPFTLKVNTLPLNFDKAEHHRKFQIHINVSYI--GERPNS 1400

  Fly  1390 NMAILEVSLPSGYTADEDS---FADIRNIERVRLVETKNGDSVVVIYFENLAKNEEKCIRIEAYR 1451
            ||.|::|.:.||:...:.|   ..|..||:|.. |.|.:    |:||.|.|. |:.........:
  Rat  1401 NMVIVDVKMVSGFIPVKPSVKKLQDQSNIQRTE-VNTNH----VLIYIEKLT-NQTMGFSFAVEQ 1459

  Fly  1452 THAVANQKPSSVVLYDYYDTNKKATEYYS 1480
            ...|.|.||:.|.:||||:|::.|.|.||
  Rat  1460 DIPVKNLKPAPVKVYDYYETDEFAIEEYS 1488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	YfaS	<76..1411	CDD:441940	404/1502 (27%)
		A2M_2	982..1279	CDD:239227	107/327 (33%)
		A2M_recep	1387..1480	CDD:462226	32/95 (34%)
Pzp	NP_665722.2	YfaS	<127..1406	CDD:441940	392/1428 (27%)
		Bait region. /evidence=ECO:0000250|UniProtKB:P01023	686..746		10/67 (15%)
		A2M_2	972..1287	CDD:239227	107/327 (33%)
		Receptor-binding domain. /evidence=ECO:0000269|PubMed:11106161	1360..1500		42/137 (31%)
		A2M_recep	1398..1488	CDD:462226	32/95 (34%)