DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep4 and A2ml1

DIOPT Version :9

Sequence 1:	NP_001260590.1	Gene:	Tep4 / 35248	FlyBaseID:	FBgn0041180	Length:	1498	Species:	Drosophila melanogaster
Sequence 2:	NP_001001179.2	Gene:	A2ml1 / 232400	MGIID:	3039594	Length:	1456	Species:	Mus musculus

Alignment Length:	1604	Identity:	393/1604 - (24%)
Similarity:	662/1604 - (41%)	Gaps:	300/1604 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGITGPSYNKTETVELATAGE 81
            ||...:.|.||.:|.:.....:.........:.:....|.|:|.|.:.....:.|...:....|.
Mouse    11 LLHFTDVVAAEPRYILWVSSVVQRFSSEKACLHLLNLNESVSLSVTLEYDGSSTTIFDQPVDEGN 75

  Fly    82 FKQIT-FKLPPLEAGEYNLTAEGVKG----LEFKNSTKLNWENFKPYIKIQTDKGKYKPGDTINY 141
            |.... ||:..:.:.:....|..|:|    :..:.|..:..|....:  :|||...:|||||:::
Mouse    76 FYACADFKVSQMSSEQLAFVALLVQGNTLKISERRSVAIAAEENATF--VQTDTPVHKPGDTVHF 138

  Fly   142 RVIFLDENLRPDTAKDEV--VVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFATLGSWSLHV- 203
            ||:.|:..|:|   .|::  ::..:|.:.|.|.|..::.|...:....|:|:....||.:::.:
Mouse   139 RVVTLNIWLKP---VDDLYPLITVQDPQSNVIFQWINVTTFRNITQLSFQLTPEPILGDYTIVIK 200

  Fly   204 -QNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQQVSVRDGEFNV 267
             |:|....|                         :|.|.:.||||:.|::.|.:.:::.|.:|.:
Mouse   201 TQSGTTVMD-------------------------HFTVNRDVLPKFEVELTAPETITIADSQFQM 240

  Fly   268 VLKANYTYGKPVNGKVLVNV--------HLDSTSSWENVDGKTVQ-TDYPGHSVVGTADMVGGKA 323
            |..|.||||:||.||..:.|        |.:|..: |..:..||| .|.....::.|......::
Mouse   241 VTCAKYTYGQPVQGKAQIKVCRELFSPAHCESNEN-EICEQFTVQLKDGCASHIINTKVFQLDRS 304

  Fly   324 KLTMDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGV------------QLYPYRYEMS 376
            .|.|.|                .:...|.|..|||::::|..|            .:.|: |...
Mouse   305 GLFMTL----------------NVNEVVTESGTGVQMSKTHSVFITSVLGTVSFENMDPF-YRRG 352

  Fly   377 CTDYSSCFSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQ-EPELP 440
            .| |.....|.......|..|:..::    .|.|.|          .||.     ||.. |....
Mouse   353 IT-YFGTLKFSGPNNTPLVDKLLQLE----LDGKPV----------GNYT-----TDENGEARFS 397

  Fly   441 TIEKKTFVFESHLNASGVAPFKV-----VLPDLPDIANF--TRYYSIELEFVDEKRDLYTTYPYR 498
            ....:.|..:..|.|..|.|...     :.|:..| |.|  :|:||....|         |....
Mouse   398 INTSEIFGAQISLKAVYVRPRSCHRSSWLSPEYLD-AYFSASRFYSQTSSF---------TKIIL 452

  Fly   499 EPKQIENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQVILNSSRPLKY-------FVYNIVGRGN 556
            ||||:   ..::||.:                     .:|.|..|..|       |.|.::.||.
Mouse   453 EPKQL---PCDQEKMF---------------------SVLYSLNPEAYKEASDVTFFYLVMVRGG 493

  Fly   557 ILET--KRVDLAEPQTTVNVTIKPTFLTTPYGRVYFYYVDETGEFRYTEETFSVEVELQNQIEIK 619
            |..:  |:|.:.......:..|.......|...::.|.:..:||.........:|...:|::.|.
Mouse   494 ISRSGQKQVRVQAWNGNFSFPISINADLAPSADLFVYTLHPSGEIVADNVRLQIEKCFKNKVSIN 558

  Fly   620 APAEVK-PGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKESFNWRLNGYDTSTPW--QGG 681
            ...:.. ||::.::.::.:|.||..|.|||:|.|||....::..||..:.|       |:  |.|
Mouse   559 FSRDKDLPGSNTSVHLQAAPDSFCALRAVDKSALLLNHGQEMTPESVYFTL-------PYIHQYG 616

  Fly   682 YSYYPG----ERTGVVTMTNAYFFYNRT--APDYNI-------LTEGFGGSSFA---MRKTTVA- 729
            | :|.|    ::.....:.....|||..  .|..||       |....|...|.   .||..|.
Mouse   617 Y-FYNGLNLDDQQAEPCIPQKDLFYNGLYYTPTGNIWDGDLSNLLSNMGLKIFTNLHYRKPEVCS 680

  Fly   730 --------------HDSHVFHSGAGGPTQAVGFSAESASASAAPV---VRKNFAETWIF----AD 773
                          ::..:.:.|...|:.|...|.:|.|.:...:   ||.||..|||:    .|
Mouse   681 SQENQPLLRTFDHPNERIMMYGGGAPPSSAFHDSVDSISHAKVAIKETVRTNFPRTWIWNLVSVD 745

