Protein Alignment Tep4 and A2M

DIOPT Version :10

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: XP_006719119.1
• Gene: A2M / 2
• HGNCID: 7
• Length: 1512
• Species: Homo sapiens
• Alignment Length: 1594
• Identity: 433/1594 - (27%)
• Similarity: 679/1594 - (42%)
• Gaps: 269/1594 - (16%)

  Fly    13 VILALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGITGPSYNKTETVELA 77
            ::|.||.|...|..:.:|.::.|..:|:.......|.:....|.||:...:.....|::...:|.
Human    14 LLLVLLPTDASVSGKPQYMVLVPSLLHTETTEKGCVLLSYLNETVTVSASLESVRGNRSLFTDLE 78

  Fly    78 TAGEFKQ-ITFKLPPLEAGE--YNLTAEGVKG--LEFKNSTKLNWENFKPYIKIQTDKGKYKPGD 137
            ...:... :.|.:|...:.|  ..||.: |||  .|||..|.:..:|....:.:||||..||||.
Human    79 AENDVLHCVAFAVPKSSSNEEVMFLTVQ-VKGPTQEFKKRTTVMVKNEDSLVFVQTDKSIYKPGQ 142

  Fly   138 TINYRVIFLDENLRPDTAKDEVV--VWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFATLGSWS 200
            |:.:||:.:|||..|   .:|::  |:.:|.|.|||.|.:..:..||:....|.||.....||:.
Human   143 TVKFRVVSMDENFHP---LNELIPLVYIQDPKGNRIAQWQSFQLEGGLKQFSFPLSSEPFQGSYK 204

  Fly   201 LHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQQVSVRDGEF 265
            :.||...         |||.:.              .|.||::||||:.|::...:.:::.:.|.
Human   205 VVVQKKS---------GGRTEH--------------PFTVEEFVLPKFEVQVTVPKIITILEEEM 246

  Fly   266 NVVLKANYTYGKPVNGKVLVNV--HLDSTSSWENVDGKTVQTDYPGHSVVGTADMVGGKAKLTMD 328
            ||.:...|||||||.|.|.|::  .....|.....|.:.....:.|        .:.........
Human   247 NVSVCGLYTYGKPVPGHVTVSICRKYSDASDCHGEDSQAFCEKFSG--------QLNSHGCFYQQ 303

  Fly   329 LKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPYRYEMSCTDYSSCFSF-KPDKEH 392
            :|.....|..|.........|.::|:.|.|:|  ||       |.....|...:..|| |.|...
Human   304 VKTKVFQLKRKEYEMKLHTEAQIQEEGTVVEL--TG-------RQSSEITRTITKLSFVKVDSHF 359

  Fly   393 ELNF----KITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELPTIEKKTFVFESHL 453
            ....    ::..|||..:.....|:   |..|...||...|...:|
Human   360 RQGIPFFGQVRLVDGKGVPIPNKVI---FIRGNEANYYSNATTDEH------------------- 402

  Fly   454 NASGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTTYPYREPKQIENPSSEEEKEWFRAE 518
               |:..|.:         |.|......|......:|....|.|:.       .|||.:|.....
Human   403 ---GLVQFSI---------NTTNVMGTSLTVRVNYKDRSPCYGYQW-------VSEEHEEAHHTA 448

  Fly   519 --VQRPKDVW--------NLKIGQEYQV----ILNSSRPLKY----FVYNIVGRGNILET----- 560
              |..|...:        .|..|....|    |||....|..    |.|.|:.:|.|:.|
Human   449 YLVFSPSKSFVHLEPMSHELPCGHTQTVQAHYILNGGTLLGLKKLSFYYLIMAKGGIVRTGTHGL 513

  Fly   561 --KRVDLAEPQTTVNVTIKPTFLTTPYGRVYFYYVDETGEFRYTEETFSVEVELQNQIEIK-APA 622
              |:.|: :...::::.:|...  .|..|:..|.|..||:.......:.||..|.|::::. :|:
Human   514 LVKQEDM-KGHFSISIPVKSDI--APVARLLIYAVLPTGDVIGDSAKYDVENCLANKVDLSFSPS 575

  Fly   623 EVKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKES------------FNWRLNGYDTS 675
            :..|.:...|.:..:|:|...|.||||||||:..:.:|:..|            |...||..|..
Human   576 QSLPASHAHLRVTAAPQSVCALRAVDQSVLLMKPDAELSASSVYNLLPEKDLTGFPGPLNDQDNE 640

  Fly   676 ------TPWQGGYSYYPGERTGVVTMTNAYFFYNRTAPDYNILTEGFGGSSFA---MRKTTVA-- 729
                  ..:..|.:|.|      |:.||....|:        ..|..|..:|.   :||..:.
Human   641 DCINRHNVYINGITYTP------VSSTNEKDMYS--------FLEDMGLKAFTNSKIRKPKMCPQ 691

  Fly   730 ---HDSHVFHSGAGGPT-QAVGFSAESASASA-----------APVVRKNFAETWIFADIESTEE 779
               ::.|       ||. ..|||.........           ...|||.|.||||:..:.....
Human   692 LQQYEMH-------GPEGLRVGFYESDVMGRGHARLVHVEEPHTETVRKYFPETWIWDLVVVNSA 749

