Protein Alignment Tep4 and TEP4

DIOPT Version :9

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: XP_318493.4
• Gene: TEP4 / 1278910
• VectorBaseID: AGAP010812
• Length: 1335
• Species: Anopheles gambiae
• Alignment Length: 1555
• Identity: 391/1555 - (25%)
• Similarity: 664/1555 - (42%)
• Gaps: 301/1555 - (19%)

  Fly    12 CVILALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVAVHQ--TKEPVTLKVGITGPSYNKTETV 74
            |.:.::.:.:..|     ..||||..|.:.::|.|.::..:  |.|. .|.:.:.|.|....:.:
Mosquito     3 CNLSSIAENLHKV-----ILIVGPKHIRAGQNYTVILSSFESNTNER-NLLLQLDGLSAGGKKLL 61

  Fly    75 ELATAGEFKQ-----ITFKLP-PLEAGEYNLTAEGVKGLEFKNSTKLNWENFKPYIKIQTDKGKY 133
            .|......:.     |:|.|| .|.||.|.||.:|..|.:|.....|..........:|..|..|
Mosquito    62 HLGQPTRVQPLSNSVISFPLPESLPAGSYKLTIDGQNGFKFHREADLLLAASTTTALVQLSKPIY 126

  Fly   134 KPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFATLGS 198
            ||||.:.:|||.|..:|:|........|...|.:||.|::...:....||:..:.::.....||.
Mosquito   127 KPGDVLQFRVIVLGGDLKPPAPSVTATVIVHDPQRNVIRRWTAVSLQLGVFEEQLQIGTVPLLGR 191

  Fly   199 WSLHVQ-NGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVN--FEVEKYVLPKYSVKMDATQQVSV 260
            :::.|. .|                         ::|:|:  |:|.:||||.:.|.:.|......
Mosquito   192 YTITVTVTG-------------------------ANEIVSKTFDVREYVLPAFEVAVKARAVPLE 231

  Fly   261 RDGEFNVVLKANYTYGKPVNGKVLVNVHLDSTSSWENVDGKTVQTDYPGHSVVGTADMVGGKAKL 325
            :....|:.|.|.|..|:||.|...|.::|:.    :.:|.:.|               ||....:
Mosquito   232 KHQRLNLTLSARYYTGQPVRGVATVELYLED----DKLDQRRV---------------VGVYGAI 277

  Fly   326 TMDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLY--PYRYEMSCTDYSSCFSFKP 388
            .:|| .|..:|.....|...::.....:|.|...:.:...:.:|  |||.|:    ......|:.
Mosquito   278 QLDL-PFNEHLSVYDDSQDVRVHVAFTQDETNRTIYKEQRITVYKLPYRVEL----VKEQPEFRA 337

  Fly   389 DKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELPTIEKKTFVFESHL 453
            ....:...::.|.||   |..|........||        |:.||           :...:.|
Mosquito   338 KVPFDCQLRVRYQDG---TPAKGAAFEVKVEG--------AYTTD-----------RRVAYTS-- 378

  Fly   454 NASGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTTYPYREPKQIE-----NPSSEEEKE 513
            :|:||  .|:.|.  |:.::         |.:|....::....:.|...::     |..|...|.
Mosquito   379 DAAGV--IKLTLQ--PEASS---------ESIDITVRVFAREVFLEKSTLKRTGGMNFVSRTGKR 430

  Fly   514 WFR-AEVQRPKDVWNLKIGQEYQVILNSSRPLKYFVYNIVGRGNI-----LETKRV--------- 563
            |.| |.::..|..  :|||:.:::.:..:..|.:|:|.:|.||.|     |:.|:|
Mosquito   431 WQRGAALRAHKQA--VKIGKPFKLKVTCNEELSFFMYYVVSRGVIVDSAFLQPKKVTEHFIEIEA 493

  Fly   564 -DLAEPQTTVNVTIKPTFLTTPYGRVYFYYVDETGEFRYTEETFSVEVELQNQIEIKAPAEVKPG 627
             |...|::.|.|      :|.....|...:||.  :|......|.::::         ..|::||
Mosquito   494 SDQMVPRSKVIV------VTVAKNVVLCDFVDI--DFEDLRNNFDLQID---------RTEIRPG 541

  Fly   628 ADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKESFNWRLNGYDTSTPWQGGYSYYPGERT-- 690
            ..:.|.::..|.:||.|.|.|:|:|...:|:|:..|..            |.....:|..||.
Mosquito   542 DQLQLNMRGPPGAFVALAAYDKSLLQYSNNHDIFWEDV------------WGVFDKFYSVERNEF 594

  Fly   691 ------GVVTMTNAYFFYNR----TAPDYNILTEGFGGSSFAMRKTTVAHDSHVFHSGAGGPTQA 745
                  |:...|..:..:::    ||.|         |||                |...||:
Mosquito   595 DLFHSLGLFARTMEHITFDKANDQTARD---------GSS----------------SSKNGPS-- 632

  Fly   746 VGFSAESASASAAPVVRKNFAETWIFA--DIESTEEEVFKWVKTIPDTITNWVVTGFSLHPQKGL 808
                  ::.||    .|.||.|:|::.  .|.|:.....|  :::|||||.|.:||||:.|..||
Mosquito   633 ------NSQAS----FRTNFLESWLWKTDKIGSSGSATTK--ESVPDTITAWHLTGFSIDPVYGL 685

