DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tep4 and C3

DIOPT Version :9

Sequence 1:NP_001260590.1 Gene:Tep4 / 35248 FlyBaseID:FBgn0041180 Length:1498 Species:Drosophila melanogaster
Sequence 2:NP_058690.2 Gene:C3 / 24232 RGDID:2232 Length:1663 Species:Rattus norvegicus


Alignment Length:1687 Identity:382/1687 - (22%)
Similarity:648/1687 - (38%) Gaps:380/1687 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 LCVILALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVAVH--QTKEPVTLKVG--ITGPSYNKT 71
            |.|:|.||.:.........|:|:.|..:....:....:..|  |...|||:.|.  :........
  Rat     9 LLVLLLLLASSLLALGSPMYSIITPNVLRLESEETFILEAHDAQGDVPVTVTVQDFLKKQVLTSE 73

  Fly    72 ETVELATAGEFKQITFKLPPLEAGEYNLTAEGVKGLEF------------KNSTKLNWENFKPYI 124
            :||.....|...:::.|:|  .:.|:|..    ||.::            :.:..:::::  .|:
  Rat    74 KTVLTGATGHLNRVSIKIP--ASKEFNAD----KGHKYVTVVANFGATVVEKAVLVSFQS--GYL 130

  Fly   125 KIQTDKGKYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDS---KRNRIKQEKHIKTTGGVYTG 186
            .|||||..|.||.|:.||:..:|.||.|......:|:...|.   ||:.:......    |:...
  Rat   131 FIQTDKTIYTPGSTVFYRIFTVDNNLLPVGKTVVIVIETPDGVPIKRDILSSHNQY----GILPL 191

  Fly   187 KFELSEFATLGSWSLHVQNGDQHHDGGIYFGGRKQ-FGGFGHRWHRSDELVNFEVEKYVLPKYSV 250
            .:.:.|...:|.|.:.          ..|....|| |.            ..|||::||||.:.|
  Rat   192 SWNIPELVNMGQWKIR----------AFYEHAPKQTFS------------AEFEVKEYVLPSFEV 234

  Fly   251 KMDATQQVSVRDGE--FNVVLKANYTYGKPVNGKVLVNVHL---DSTSSWENVDGKTVQTDYPGH 310
            .::.|::....|..  ..|.:.|.:.|||.|:|...|...:   |...|......:.:..|..|.
  Rat   235 LVEPTEKFYYIDDPKGLEVSITARFLYGKNVDGTAFVIFGVQDEDKKISLAQSLTRVLIEDGSGE 299

  Fly   311 SVVGTADMVGGKAKLTMDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPYRYEM 375
            :|:        ..|:.||....:|.......|.|..:|..:......|:. |..|:.:....|::
  Rat   300 AVL--------SRKVLMDGVRPSSPEALVGKSLYVSVTVILHSGSDMVEA-ERSGIPIVTSPYQI 355

  Fly   376 SCTDYSSCFSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELP 440
            ..|....  .|||....:|...:|..|||.......|.:....:.:.::                
  Rat   356 HFTKTPK--FFKPAMPFDLMVFVTNPDGSPARRVPVVTQGSDAQALTQD---------------- 402

  Fly   441 TIEKKTFVFESHLNASGVAPFKVVLPD---------------LPDIANFTRYYSIELEFVDEKRD 490
                           .|||...|..|:               :||....||....:         
  Rat   403 ---------------DGVAKLSVNTPNNRQPLTITVRTKKEGIPDARQATRTMQAQ--------- 443

  Fly   491 LYTTYPYREPKQIENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQVILNSSRPLKYFVYNIVGRG 555
                 ||   ..:.|.::.......|.|: :|.|  ||.:....:........::|:.|.::.:|
  Rat   444 -----PY---STMHNSNNYLHLSVSRVEL-KPGD--NLNVNFHLRTDAGQEAKIRYYTYLVMNKG 497

