DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep4 and Cd109

DIOPT Version :9

Sequence 1:	NP_001260590.1	Gene:	Tep4 / 35248	FlyBaseID:	FBgn0041180	Length:	1498	Species:	Drosophila melanogaster
Sequence 2:	NP_694738.1	Gene:	Cd109 / 235505	MGIID:	2445221	Length:	1442	Species:	Mus musculus

Alignment Length:	1562	Identity:	424/1562 - (27%)
Similarity:	703/1562 - (45%)	Gaps:	218/1562 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RRADAFAVSLCVILALLQTMEPVKAEG-KYTIVGPGTIHSHRDYNVAVAVHQTKEP-VTLKVGIT 64
            ||..:.|..||:....|      .|.| ::.:..||.|....:..:.|.:.:...| |.:|..:.
Mouse     4 RRLLSAAHLLCLCAVAL------AAPGSRFLVTAPGIIRPGANVTIGVDLLENSPPQVLVKAQVF 62

  Fly    65 GPSYNKTETVELATA----GEFKQITFKLPPLEAG----EYNLTAEGVKGLEFKNSTKLNWENFK 121
            ..:.||:.::..|..    |.||.:.....||.:.    |.::..:....:.|.|.|:|.:|:..
Mouse    63 KIASNKSRSILEAEGVFHRGHFKTLVLPALPLSSADKIYELHINGQSENEIVFSNRTRLTFESKS 127

  Fly   122 PYIKIQTDKGKYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTG 186
            ..:.|||||..|||...:.:||:.|..:|:|  .:..|.::.:|.|.|.|:|....|...||.:.
Mouse   128 ISVLIQTDKAFYKPKQEVKFRVLTLCSDLKP--YRTSVDIFIKDPKSNVIQQWFSQKGDLGVVSK 190

  Fly   187 KFELSEFATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVK 251
            .|:||.....|.||:.||..||                   ::::|     |:|.:|||||:.|.
Mouse   191 TFQLSSNPIFGDWSIQVQVNDQ-------------------QYYQS-----FQVLEYVLPKFEVT 231

  Fly   252 MDATQQVSVRDGEFNVVLKANYTYGKPVNGKVLVNVHLDSTSSWENVDGKTVQTDYPGHSVVGTA 316
            :......|::..:.|..:.|.|||||||.|.  :::.....|.|......|...:..|.:   ..
Mouse   232 VQTPLYCSLKSKQLNGSVIAKYTYGKPVKGS--LSLTFLPLSFWGKKKNITKSFEINGFA---NF 291

  Fly   317 DMVGGKAKLTMDLKDFASYLPHKTSSSY----------AQITATVEEDFTGVKLNETGGVQLYPY 371
            .....:.|..|:||.    |...:..||          |:|.|||.|..||:....:..|....:
Mouse   292 SFDNYEMKKVMNLKP----LTDVSEGSYENVDPSFPGPAEIIATVTESLTGISRMASTNVFFKQH 352

  Fly   372 RYEMSCTDYSSCFSFKPDKEHELNFKITYVDGSLIT------DTKSVVKAKFTEGIRRNYAFYAF 430
            .|.:...||::.  .||........|::..||:.:|      |..:||..:     :.|:.
Mouse   353 DYIIEIFDYTTV--LKPSLNFTATVKVSRSDGNQLTPEEIENDLVTVVTQR-----KNNHP---- 406

  Fly   431 GTDHQEPELPTIEKKTFVFESHLNASGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTTY 495
             ...::.|:..|:...:.    :..:|:  .|:..|    :.:.:....::..|:|....:....
Mouse   407 -ESQRDQEMDYIQTVNYT----IPQNGI--IKIEFP----VMSISGELQLKAYFLDGTSSVTVHS 460

  Fly   496 PYREPKQIENPSSEEEKEWFRAEVQ-RPKDVWNLKIGQEYQVILNSSRPLKYFVYNIVGRGNILE 559
            .:..|.              :..:| :.:|.: :|:|..:.::::.:|..|...|.::.:|.::
Mouse   461 MFTSPS--------------KTYIQLKTRDEY-IKVGSPFDLMVSGNRQFKDLSYMVISKGQLV- 509

