Protein Alignment Tep4 and Mug2

DIOPT Version :9

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: XP_006505762.1
• Gene: Mug2 / 17837
• MGIID: 99836
• Length: 1490
• Species: Mus musculus
• Alignment Length: 1637
• Identity: 422/1637 - (25%)
• Similarity: 691/1637 - (42%)
• Gaps: 333/1637 - (20%)

  Fly     2 RRADAFAVSLC---VILALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGI 63
            |||     .||   |:||.|.:...:..:.||.::.|..:::.....:.:.::...|.||:...:
Mouse     5 RRA-----QLCLFSVLLAFLPSASSLNGDSKYMVLVPSQLYTETPEKICLHLYHLNETVTVTASL 64

  Fly    64 TGPSYNKTETVELATAGE-FKQITFKLPPLEA-GEYNLTAEGVKG--LEFKNSTKLNWENFKPYI 124
            ...:..:....||....: |:.::|.:|.|.: .|.......:||  .||.....:..:|.:..:
Mouse    65 VSQTGRRNLFDELVVDKDLFQCVSFIIPTLNSPDEEEFLYVDIKGPTHEFSKRNAVLVKNKESVV 129

  Fly   125 KIQTDKGKYKPGDTINYRVIFLDENLRPDTAKDEV--VVWFEDSKRNRIKQEKHIKTTGGVYTGK 187
            .:||||..||||.::.:||:.:|:.|||   .:|:  :.:.||.|:|||.|.:.|||..|:....
Mouse   130 FVQTDKPVYKPGQSVKFRVVSMDKTLRP---LNELLPLAYIEDPKKNRIMQWRDIKTENGLKQMS 191

  Fly   188 FELSEFATLGSWSL--HVQNG--DQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKY 248
            |.|:.....|.:.:  |.|:|  ::|                           :|.|.::|||::
Mouse   192 FSLAAEPIQGPYKIVVHKQSGVKEEH---------------------------SFTVMEFVLPRF 229

  Fly   249 SVKMDATQQVSVRDGEFNVVLKANYTYGKPVNGKVLVNVHLDSTSSWENVDGKTVQTDYPGHSV- 312
            :|.:.....:||.|....|.:...|||||||.|:|.:::..::.:..:.|:.|   .|..|.|.
Mouse   230 NVDLKVPNAISVNDEVLQVTVCGKYTYGKPVPGQVKISICHETEAGCKEVNSK---LDNNGCSTQ 291

  Fly   313 -VGTADMVGGKAKLTMDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPYRYEMS 376
             |...::...|       :::...|.|        :.|||.|:.||::.|..|..::.....::.
Mouse   292 EVNITELQSKK-------RNYEVQLFH--------VNATVTEEGTGLEFNGYGTTKIERITNKLI 341

  Fly   377 CTDYSSCFSFKPDKEHELNF--KITYVD--GSLITDTKSVVKAK---FTEGIRRNYAFYAFGTDH 434
            .....|.|      .|.:.|  |:..||  |..|.:.:..:||:   :|.         |..||.
Mouse   342 FLKADSHF------RHGIPFFVKVRLVDIKGDPIPNERVFIKAQVLGYTS---------ATTTDQ 391

  Fly   435 QEPELPTIEKKTFVFESHLNASGVAPFKVVLPDLPDIANFTR-----------------YYSIEL 482
            .                     |:|.|.:      |.|.|:.                 :|.:|.
Mouse   392 H---------------------GLAKFSI------DTAGFSGSSLHIKVNHKGKDSCYFFYCMEE 429

  Fly   483 EFVDEKRDLYTTYPYREPKQIENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQVILNSSRPLK-- 545
            .:...:...|..|           |..:...:...|.........:...|.:.::......||
Mouse   430 RYASAEHVAYAVY-----------SLSKSYIYLVKETSSILPCNQIHTVQAHFILKGDLGVLKEL 483

