Protein Alignment Tep4 and TEP10

DIOPT Version :9

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: XP_309892.2
• Gene: TEP10 / 1271144
• VectorBaseID: AGAP010819
• Length: 1311
• Species: Anopheles gambiae
• Alignment Length: 1523
• Identity: 385/1523 - (25%)
• Similarity: 663/1523 - (43%)
• Gaps: 295/1523 - (19%)

  Fly    33 VGPGTIHSHRDYNVAVA-VHQTKEPVTLKVGITG------PSYNKTETVELATAGEFKQITFKLP 90
            |||..|..:::|.:.:: .:.....:.|.|.:.|      ...|.|..::: .....:.|:|.:|
Mosquito    25 VGPKYIRDNQNYTLTISNFYSNPSKMDLMVTLEGQIDNGLSVLNVTRMIDV-QRNSIRMISFSIP 88

  Fly    91 P-LEAGEYNLTAEGVKGLEFKNSTKLNWENFKPYIK------IQTDKGKYKPGDTINYRVIFLDE 148
            . |.:|.|.:|.:|.:|..|...|:|      .|:|      ||.||..:.|||.:|:|||.||.
Mosquito    89 DNLSSGNYKITIDGRQGFNFHMETEL------LYLKKSVAGLIQIDKPIFNPGDKVNFRVIVLDT 147

  Fly   149 NLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFATLGSWSLHVQNGDQHHDGG 213
            .|:|......|.|...|.:||.|::....|...||:.|..:::.....|.|::.||
Mosquito   148 ELKPPARVKSVHVTIRDPQRNVIRKWSTAKLYAGVFEGDLQIAPTPMFGVWNILVQ--------- 203

  Fly   214 IYFGGRKQFGGFGHRWHRSDELVN--FEVEKYVLPKYSVKMDATQQVSVRDGEFNVVLKANYTYG 276
                            ...:|||:  |||::|||..::|::..:..........|:.::||..:|
Mosquito   204 ----------------VEGEELVSKTFEVKEYVLSTFAVQVMPSVIPLEEHQALNLTIEANDYFG 252

  Fly   277 KPVNGKVLVNVHLDSTSSWENVDGKTVQTDYPGHSVVGTADMVGGKAKLTMDLKDFASYLPHKTS 341
            |||.|...|.::||.    :.:|.|...|.|      ||     |:.:| :....|..|:..:.
Mosquito   253 KPVQGVAKVELYLDD----DMIDQKKELTVY------GT-----GQVEL-LFFDKFEMYVDQQD- 300

  Fly   342 SSYAQITATVEEDFTGVKLNETGGVQLYPYRYEMSCTDYSSCFSFKPDKEHELNFKITYVDGSLI 406
               .::..|..|.:|...:.:...:.:|.:.|.:.....:.  .|.|....:...:.|:.||:..
Mosquito   301 ---VRVKVTFIEHYTNRTVVKQSQITVYKHAYRVQLIKGNP--HFHPGLPFKCVLQFTHHDGTPA 360

  Fly   407 TDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELPTIEKKTFVFESHLNASGVAPFKVVLPDLPDI 471
            |.....|:   ..||       .|||.                   :.:......|:.|.....|
Mosquito   361 TGITGKVE---VSGI-------GFGTT-------------------VTSDNDGLVKLELQPSEGI 396

  Fly   472 ANFTRYYSIELEFVDEKRDLYTTYPYREPKQIENPSSEEE---KEWFRAEVQRPKDVWNLKIGQE 533
            .      ||::.|::.:..|.          .|....:||   ..:.:.|::...:::.|
Mosquito   397 E------SIDVSFLNNQNGLI----------FEETMYKEESYTNAYIKLELKSSINLYKL----- 440

  Fly   534 YQVILNSSRPLKYFVYNIVGRGNILETKRVDLAEPQT---TVNVTIK-----PTFLTTPYGRVYF 590
            .:.::..:....:|||.:|.:|||::...:.|.:..|   .:|.|.|     ...:.|..||...
Mosquito   441 MRFMVTCTERTTFFVYYVVSKGNIIDADFIRLNKEMTYHLQLNATEKMIPKAKILIATVVGRTVV 505

  Fly   591 YYVDETGEFRYTEETFSVEVELQNQIEIKAPAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLLG 655
            |...:. :|:.....|.:.|:.|         |:|||..:.|.:...|.::|||.|.|:::||..
Mosquito   506 YDCMDL-DFQEFRNNFDLSVDEQ---------EIKPGRQIELSMSGRPGAYVGLAAYDKALLLFN 560

  Fly   656 SNNDLNKESFNWRLNGYDTSTPWQGGYSYYPGERTGVVTMTNAYFFYNRTAPDYNILTEGFGGSS 720
            .|:||..|.|   |..:|      |.:||    |.....:.::...:.:|..|  ||.|
Mosquito   561 QNHDLFWEDF---LKVFD------GFHSY----RENDYDLFHSMGLFAKTLDD--ILFE------ 604

  Fly   721 FAMRKTTVAHDSHVFHSGAGGPTQAVGFSAESASASAAPVVRKNFAETWIFADIESTEEEVFKWV 785
                     :.:|.              |..|.......||||.|.|:|::.::........|..
Mosquito   605 ---------NSNHK--------------SERSGQQMEQTVVRKQFVESWLWKNVTIGSSGSLKLT 646

