DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep4 and Hc

DIOPT Version :9

Sequence 1:	NP_001260590.1	Gene:	Tep4 / 35248	FlyBaseID:	FBgn0041180	Length:	1498	Species:	Drosophila melanogaster
Sequence 2:	XP_017171158.1	Gene:	Hc / 15139	MGIID:	96031	Length:	1684	Species:	Mus musculus

Alignment Length:	1681	Identity:	379/1681 - (22%)
Similarity:	645/1681 - (38%)	Gaps:	390/1681 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 YTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGITGPSYNKTETVELATAGEFKQITFKLPPLEA 94
            |.|..|..:......||.:.||...|.....:.:  .||..            |::||     .:
Mouse    27 YVISAPKILRVGSSENVVIQVHGYTEAFDATLSL--KSYPD------------KKVTF-----SS 72

  Fly    95 GEYNLTAEGVKGLEFKNSTKLNWE-NFKP---------YIK----------------------IQ 127
            |..||:.|.    :|:|:..|..: |..|         |::                      |.
Mouse    73 GYVNLSPEN----KFQNAALLTLQPNQVPREESPVSHVYLEVVSKHFSKSKKIPITYNNGILFIH 133

  Fly   128 TDKGKYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSE 192
            |||..|.|..::..||..|.::|:|  ||.|.|:.|.|.:.:.:...:....||.:....|::..
Mouse   134 TDKPVYTPDQSVKIRVYSLGDDLKP--AKRETVLTFIDPEGSEVDIVEENDYTGIISFPDFKIPS 196

  Fly   193 FATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQQ 257
            ....|.|::....             :|.|...|..:        ||:::||||::||.::..:.
Mouse   197 NPKYGVWTIKANY-------------KKDFTTTGTAY--------FEIKEYVLPRFSVSIELERT 240

  Fly   258 -VSVRD-GEFNVVLKANYTYGKPV-NGKVLVNVHLDSTSSWENVDGKTVQTDYPGHSVVGTADMV 319
             :..:: ..|.:.:||.|.|.|.| :.:|.....|.     |::..:..|.   .|.....|.:|
Mouse   241 FIGYKNFKNFEITVKARYFYNKVVPDAEVYAFFGLR-----EDIKDEEKQM---MHKATQAAKLV 297

  Fly   320 GGKAKLTMDLKDFASYLPHKT----SSSYAQITATVEEDFTGVKLN-ETGGVQ--LYPYRYEMSC 377
            .|.|:::.|.:.....|.:.:    ::.|..|..||.|...|.... |..||:  |.||...:..
Mouse   298 DGVAQISFDSETAVKELSYNSLEDLNNKYLYIAVTVTESSGGFSEEAEIPGVKYVLSPYTLNLVA 362

  Fly   378 TDY----SSCFSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPE 438
            |..    ...||.|...:..|...:..|..:|:..|..|                       ..|
Mouse   363 TPLFVKPGIPFSIKAQVKDSLEQAVGGVPVTLMAQTVDV-----------------------NQE 404

  Fly   439 LPTIEKKTFVFESHLNASGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTTYPYREPKQI 503
            ...:|.|..:  :| :..|||.|.:.||....:..|               ::.|..| ..|:
Mouse   405 TSDLETKRSI--TH-DTDGVAVFVLNLPSNVTVLKF---------------EIRTDDP-ELPE-- 448

  Fly   504 ENPSSEEEK--------------EWFRAEVQRPKDVWNLKIGQEYQVILNSSRP----LKYFVYN 550
            ||.:|:|.:              .|  .|..:|     :.:|:...:::....|    :.::.|.
Mouse   449 ENQASKEYEAVAYSSLSQSYIYIAW--TENYKP-----MLVGEYLNIMVTPKSPYIDKITHYNYL 506

