DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tep4 and A2M

DIOPT Version :9

Sequence 1:NP_001260590.1 Gene:Tep4 / 35248 FlyBaseID:FBgn0041180 Length:1498 Species:Drosophila melanogaster
Sequence 2:XP_006719119.1 Gene:A2M / 2 HGNCID:7 Length:1512 Species:Homo sapiens


Alignment Length:1594 Identity:433/1594 - (27%)
Similarity:679/1594 - (42%) Gaps:269/1594 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 VILALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGITGPSYNKTETVELA 77
            ::|.||.|...|..:.:|.::.|..:|:.......|.:....|.||:...:.....|::...:|.
Human    14 LLLVLLPTDASVSGKPQYMVLVPSLLHTETTEKGCVLLSYLNETVTVSASLESVRGNRSLFTDLE 78

  Fly    78 TAGEFKQ-ITFKLPPLEAGE--YNLTAEGVKG--LEFKNSTKLNWENFKPYIKIQTDKGKYKPGD 137
            ...:... :.|.:|...:.|  ..||.: |||  .|||..|.:..:|....:.:||||..||||.
Human    79 AENDVLHCVAFAVPKSSSNEEVMFLTVQ-VKGPTQEFKKRTTVMVKNEDSLVFVQTDKSIYKPGQ 142

  Fly   138 TINYRVIFLDENLRPDTAKDEVV--VWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFATLGSWS 200
            |:.:||:.:|||..|   .:|::  |:.:|.|.|||.|.:..:..||:....|.||.....||:.
Human   143 TVKFRVVSMDENFHP---LNELIPLVYIQDPKGNRIAQWQSFQLEGGLKQFSFPLSSEPFQGSYK 204

  Fly   201 LHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQQVSVRDGEF 265
            :.||...         |||.:.              .|.||::||||:.|::...:.:::.:.|.
Human   205 VVVQKKS---------GGRTEH--------------PFTVEEFVLPKFEVQVTVPKIITILEEEM 246

  Fly   266 NVVLKANYTYGKPVNGKVLVNV--HLDSTSSWENVDGKTVQTDYPGHSVVGTADMVGGKAKLTMD 328
            ||.:...|||||||.|.|.|::  .....|.....|.:.....:.|        .:.........
Human   247 NVSVCGLYTYGKPVPGHVTVSICRKYSDASDCHGEDSQAFCEKFSG--------QLNSHGCFYQQ 303

  Fly   329 LKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPYRYEMSCTDYSSCFSF-KPDKEH 392
            :|.....|..|.........|.::|:.|.|:|  ||       |.....|...:..|| |.|...
Human   304 VKTKVFQLKRKEYEMKLHTEAQIQEEGTVVEL--TG-------RQSSEITRTITKLSFVKVDSHF 359

  Fly   393 ELNF----KITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELPTIEKKTFVFESHL 453
            ....    ::..|||..:.....|:   |..|...||...|...:|                   
Human   360 RQGIPFFGQVRLVDGKGVPIPNKVI---FIRGNEANYYSNATTDEH------------------- 402

  Fly   454 NASGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTTYPYREPKQIENPSSEEEKEWFRAE 518
               |:..|.:         |.|......|......:|....|.|:.       .|||.:|.....
Human   403 ---GLVQFSI---------NTTNVMGTSLTVRVNYKDRSPCYGYQW-------VSEEHEEAHHTA 448

  Fly   519 --VQRPKDVW--------NLKIGQEYQV----ILNSSRPLKY----FVYNIVGRGNILET----- 560
              |..|...:        .|..|....|    |||....|..    |.|.|:.:|.|:.|     
Human   449 YLVFSPSKSFVHLEPMSHELPCGHTQTVQAHYILNGGTLLGLKKLSFYYLIMAKGGIVRTGTHGL 513

  Fly   561 --KRVDLAEPQTTVNVTIKPTFLTTPYGRVYFYYVDETGEFRYTEETFSVEVELQNQIEIK-APA 622
              |:.|: :...::::.:|...  .|..|:..|.|..||:.......:.||..|.|::::. :|:
Human   514 LVKQEDM-KGHFSISIPVKSDI--APVARLLIYAVLPTGDVIGDSAKYDVENCLANKVDLSFSPS 575

  Fly   623 EVKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKES------------FNWRLNGYDTS 675
            :..|.:...|.:..:|:|...|.||||||||:..:.:|:..|            |...||..|..
Human   576 QSLPASHAHLRVTAAPQSVCALRAVDQSVLLMKPDAELSASSVYNLLPEKDLTGFPGPLNDQDNE 640

  Fly   676 ------TPWQGGYSYYPGERTGVVTMTNAYFFYNRTAPDYNILTEGFGGSSFA---MRKTTVA-- 729
                  ..:..|.:|.|      |:.||....|:        ..|..|..:|.   :||..:.  
Human   641 DCINRHNVYINGITYTP------VSSTNEKDMYS--------FLEDMGLKAFTNSKIRKPKMCPQ 691

  Fly   730 ---HDSHVFHSGAGGPT-QAVGFSAESASASA-----------APVVRKNFAETWIFADIESTEE 779
               ::.|       ||. ..|||.........           ...|||.|.||||:..:.....
Human   692 LQQYEMH-------GPEGLRVGFYESDVMGRGHARLVHVEEPHTETVRKYFPETWIWDLVVVNSA 749

  Fly   780 EVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPAL 844
            .|.:...|:|||||.|....|.|....|||::: ..:::.||||||.:.:||||.|||...:.|.
Human   750 GVAEVGVTVPDTITEWKAGAFCLSEDAGLGISS-TASLRAFQPFFVELTMPYSVIRGEAFTLKAT 813