  Fly   560 TKRVDLAEPQTTVNVTIKPTFLTTPYGRVYFYYVDETGEFRYTEETFSVEVELQNQIEIK---AP 621
                 .|..|::...::.|.....|...:..||:.|.||.  ..:...:.|:|..:.::|   :.
Mouse   510 -----AAGKQSSRTFSLTPEASWAPKACIIAYYIAEDGEI--INDILKIPVQLVFENKVKLFWSK 567

  Fly   622 AEVKPGADVALEIK-TSPKSFVGLLAVDQSVLLLGSNNDLNKESFNWRLNGYDTSTPWQGGYSYY 685
            ..|||...|:|.|. |...|.||::|||:||.|:.::|.:..|:....|..|:|        .||
Mouse   568 PTVKPSDKVSLRISATQSDSLVGIVAVDKSVTLMENSNSITMETMVHELELYNT--------EYY 624

  Fly   686 PG---------ERTGVVTMTNAYFFYNRTAPDYNILTEGFGGSSFAMRKTTVAHDSHVFHSGAGG 741
            .|         :..|:..:|:|....:.....|:  ||.: ...||..                .
Mouse   625 LGMFMNSFAVFQECGLWVLTDATLIRDSIDEVYD--TEEY-SERFAEE----------------N 670

  Fly   742 PTQAVGFSAESASASAAPVVRKNFAETWIFADIESTEEEVFKWVKTIPDTITNWVVTGFSLHPQK 806
            ....|.|  |.||:.....|||||.||||:.|.....:...::..|:||:||:||.:.|.:....
Mouse   671 EANLVDF--EDASSVNNVHVRKNFPETWIWLDAYMGSKIYEEFEVTVPDSITSWVASAFVISEDL 733

  Fly   807 GLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVDA 871
            |.|:|.....::.|||||:.:.|||||.|||...:...:.|||..|:.|.:.::..| .:|.:..
Mouse   734 GFGLTTVPAELQAFQPFFLFLNLPYSVIRGEEFALEVSIVNYLKDTIKVVILIEESD-SFDILMT 797

  Fly   872 SNEVIGDQKRTQNIRVGANEAAGASFLIRPKVIGNILLKFKAISPLAGDAIHKPLKVVPEGITQY 936
            ||:..|...| :.::|..:......|.|:|..:|.|.:...|.||.|.||:.:.:.|.||||.:.
Mouse   798 SNDTNGTIYR-KTVQVPRDNGVTLVFPIKPTHLGEIPITVTAASPTASDAVTQTIVVKPEGIEKS 861

  Fly   937 QNRAFFINLKDTG-EFK-NTFELEVPEDVVPDSERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQ 999
            .:::..::|.|:. |.| .:.....|.|.|..||||:...:||:||..:..|.:|:|:|.|||||
Mouse   862 YSKSVLLDLTDSNVESKQQSMRFSFPPDTVIGSERVQITAIGDILGSSINGLSSLIRMPYGCGEQ 926

  Fly  1000 TMSKLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVR 1064
            .|....||..:.|||...|:||..|..:....::.|||..|.|:.:|||||:||       |...
Mouse   927 NMIYFAPNIYILDYLTKQKQLTVNLKEKALSYMRQGYQRELLYQREDGSFSAFG-------DIDS 984

  Fly  1065 NGSTWLTAYVLRSFSKIKDIIDLDEQILAKGYEFLLTRQAENGSFTEHGEYFYS----SQRSLLT 1125
            :|||||:|:|||.|.:....||:|:.:|.:.|.:|...:..||.|.|.|...:|    ..:|.:|
Mouse   985 SGSTWLSAFVLRCFLEADYYIDIDQDVLHRTYTWLNAHKKFNGEFWEPGRVIHSELQGGTKSPVT 1049

