Protein Alignment Tep4 and CD109

DIOPT Version :10

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: NP_598000.2
• Gene: CD109 / 135228
• HGNCID: 21685
• Length: 1445
• Species: Homo sapiens
• Alignment Length: 1546
• Identity: 455/1546 - (29%)
• Similarity: 722/1546 - (46%)
• Gaps: 218/1546 - (14%)

  Fly    11 LCVILALLQTMEPVKAEG-KYTIVGPGTIHSHRDYNVAV-AVHQTKEPVTLKVGITGPSYNKTET 73
            |||..|.|..     |.| ::.:..||.|....:..:.| .:......||:|..:...:.|.|.:
Human    13 LCVCTAALAV-----APGPRFLVTAPGIIRPGGNVTIGVELLEHCPSQVTVKAELLKTASNLTVS 72

  Fly    74 VELATAGEFKQITFK---LPPL------EAGEYNLTAEGVKGLEFKNSTKLNWENFKPYIKIQTD 129
            | |...|.|::.:||   ||.|      |..|..:|......:.|.|||:|::|..:..:.||||
Human    73 V-LEAEGVFEKGSFKTLTLPSLPLNSADEIYELRVTGRTQDEILFSNSTRLSFETKRISVFIQTD 136

  Fly   130 KGKYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFA 194
            |..|||...:.:|::.|..:.:|  .|..:.:..:|.|.|.|:|....::..||.:..|:||...
Human   137 KALYKPKQEVKFRIVTLFSDFKP--YKTSLNILIKDPKSNLIQQWLSQQSDLGVISKTFQLSSHP 199

  Fly   195 TLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQQVS 259
            .||.||:.||..||     .|:                   .:|:|.:|||||:.|.:......|
Human   200 ILGDWSIQVQVNDQ-----TYY-------------------QSFQVSEYVLPKFEVTLQTPLYCS 240

  Fly   260 VRDGEFNVVLKANYTYGKPVNGKV-LVNVHLDSTSSWENVDGKTVQTDYPGHSVVGTADMVGGKA 323
            :.....|..:.|.|||||||.|.| |..:.|......:|:. ||.:.:...:......:|
Human   241 MNSKHLNGTITAKYTYGKPVKGDVTLTFLPLSFWGKKKNIT-KTFKINGSANFSFNDEEM----- 299

  Fly   324 KLTMDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPYRYEMSCTDYSSCFSFKP 388
            |..||..:..|.....:|....:|..||.|..||:..|.:..|....:.|.:...||::.  .||
Human   300 KNVMDSSNGLSEYLDLSSPGPVEILTTVTESVTGISRNVSTNVFFKQHDYIIEFFDYTTV--LKP 362

  Fly   389 DKEHELNFKITYVDGSLIT--DTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELPTIEKKTFVFES 451
            ........|:|..||:.:|  :.::.|....|:   |||..|..|::....::..::|..:.
Human   363 SLNFTATVKVTRADGNQLTLEERRNNVVITVTQ---RNYTEYWSGSNSGNQKMEAVQKINYT--- 421

  Fly   452 HLNASGVAPFKVVLPDLPDIANFTRYYSIELE----FVDEKRDLYTTYPYREPKQ--IENPSSEE 510
             :..||.  ||:..|.|.|        |.||:    |:..|..:.....::.|.:  |:..:.:|
Human   422 -VPQSGT--FKIEFPILED--------SSELQLKAYFLGSKSSMAVHSLFKSPSKTYIQLKTRDE 475

  Fly   511 EKEWFRAEVQRPKDVWNLKIGQEYQVILNSSRPLKYFVYNIVGRGNILETKRVDLAEPQTTVNVT 575
                            |:|:|..::::::.::.||...|.:|.||.::...:      |.:...:
Human   476 ----------------NIKVGSPFELVVSGNKRLKELSYMVVSRGQLVAVGK------QNSTMFS 518

  Fly   576 IKPTFLTTPYGRVYFYYVDETGEFRYTEETFSVEVELQNQIEI---KAPAEVKPGADVALEIK-T 636
            :.|....||...|..||:::.||.........|::..:|:|::   |..||  |...|:|.|. |
Human   519 LTPENSWTPKACVIVYYIEDDGEIISDVLKIPVQLVFKNKIKLYWSKVKAE--PSEKVSLRISVT 581

  Fly   637 SPKSFVGLLAVDQSVLLLGSNNDLNKESFNWRLNGYDTSTPWQGGYSYYPG---------ERTGV 692
            .|.|.||::|||:||.|:.::||:..|:....|..|:|        .||.|         :..|:
Human   582 QPDSIVGIVAVDKSVNLMNASNDITMENVVHELELYNT--------GYYLGMFMNSFAVFQECGL 638

  Fly   693 VTMTNAYFFYNRTAPDYNILTEG-FGGSSFAMR--KTTVAH--DSHVFHSGAGGPTQAVGFSAES 752
            ..:|:|    |.| .||   .:| :..:.:|.|  :....|  |.|.|
Human   639 WVLTDA----NLT-KDY---IDGVYDNAEYAERFMEENEGHIVDIHDF----------------- 678

