DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep4 and A2m

DIOPT Version :9

Sequence 1:	NP_001260590.1	Gene:	Tep4 / 35248	FlyBaseID:	FBgn0041180	Length:	1498	Species:	Drosophila melanogaster
Sequence 2:	NP_036620.2	Gene:	A2m / 24153	RGDID:	2004	Length:	1472	Species:	Rattus norvegicus

Alignment Length:	1567	Identity:	421/1567 - (26%)
Similarity:	679/1567 - (43%)	Gaps:	213/1567 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LCVILALLQTMEPVKAEGK----YTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGITGPSYNKT 71
            |.::|.||..:.|..|...    |.::.|..:|:..............|.|.::|.:.....|::
  Rat    12 LPLLLRLLLLLLPTDASAPQKPIYMVMVPSLLHAGTPEKACFLFSHLNETVAVRVSLESVRGNQS 76

  Fly    72 ETVELATAGE-FKQITFKLPPLEAGEYNLTAEGVKGL--EFKNSTKLNWENFKPYIKIQTDKGKY 133
            ...:|....: |...:|.:|...:.|.......|||.  ||:..:.:..:..:..:..||||..|
  Rat    77 LFTDLVVDKDLFHCTSFTVPQSSSDEVMFFTVQVKGATHEFRRRSTVLVKKKESLVFAQTDKPIY 141

  Fly   134 KPGDTINYRVIFLDENLRPDTAKDEVV--VWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFATL 196
            |||.|:.:||:.|||:..|   .:|::  ::.:|.|.|||.|.::....||:....|.||...|.
  Rat   142 KPGQTVRFRVVSLDESFHP---LNELIPLLYIQDPKNNRIAQWQNFNLEGGLKQLSFPLSSEPTQ 203

  Fly   197 GSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVN--FEVEKYVLPKYSVKMDATQQVS 259
            ||:.:.::.                         .|...|.  |.||::||||:.|::...:.::
  Rat   204 GSYKVVIRT-------------------------ESGRTVEHPFSVEEFVLPKFEVRVTVPETIT 243

  Fly   260 VRDGEFNVVLKANYTYGKPVNGKVLVNVHLDSTSSWENVDGKTVQTDYPGHSVV---GTADMVGG 321
            :.:.|.||.:...|||||||.|:|.||: ....|:..|..|:        .||.   ..:..:.|
  Rat   244 ILEEEMNVSVCGIYTYGKPVPGRVTVNI-CRKYSNPSNCFGE--------ESVAFCEKLSQQLDG 299

  Fly   322 KAKLTMDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPYRYEMSCTDYSSCFSF 386
            :...:..:|..:..|..:.......:.|.::|:.|||:....|..::.....::|..:..|.|
  Rat   300 RGCFSQLVKTKSFQLKRQEYEMQLDVHAKIQEEGTGVEETGKGLTKITRTITKLSFVNVDSHF-- 362

  Fly   387 KPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELPTIEKKTFVFES 451
                    ...|.:|...|:.|.:         |....|.....|.|.....:.|...|
  Rat   363 --------RQGIPFVGQVLLVDGR---------GTPIPYETIFIGADEANLYINTTTDK------ 404

  Fly   452 HLNASGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTTYPYREPKQIENPSSEEEKE-WF 515
                .|:|.|.:...|:         ....|....:.:|....|.:|.       .:||..| |.
  Rat   405 ----HGLARFSINTDDI---------MGTSLTVRAKYKDSNACYGFRW-------LTEENVEAWH 449

  Fly   516 RA-EVQRPKDVW--------NLKIGQEYQV----ILN--SSRPLK--YFVYNIVGRGNILE--TK 561
            .| .|..|...:        .|:..|..:|    |||  :.:.||  .|.|.::.:|.|:.  |.
  Rat   450 TAYAVFSPSRSFLHLESLPDKLRCDQTLEVQAHYILNGEAMQELKELVFYYLMMAKGGIVRAGTH 514

  Fly   562 RVDLAEPQTTVNVTIKPTFLT--TPYGRVYFYYVDETGEFRYTEETFSVEVELQNQIE-IKAPAE 623
            .:.|.:.|...:.:|..:..|  .|..|:..|.:...||.......:.:|..|.|::: :..|..
  Rat   515 VLPLKQGQMRGHFSILISMETDLAPVARLVLYAILPNGEVVGDTAKYEIENCLANKVDLVFRPNS 579

  Fly   624 VKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKESFNWRLNGYDTSTPWQGGYSYYPGE 688
            ..|.....|.:..||:|..||.||||||||:....:|: .|..:.|......|.:..|......:
  Rat   580 GLPATRALLSVMASPQSLCGLRAVDQSVLLMKPETELS-ASLIYDLLPVKDLTGFPQGADQREED 643

  Fly   689 RTGVVTMTNAYFFYNRTAPDYNILTEGFGG----------SSFAMRKTTVA---HDSH----VFH 736
            ..|.|...:.|......:|..|...|...|          ::..:||..|.   .|:.    .:|
  Rat   644 TNGCVKQNDTYINGILYSPVQNTNEEDMYGFLKDMGLKVFTNSNIRKPKVCERLRDNKGIPAAYH 708

  Fly   737 SGAGGPTQAVGFSAESASASAAPVVRKNFAETWIFADIESTEEEVFKWVKTIPDTITNWVVTGFS 801
            ..:.....|...|:||.:.:.    |..|.||||:..:......|.:...|:|||||.|....|.
  Rat   709 LVSQSHMDAFLESSESPTETR----RSYFPETWIWDLVVVDSAGVAEVEVTVPDTITEWKAGAFC 769

