DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tep4 and CD109

DIOPT Version :9

Sequence 1:NP_001260590.1 Gene:Tep4 / 35248 FlyBaseID:FBgn0041180 Length:1498 Species:Drosophila melanogaster
Sequence 2:NP_598000.2 Gene:CD109 / 135228 HGNCID:21685 Length:1445 Species:Homo sapiens


Alignment Length:1546 Identity:455/1546 - (29%)
Similarity:722/1546 - (46%) Gaps:218/1546 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 LCVILALLQTMEPVKAEG-KYTIVGPGTIHSHRDYNVAV-AVHQTKEPVTLKVGITGPSYNKTET 73
            |||..|.|..     |.| ::.:..||.|....:..:.| .:......||:|..:...:.|.|.:
Human    13 LCVCTAALAV-----APGPRFLVTAPGIIRPGGNVTIGVELLEHCPSQVTVKAELLKTASNLTVS 72

  Fly    74 VELATAGEFKQITFK---LPPL------EAGEYNLTAEGVKGLEFKNSTKLNWENFKPYIKIQTD 129
            | |...|.|::.:||   ||.|      |..|..:|......:.|.|||:|::|..:..:.||||
Human    73 V-LEAEGVFEKGSFKTLTLPSLPLNSADEIYELRVTGRTQDEILFSNSTRLSFETKRISVFIQTD 136

  Fly   130 KGKYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFA 194
            |..|||...:.:|::.|..:.:|  .|..:.:..:|.|.|.|:|....::..||.:..|:||...
Human   137 KALYKPKQEVKFRIVTLFSDFKP--YKTSLNILIKDPKSNLIQQWLSQQSDLGVISKTFQLSSHP 199

  Fly   195 TLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQQVS 259
            .||.||:.||..||     .|:                   .:|:|.:|||||:.|.:......|
Human   200 ILGDWSIQVQVNDQ-----TYY-------------------QSFQVSEYVLPKFEVTLQTPLYCS 240

  Fly   260 VRDGEFNVVLKANYTYGKPVNGKV-LVNVHLDSTSSWENVDGKTVQTDYPGHSVVGTADMVGGKA 323
            :.....|..:.|.|||||||.|.| |..:.|......:|:. ||.:.:...:......:|     
Human   241 MNSKHLNGTITAKYTYGKPVKGDVTLTFLPLSFWGKKKNIT-KTFKINGSANFSFNDEEM----- 299

  Fly   324 KLTMDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPYRYEMSCTDYSSCFSFKP 388
            |..||..:..|.....:|....:|..||.|..||:..|.:..|....:.|.:...||::.  .||
Human   300 KNVMDSSNGLSEYLDLSSPGPVEILTTVTESVTGISRNVSTNVFFKQHDYIIEFFDYTTV--LKP 362

  Fly   389 DKEHELNFKITYVDGSLIT--DTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELPTIEKKTFVFES 451
            ........|:|..||:.:|  :.::.|....|:   |||..|..|::....::..::|..:.   
Human   363 SLNFTATVKVTRADGNQLTLEERRNNVVITVTQ---RNYTEYWSGSNSGNQKMEAVQKINYT--- 421

  Fly   452 HLNASGVAPFKVVLPDLPDIANFTRYYSIELE----FVDEKRDLYTTYPYREPKQ--IENPSSEE 510
             :..||.  ||:..|.|.|        |.||:    |:..|..:.....::.|.:  |:..:.:|
Human   422 -VPQSGT--FKIEFPILED--------SSELQLKAYFLGSKSSMAVHSLFKSPSKTYIQLKTRDE 475

  Fly   511 EKEWFRAEVQRPKDVWNLKIGQEYQVILNSSRPLKYFVYNIVGRGNILETKRVDLAEPQTTVNVT 575
                            |:|:|..::::::.::.||...|.:|.||.::...:      |.:...:
Human   476 ----------------NIKVGSPFELVVSGNKRLKELSYMVVSRGQLVAVGK------QNSTMFS 518

  Fly   576 IKPTFLTTPYGRVYFYYVDETGEFRYTEETFSVEVELQNQIEI---KAPAEVKPGADVALEIK-T 636
            :.|....||...|..||:::.||.........|::..:|:|::   |..||  |...|:|.|. |
Human   519 LTPENSWTPKACVIVYYIEDDGEIISDVLKIPVQLVFKNKIKLYWSKVKAE--PSEKVSLRISVT 581

  Fly   637 SPKSFVGLLAVDQSVLLLGSNNDLNKESFNWRLNGYDTSTPWQGGYSYYPG---------ERTGV 692
            .|.|.||::|||:||.|:.::||:..|:....|..|:|        .||.|         :..|:
Human   582 QPDSIVGIVAVDKSVNLMNASNDITMENVVHELELYNT--------GYYLGMFMNSFAVFQECGL 638

  Fly   693 VTMTNAYFFYNRTAPDYNILTEG-FGGSSFAMR--KTTVAH--DSHVFHSGAGGPTQAVGFSAES 752
            ..:|:|    |.| .||   .:| :..:.:|.|  :....|  |.|.|                 
Human   639 WVLTDA----NLT-KDY---IDGVYDNAEYAERFMEENEGHIVDIHDF----------------- 678

  Fly   753 ASASAAPVVRKNFAETWIFADIESTEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNI 817
             |..::|.|||:|.||||:.|.........::..|:||:||:||.|||.:....|||:|.....:
Human   679 -SLGSSPHVRKHFPETWIWLDTNMGYRIYQEFEVTVPDSITSWVATGFVISEDLGLGLTTTPVEL 742