  Fly   809 GVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVDASN 873
            |:......:.|.|||::...:|||:||||::.:..:|||..||.....:||.:.|.:.:||   .
Mosquito   686 GIIKQPLQLTTVQPFYIVPNMPYSIKRGELVELQFIVFNNFPKKYKASVTLFSVDNQTEFV---G 747

  Fly   874 EVIGDQKRTQNIRVGANEAAGASFLIRPKVIGNILLKFKAISPLAGDAIHKPLKVVPEGITQ--- 935
            ....:...|::|....:.....:|||:.:.:|.:.::..|....|.|:|...::|:||.:.:
Mosquito   748 RPATETSYTKSIEASPDTGVPVAFLIKARKLGEMTVRVDASIEPAKDSIESVIRVIPESLVKREM 812

  Fly   936 ---------YQNRAFFINL-----KDTGEFKNTFELEVPEDVVPDSERVEFGLVGDLLGPVVKNL 986
                     |||::|.:.|     .|.|                 :.:::|.|..::|..|:.||
Mosquito   813 ISRFFCHNTYQNQSFVLGLDFDRKADAG-----------------TRKIDFILTPNILTSVMDNL 860

  Fly   987 ENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSS 1051
            |:||.:|:|||||.|.:|||..||.|||.||......|..:....|:.|||:.:.||..||||.
Mosquito   861 ESLLSVPTGCGEQNMMRLVPIVLVLDYLTSIGSADKQLTAKAIGLLRAGYQNQMRYRQPDGSFG- 924

  Fly  1052 FGPTKWRQEDPVRNGSTWLTAYVLRSF-SKIKDIIDLDEQILAKGYEFLLTRQAENGSFTEHGEY 1115
                .|.:.    .|:.:|||:|.::. :..|.|.:::..::.:.:::|..||...|.|.|.|..
Mosquito   925 ----LWEKS----GGAVFLTAFVGKTLATAAKYISEIEPSMVEQAFDWLAARQHSTGRFDEVGPV 981

  Fly  1116 FYSSQ----RSLLTLTANSLLALLEEEK---PNQAAIDKAVAYLSANTAESIELLPKSIAIYA-- 1171
            |:...    |..:.||:..|:||||:.|   .::|||:|.:.|::.......:....:||.||
Mosquito   982 FHRDMQGGLRQGIALTSFVLIALLEQPKVATKHRAAIEKGIDYVTQTLGSIEDSYDLAIATYALL 1046

  Fly  1172 LQKAKAPEA-AKQVASLKSLAKHEDDRTWWTEDLDKLRASKNCGRWWCWIWSQDVEITSYALLSL 1235
            |||..:.|. .:::..|.::.::..:| :|..|                  :..:|.|:|.|||.
Mosquito  1047 LQKHSSGERFLEKLIGLSTVQQNGTER-FWARD------------------AHGIETTAYGLLSF 1092

  Fly  1236 LDSDQETADSVLNTVRWLIAQRNGFGGFASSQDTVVGLTALIKFAEKSGYEAAKWEVTVSNKGKR 1300
            :.:::....:  :.:|||:.||...|.|..:|||.|||.||.|.|||.......:.|.:.:.|:
Mosquito  1093 VLAEKYVDGT--SIMRWLVKQRYTPGSFPRTQDTFVGLKALTKLAEKISPSRNDYSVQLRHAGR- 1154

  Fly  1301 EKTEKLNTSEENDLLLQTVEFPQGTKSLEFEAKGTGAAMVQISYQYNLVEKEPKPSFKIQTTVLP 1365
             |.|...||::...|....:....|..||....|.|..::|:.|:|.:..:.....|.::.....
Mosquito  1155 -KKEFRVTSQDIGTLQNAQQGVDETAQLELHVAGIGFGLLQVVYEYGVDLRNFTAQFVLELQKSV 1218

  Fly  1366 ESSPANLELSVCVDYVEEGESKESNMAILEVSLPSGYTADE--DSFADIRNIERVRLVETKNGDS 1428
            .::...|:|.||..:..:.....|||.::||:.|||||.::  ...........::..|.:.|.:
Mosquito  1219 TNANHQLQLEVCSSFTPQLSDGRSNMVLVEVNFPSGYTVEQRGQPITGATKHNPIQKTEVRFGAT 1283

  Fly  1429 VVVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKKATEYYSIKSKLCDI 1488
            .||:|:.::.. |..|..|.|||...|..::|:.|:::||||.....        |||.|
Mosquito  1284 SVVVYYNSMGP-ERNCFTITAYRRQKVTLKRPAYVLVHDYYDPTSVV--------KLCKI 1334

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081	24/93 (26%)
		A2M_N_2	528..653	CDD:285005	34/139 (24%)
		A2M	768..859	CDD:278630	34/92 (37%)
		A2M_2	982..1279	CDD:239227	97/307 (32%)
		A2M_comp	1035..1281	CDD:284982	73/256 (29%)
		A2M_recep	1389..1479	CDD:284981	28/91 (31%)
TEP4	XP_318493.4	A2M_N	117..211	CDD:280081	27/118 (23%)
		A2M_N_2	441..567	CDD:285005	35/144 (24%)
		A2M	645..736	CDD:278630	34/92 (37%)
		A2M_2	856..1134	CDD:239227	97/307 (32%)
		A2M_comp	909..1133	CDD:284982	72/253 (28%)
		A2M_recep	1242..1325	CDD:284981	27/83 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	51	1.000	Domainoid score	I18731
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.880