  Fly   556 NILETKRVDLAEP---QTTVNVTIKPTFLTTPYGRVYFYY--VDETGEFRYTEETFSVEVE--LQ 613
            .:|:..| .:.||   ...:::.|.|.|:  |..|:..||  :...|:.....::..|:|:  ..
  Rat   498 KLLKAGR-QVREPGQDLVVLSLPITPEFI--PSFRLVAYYTLIGANGQREVVADSVWVDVKDSCV 559

  Fly   614 NQIEIKA-------PAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKESFNWRLNG 671
            ..:.:|.       ||   ||....|.|:.:..:.|||:|||:.|.:|...|.|.:...      
  Rat   560 GTLVVKGDPRDNRQPA---PGHQTTLRIEGNQGARVGLVAVDKGVFVLNKKNKLTQSKI------ 615

  Fly   672 YDT-------STPWQGGYSYYPG------------------------------------------ 687
            :|.       .||..|  ..|.|                                          
  Rat   616 WDVVEKADIGCTPGSG--KNYAGVFMDAGLTFKTNQGLQTDQREDPECAKPAARRRRSVQLMERR 678

  Fly   688 -ERTGVVT-----------MTNAYFFYN--RTAPDYNILTEG------FGGSSFAMRKTTVAH-D 731
             ::.|..|           |.:....|:  |.|   .::|:|      |......:.|....| .
  Rat   679 MDKAGQYTDKGLRKCCEDGMRDIPMKYSCQRRA---RLITQGESCLKAFMDCCNYITKLREQHRR 740

  Fly   732 SHVFHSGAGGPTQAVGFSAESASASAAP----VVRKNFAETWIFADIESTEEEVFKWVKT----- 787
            .||           :|.:.........|    :.|.:|.|:|::. ||..:|.....:.|     
  Rat   741 DHV-----------LGLARSDVDEDIIPEEDIISRSHFPESWLWT-IEELKEPEKNGISTKVMNI 793

  Fly   788 -IPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYL-P 850
             :.|:||.|.:...||..:||:.|. |...|...|.||:.:||||||.|.|.:.:.|::|||. .
  Rat   794 FLKDSITTWEILAVSLSDKKGICVA-DPYEITVMQDFFIDLRLPYSVVRNEQVEIRAVLFNYREQ 857

  Fly   851 KTLDVELTLDNEDQEYDFVDASNEVIGDQKRTQNIRVGANEAAGASFLIRPKVIG--NILLKFKA 913
            :.|.|.:.|.:.........|.      ::..|.|.:....:....::|.|..||  .:.:|...
  Rat   858 EKLKVRVELLHNPAFCSMATAK------KRYYQTIEIPPKSSVAVPYVIVPLKIGLQEVEVKAAV 916

  Fly   914 ISPLAGDAIHKPLKVVPEGITQYQNRAFFINLKD---TGEFKNTFELEVP----EDVVPDSE-RV 970
            .:....|.:.|.|||||||:.  .|:...:...|   .|:.....| :||    .|.|||:: ..
  Rat   917 FNHFISDGVKKILKVVPEGMR--VNKTVAVRTLDPEHLGQGGVQRE-DVPAADLSDQVPDTDSET 978

  Fly   971 EFGLVGDLLGPVVKN------LENLLRLPSGCGEQTMSKLVPNYLVRDYLK--------SIKKLT 1021
            ...|.|..:..:.::      |::|:..|||||||.|..:.|..:...||.        .::|..
  Rat   979 RILLQGTPVAQMAEDAVDGERLKHLIVTPSGCGEQNMIGMTPTVIAVHYLDQTEQWEKFGLEKRQ 1043

  Fly  1022 PALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSFSKIKDIID 1086
            .||:.     ::.||...|.::....::::|..         |..||||||||::.||...::|.
  Rat  1044 EALEL-----IKKGYTQQLAFKQPSSAYAAFNN---------RPPSTWLTAYVVKVFSLAANLIA 1094

  Fly  1087 LDEQILAKGYEFL-LTRQAENGSFTEHGEY--------FYSSQRSLLTLTANSLLALLE-----E 1137
            :|.|:|....::| |.:|..:|.|.|.|..        |.:::.:.::|||..|:||.|     |
  Rat  1095 IDSQVLCGAVKWLILEKQKPDGVFQEDGPVIHQEMIGGFRNTKEADVSLTAFVLIALQEARDICE 1159

