DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tep4 and A2ML1

DIOPT Version :9

Sequence 1:NP_001260590.1 Gene:Tep4 / 35248 FlyBaseID:FBgn0041180 Length:1498 Species:Drosophila melanogaster
Sequence 2:XP_011518868.1 Gene:A2ML1 / 144568 HGNCID:23336 Length:1467 Species:Homo sapiens


Alignment Length:1634 Identity:415/1634 - (25%)
Similarity:676/1634 - (41%) Gaps:371/1634 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 AVAVHQTKEPVTLKVGITGPSYNK--------------TETVE--------LATAGEFKQ----I 85
            |:|.......|||...:..||..|              |.|:|        |..:|..|:    |
Human    15 AIAEELPNYLVTLPARLNFPSVQKVCLDLSPGYSDVKFTVTLETKDKTQKLLEYSGLKKRHLHCI 79

  Fly    86 TFKLPPLEAGEYNLTAEGVKG----LEFKNSTKLNWENFKPYIKIQTDKGKYKPGDTINYRVIFL 146
            :|.:||...|...:....|.|    :.|:...|:..:.......:||||..|.||..:.:|::.:
Human    80 SFLVPPPAGGTEEVATIRVSGVGNNISFEEKKKVLIQRQGNGTFVQTDKPLYTPGQQVYFRIVTM 144

  Fly   147 DENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFATLGSWSLHVQNGDQHHD 211
            |.|..|...|..:|. .:|...|||.|...:....|:....|:|:..|.||::::.|..|     
Human   145 DSNFVPVNDKYSMVE-LQDPNSNRIAQWLEVVPEQGIVDLSFQLAPEAMLGTYTVAVAEG----- 203

  Fly   212 GGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQQVSVRDGEFNVVLKANYTYG 276
                    |.||             .|.||:|||||:.|::...:::|.....|.|.:...||||
Human   204 --------KTFG-------------TFSVEEYVLPKFKVEVVEPKELSTVQESFLVKICCRYTYG 247

  Fly   277 KPVNGKVLVNVHLDSTSSW-------------ENVDGKTVQTDYPGHSVVGTADMVGGKAKLTMD 328
            ||:.|.|.|:|...:.:.|             .|:.|   |||..| ......||.      |.|
Human   248 KPMLGAVQVSVCQKANTYWYREVEREQLPDKCRNLSG---QTDKTG-CFSAPVDMA------TFD 302

  Fly   329 LKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPYRYEMSCTDYSSCFSFKPDKEHE 393
            |..:|       .|....|.|||.|:.|||:.|.|..:.:.|....|:..|.|:  .:.|:....
Human   303 LIGYA-------YSHQINIVATVVEEGTGVEANATQNIYISPQMGSMTFEDTSN--FYHPNFPFS 358

  Fly   394 LNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFY--AFGTDHQEPELPTIEKKTFVFESHLNAS 456
            ...::...|.|.:                :|:..:  .:||:       ....:|.|.::    :
Human   359 GKIRVRGHDDSFL----------------KNHLVFLVIYGTN-------GTFNQTLVTDN----N 396

  Fly   457 GVAPF----------------KVVLPDL---PDIANFTRYYS---IELEFVDEKRDLY-TTYPYR 498
            |:|||                |..:.||   |:  ...|||.   :.|      |..| ||..:.
Human   397 GLAPFTLETSGWNGTDVSLEGKFQMEDLVYNPE--QVPRYYQNAYLHL------RPFYSTTRSFL 453

  Fly   499 EPKQIENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQVILNSSRPLKYFV--------------Y 549
            ...::..|                     ||.||..:|:::      |::              |
Human   454 GIHRLNGP---------------------LKCGQPQEVLVD------YYIDPADASPDQEISFSY 491

  Fly   550 NIVGRGNI-------LETKRVDLAEPQTTVNVTIKPTFLTTPYGRVYFYYVDETGEFRYTEETFS 607
            .::|:|::       |.:|:..|   :.:.::::..|....|...:..|.:..:|.....:..||
Human   492 YLIGKGSLVMEGQKHLNSKKKGL---KASFSLSLTFTSRLAPDPSLVIYAIFPSGGVVADKIQFS 553

  Fly   608 VEVELQNQIEI--------------KAPAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNN 658
            ||:...||.::              .:|::..|||:|.|:::.:|.|...|.|||:|||||..:.
Human   554 VEMCFDNQADLIPKLYLSLPQVSLGFSPSQQLPGAEVELQLQAAPGSLCALRAVDESVLLLRPDR 618

  Fly   659 DLNKES-----------FNWRLNGYD---TSTPW-----------QGGYS-----YYPGERTGVV 693
            :|:..|           :.:::..||   .|.||           ||..|     :.|....|  
Human   619 ELSNRSVYGMFPFWYGHYPYQVAEYDQCPVSGPWDFPQPLIDPMPQGHSSQRSIIWRPSFSEG-- 681

  Fly   694 TMTNAYFFY-------------------NRTAPDYNILTEGFGGSSFAMRKTTVAHDSHVFHSGA 739
              |:.:.|:                   :..:|:|:......||...|...:|..|         
Human   682 --TDLFSFFRDVGLKILSNAKIKKPVDCSHRSPEYSTAMGAGGGHPEAFESSTPLH--------- 735

  Fly   740 GGPTQAVGFSAESASASAAPVVRKNFAETWIFADI----ESTEEEVFKWVKTIPDTITNWVVTGF 800
                     .||.:.      ||:.|.|||:: |:    .|.:|.|.   .|:||.||.|....|
Human   736 ---------QAEDSQ------VRQYFPETWLW-DLFPIGNSGKEAVH---VTVPDAITEWKAMSF 781