  Fly   753 ASASAAPVVRKNFAETWIFADIESTEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNI 817
             |..::|.|||:|.||||:.|.........::..|:||:||:||.|||.:....|||:|.....:
Human   679 -SLGSSPHVRKHFPETWIWLDTNMGYRIYQEFEVTVPDSITSWVATGFVISEDLGLGLTTTPVEL 742

  Fly   818 KTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVDASNEV--IGDQK 880
            :.|||||:.:.|||||.|||...:...:||||....:|::.::..| ::|.:..|||:  .|.|
Human   743 QAFQPFFIFLNLPYSVIRGEEFALEITIFNYLKDATEVKVIIEKSD-KFDILMTSNEINATGHQ- 805

  Fly   881 RTQNIRVGANEAAGASFLIRPKVIGNILLKFKAISPLAGDAIHKPLKVVPEGITQYQNRAFFINL 945
              |.:.|.:.:.|...|.|||..:|.|.:...|:||.|.||:.:.:.|..|||.:..:::..::|
Human   806 --QTLLVPSEDGATVLFPIRPTHLGEIPITVTALSPTASDAVTQMILVKAEGIEKSYSQSILLDL 868

  Fly   946 KDT--GEFKNTFELEVPEDVVPDSERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSKLVPNY 1008
            .|.  .....|.....|.:.|..||||:...:||:|||.:..|.:|:|:|.|||||.|....||.
Human   869 TDNRLQSTLKTLSFSFPPNTVTGSERVQITAIGDVLGPSINGLASLIRMPYGCGEQNMINFAPNI 933

  Fly  1009 LVRDYLKSIKKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAY 1073
            .:.|||...|:||..|..:....::.|||..|.|:.:|||||:||     ..||  :|||||:|:
Human   934 YILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDGSFSAFG-----NYDP--SGSTWLSAF 991

  Fly  1074 VLRSFSKIKDIIDLDEQILAKGYEFLLTRQAENGSFTEHGEYFYS----SQRSLLTLTANSLLAL 1134
            |||.|.:....||:|:.:|.:.|.:|...|..||.|.:.|...:|    ..:|.:||||..:.:|
Human   992 VLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLTAYIVTSL 1056

  Fly  1135 LEEEK--PNQAAIDKAVAYLSANTAESI-ELLPKSIAIYALQKAKAPEAAKQVASLKSLAKHEDD 1196
            |...|  || ..:.:::.:|.:..:..| :....::..|||....:|:|.:.:..|...|:.|..
Human  1057 LGYRKYQPN-IDVQESIHFLESEFSRGISDNYTLALITYALSSVGSPKAKEALNMLTWRAEQEGG 1120

  Fly  1197 RTWWTEDLDKLRASKNCGRWWCWIW---SQDVEITSYALLSLLDSDQETADSVLNTVRWLIAQRN 1258
            ..:|.....||..|          |   |.|:|:.:|||||.....| |::.: ..:|||..|||
Human  1121 MQFWVSSESKLSDS----------WQPRSLDIEVAAYALLSHFLQFQ-TSEGI-PIMRWLSRQRN 1173

  Fly  1259 GFGGFASSQDTVVGLTALIKFAEKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQTVEFP- 1322
            ..|||||:|||.|.|.||.:||.....|....:|||:........ |......|.|||||.|..
Human  1174 SLGGFASTQDTTVALKALSEFAALMNTERTNIQVTVTGPSSPSPV-KFLIDTHNRLLLQTAELAV 1237

  Fly  1323 -QGTKSLEFEAKGTGAAMVQISYQYNLVEK---------EPKPSFKIQTTVLPESSPAN-LELSV 1376
             |.| ::...|.|.|.|:.|::..||:...         :.:.:|.:...|.......| ::|:|
Human  1238 VQPT-AVNISANGFGFAICQLNVVYNVKASGSSRRRRSIQNQEAFDLDVAVKENKDDLNHVDLNV 1301

  Fly  1377 CVDYVEEGESKESNMAILEVSLPSGYTADEDSFADIRNIERVRLVETKNGDSVVVIYFENLAKNE 1441
            |..:...|   .|.||::||:|.||:....::   |...|.|:.||..:|.  :.:|.:::  ||
Human  1302 CTSFSGPG---RSGMALMEVNLLSGFMVPSEA---ISLSETVKKVEYDHGK--LNLYLDSV--NE 1356

  Fly  1442 EK-CIRIEAYRTHAVANQKPSSVVLYDYYDTNKKATEYYSIKSKL--CDIC 1489
            .: |:.|.|.|...|:|.:.:||.:.|||:..::|...|:.:.||  ||:|
Human  1357 TQFCVNIPAVRNFKVSNTQDASVSIVDYYEPRRQAVRSYNSEVKLSSCDLC 1407

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	YfaS	<76..1411	CDD:441940	411/1396 (29%)
		A2M_2	982..1279	CDD:239227	108/306 (35%)
		A2M_recep	1387..1480	CDD:462226	29/93 (31%)
CD109	NP_598000.2	YfaS	<127..1249	CDD:441940	373/1256 (30%)
		Bait region (approximate). /evidence=ECO:0000250	593..702		38/142 (27%)
		A2M_2	907..1194	CDD:239227	108/306 (35%)
		A2M_recep	1309..1396	CDD:462226	30/96 (31%)