  Fly   780 EVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPAL 844
            .|.:...|:|||||.|....|.|....|||::: ..:::.||||||.:.:||||.|||...:.|.
Human   750 GVAEVGVTVPDTITEWKAGAFCLSEDAGLGISS-TASLRAFQPFFVELTMPYSVIRGEAFTLKAT 813

  Fly   845 VFNYLPKTLDVELTLDNEDQEYDFVDASNEVIGDQKRTQNIRVGANEAAGASFLIRPKVIGNILL 909
            |.|||||.:.|.:.|:        ...:...:..:|......:.||.....|:.:.||.:||:..
Human   814 VLNYLPKCIRVSVQLE--------ASPAFLAVPVEKEQAPHCICANGRQTVSWAVTPKSLGNVNF 870

  Fly   910 KFKA----ISPLAG------------DAIHKPLKVVPEGITQYQNRAFFINL--KDTGEFKNTFE 956
            ...|    ...|.|            |.:.|||.|.|||:   :....|.:|  ...||......
Human   871 TVSAEALESQELCGTEVPSVPEHGRKDTVIKPLLVEPEGL---EKETTFNSLLCPSGGEVSEELS 932

  Fly   957 LEVPEDVVPDSERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKKLT 1021
            |::|.:||.:|.|....::||:||..::|.:|||::|.|||||.|....||..|.|||...::||
Human   933 LKLPPNVVEESARASVSVLGDILGSAMQNTQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQLT 997

  Fly  1022 PALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSFSKIKDIID 1086
            |.:.::....|..|||..|:|:|.|||:|:||....|.:     |:|||||:||::|::.:..|.
Human   998 PEIKSKAIGYLNTGYQRQLNYKHYDGSYSTFGERYGRNQ-----GNTWLTAFVLKTFAQARAYIF 1057

  Fly  1087 LDEQILAKGYEFLLTRQAENGSFTEHGEYFYSSQR----SLLTLTANSLLALLE-EEKPNQAAID 1146
            :||..:.:...:|..||.:||.|...|....::.:    ..:||:|...:|||| ........:.
Human  1058 IDEAHITQALIWLSQRQKDNGCFRSSGSLLNNAIKGGVEDEVTLSAYITIALLEIPLTVTHPVVR 1122

  Fly  1147 KAVAYLSA--NTAE----SIELLPKSIAIYALQKAKAPEAAKQVASLKSL---AKHEDDRTWWTE 1202
            .|:..|.:  .||:    ...:..|::..||...|...:..|:|  ||||   |..:|:...| |
Human  1123 NALFCLESAWKTAQEGDHGSHVYTKALLAYAFALAGNQDKRKEV--LKSLNEEAVKKDNSVHW-E 1184

  Fly  1203 DLDKLRASKNCGRWW-CWIWSQDVEITSYALLSLLDSD----QETADSVLNTVRWLIAQRNGFGG 1262
            ...|.:|.  .|.:: ....|.:||:|||.||:.|.:.    .|...|..|.|:|:..|:|..||
Human  1185 RPQKPKAP--VGHFYEPQAPSAEVEMTSYVLLAYLTAQPAPTSEDLTSATNIVKWITKQQNAQGG 1247

  Fly  1263 FASSQDTVVGLTALIKFA----EKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQTVEFPQ 1323
            |:|:|||||.|.||.|:.    .::|..|   :||:.:.|  ..:.|......|.||||.|..|:
Human  1248 FSSTQDTVVALHALSKYGAATFTRTGKAA---QVTIQSSG--TFSSKFQVDNNNRLLLQQVSLPE 1307

  Fly  1324 GTKSLEFEAKGTGAAMVQISYQYNLV-EKEPKPSFKIQTTVLPES-----SPANLELSVCVDYVE 1382
            .......:..|.|...:|.|.:||:: |||..| |.:....||::     :..:.::|:.|.|.
Human  1308 LPGEYSMKVTGEGCVYLQTSLKYNILPEKEEFP-FALGVQTLPQTCDEPKAHTSFQISLSVSYT- 1370

  Fly  1383 EGESKESNMAILEVSLPSGYTADEDSFADIRNIERVRLV-ETKNGDSVVVIYFENLAKNEEKCIR 1446
             |....|||||::|.:.||:...:.:   ::.:||...| .|:...:.|:||.:.:: |:...:.
Human  1371 -GSRSASNMAIVDVKMVSGFIPLKPT---VKMLERSNHVSRTEVSSNHVLIYLDKVS-NQTLSLF 1430

  Fly  1447 IEAYRTHAVANQKPSSVVLYDYYDTNKKATEYYS 1480
            ....:...|.:.||:.|.:||||:|::.|...|:
Human  1431 FTVLQDVPVRDLKPAIVKVYDYYETDEFAIAEYN 1464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	YfaS	<76..1411	CDD:441940	401/1459 (27%)
		A2M_2	982..1279	CDD:239227	109/315 (35%)
		A2M_recep	1387..1480	CDD:462226	26/93 (28%)
A2M	XP_006719119.1	YfaS	<129..1338	CDD:441940	370/1343 (28%)
		A2M	738..828	CDD:459711	37/90 (41%)
		A2M_2	958..1264	CDD:239227	109/315 (35%)
		A2M_recep	1374..1464	CDD:462226	26/93 (28%)