  Fly  1138 EKPNQ--AAIDKAVAYLSANTAESIELLPKSIAIYAL---QKAKAPEAAKQVASLKSLAKHEDDR 1197
            .:.|.  .:|:||..||.|:..........:||.|||   .|.:.|...|.:.:.|       ||
  Rat  1160 GQVNSLPGSINKAGEYLEASYLNLQRPYTVAIAGYALALMNKLEEPYLTKFLNTAK-------DR 1217

  Fly  1198 TWWTEDLDKLRASKNCGRWWCWIWSQDVEITSYALLSLLDSDQETADSVLNTVRWLIAQRNGFGG 1262
            ..|.|...:|               .:||.||||||:||  ..:..|||...||||..||...||
  Rat  1218 NRWEEPGQQL---------------YNVEATSYALLALL--LLKDFDSVPPVVRWLNEQRYYGGG 1265

  Fly  1263 FASSQDTVVGLTALIKF-AEKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQTVEFPQGTK 1326
            :.|:|.|.:...||.:: .:...::....:|:: :...|..........|:..||::.|..|...
  Rat  1266 YGSTQATFMVFQALAQYQTDVPDHKDLNMDVSL-HLPSRSSPTVFRLLWESGSLLRSEETKQNEG 1329

  Fly  1327 -SLEFEAKGTGAAMVQISYQYNLVEKEPKPSFKIQTTV--------LPESSPANLELSVCVDYVE 1382
             ||..:.||.|...|...|...:..|.....|.::.|:        .|:.:.:::.|.:|..|:.
  Rat  1330 FSLTAKGKGQGTLSVVTVYHAKVKGKATCKKFDLRVTIKPAPETAKKPQDAKSSMILDICTRYLG 1394

  Fly  1383 EGESKESNMAILEVSLPSGYTADEDSFADI-----RNIERVRLVETKNGDSVVVIYFENLAKNEE 1442
            :   .::.|:||::|:.:|:..|.:....:     |.|.:..:.:..:..:.::||.|.::.:||
  Rat  1395 D---VDATMSILDISMMTGFIPDTNDLELLSSGVDRYISKYEMDKAFSNKNTLIIYLEKISHSEE 1456

  Fly  1443 KCIRIEAYRTHAVANQKPSSVVLYDYYDTNKKATEYY------SIKSKLCD----ICEGDDC 1494
            .|:..:.::...|...:|.||.:|.||:..:..|.:|      .:.||||.    .|..::|
  Rat  1457 DCLSFKVHQFFNVGLIQPGSVKVYSYYNLEESCTRFYHPEKDDGMLSKLCHNEMCRCAEENC 1518

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep4NP_001260590.1 A2M_N 126..219 CDD:280081 24/95 (25%)
A2M_N_2 528..653 CDD:285005 32/138 (23%)
A2M 768..859 CDD:278630 33/97 (34%)
A2M_2 982..1279 CDD:239227 98/329 (30%)
A2M_comp 1035..1281 CDD:284982 82/265 (31%)
A2M_recep 1389..1479 CDD:284981 22/94 (23%)
C3NP_058690.2 A2M_N 129..224 CDD:280081 29/120 (24%)
A2M_N_2 457..603 CDD:285005 37/154 (24%)
ANATO 678..747 CDD:237984 14/82 (17%)
A2M 770..866 CDD:278630 33/97 (34%)
complement_C3_C4_C5 996..1282 CDD:239226 98/323 (30%)
A2M_comp 1051..1282 CDD:284982 82/263 (31%)
A2M_recep 1398..1493 CDD:284981 22/94 (23%)
NTR_complement_C3 1513..1661 CDD:239638 2/6 (33%)
Interaction with CFP/properdin. /evidence=ECO:0000250|UniProtKB:P01024 1634..1659
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166343885
Domainoid 1 1.000 50 1.000 Domainoid score I11352
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.840

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