  Fly   802 LHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEY 866
            |....|||: :.....:.||||||.:.:||||.|||...:.|.|.||||..:.|.:.|:...
  Rat   770 LSNDTGLGL-SPVVQFQAFQPFFVELTMPYSVIRGEAFTLKATVLNYLPTCIRVAVQLEASP--- 830

  Fly   867 DFVDASNEVIGDQKRTQNIRVGANEAAGASFLIRPKVIGNILLKFKA--------------ISPL 917
            ||:.|..|     |..::..:..|:...||:.:.||.:||:.....|              :.|.
  Rat   831 DFLAAPEE-----KEQRSHCICMNQRHTASWAVIPKSLGNVNFTVSAEALNSKELCGNEVPVVPE 890

  Fly   918 AG--DAIHKPLKVVPEGITQYQNRAFFINL--KDTGEFKNTFELEVPEDVVPDSERVEFGLVGDL 978
            .|  |.|.|.|.|.|||:   :|...|.:|  ....|......|::|.|||.:|.|....::||:
  Rat   891 QGKKDTIIKSLLVEPEGL---ENEVTFNSLLCPMGAEVSELIALKLPSDVVEESARASVTVLGDI 952

  Fly   979 LGPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHMLHYR 1043
            ||..::|.::||::|.|||||.|....||..|.|||...::||..:.|:....|..|||..|:|:
  Rat   953 LGSAMQNTQDLLKMPYGCGEQNMVLFAPNIYVLDYLNETQQLTQEIKTKAIAYLNTGYQRQLNYK 1017

  Fly  1044 HDDGSFSSFGPTKWRQEDPVRN-GSTWLTAYVLRSFSKIKDIIDLDEQILAKGYEFLLTRQAENG 1107
            |.|||:|:||      :.|.|| .:|||||:||:||::.:..|.:||..:.:...:|..:|.:||
  Rat  1018 HRDGSYSTFG------DKPGRNHANTWLTAFVLKSFAQARKYIFIDEVHITQALLWLSQQQKDNG 1076

  Fly  1108 SFTEHGEYFYSSQR----SLLTLTANSLLALLEEEKP------NQAAIDKAVAYLSA-NTAESIE 1161
            .|...|....::.:    ..:||:|...:||||...|      ..|......|:.|| ..|....
  Rat  1077 CFRSSGSLLNNAMKGGVEDEVTLSAYITIALLEMSLPVTHPVVRNALFCLDTAWKSARGGAGGSH 1141

  Fly  1162 LLPKSIAIYALQKAKAPEAAKQVASLKSL---AKHEDDRTWWTEDLDKLRASKNCGRWW-CWIWS 1222
            :..|::..||...|...:..|::  ||||   |..|:|...||.   ..:.|.:...|: ....|
  Rat  1142 VYTKALLAYAFALAGNQDTKKEI--LKSLDEEAVKEEDSVHWTR---PQKPSVSVALWYQPQAPS 1201

  Fly  1223 QDVEITSYALLSLLDSD----QETADSVLNTVRWLIAQRNGFGGFASSQDTVVGLTALIKFAEKS 1283
            .:||:|:|.||:.|.::    ||...:.:..|:||..|:|..|||:|:|||||.|.||.|:...:
  Rat  1202 AEVEMTAYVLLAYLTTEPAPTQEDLTAAMLIVKWLTKQQNSHGGFSSTQDTVVALHALSKYGSAT 1266

  Fly  1284 GYEAAK-WEVTVSNKGKREKTEKLNTSEENDLLLQTVEFPQGTKSLEFEAKGTGAAMVQISYQYN 1347
            ...|.| .:||:.:.|  ..:.|...:..|.||||.|..|........:..|.|...:|.|.:|:
  Rat  1267 FTRAKKAAQVTIHSSG--TFSTKFQVNNNNQLLLQRVTLPTVPGDYTVKVTGEGCVYLQTSLKYS 1329

  Fly  1348 LVEKEPKPSFKIQTTVLP---ESSPANLELSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSF 1409
            ::.:|.:..|.:....||   |...|:....:.::....|...||||||.:|.:.||:...:.:
  Rat  1330 VLPREEEFPFTVVVQTLPGTCEDPKAHTSFQISLNISYTGSRSESNMAIADVKMVSGFIPLKPT- 1393

  Fly  1410 ADIRNIER-VRLVETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNK 1473
              ::.:|| |.:..|:..::.|:||.:.:: |:...:.....:...:.:.||:.|.:||||:.::
  Rat  1394 --VKMLERSVHVSRTEVSNNHVLIYLDKVS-NQTVNLSFTVQQDIPIRDLKPAVVKVYDYYEKDE 1455

  Fly  1474 KATEYYS 1480
            .|...||
  Rat  1456 FAVAKYS 1462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081	30/94 (32%)
		A2M_N_2	528..653	CDD:285005	39/137 (28%)
		A2M	768..859	CDD:278630	36/90 (40%)
		A2M_2	982..1279	CDD:239227	109/316 (34%)
		A2M_comp	1035..1281	CDD:284982	90/265 (34%)
		A2M_recep	1389..1479	CDD:284981	24/90 (27%)
A2m	NP_036620.2	A2M_N	132..224	CDD:280081	33/119 (28%)
		A2M_N_2	464..609	CDD:285005	39/144 (27%)
		Bait region	620..750		25/133 (19%)
		A2M	736..826	CDD:278630	36/90 (40%)
		A2M_2	956..1262	CDD:239227	109/316 (34%)
		A2M_comp	1008..1263	CDD:284982	90/265 (34%)
		A2M_recep	1374..1461	CDD:284981	24/90 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343865
Domainoid	1	1.000	77	1.000	Domainoid score	I8631
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X292
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650