  Fly   845 VFNYLPKTLDVELTLDNEDQEYDFVDASNEVIGDQKRTQNIRVGANEAAGASFLIRPKVIGNILL 909
            |.|||||.:.|.:.|:        ...:...:..:|......:.||.....|:.:.||.:||:..
Human   814 VLNYLPKCIRVSVQLE--------ASPAFLAVPVEKEQAPHCICANGRQTVSWAVTPKSLGNVNF 870

  Fly   910 KFKA----ISPLAG------------DAIHKPLKVVPEGITQYQNRAFFINL--KDTGEFKNTFE 956
            ...|    ...|.|            |.:.|||.|.|||:   :....|.:|  ...||......
Human   871 TVSAEALESQELCGTEVPSVPEHGRKDTVIKPLLVEPEGL---EKETTFNSLLCPSGGEVSEELS 932

  Fly   957 LEVPEDVVPDSERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKKLT 1021
            |::|.:||.:|.|....::||:||..::|.:|||::|.|||||.|....||..|.|||...::||
Human   933 LKLPPNVVEESARASVSVLGDILGSAMQNTQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQLT 997

  Fly  1022 PALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSFSKIKDIID 1086
            |.:.::....|..|||..|:|:|.|||:|:||....|.:     |:|||||:||::|::.:..|.
Human   998 PEIKSKAIGYLNTGYQRQLNYKHYDGSYSTFGERYGRNQ-----GNTWLTAFVLKTFAQARAYIF 1057

  Fly  1087 LDEQILAKGYEFLLTRQAENGSFTEHGEYFYSSQR----SLLTLTANSLLALLE-EEKPNQAAID 1146
            :||..:.:...:|..||.:||.|...|....::.:    ..:||:|...:|||| ........:.
Human  1058 IDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGVEDEVTLSAYITIALLEIPLTVTHPVVR 1122

  Fly  1147 KAVAYLSA--NTAE----SIELLPKSIAIYALQKAKAPEAAKQVASLKSL---AKHEDDRTWWTE 1202
            .|:..|.:  .||:    ...:..|::..||...|...:..|:|  ||||   |..:|:...| |
Human  1123 NALFCLESAWKTAQEGDHGSHVYTKALLAYAFALAGNQDKRKEV--LKSLNEEAVKKDNSVHW-E 1184

  Fly  1203 DLDKLRASKNCGRWW-CWIWSQDVEITSYALLSLLDSD----QETADSVLNTVRWLIAQRNGFGG 1262
            ...|.:|.  .|.:: ....|.:||:|||.||:.|.:.    .|...|..|.|:|:..|:|..||
Human  1185 RPQKPKAP--VGHFYEPQAPSAEVEMTSYVLLAYLTAQPAPTSEDLTSATNIVKWITKQQNAQGG 1247

  Fly  1263 FASSQDTVVGLTALIKFA----EKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQTVEFPQ 1323
            |:|:|||||.|.||.|:.    .::|..|   :||:.:.|  ..:.|......|.||||.|..|:
Human  1248 FSSTQDTVVALHALSKYGAATFTRTGKAA---QVTIQSSG--TFSSKFQVDNNNRLLLQQVSLPE 1307

  Fly  1324 GTKSLEFEAKGTGAAMVQISYQYNLV-EKEPKPSFKIQTTVLPES-----SPANLELSVCVDYVE 1382
            .......:..|.|...:|.|.:||:: |||..| |.:....||::     :..:.::|:.|.|. 
Human  1308 LPGEYSMKVTGEGCVYLQTSLKYNILPEKEEFP-FALGVQTLPQTCDEPKAHTSFQISLSVSYT- 1370

  Fly  1383 EGESKESNMAILEVSLPSGYTADEDSFADIRNIERVRLV-ETKNGDSVVVIYFENLAKNEEKCIR 1446
             |....|||||::|.:.||:...:.:   ::.:||...| .|:...:.|:||.:.:: |:...:.
Human  1371 -GSRSASNMAIVDVKMVSGFIPLKPT---VKMLERSNHVSRTEVSSNHVLIYLDKVS-NQTLSLF 1430

  Fly  1447 IEAYRTHAVANQKPSSVVLYDYYDTNKKATEYYS 1480
            ....:...|.:.||:.|.:||||:|::.|...|:
Human  1431 FTVLQDVPVRDLKPAIVKVYDYYETDEFAIAEYN 1464

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep4NP_001260590.1 A2M_N 126..219 CDD:280081 33/94 (35%)
A2M_N_2 528..653 CDD:285005 38/140 (27%)
A2M 768..859 CDD:278630 37/90 (41%)
A2M_2 982..1279 CDD:239227 109/315 (35%)
A2M_comp 1035..1281 CDD:284982 89/268 (33%)
A2M_recep 1389..1479 CDD:284981 26/90 (29%)
A2MXP_006719119.1 YfaS <124..>1071 CDD:225248 286/1071 (27%)
A2M_N 129..221 CDD:280081 36/117 (31%)
A2M_N_2 461..606 CDD:285005 38/147 (26%)
A2M 738..828 CDD:278630 37/90 (41%)
A2M_2 958..1264 CDD:239227 109/315 (35%)
A2M_comp 1010..1266 CDD:284982 89/265 (34%)
A2M_recep 1376..1463 CDD:284981 26/90 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149965
Domainoid 1 1.000 84 1.000 Domainoid score I8230
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100452
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X292
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.650

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