DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep4 and C3

DIOPT Version :9

Sequence 1:	NP_001260590.1	Gene:	Tep4 / 35248	FlyBaseID:	FBgn0041180	Length:	1498	Species:	Drosophila melanogaster
Sequence 2:	NP_033908.2	Gene:	C3 / 12266	MGIID:	88227	Length:	1663	Species:	Mus musculus

Alignment Length:	1683	Identity:	386/1683 - (22%)
Similarity:	652/1683 - (38%)	Gaps:	372/1683 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LCVILALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVAVH--QTKEPVTLKVG--ITGPSYNKT 71
            |.|:|.||.:.........|:|:.|..:....:..:.:..|  |...|||:.|.  :........
Mouse     9 LLVLLLLLASSPLALGIPMYSIITPNVLRLESEETIVLEAHDAQGDIPVTVTVQDFLKRQVLTSE 73

  Fly    72 ETVELATAGEFKQITFKLPPLEAGEYNLTAEGVKGLE---------FKNSTKLNWENFKPYIKIQ 127
            :||....:|..:.::.|:|  .:.|:|...||.|.:.         .:.:..:::::  .|:.||
Mouse    74 KTVLTGASGHLRSVSIKIP--ASKEFNSDKEGHKYVTVVANFGETVVEKAVMVSFQS--GYLFIQ 134

  Fly   128 TDKGKYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQE------KHIKTTGGVYTG 186
            |||..|.||.|:.||:..:|.||.|  ....||:..|......:|::      :|     |:...
Mouse   135 TDKTIYTPGSTVLYRIFTVDNNLLP--VGKTVVILIETPDGIPVKRDILSSNNQH-----GILPL 192

  Fly   187 KFELSEFATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVK 251
            .:.:.|...:|.|.:.          ..|....||...           ..|||::||||.:.|:
Mouse   193 SWNIPELVNMGQWKIR----------AFYEHAPKQIFS-----------AEFEVKEYVLPSFEVR 236

  Fly   252 MDATQQVSVRD--GEFNVVLKANYTYGKPVNGKVLVNVHL---DSTSSWENVDGKTVQTDYPGHS 311
            ::.|:.....|  ....|.:.|.:.|||.|:|...|...:   |...|..:...:.|..|..|.:
Mouse   237 VEPTETFYYIDDPNGLEVSIIAKFLYGKNVDGTAFVIFGVQDGDKKISLAHSLTRVVIEDGVGDA 301

  Fly   312 VV-----------GTADMVGGKAKLTMDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGG 365
            |:           ..||.:.||                   |.|..:|..:......|:. |..|
Mouse   302 VLTRKVLMEGVRPSNADALVGK-------------------SLYVSVTVILHSGSDMVEA-ERSG 346

  Fly   366 VQLYPYRYEMSCTDYSSCFSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAF 430
            :.:....|::..|....  .|||....:|...:|..|||..:....|.:....:.:.::
Mouse   347 IPIVTSPYQIHFTKTPK--FFKPAMPFDLMVFVTNPDGSPASKVLVVTQGSNAKALTQD------ 403

  Fly   431 GTDHQEPELPTIEKKTFVFESHLNASGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTT- 494
                                     .|||...:..|:.......|  ...:.:.:.|.|....|
Mouse   404 -------------------------DGVAKLSINTPNSRQPLTIT--VRTKKDTLPESRQATKTM 441

  Fly   495 --YPYREPKQIENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQVILNSSRPLKYFVYNIVGRGNI 557
              :||   ..:.|.::.......|.|: :|.|  ||.:....:........::|:.|.::.:|.:
Mouse   442 EAHPY---STMHNSNNYLHLSVSRMEL-KPGD--NLNVNFHLRTDPGHEAKIRYYTYLVMNKGKL 500

  Fly   558 LETKRVDLAEP---QTTVNVTIKPTFLTTPYGRVYFYY--VDETGEFRYTEETFSVEVE--LQNQ 615
            |:..| .:.||   ...:::.|.|.|:  |..|:..||  :..:|:.....::..|:|:  ....
Mouse   501 LKAGR-QVREPGQDLVVLSLPITPEFI--PSFRLVAYYTLIGASGQREVVADSVWVDVKDSCIGT 562

  Fly   616 IEIKA-PAE--VKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKESFNWRLNGYDT--- 674
            :.:|. |.:  :.||....|.|:.:..:.|||:|||:.|.:|...|.|.:...      :|.
Mouse   563 LVVKGDPRDNHLAPGQQTTLRIEGNQGARVGLVAVDKGVFVLNKKNKLTQSKI------WDVVEK 621

  Fly   675 ----STPWQGGYSYYPG-------------------------------------------ERTGV 692
                .||..|  ..|.|                                           ::.|.
Mouse   622 ADIGCTPGSG--KNYAGVFMDAGLAFKTSQGLQTEQRADLECTKPAARRRRSVQLMERRMDKAGQ 684

  Fly   693 VT-----------MTNAYFFYN--RTAPDYNILTEG------FGGSSFAMRKTTVAH-DSHVFHS 737
            .|           |.:....|:  |.|   .::|:|      |......:.|....| ..||
Mouse   685 YTDKGLRKCCEDGMRDIPMRYSCQRRA---RLITQGENCIKAFIDCCNHITKLREQHRRDHV--- 743

  Fly   738 GAGGPTQAVGFSAESASASAAP----VVRKNFAETWIFADIESTEEEVFKWVKT------IPDTI 792
                    :|.:.........|    :.|.:|.::|::. ||..:|.....:.|      :.|:|
Mouse   744 --------LGLARSELEEDIIPEEDIISRSHFPQSWLWT-IEELKEPEKNGISTKVMNIFLKDSI 799