  Fly   551 IVGRGNILETKRVDLAEPQTTVNVTIKPTFLTTPYGRVYFYYV---DETGEFRYTEETFSVEVEL 612
            |:.:|.|::....:.....|..|:.|..|....|..|:..||:   ::|.|........::|.:.
Mouse   507 ILSKGKIVQYGTREKLFSSTYQNINIPVTQNMVPSARLLVYYIVTGEQTAELVADAVWINIEEKC 571

  Fly   613 QNQIEIK-APAE--VKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSN---------NDLNKESF 665
            .||:::. :|.|  ..||..|:|::.|...|:|.|.|||::|..:..|         ..|:::|
Mouse   572 GNQLQVHLSPDEYVYSPGQTVSLDMVTEADSWVALSAVDRAVYKVQGNAKRAMQRVFQALDEKS- 635

  Fly   666 NWRLNGYDTSTPWQGGYSYYPGERTGVVTMTNAYFFYNRTAPDYNILTEG--------------- 715
                   |......||:     :...|..:....|..|..|.|.:...:.
Mouse   636 -------DLGCGAGGGH-----DNADVFHLAGLTFLTNANADDSHYRDDSCKEILRSKRNLHLLR 688

  Fly   716 -------------------FGGSSFAMRKTTVAHDSHVFHSGAGGP----------TQAVGFSAE 751
                               :.|:.....:|.....:.|    ..||          |.|.....|
Mouse   689 QKIEEQAAKYKHSVPKKCCYDGARVNFYETCEERVARV----TIGPLCIRAFNECCTIANKIRKE 749

  Fly   752 SAS----------ASAAPV----VRKNFAETWIFADIESTEEEVFKWVK------TIPDTITNWV 796
            |..          .:..||    :|..|.|:|::        |:.:..|      |:||::|.|.
Mouse   750 SPHKPVQLGRIHIKTLLPVMKADIRSYFPESWLW--------EIHRVPKRKQLQVTLPDSLTTWE 806

  Fly   797 VTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDN 861
            :.|..: ...|:.|. |....|.|:..|:.:.:||||.|||.|.:...|:||:  |...:..:..
Mouse   807 IQGIGI-SDNGICVA-DTLKAKVFKEVFLEMNIPYSVVRGEQIQLKGTVYNYM--TSGTKFCVKM 867

  Fly   862 EDQEYDFVDASNEVIGDQKRTQNI---RVGANEAAGASFLIRPKVIGNILLKFKAISPLAGDAIH 923
            ...|......|:.......|....   |:..:.:...:|.:.|..||...:.|...:....|.:.
Mouse   868 SAVEGICTSGSSAASLHTSRPSRCVFQRIEGSSSHLVTFTLLPLEIGLHSINFSLETSFGKDILV 932

  Fly   924 KPLKVVPEGITQYQNRAFFINLKDTGEFKN---TFELEVPEDVVPDS--ER---VEFGLVGDLLG 980
            |.|:|||||:.:.......::.|......|   .|...:|.|:||.:  ||   |:..|||:.|.
Mouse   933 KTLRVVPEGVKRESYAGVILDPKGIRGIVNRRKEFPYRIPLDLVPKTKVERILSVKGLLVGEFLS 997

  Fly   981 PVV--KNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKK---LTPALDTRIKR-----NLQDG 1035
            .|:  :.:..|..||.|..|..:..:.|.:.|..||::...   ..|  ||..||     .::.|
Mouse   998 TVLSKEGINILTHLPKGSAEAELMSIAPVFYVFHYLEAGNHWNIFYP--DTLSKRQSLEKKIKQG 1060

  Fly  1036 YQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSFSKIKDIIDLDEQILAKGYEFLL 1100
            ...::.||:.|.|:|     .|:.    .:.||||||:.||...::...:..||..:.....:|:
Mouse  1061 VVSVMSYRNADYSYS-----MWKG----ASASTWLTAFALRVLGQVAKYVKQDENSICNSLLWLV 1116

  Fly  1101 TR-QAENGSFTEHGEYF---------YSSQRSLLTLTANSLLALLE--EEKPN---QAAIDKAVA 1150
            .: |.|||||.|:.:|.         ..:|...|.|||.|::.:.:  :..|.   ..|:|||.:
Mouse  1117 EKCQLENGSFKENSQYLPIKLQGTLPAEAQEKTLYLTAFSVIGIRKAVDICPTMKIHTALDKADS 1181