  Fly  1126 LTANSLLALLEEEK--PNQAAIDKAVAYLSANTAESI-ELLPKSIAIYALQKAKAPEAAKQVASL 1187
            |||..:.::|..:|  || ..:..::.:|....:..| :....:|..|||....:|:|.:.:..|
Mouse  1050 LTAYIVTSVLGYKKYQPN-IDVQDSIKFLEFEFSRGISDNYTLAIISYALSTVGSPKAEEALNLL 1113

  Fly  1188 KSLAKHEDDRTWWTEDLDKLRASKNCGRWWCWIW---SQDVEITSYALLSLLDSDQETADSV--- 1246
            ...::.|.|..:|......|..|          |   |.|:||.:||||:      .|...|
Mouse  1114 MQRSEKEGDTQFWLSSGPALSGS----------WQPRSVDIEIAAYALLA------HTLHHVSEG 1162

  Fly  1247 LNTVRWLIAQRNGFGGFASSQDTVVGLTALIKFAEKSGYEAAKWEVTVSNKGKREKTEKLNTSEE 1311
            :..:||||.|||..|||.|:|||||.|.||.:|:.....|....::||:..|..........|:.
Mouse  1163 IPVMRWLIQQRNSLGGFVSTQDTVVALKALSEFSALVHKENTDIQLTVTGPGIPRSIHFRIDSQN 1227

  Fly  1312 NDLLLQTVEFPQGTKSLEFEAKGTGAAMVQISYQYNLV---------EKEPKPSFKIQTTVLPES 1367
            ..||.|.........::...|.|:|.|:.|::..||:.         ..|.:..|.:...|..|.
Mouse  1228 LFLLHQEELHALDPITVNVSAHGSGFAICQLNVDYNVKGSGSSKRRRSTENQEVFDLDVIVNNED 1292

  Fly  1368 SPANLELSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSFADIRNIERVRLVETKNGDSVVVI 1432
            ..::|.|:||..::   .|:.:.|.::||:|.||::|..||   |...|.::.||..||.  :.:
Mouse  1293 DISHLNLNVCTSHL---GSERTGMVLMEVNLLSGFSASSDS---IPLSETLKKVEYDNGK--LNL 1349

  Fly  1433 YFENLAKNEEK-CIRIEAYRTHAVANQKPSSVVLYDYYDTNKKATEYYSIKSKL--CDICEGDDC 1494
            |.:::  ||.: |:.|...|.:.|:|.:..||.:.|||:..::|...|:.:.||  |.:....:|
Mouse  1350 YLDSV--NESQFCVNIPTVRDYKVSNIRDGSVSVMDYYEPRRQAVRSYNTQVKLSSCYLSPDTNC 1412

  Fly  1495 KS 1496
            ||
Mouse  1413 KS 1414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081	32/92 (35%)
		A2M_N_2	528..653	CDD:285005	33/128 (26%)
		A2M	768..859	CDD:278630	33/90 (37%)
		A2M_2	982..1279	CDD:239227	107/309 (35%)
		A2M_comp	1035..1281	CDD:284982	89/258 (34%)
		A2M_recep	1389..1479	CDD:284981	29/90 (32%)
Cd109	NP_694738.1	YfaS	<122..>1002	CDD:225248	270/997 (27%)
		A2M_N	129..220	CDD:280081	34/116 (29%)
		A2M_N_2	475..598	CDD:285005	32/131 (24%)
		Bait region (approximate). /evidence=ECO:0000250	595..704		35/137 (26%)
		A2M	695..782	CDD:278630	32/86 (37%)
		A2M_2	909..1195	CDD:239227	107/309 (35%)
		A2M_comp	961..1197	CDD:284982	89/259 (34%)
		A2M_recep	1311..1395	CDD:284981	29/90 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840006
Domainoid	1	1.000	75	1.000	Domainoid score	I9015
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	558	1.000	Inparanoid score	I1099
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45959
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	1	1.000	-	-		FOG0002157
OrthoInspector	1	1.000	-	-		otm42370
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.810