DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep4 and A2m

DIOPT Version :9

Sequence 1:	NP_001260590.1	Gene:	Tep4 / 35248	FlyBaseID:	FBgn0041180	Length:	1498	Species:	Drosophila melanogaster
Sequence 2:	NP_783327.2	Gene:	A2m / 232345	MGIID:	2449119	Length:	1474	Species:	Mus musculus

Alignment Length:	1579	Identity:	429/1579 - (27%)
Similarity:	691/1579 - (43%)	Gaps:	242/1579 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LCVILALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGITGPSYNKTETVE 75
            |.::|.||.|......:..|.::.|..:|:.......:..:...|.||:||.:.....|::...:
Mouse    19 LLLLLLLLPTNASAPQKPIYMVMVPSLLHAGTPEKGCLLFNHLNETVTVKVSMESVRGNQSLFTD 83

  Fly    76 LATAGE-FKQITFKLPPLEAGEYNLTAEGVKG--LEFKNSTKLNWENFKPYIKIQTDKGKYKPGD 137
            |....: |...:|.:|...:.|.......|||  .||:..:.:..:..:..:..||||..||||.
Mouse    84 LVVDKDLFHCASFIVPQSSSNEVMFLTVQVKGPTHEFRRRSTVLIKTKESLVFAQTDKPIYKPGQ 148

  Fly   138 TINYRVIFLDENLRPDTAKDEVV--VWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFATLGSWS 200
            .:.:||:.||||..|   .:|::  ::.:|||:|||.|.::.:..||:....|.||...|.||:.
Mouse   149 MVRFRVVSLDENFHP---LNELIPLLYIQDSKKNRIAQWQNFRLEGGLKQLSFPLSSEPTQGSYK 210

  Fly   201 LHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVN--FEVEKYVLPKYSVKMDATQQVSVRDG 263
            :.::.                         .|...|.  |.|:::||||:.||:...:.:::.:.
Mouse   211 VVIRT-------------------------ESGRTVEHPFSVKEFVLPKFEVKVAVPETITILEE 250

  Fly   264 EFNVVLKANYTYGKPVNGKVLVNV--HLDSTSSWENVDGKTVQTDYPGHSVVGTADMVGGKAKLT 326
            |.||.:...|||||||.|.|.||:  ...:.||....:.......:        :..:.|:...:
Mouse   251 EMNVSVCGIYTYGKPVPGHVTVNICRKYSNPSSCFGEESLAFCEKF--------SQQLDGRGCFS 307

  Fly   327 MDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETG-GVQLYPYRYEMSCTDYSSCFSFKPDK 390
            ..:|..:..|..:.......:.|.::|:.|||:  ||| |:        ...|...:..||....
Mouse   308 QLVKTKSFQLKRQEYEMQLDVNAKIQEEGTGVE--ETGKGL--------TKITRTITKLSFVNVD 362

  Fly   391 EHELNFK--ITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELPTIEKKTFVFESHL 453
            .|   |:  |.:|...|:.|.:         |....|.....|.|.....:.|...|
Mouse   363 TH---FRQGIPFVGQVLLVDGR---------GTPIPYEMIFIGADEANQNINTTTDK-------- 407

  Fly   454 NASGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTTYPYREPKQIENPSSEEEKE-WF-- 515
              :|:|.|.:...|:         ....|....:.:|....|.:|.       .:||..| |.
Mouse   408 --NGLARFSINTDDI---------MGTSLTVRAKYKDSNVCYGFRW-------LTEENVEAWHTA 454

  Fly   516 -------RAEVQRPKDVWNLKIGQEYQV----ILNSSRPLK----YFVYNIVGRGNILE--TKRV 563
                   |:.|......:.|:..|...|    |||....|:    .|.|.::.:|.|:.  |..:
Mouse   455 NAVFSPSRSFVHLESLPYKLRCEQTLAVQAHYILNDEAVLERKELVFYYLMMAKGGIVRAGTHVL 519

  Fly   564 DLAEPQTTVNVTIKPTFLT--TPYGRVYFYYVDETGEFRYTEETFSVEVE--LQNQIEIKAPAEV 624
            .:.:.....:.:|..:..|  .|..|:..|.:...||  ...:|...|:|  |.|::::.....:
Mouse   520 PVTQGHKKGHFSILISMETDLAPVARLVLYTILPNGE--VVGDTVKYEIEKCLANKVDLVFHPNI 582

  Fly   625 -KPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKESFNWRLNGYDTSTPWQGGYSYYPGE 688
             .|.....|.:..||:|..||.||||||||.....:|: .|..:.|......|.:..|.:....:
Mouse   583 GLPATRAFLSVMASPQSLCGLRAVDQSVLLTKPEAELS-ASLVYDLLPVKDLTGFPKGVNQQEED 646

  Fly   689 RTGVVTMTNAYFFYNRTAPDYNILTEGFGG----------SSFAMRKTTVAHDSHV------FHS 737
            ..|.:...:.|......:|..|...|...|          ::..:||..|.....|      :|.
Mouse   647 TNGCLKQNDTYINGILYSPVQNTNEEDMYGFLKDMGLKVFTNLNIRKPKVCERLGVNKIPAAYHL 711

  Fly   738 GAGGPTQAVGFSAESASASAAPVVRKNFAETWIF--ADIEST---EEEVFKWVKTIPDTITNWVV 797
            .:.|...|...|:||.:.:    .|..|.||||:  ..::||   |.||     |:|||||.|..
Mouse   712 VSQGHMDAFLESSESPTET----TRSYFPETWIWDLVIVDSTGVAEMEV-----TVPDTITEWKA 767

