Protein Alignment Tep4 and LOC1275865

DIOPT Version :10

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: XP_315149.6
• Gene: LOC1275865 / 1275865
• VectorBaseID: AGAMI1_014347
• Length: 1338
• Species: Anopheles gambiae
• Alignment Length: 1550
• Identity: 378/1550 - (24%)
• Similarity: 658/1550 - (42%)
• Gaps: 298/1550 - (19%)

  Fly     9 VSLCVILALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVA-VHQTKEPVTLKVGITGPSYNKTE 72
            |.:.::::||.:...|      .:|||..:.|:::|.:.:: .:.....|.|.:.:.|.|.|:|.
Mosquito    12 VRMLLVISLLGSSWGV------LVVGPKFVRSNQEYALVISNFNSGSSKVNLMLHMEGFSKNQTS 70

  Fly    73 TVELATAGEFKQ-----ITFKLPPLEAG-EYNLTAEGVKGLEFKNSTKLNWENFKPYIKIQTDKG 131
            ...:....:.::     ::|.:|.:.:. :..||..|.:|..|.....|...:......||.||.
Mosquito    71 VFAIRKPVDVRRFMSRIVSFDIPNIASPVDIKLTMVGQRGFSFHEEEHLVHRSKSISGLIQIDKP 135

  Fly   132 KYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFATL 196
            .::|||.:.:|.|.||..|:|......|.|..:|..:|:|:.....|...||:....:|:....|
Mosquito   136 VFRPGDLVKFRAIVLDTELKPPARIKSVNVTIQDPHQNKIRGWPVAKLYAGVFENDLQLAPAPLL 200

  Fly   197 GSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELV--NFEVEKYVLPKYSVKMDATQQVS 259
            |.|::.||.|:                         ::||  .|||::|||..|.|::..:....
Mosquito   201 GVWNITVQVGE-------------------------EQLVFKTFEVKEYVLTSYDVQVMPSVIPL 240

  Fly   260 VRDGEFNVVLKANYTYGKPVNGKVLVNVHLDSTSSWENVDGKTVQTDYPGHSVVGTADMVGGKAK 324
            |.....|:.:.|||.:||||.|...|.::|        ||                 |.:..|.:
Mosquito   241 VEHQTLNLTIVANYHFGKPVQGVAKVELYL--------VD-----------------DTLDQKKE 280

  Fly   325 LTM------DLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPYRYEMSCTDYSSC 383
            |||      :|: |...|.........::..|..|..|...:.:...:.:|.:.|....|..|.
Mosquito   281 LTMYGMGQVELR-FNELLELYEDQQDVRVKLTFTEQHTNRTVVKEQAITVYKHPYRAQLTKESP- 343

  Fly   384 FSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELPTIEKKTFV 448
             .|:|....:....:.|.||
Mosquito   344 -QFRPGTPFKCTLTLIYHDG--------------------------------------------- 362

  Fly   449 FESHLNASGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTT----------YPYREPKQI 503
                 ..:|..||               :.::|.|.||.:: .|||          .|....:.|
Mosquito   363 -----RPAGHVPF---------------FVNVEGEDVDHQQ-TYTTGRDGTIKLLMRPTELTETI 406

  Fly   504 ENPSSEEEKE----------------WFRAEVQRPKDVWNLKIGQEYQVILNSSRPLKYFVYNIV 552
            :...||:..|                :.:.|::.|     :|:|:..::::..:..:.:|:|.::
Mosquito   407 DITVSEDNSEFTYTERIEKVHADTNVFLKLELKSP-----IKLGKLIRLMVTCNERMTFFIYYVI 466

  Fly   553 GRGNILETKRVDLAEP--QTTVNVTIKPTFLTTPYGRVYFYYVDETGEFRYTEETFSVEVELQ-- 613
            .:|||::   .....|  ||.....:..:....|...::...|.:.     .....|:|::|:
Mosquito   467 SKGNIVD---AGFVRPNRQTKFMFQLTASEKMIPKAHIFVATVSQD-----VVVWDSLEIDLKQF 523

  Fly   614 -NQIEIKA-PAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKESFNWRLNGYDTST 676
             |.::|.. ..|:|||.::.|.:|..|.::|||.|.|:.:|.....:||..|..   :..:||..
Mosquito   524 SNHLDIIIDEKELKPGQEIELLLKGRPSAYVGLAAYDKGLLAYSKQHDLFWEDV---MQVFDTFH 585

  Fly   677 PWQGGYSYYPGERTGVVTMTNAYFFYNRTAPDYNILTEGFGGSSFAMRKTTVAHDSHVFHSGAGG 741
                            .|..|.:..:|    ...:.....||:......||
Mosquito   586 ----------------ATDQNEFDVFN----SMGLFARLSGGNRIGAIPTT-------------- 616

  Fly   742 PTQAVGFSAESASASAAPVVRKNFAETWIFADI------ESTEEEVFKWVKTIPDTITNWVVTGF 800
             |:..| ||.|...|.....|.||.|:|::.::      ..|..||      :|||.|:|.:|||
Mosquito   617 -TERFG-SAASRPISRLVAYRTNFLESWLWQNVSIGRTGSRTVHEV------LPDTTTSWYLTGF 673