  Fly   546 YFVYNIVGRGNILET-KRVDLAEP-----QTTVNVTIKPTFLTTPYGRVYFYYVDETGEFRYTEE 604
            .|.|.::.:|:|::| ......||     :...::.|...|...|..::..|.:...||......
Mouse   484 VFYYLVMAQGSIIQTGNHTHQVEPGEAPVKGNFDLEIPVEFSMAPMAKMLIYTILPDGEVIADSV 548

  Fly   605 TFSVEVELQNQIEIK-APAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKESFNWR 668
            .|.:|..|:|::::. :.::..|.:...|::..||:|..||.|||||||||...::|   |.:|.
Mouse   549 NFEIEKCLRNKVDLSFSSSQSLPASQTRLQVTASPQSLCGLRAVDQSVLLLKPEDEL---SPSWI 610

  Fly   669 LNGYDTSTPWQGGYSYYPGERTGVVTMTNAYFFYNRTAPDYNILTEGFGG----SSFAMRKTT-- 727
            .|              .||.:            :|:..|. :.|:|....    ||:...|.|
Mouse   611 YN--------------LPGMQ------------HNKFIPS-SSLSEDREDCILYSSWVAEKHTDW 648

  Fly   728 VAH--DSHVFH---------------------------SGAGGPTQAVGFSAESASA-------- 755
            |.|  :..|:.                           ||..|... :.||:|.:..
Mouse   649 VPHGREKDVYRYVEDMDLKAFTNLKIKLPKICFDSAPMSGPRGKFD-LAFSSEVSGTLQKGSSKR 712

  Fly   756 ---------------SAAPVVRKNFAETWIFADIESTEEEVFKWVKTIPDTITNWVVTGFSLHPQ 805
                           ..|..:||.|.|||::..:......|.:...|:|||||.|......|...
Mouse   713 PQPEEPPREDPPPKDPLAETIRKYFPETWVWDIVTVNSTGVAEVEMTVPDTITEWKAGALCLSND 777

  Fly   806 KGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVD 870
            .|||::: ...::.||||||.|.|||||.|||...:.|.|.||||.::.:.:.|:...   ||..
Mouse   778 TGLGLSS-VVPLQAFQPFFVEVSLPYSVVRGEAFMLKATVMNYLPTSMRMSVQLEASP---DFTA 838

  Fly   871 ASNEVIGDQKRTQNIRVGANEAAGASFLIRPKVIGNILLKFK--------------AISPLAG-- 919
            ..   :||..  .:..:.||....:|:|:.||.:||:.....              |..|..|
Mouse   839 VP---VGDDH--DSYCLSANGRHTSSWLVTPKSLGNVNFSVSVEAQQSSEPCGSEVATVPETGRK 898

  Fly   920 DAIHKPLKVVPEGITQYQ--NRAFFINLKDTGEFKNTFELEVPEDVVPDSERVEFGLVGDLLGPV 982
            |.:.|.|.|.||||.|..  |..|   .....|......|.:|..||.||.|..|.::||:|...
Mouse   899 DTVVKVLIVEPEGIKQEHTFNSLF---CASDAEISEKMSLVLPPTVVKDSARAHFSVMGDILSSA 960

  Fly   983 VKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHMLHYRHDDG 1047
            :||.:|||.:|.|||||.|....||..|..||...::||..:.|:....|:.|||..|:|:|.||
Mouse   961 IKNTQNLLHMPYGCGEQNMVLFAPNIYVLKYLDKTQQLTQKIKTKALGFLRAGYQRELNYKHKDG 1025

  Fly  1048 SFSSFGPTKWRQEDPVRNGSTWLTAYVLRSFSKIKDIIDLDEQILAKGYEFLLTRQAENGSFTEH 1112
            |:|:||     .::..|.|:|||||:||:||::.:..|.:||..:...:.:|..:|.:||.|...
Mouse  1026 SYSAFG-----DQNGEREGNTWLTAFVLKSFAQARAFIFIDESHITHAFTWLSQQQKDNGCFRSS 1085