  Fly   774 IESTEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEV 838
            ...|....|    .:|||||.|..:.|.::...|.|: :.:.:::..|||||.|..|:||.|.|.
Mouse   746 SSGTANVSF----LVPDTITQWEASAFCVNGNAGFGI-SPKVSLQISQPFFVEVTSPFSVVRSEQ 805

  Fly   839 INVPALVFNYLPKTLDVELTLDNEDQEYDFVDASNEVIGDQKRTQNIRVGANEAAGASFLIRPKV 903
            .::...|||||...:::.:.|:..:.    .:||   |..|:.|.:..:.|.|.....:.|.||.
Mouse   806 SDMVVTVFNYLTTCVEISVQLEASEN----YEAS---INTQRNTDSEVLQAGEQKTYVWTIIPKT 863

  Fly   904 IGNILLKFKAISPLA---------------GDAIHKPLKVVPEGITQYQNRAFFINLKDTGEFKN 953
            :|.:.:...|.|..:               .|.:.|.:.|..|||.:...::|.|..|.|...|.
Mouse   864 LGKVNVTVVATSKQSRACPNDASKEQDVHWKDTVVKTMLVEAEGIEKEATQSFLICPKGTKASKQ 928

  Fly   954 TFELEVPEDVVPDSERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIK 1018
            |. ||:|.:||..|.|....:|||:||..::|||:||::|.|||||.:::|..:..:.||||:..
Mouse   929 TL-LELPSNVVEGSVRSFVTIVGDILGVAMQNLESLLQMPYGCGEQNIAQLASDVYILDYLKATD 992

  Fly  1019 KLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSFSKIKD 1083
            :||..|.::.:|.|.:|||:.|.:::.|||:..|..:.       :.|||||:|...::..|:|:
Mouse   993 QLTEELKSKAQRLLSNGYQNHLSFKNYDGSYDVFCQSN-------QEGSTWLSALSFKTVEKMKE 1050

  Fly  1084 IIDLDEQILAKGYEFLLTRQAENGSFTEHGEYFYSSQRSL------LTLTA-------------- 1128
            .|.::|.:..:...:|:.:|..||.|....::..::|...      :.|||
Mouse  1051 YIFIEETVPKQTLIWLVKKQKSNGCFRRDEKHVDTAQEGREGDQEDIALTAYVVGVFLEVGLNAS 1115

  Fly  1129 -----NSLLALLEEEKPNQAAIDKAV--AYLSANTAESIELLPKSIAIYALQKAKAPEAAKQVAS 1186
                 |.|..|.|       |....|  .|..|            |..|....|...:.||.:.|
Mouse  1116 FPALRNGLYCLEE-------AFSNGVTNGYTQA------------ILAYVFALAGKEQQAKSLLS 1161

  Fly  1187 L--KSLAKHEDDRTWWTEDLDKLRASKNCGRWWCWIWSQDVEITSYALLSLLDSDQETADSVLNT 1249
            :  ||..| .::..:|  :.|:...:.|...:.....|.:.|.|.|.||::|..|.:..|.....
Mouse  1162 ILDKSATK-TNNMIYW--ERDEKPETDNSPSFIPSALSGETEKTCYVLLAVLSQDTQDLDYASKI 1223

  Fly  1250 VRWLIAQRNGFGGFASSQDTVVGLTALIKFAEKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDL 1314
            |:||..:.|..|||::.|||.|.|.||.::.:.:|..... .:|:|::   |..|....:....|
Mouse  1224 VQWLAQRMNSHGGFSAMQDTTVCLLALTQYMKLTGSNPQN-TITLSSE---ESEEVFYVNRNKRL 1284

  Fly  1315 LLQTVEFPQGTKSLEFEAKGTGAAMVQISYQYNLVEKEPKPSFKIQTTVLPESS----PANLELS 1375
            |:|..:..:|.:....:.:|.|.:.:|.:.:||:...:....|.:.......:|    ....||:
Mouse  1285 LVQHSKVSKGHQQYTVDVEGDGCSFIQATLRYNVPLPKEASGFSLSVKTGKSNSSDEFQTKFELT 1349

  Fly  1376 VCVDYVEEGESKESNMAIL-EVSLPSGYTADEDSFADIRNIERVRLVETKNGDSVVVIYFENLAK 1439
            |.:.|.   .::||::.:| :|.:.||:|....|..:::...:|...:.|||.  |:.|.||:.|
Mouse  1350 VTLTYT---GARESSVTVLVDVKMLSGFTPVVSSTEELKFNSQVTKTDIKNGH--VLFYLENVPK 1409

  Fly  1440 NEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKKATEYYSIKS 1483
             |...:.....:|:.|||.:|:.|.:|. |:..:.|.:.|:|.|
Mouse  1410 -EATSLTFSIEQTNHVANIQPAPVTVYS-YEKGEYAFDSYNINS 1451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081	26/96 (27%)
		A2M_N_2	528..653	CDD:285005	29/134 (22%)
		A2M	768..859	CDD:278630	31/94 (33%)
		A2M_2	982..1279	CDD:239227	91/325 (28%)
		A2M_comp	1035..1281	CDD:284982	70/274 (26%)
		A2M_recep	1389..1479	CDD:284981	26/90 (29%)
A2ml1	NP_001001179.2	A2M_N	121..204	CDD:280081	24/87 (28%)
		A2M_N_2	450..593	CDD:285005	35/166 (21%)
		A2M	736..826	CDD:278630	31/94 (33%)
		A2M_2	956..1253	CDD:239227	91/325 (28%)
		A2M_comp	1008..1253	CDD:284982	70/273 (26%)
		A2M_recep	1364..1447	CDD:284981	25/86 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840014
Domainoid	1	1.000	66	1.000	Domainoid score	I9869
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.650