  Fly   801 SLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDV--ELTLDNED 863
            .....:|.|: :....:..|:||||.:.|||||.|||...:.|.:||||...:.|  :|...:|.
Human   782 CTSQSRGFGL-SPTVGLTAFKPFFVDLTLPYSVVRGESFRLTATIFNYLKDCIRVQTDLAKSHEY 845

  Fly   864 QEYDFVDA--SNEVIGDQKRTQNIRVGANEAAGASFLIRPKVI-------GNILLKFKAISPLAG 919
            |...:.|:  |:.:..|..:|.:..:.|.:....:|.|..|::       |.     |...|..|
Human   846 QLESWADSQTSSCLCADDAKTHHWNITAVKLGHINFTISTKILDSNEPCGGQ-----KGFVPQKG 905

  Fly   920 --DAIHKPLKVVPEGITQYQNRAFFINLKDTGEF-KNTFELEVPEDVVPDSERVEFGLVGDLLGP 981
              |.:.||:.|.|||:...:..:..:..|  |:. ..:..||:|.|:||||.:....::||::|.
Human   906 RSDTLIKPVLVKPEGVLVEKTHSSLLCPK--GKVASESVSLELPVDIVPDSTKAYVTVLGDIMGT 968

  Fly   982 VVKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHMLHYRHDD 1046
            .::||:.|:::|||||||.|....|...|..||:....||..:.:|....|:.|||..|.|:|.:
Human   969 ALQNLDGLVQMPSGCGEQNMVLFAPIIYVLQYLEKAGLLTEEIRSRAVGFLEIGYQKELMYKHSN 1033

  Fly  1047 GSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSFSKIKDIIDLDEQILAKGYEFLLTRQAENGSFTE 1111
            ||:|:||     :.|  .||:|||||:|.:.|.:.:..|.:|.:.:....:::...|..:|.:..
Human  1034 GSYSAFG-----ERD--GNGNTWLTAFVTKCFGQAQKFIFIDPKNIQDALKWMAGNQLPSGCYAN 1091

  Fly  1112 HGEYFYSSQR----SLLTLTANSLLALLEEEKP-NQAAIDKAVAYLSANTAESIELLPKSIAIYA 1171
            .|...:::.:    ..::|||....||||..|. :...:.:.:..|..:...:..|..:::..|.
Human  1092 VGNLLHTAMKGGVDDEVSLTAYVTAALLEMGKDVDDPMVSQGLRCLKNSATSTTNLYTQALLAYI 1156

  Fly  1172 LQKAKAPEAAKQVASLKSLAKH---EDDRTWWTEDLDKLRASKNCGRWWCWIWSQ----DVEITS 1229
            .  :.|.|...:...||.|.:.   ..:..:|::   |...|.|...     ||:    |||:|:
Human  1157 F--SLAGEMDIRNILLKQLDQQAIISGESIYWSQ---KPTPSSNASP-----WSEPAAVDVELTA 1211

  Fly  1230 YALLSLLDSDQETADSV---LNTVRWLIAQRNGFGGFASSQDTVVGLTALIKFAEKSGYEAAKWE 1291
            ||||:.|.....|...:   .:.|.||..|.|.:|||:|:|||||.|.||.|:|..:...:.:..
Human  1212 YALLAQLTKPSLTQKEIAKATSIVAWLAKQHNAYGGFSSTQDTVVALQALAKYATTAYMPSEEIN 1276

  Fly  1292 VTVSNKGKREKTEKLNTSEENDLLLQTVEFPQGTKSLEFEAKGTGAAMVQISYQYNLVEKEPKPS 1356
            :.|.:....::|  .|....|.|:.|....|........||.|.|...||...:||::......:
Human  1277 LVVKSTENFQRT--FNIQSVNRLVFQQDTLPNVPGMYTLEASGQGCVYVQTVLRYNILPPTNMKT 1339

  Fly  1357 FKIQTTV-----LPESSPANLELSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSFADIRNIE 1416
            |.:...:     ...:||.:|.|::...||  |....|||||:||.:.||::..|.:...:....
Human  1340 FSLSVEIGKARCEQPTSPRSLTLTIHTSYV--GSRSSSNMAIVEVKMLSGFSPMEGTNQLLLQQP 1402

  Fly  1417 RVRLVETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKKATEYYSI 1481
            .|:.||.  |...:.||.:.|.||.: .......::..|.|.||:::.:||||..:::||..|| 
Human  1403 LVKKVEF--GTDTLNIYLDELIKNTQ-TYTFTISQSVLVTNLKPATIKVYDYYLPDEQATIQYS- 1463

  Fly  1482 KSKLCDICE 1490
                 |.||
Human  1464 -----DPCE 1467

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep4NP_001260590.1 A2M_N 126..219 CDD:280081 26/92 (28%)
A2M_N_2 528..653 CDD:285005 36/159 (23%)
A2M 768..859 CDD:278630 35/96 (36%)
A2M_2 982..1279 CDD:239227 94/311 (30%)
A2M_comp 1035..1281 CDD:284982 76/260 (29%)
A2M_recep 1389..1479 CDD:284981 29/89 (33%)
A2ML1XP_011518868.1 A2M_N 122..211 CDD:280081 30/115 (26%)
YfaS <123..>1055 CDD:225248 277/1089 (25%)
A2M_N_2 455..613 CDD:285005 37/187 (20%)
A2M 749..839 CDD:278630 34/94 (36%)
A2M_2 969..1264 CDD:239227 94/311 (30%)
A2M_comp 1021..1266 CDD:284982 76/261 (29%)
A2M_recep 1375..1462 CDD:284981 29/89 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149969
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100452
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X292
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.650

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