  Fly   818 KTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVDASNEV--IGDQK 880
            :.|||||:.:.|||||.|||...:...:||||....:|::.::..| ::|.:..|||:  .|.| 
Human   743 QAFQPFFIFLNLPYSVIRGEEFALEITIFNYLKDATEVKVIIEKSD-KFDILMTSNEINATGHQ- 805

  Fly   881 RTQNIRVGANEAAGASFLIRPKVIGNILLKFKAISPLAGDAIHKPLKVVPEGITQYQNRAFFINL 945
              |.:.|.:.:.|...|.|||..:|.|.:...|:||.|.||:.:.:.|..|||.:..:::..::|
Human   806 --QTLLVPSEDGATVLFPIRPTHLGEIPITVTALSPTASDAVTQMILVKAEGIEKSYSQSILLDL 868

  Fly   946 KDT--GEFKNTFELEVPEDVVPDSERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSKLVPNY 1008
            .|.  .....|.....|.:.|..||||:...:||:|||.:..|.:|:|:|.|||||.|....||.
Human   869 TDNRLQSTLKTLSFSFPPNTVTGSERVQITAIGDVLGPSINGLASLIRMPYGCGEQNMINFAPNI 933

  Fly  1009 LVRDYLKSIKKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAY 1073
            .:.|||...|:||..|..:....::.|||..|.|:.:|||||:||     ..||  :|||||:|:
Human   934 YILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDGSFSAFG-----NYDP--SGSTWLSAF 991

  Fly  1074 VLRSFSKIKDIIDLDEQILAKGYEFLLTRQAENGSFTEHGEYFYS----SQRSLLTLTANSLLAL 1134
            |||.|.:....||:|:.:|.:.|.:|...|..||.|.:.|...:|    ..:|.:||||..:.:|
Human   992 VLRCFLEADPYIDIDQNVLHRTYTWLKGHQKSNGEFWDPGRVIHSELQGGNKSPVTLTAYIVTSL 1056

  Fly  1135 LEEEK--PNQAAIDKAVAYLSANTAESI-ELLPKSIAIYALQKAKAPEAAKQVASLKSLAKHEDD 1196
            |...|  || ..:.:::.:|.:..:..| :....::..|||....:|:|.:.:..|...|:.|..
Human  1057 LGYRKYQPN-IDVQESIHFLESEFSRGISDNYTLALITYALSSVGSPKAKEALNMLTWRAEQEGG 1120

  Fly  1197 RTWWTEDLDKLRASKNCGRWWCWIW---SQDVEITSYALLSLLDSDQETADSVLNTVRWLIAQRN 1258
            ..:|.....||..|          |   |.|:|:.:|||||.....| |::.: ..:|||..|||
Human  1121 MQFWVSSESKLSDS----------WQPRSLDIEVAAYALLSHFLQFQ-TSEGI-PIMRWLSRQRN 1173

  Fly  1259 GFGGFASSQDTVVGLTALIKFAEKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQTVEFP- 1322
            ..|||||:|||.|.|.||.:||.....|....:|||:........ |......|.|||||.|.. 
Human  1174 SLGGFASTQDTTVALKALSEFAALMNTERTNIQVTVTGPSSPSPV-KFLIDTHNRLLLQTAELAV 1237

  Fly  1323 -QGTKSLEFEAKGTGAAMVQISYQYNLVEK---------EPKPSFKIQTTVLPESSPAN-LELSV 1376
             |.| ::...|.|.|.|:.|::..||:...         :.:.:|.:...|.......| ::|:|
Human  1238 VQPT-AVNISANGFGFAICQLNVVYNVKASGSSRRRRSIQNQEAFDLDVAVKENKDDLNHVDLNV 1301

  Fly  1377 CVDYVEEGESKESNMAILEVSLPSGYTADEDSFADIRNIERVRLVETKNGDSVVVIYFENLAKNE 1441
            |..:...|   .|.||::||:|.||:....::   |...|.|:.||..:|.  :.:|.:::  ||
Human  1302 CTSFSGPG---RSGMALMEVNLLSGFMVPSEA---ISLSETVKKVEYDHGK--LNLYLDSV--NE 1356

  Fly  1442 EK-CIRIEAYRTHAVANQKPSSVVLYDYYDTNKKATEYYSIKSKL--CDIC 1489
            .: |:.|.|.|...|:|.:.:||.:.|||:..::|...|:.:.||  ||:|
Human  1357 TQFCVNIPAVRNFKVSNTQDASVSIVDYYEPRRQAVRSYNSEVKLSSCDLC 1407

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep4NP_001260590.1 A2M_N 126..219 CDD:280081 31/92 (34%)
A2M_N_2 528..653 CDD:285005 37/128 (29%)
A2M 768..859 CDD:278630 36/90 (40%)
A2M_2 982..1279 CDD:239227 108/306 (35%)
A2M_comp 1035..1281 CDD:284982 90/255 (35%)
A2M_recep 1389..1479 CDD:284981 29/90 (32%)
CD109NP_598000.2 YfaS <66..>1000 CDD:225248 311/1054 (30%)
A2M_N 130..221 CDD:280081 32/116 (28%)
A2M_N_2 470..596 CDD:285005 37/149 (25%)
Bait region (approximate). /evidence=ECO:0000250 593..702 38/142 (27%)
A2M 693..782 CDD:278630 36/88 (41%)
A2M_2 907..1194 CDD:239227 108/306 (35%)
A2M_comp 959..1196 CDD:284982 90/256 (35%)
A2M_recep 1311..1395 CDD:284981 29/90 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165149961
Domainoid 1 1.000 84 1.000 Domainoid score I8230
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 613 1.000 Inparanoid score I912
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45959
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 1 1.000 - - FOG0002157
OrthoInspector 1 1.000 - - otm40305
orthoMCL 1 0.900 - - OOG6_100452
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1211.810

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