  Fly  1151 YLSANTAESIELLPKSIAIYALQKAKA--PEAAKQVASLKSLAKHEDD---RTWWTEDLDK---- 1206
            :|..||..|......:|..|||.....  |.....|::|:..|..:.|   ..:|.:.|.:
Mouse  1182 FLLENTLPSKSTFTLAIVAYALSLGDRTHPRFRLIVSALRKEAFVKGDPPIYRYWRDTLKRPDSS 1246

  Fly  1207 LRASKNCGRWWCWIWSQDVEITSYALL-SLLDSDQETADSVLNTVRWLIAQRNGFGGFASSQDTV 1270
            :.:|...|.         ||.|:|||| ||...|...|:.:   ::||..::...|||.|:|||:
Mouse  1247 VPSSGTAGM---------VETTAYALLASLKLKDMNYANPI---IKWLSEEQRYGGGFYSTQDTI 1299

  Fly  1271 VGLTALIKFAEKSGYEAAKWEVTVSNK-----GKREKTEK------LNTSEENDLLLQTVEFPQG 1324
            ..:..|.:::..........::.|:.|     .|.:.|||      :..|..:||::.|
Mouse  1300 NAIEGLTEYSLLLKQIHLDMDINVAYKHEGDFHKYKVTEKHFLGRPVEVSLNDDLVVST------ 1358

  Fly  1325 TKSLEFEAKGTGAAMVQISYQYNLVEK----EPKPSF--KIQTTVLPESSPANL------ELSVC 1377
                   ...:|.|.|   |...:|.|    |...||  ||.|..:..||...|      .:..|
Mouse  1359 -------GYSSGLATV---YVKTVVHKISVSEEFCSFYLKIDTQDIEASSHFRLSDSGFKRIIAC 1413

  Fly  1378 VDY--VEEGESKESNMAILEVSLPSGYTA-DEDSFADIRNIERVRLVETKNGDSVVVIYFENLAK 1439
            ..|  .:|..:..|:.|::::|||:|..| :||..|.:..:::: |.:.:..|..|::...::..
Mouse  1414 ASYKPSKEESTSGSSHAVMDISLPTGIGANEEDLRALVEGVDQL-LTDYQIKDGHVILQLNSIPS 1477

  Fly  1440 NEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKKATEYYSIK-SKLCDICEGDDC 1494
            .:..|:|...:....|....|::..:|:|:..:|:.|..|||. ::|..:|||..|
Mouse  1478 RDFLCVRFRIFELFQVGFLNPATFTVYEYHRPDKQCTMIYSISDTRLQKVCEGAAC 1533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081	22/92 (24%)
		A2M_N_2	528..653	CDD:285005	33/134 (25%)
		A2M	768..859	CDD:278630	27/96 (28%)
		A2M_2	982..1279	CDD:239227	90/331 (27%)
		A2M_comp	1035..1281	CDD:284982	75/270 (28%)
		A2M_recep	1389..1479	CDD:284981	21/90 (23%)
Hc	XP_017171158.1	MG1	27..124	CDD:375333	23/119 (19%)
		A2M_N	130..223	CDD:376626	26/115 (23%)
		MG3	225..309	CDD:375334	23/91 (25%)
		MG4	358..461	CDD:375332	27/146 (18%)
		A2M_N_2	474..614	CDD:377903	34/144 (24%)
		ANATO	690..758	CDD:237984	9/71 (13%)
		A2M	780..867	CDD:365945	27/98 (28%)
		complement_C3_C4_C5	1003..1308	CDD:239226	89/327 (27%)
		A2M_recep	1427..1517	CDD:369460	21/90 (23%)
		NTR_like	1535..1683	CDD:382999
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840002
Domainoid	1	1.000	49	1.000	Domainoid score	I11717
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.800