  Fly  1113 GEYFYSSQR----SLLTLTANSLLALLEEEKP-NQAAIDKAVAYLSANTAESIE-------LLPK 1165
            |..|::..:    ..:||:|...:||||...| ....:.||::.|.::. ::||       :..|
Mouse  1086 GSLFHNDIKGGVDDEMTLSAYITMALLESSLPARHPVVSKALSCLESSW-KTIEQGRNANFVYTK 1149

  Fly  1166 SIAIYALQKAKAPEAAKQVASLKSL---AKHEDDRTWW---------TEDLDKLRASKNCGRWWC 1218
            ::..||.  |.|....|:...||||   |..||:...|         ..:|.|.:||
Mouse  1150 ALMAYAF--ALAGNQDKRNEILKSLDEEAIKEDNSIHWERPQKPRKSEHNLYKPQAS-------- 1204

  Fly  1219 WIWSQDVEITSYALLSLLDSDQETADSVL----NTVRWLIAQRNGFGGFASSQDTVVGLTALIKF 1279
               |.:||:.:|.:|:.|.:....:...|    :|:.||..|:|..|||:|:|||||.|.||.|:
Mouse  1205 ---SVEVEMNAYVVLARLTAQPAPSPEDLTLSRSTIMWLTKQQNSNGGFSSTQDTVVALDALSKY 1266

  Fly  1280 AEKSGYEAAKWE-VTVSNKGKREKTEKLNTSEENDLLLQTVEFPQGTKSLEFEAKGTGAAMVQIS 1343
            ...:.....|.. ||:.:.|  ..::|......|.||||.|..|...........|.|....|.:
Mouse  1267 GAVTFSRRQKTSLVTIQSTG--SFSQKFQVENSNCLLLQQVPLPDIPGDYTISVSGEGCVYAQTT 1329

  Fly  1344 YQYNL-VEKEPKP-SFKIQTTVLPESSPA---NLELSVCVDYVEEGESKESNMAILEVSLPSGYT 1403
            .:||: :||:... :.::||..|..::|.   :.::|:.:.|.  |....|||.|.:|.:.||:.
Mouse  1330 LRYNMHLEKQQSAFALRVQTVPLTCNNPKGHNSFQISLEISYT--GSRPASNMVIADVKMLSGFI 1392

  Fly  1404 ADEDSFADIRNIERVRLVETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDY 1468
            ..:.:...:..:|.:...|..|.:  |::|.:.:. |:.........:..:|.|.:|:.|.:|||
Mouse  1393 PLKPTVKKLERLEHISRTEVSNNN--VLLYLDQVT-NQTLAFSFIIQQDISVRNLQPAIVKVYDY 1454

  Fly  1469 YDTNKKATEYYS 1480
            |:|::.|...||
Mouse  1455 YETDEVAYAEYS 1466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081	33/98 (34%)
		A2M_N_2	528..653	CDD:285005	33/133 (25%)
		A2M	768..859	CDD:278630	35/90 (39%)
		A2M_2	982..1279	CDD:239227	109/324 (34%)
		A2M_comp	1035..1281	CDD:284982	89/273 (33%)
		A2M_recep	1389..1479	CDD:284981	23/89 (26%)
Mug2	XP_006505762.1	A2M_N	129..221	CDD:376626	34/121 (28%)
		MG3	223..299	CDD:375334	23/78 (29%)
		MG4	340..434	CDD:375332	23/135 (17%)
		A2M_N_2	459..599	CDD:377903	34/139 (24%)
		A2M	740..830	CDD:365945	35/90 (39%)
		A2M_2	960..1266	CDD:239227	109/324 (34%)
		A2M_recep	1378..1465	CDD:369460	23/89 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840030
Domainoid	1	1.000	75	1.000	Domainoid score	I9015
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H136663
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100452
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X292
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.650