  Fly   798 TGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNE 862
            ..|.|....|||: :...:.:.||||||.:.:||||.|||...:.|.|.|||...:.|.:.|:..
Mouse   768 GAFCLSNDTGLGL-SPVIDFQAFQPFFVDLTMPYSVIRGEAFTLKATVLNYLQTCIRVGVQLEAS 831

  Fly   863 DQEYDFVDASNEVIGDQKRTQNIRVGANEAAGASFLIRPKVIGNILLKFKA-------------- 913
            .   ||:....|     |..::..:..||....|:.:.||.:||:.....|
Mouse   832 P---DFLATPEE-----KEQKSHCICMNERHTMSWAVIPKSLGNVNFTVSAEALDSKELCRNEVP 888

  Fly   914 ISPLAG--DAIHKPLKVVPEGITQYQNRAFFINLK-DTG-EFKNTFELEVPEDVVPDSERVEFGL 974
            :.|..|  |.|.|.|.|.|||:   :|...|.:|. .|| |......|::|.|||.:|.|....:
Mouse   889 VVPERGKKDTIIKSLLVEPEGL---ENEVTFNSLLCPTGAEVSEQISLKLPSDVVEESARASVTV 950

  Fly   975 VGDLLGPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHM 1039
            :||:||..::|.::||::|.|||||.|....||..|.|||...::||..:.|:....|..|||..
Mouse   951 LGDILGSAMQNTQDLLKMPYGCGEQNMVLFAPNIYVLDYLNETEQLTQEIKTKAITYLNTGYQRQ 1015

  Fly  1040 LHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSFSKIKDIIDLDEQILAKGYEFLLTRQA 1104
            |:|:|.|||:|:||....|.     :.:|||||:||:||::.:..|.:||..:.:...:|..:|.
Mouse  1016 LNYKHRDGSYSTFGDKPGRS-----HANTWLTAFVLKSFAQARRYIFIDESHITQALTWLSQQQK 1075

  Fly  1105 ENGSFTEHGEYFYSSQR----SLLTLTANSLLALLEEEKP------NQAAIDKAVAYLSANT-AE 1158
            :||.|...|....::.:    ..:||:|...:||||...|      ..|......|:.||.. |.
Mouse  1076 DNGCFRSSGSLLNNAMKGGVEDEVTLSAYITIALLEMSLPVTHPVVRNALFCLDTAWKSARRGAS 1140

  Fly  1159 SIELLPKSIAIYALQKAKAPEAAKQVASLKSL---AKHEDDRTWWTEDLDKLRASKNCGRWWCWI 1220
            ...:..|::..||...|...:..|::  ||||   |..||:...||      ||.|  .|....:
Mouse  1141 GNHVYTKALLAYAFALAGNQDTKKEI--LKSLDEEAVKEDNSVHWT------RAQK--PRVPADL 1195

  Fly  1221 W------SQDVEITSYALLSLLDSD----QETADSVLNTVRWLIAQRNGFGGFASSQDTVVGLTA 1275
            |      |.:||:|:|.||:.|.::    :|...:.:..|:||..|:|..|||:|:|||||.|.|
Mouse  1196 WYQPQAPSAEVEMTAYVLLAYLTTELVPTREDLTAAMLIVKWLTKQQNSHGGFSSTQDTVVALHA 1260

  Fly  1276 LIKFAEKSGYEAAK-WEVTVSNKGKREKTEKLNTSEENDLLLQTVEFPQGTKSLEFEAK--GTGA 1337
            |.|:...:...|.| ..||:.:.|  ....|...:.:|.||||.|..|  |...::.||  |.|.
Mouse  1261 LSKYGAATFTRAKKAAHVTIQSSG--AFYTKFQVNNDNQLLLQRVTLP--TVPGDYTAKVAGEGC 1321

  Fly  1338 AMVQISYQYNLVEKEPKPSFKIQTTVLPES-----SPANLELSVCVDYVEEGESKESNMAILEVS 1397
            ..:|.|.:|:::.:|.:..|.:....||.:     :....::|:.:.|:  |...:|||||.:|.
Mouse  1322 VYLQTSLKYSVLPREKEFPFALVVQTLPGTCEDLKAHTTFQISLNISYI--GSRSDSNMAIADVK 1384

  Fly  1398 LPSGYTADEDSFADIRNIER-VRLVETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQKPS 1461
            :.||:...:.:   ::.:|| |.:..|:..::.|:||.:.:: |:...:.....:...|.:.||:
Mouse  1385 MVSGFIPLKPT---VKMLERSVHVSRTEVSNNHVLIYLDKVS-NQMLTLFFMVQQDIPVRDLKPA 1445

  Fly  1462 SVVLYDYYDTNKKATEYYS 1480
            .|.:||||:.::.|...||
Mouse  1446 IVKVYDYYEKDEFAVAKYS 1464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081	31/94 (33%)
		A2M_N_2	528..653	CDD:285005	37/139 (27%)
		A2M	768..859	CDD:278630	39/95 (41%)
		A2M_2	982..1279	CDD:239227	109/320 (34%)
		A2M_comp	1035..1281	CDD:284982	90/269 (33%)
		A2M_recep	1389..1479	CDD:284981	25/90 (28%)
A2m	NP_783327.2	A2M_N	135..227	CDD:280081	34/119 (29%)
		A2M_N_2	473..612	CDD:285005	37/140 (26%)
		Bait region. /evidence=ECO:0000250\|UniProtKB:P01023	623..752		27/132 (20%)
		A2M	738..828	CDD:278630	39/95 (41%)
		A2M_2	958..1264	CDD:239227	109/320 (34%)
		A2M_comp	1010..1266	CDD:284982	90/270 (33%)
		A2M_recep	1376..1463	CDD:284981	25/90 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840018
Domainoid	1	1.000	227	1.000	Domainoid score	I2492
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X292
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650