  Fly   801 SLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQE 865
            |:.|..|||:........|.|||::...||||:||||...:...:||.|......::||.|...:
Mosquito   674 SIDPVYGLGIIKKPIQFTTVQPFYIVDSLPYSIKRGEAAVLQFTLFNNLGAEYIADVTLYNVANQ 738

  Fly   866 YDFVDASNEVIGDQKRTQNIRVGANEAAGASFLIRPKVIGNILLKFKAISPLAG---DAIHKPLK 927
            .:|::..::   |...|:::.|........||.::.:.:|.::::.|| |.:.|   ||:.|.::
Mosquito   739 TEFIERPDK---DLSYTKSVSVPPKVGVPISFGVKARKLGEMVVRIKA-SIMTGKETDAMEKVIR 799

  Fly   928 VVPEGITQYQNRAFFINLKDTGEFKNTFELEVPEDVVPDSERVEFGLVGDLLGPVVKNLENLLRL 992
            |:||.|...:....|.::::.|:.:.|..|::|:::  .:.::|..:..:||.||:.||::||.:
Mosquito   800 VMPENIMFEKTETRFFSMEEYGKQELTISLDIPKNI--STVQIECRISSNLLSPVIHNLDSLLDV 862

  Fly   993 PSGCGEQTMSKLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKW 1057
            ||..|..:|...:|..:|.||||::...|..|..:....|::|||..|.||..||||.:     |
Mosquito   863 PSASGAPSMINFIPPLVVLDYLKAVSSTTTHLIEKATGLLRNGYQLELKYRQRDGSFGN-----W 922

  Fly  1058 RQEDPVRNGSTWLTAYVLRSF-SKIKDIIDLDEQILAKGYEFLLTRQAENGSFTEHGEYFYSS-- 1119
            |..    .||.::||.|..|. :..|.|.::|..::.:.:|:|..:|..:|.|.|.....|.|
Mosquito   923 RDS----KGSVFVTALVGTSLEAASKHITEVDLTLVDRLFEWLAAKQHSSGRFDEEQPITYHSLQ 983

  Fly  1120 --QRSLLTLTANSLLALLEEEK---PNQAAIDKAVAYLSANTAESI-ELLPKSIAIYALQKAKAP 1178
              .|:.:.||:..|:|.|:..|   .:::.|:|.:.|: ||..||| ::...|:|.|||..|...
Mosquito   984 GGSRNGIALTSFVLIAFLQNTKASAQHRSIIEKGIQYV-ANQLESIADVYDLSLATYALMLADHR 1047

  Fly  1179 EAAKQVASLKSLAKHEDDRTWWTEDLDKLRASKNCGRWWCWIWSQDVEITSYALLSLLDSDQETA 1243
            :.:..:..|..|....::..:|...                  :..:|.|:||||||:.: :..|
Mosquito  1048 QKSSALNKLIELGIATNETRYWPRH------------------TASIETTAYALLSLVHA-KRYA 1093

  Fly  1244 DSVLNTVRWLIAQRNGFGGFASSQDTVVGLTALIKFAE-----KSGYEAAKWEVTVSNKGKREKT 1303
            |.:: .:.||:.|::..|.|..:|||.||:.||...:|     |:.|.|      :...||..|.
Mosquito  1094 DGLM-VMHWLVNQQSATGSFPRTQDTFVGIRALAALSEAIAPQKNDYTA------IVLHGKARKV 1151

  Fly  1304 EKLNTSEENDLLLQTVEFPQGTKSLEFEAKGTGAAMVQISYQYNLVEKEPKPSFKIQTTVLPESS 1368
            .|:..||.:.....  |.|..:|.:.|.|.|.|..|..:::||.:..:..:..|.::......:.
Mosquito  1152 YKVAASEADQEYRD--ELPGDSKLVRFSANGRGFGMFTVAFQYGIDVRNIEHGFSLRLVDQFSNE 1214

  Fly  1369 PANLELSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSFADIRNIERVRLVETKNGDSVVVIY 1433
            ...|:|.||..:..:.....||:|::||:.||||.....|..|.......:.||.:.|.:.:|||
Mosquito  1215 AYTLQLQVCTSFSPQLMHTRSNLALVEVNFPSGYVVSRKSLVDETRRNPFKDVEVRYGQTSLVIY 1279

  Fly  1434 FENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKKATEYYSIKSKLCDI 1488
            :|.|.. ||.|..:.|.|...||..:.:.|:::|.||...:|.::|.:.....||
Mosquito  1280 YETLGP-EENCFSVTANRLFRVAFHRQAYVMVHDTYDEKFRAIKFYQVPHDGADI 1333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	YfaS	<76..1411	CDD:441940	339/1403 (24%)
		A2M_2	982..1279	CDD:239227	93/305 (30%)
		A2M_recep	1387..1480	CDD:462226	31/92 (34%)
LOC1275865	XP_315149.6	None