  Fly   786 KTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLP 850
            :.:|||:|:|.:||||:.|..|||:.|:.....|.||||:...||||:||.|...:..:|.:.|.
Mosquito   647 EVVPDTMTSWYLTGFSIDPVVGLGIINNPIEFTTVQPFFILECLPYSIKRDEASEIQFIVVSNLQ 711

  Fly   851 KTLDVELTLDNEDQEYDFVDASNEVIGDQKRTQNIRVGANEAAGASFLIRPKVIGNILLKFKA-- 913
            :...|::||.||:.|.:.:..|   |.:...|:::.|........|||::.|.:|.::::.||
Mosquito   712 EGHTVDVTLYNENNEMEIIGRS---IANVNYTKSVHVLPKVGKPISFLVKAKKLGEMMVRVKASI 773

  Fly   914 ISPLAGDAIHKPLKVVPEGITQ------------YQNRAFFIN-----LKDTGEFKNTFELEVPE 961
            .:.:|.||:.|.::|:||.:.|            :||:.|.:|     ..:.|..|  |||.|..
Mosquito   774 SNGIATDALEKVIRVMPESLVQSRVESFGFFMDTHQNQTFLVNPSIDKKANKGSVK--FELRVNP 836

  Fly   962 DVVPDSERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKKLTPALDT 1026
                           :||..|.:||:|:....|||.|.....|  :::|.|||.:|....|
Mosquito   837 ---------------NLLITVQENLDNIRADISGCSESIKDML--HFVVHDYLVAIGSTHP---- 880

  Fly  1027 RIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSF-SKIKDIIDLDEQ 1090
                          :..:|:....|.|  .||.:       .:.||:::.:. ...|.|...|..
Mosquito   881 --------------YESNDNKCIKSNG--SWRNQ-------VFETAFLVNALQDAAKYIYFTDRL 922

  Fly  1091 ILAKGYEFLLTRQAENGSFTE-HGEYFYSSQRSLLTLTANSLLALLEEEK---PNQAAIDKAVAY 1151
            ...|.:::|.::|..:|||.| ..:..|  :||.:.||:..|..:||.|.   .:...|:|.:::
Mosquito   923 KREKAFDWLASQQHHSGSFKETETDLHY--KRSDVALTSYVLAVMLENESAKVQHAVVIEKGMSF 985

  Fly  1152 LS-----ANTAESIELLPKSIAIYALQKAKAPEAAKQVASLKSLAKHEDDRTWWTEDLDKLRASK 1211
            ||     ..:|..:.::..::.:|..:...|  |.:::..:.::..:..:|.|.|
Mosquito   986 LSDQLDLITSANDLAIVTYAMMLYGHRLKDA--AFEKLIDVSTITNNGAERYWNT---------- 1038

  Fly  1212 NCGRWWCWIWSQDVEITSYALLSLLDSDQETADSVLNTVRWLIAQRNGFGGFASSQDTVVGLTAL 1276
                      |..||.|||||||.:.:::..|  .|..:|||:.||:.....|..::|.:.|.||
Mosquito  1039 ----------SNSVEATSYALLSHVVANKLLA--ALPIMRWLVNQRSDLDSVAGQENTYLRLKAL 1091

  Fly  1277 IKFAEKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQTVEFPQGTKSLEFEAKGTGAAMVQ 1341
            .:...|  ...::.:.||..|.|  ::.:|...::...::|.:..|||.:.:|....|.||.:::
Mosquito  1092 SRMTNK--ISPSRNDYTVQLKYK--QSTRLLRFDKYSNMIQNITTPQGVRKIEITVMGIGAGLLE 1152

  Fly  1342 ISYQYNLVEKEPKPSFKIQTTVLPESSPANLELSVCVDYVEEGESKESNMAILEVSLPSGYTADE 1406
            :.|||:|.....:..|::.......||...|.|.|||.::.......||||::||:|||||..|.
Mosquito  1153 VIYQYSLNLTNFENRFQLDLQKQKTSSDHELRLKVCVSFIPTVSESRSNMALIEVTLPSGYVVDH 1217

  Fly  1407 DSFADIRNIERVRLVETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYDT 1471
            :..::...:..:...|.:.|.:.||:|::|:: |...|..:.|||...||.::|:.||:||||||
Mosquito  1218 NPISEQTTVNPIDHFEIRYGGASVVVYYKNMS-NVRNCFTVTAYRRFKVALKRPAYVVVYDYYDT 1281

  Fly  1472 NKKATEYYSI-KSKLCDICEGDDCKSKC 1498
            ||.|.:.|.: |..:|:|||.|||.::|
Mosquito  1282 NKNAIKMYEVDKQNVCEICEEDDCPAEC 1309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081	29/92 (32%)
		A2M_N_2	528..653	CDD:285005	32/132 (24%)
		A2M	768..859	CDD:278630	31/90 (34%)
		A2M_2	982..1279	CDD:239227	74/306 (24%)
		A2M_comp	1035..1281	CDD:284982	59/255 (23%)
		A2M_recep	1389..1479	CDD:284981	37/89 (42%)
TEP10	XP_309892.2	A2M_N	123..216	CDD:280081	33/117 (28%)
		A2M_N_2	441..558	CDD:285005	31/126 (25%)
		A2M	629..720	CDD:278630	31/90 (34%)
		ISOPREN_C2_like	844..1092	CDD:298658	72/302 (24%)
		A2M_recep	1200..1289	CDD:284981	37/89 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	51	1.000	Domainoid score	I18731
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.880