  Fly   793 TNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYL-PKTLDVE 856
            |.|.:...||..:||:.|. |...|:..|.||:.:||||||.|.|.:.:.|::|||. .:.|.|.
Mouse   800 TTWEILAVSLSDKKGICVA-DPYEIRVMQDFFIDLRLPYSVVRNEQVEIRAVLFNYREQEELKVR 863

  Fly   857 LTLDNEDQEYDFVDASNEVIGDQKRTQNIRVGANEAAGASFLIRPKVIGNILLKFKA--ISPLAG 919
            :.|.:.........|.|...      |.|::....:....::|.|..||...::.||  .:....
Mouse   864 VELLHNPAFCSMATAKNRYF------QTIKIPPKSSVAVPYVIVPLKIGQQEVEVKAAVFNHFIS 922

  Fly   920 DAIHKPLKVVPEGITQYQNRAFFINLKDTGEF--KNTFELEVP----EDVVPDSE-RVEFGLVGD 977
            |.:.|.|||||||:.  .|:...|:..|..:.  ....:::||    .|.|||:: .....|.|
Mouse   923 DGVKKTLKVVPEGMR--INKTVAIHTLDPEKLGQGGVQKVDVPAADLSDQVPDTDSETRIILQG- 984

  Fly   978 LLGPVV---------KNLENLLRLPSGCGEQTMSKLVPNYLVRDYLK--------SIKKLTPALD 1025
              .|||         :.|::|:..|:|||||.|..:.|..:...||.        .|:|...||:
Mouse   985 --SPVVQMAEDAVDGERLKHLIVTPAGCGEQNMIGMTPTVIAVHYLDQTEQWEKFGIEKRQEALE 1047

  Fly  1026 TRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSFSKIKDIIDLDEQ 1090
            .     ::.||...|.::....::::|..         |..||||||||::.||...::|.:|..
Mouse  1048 L-----IKKGYTQQLAFKQPSSAYAAFNN---------RPPSTWLTAYVVKVFSLAANLIAIDSH 1098

  Fly  1091 ILAKGYEFL-LTRQAENGSFTEHGEY--------FYSSQRSLLTLTANSLLALLE-----EEKPN 1141
            :|....::| |.:|..:|.|.|.|..        |.:::.:.::|||..|:||.|     |.:.|
Mouse  1099 VLCGAVKWLILEKQKPDGVFQEDGPVIHQEMIGGFRNAKEADVSLTAFVLIALQEARDICEGQVN 1163

  Fly  1142 Q--AAIDKAVAYLSANTAESIELLPKSIAIYAL---QKAKAPEAAKQVASLKSLAKHEDDRTWWT 1201
            .  .:|:||..|:.|:..........:||.|||   .|.:.|...|.:.:.|       ||..|.
Mouse  1164 SLPGSINKAGEYIEASYMNLQRPYTVAIAGYALALMNKLEEPYLGKFLNTAK-------DRNRWE 1221

  Fly  1202 EDLDKLRASKNCGRWWCWIWSQDVEITSYALLSLLDSDQETADSVLNTVRWLIAQRNGFGGFASS 1266
            |...:|               .:||.||||||:||  ..:..|||...||||..||...||:.|:
Mouse  1222 EPDQQL---------------YNVEATSYALLALL--LLKDFDSVPPVVRWLNEQRYYGGGYGST 1269

  Fly  1267 QDTVVGLTALIKF-AEKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQTVEFPQGTK-SLE 1329
            |.|.:...||.:: .:...::....:|:. :...|..........||..||::.|..|... ||.
Mouse  1270 QATFMVFQALAQYQTDVPDHKDLNMDVSF-HLPSRSSATTFRLLWENGNLLRSEETKQNEAFSLT 1333

  Fly  1330 FEAKGTGAAMVQISYQYNLVEKEPKPSFKI--------QTTVLPESSPANLELSVCVDYVEEGES 1386
            .:.||.|...|...|...|..|.....|.:        :|...||.:...:.|.:|..|:.:
Mouse  1334 AKGKGRGTLSVVAVYHAKLKSKVTCKKFDLRVSIRPAPETAKKPEEAKNTMFLEICTKYLGD--- 1395

  Fly  1387 KESNMAILEVSLPSGYTADEDSFADI-----RNIERVRLVETKNGDSVVVIYFENLAKNEEKCIR 1446
            .::.|:||::|:.:|:..|......:     |.|.:..:.:..:..:.::||.|.::..||.|:.
Mouse  1396 VDATMSILDISMMTGFAPDTKDLELLASGVDRYISKYEMNKAFSNKNTLIIYLEKISHTEEDCLT 1460

  Fly  1447 IEAYRTHAVANQKPSSVVLYDYYDTNKKATEYY------SIKSKLCDI----CEGDDC 1494
            .:.::...|...:|.||.:|.||:..:..|.:|      .:.||||..    |..::|
Mouse  1461 FKVHQYFNVGLIQPGSVKVYSYYNLEESCTRFYHPEKDDGMLSKLCHSEMCRCAEENC 1518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081	25/98 (26%)
		A2M_N_2	528..653	CDD:285005	31/134 (23%)
		A2M	768..859	CDD:278630	33/97 (34%)
		A2M_2	982..1279	CDD:239227	98/332 (30%)
		A2M_comp	1035..1281	CDD:284982	80/265 (30%)
		A2M_recep	1389..1479	CDD:284981	22/94 (23%)
C3	NP_033908.2	A2M_N	130..225	CDD:280081	29/122 (24%)
		A2M_N_2	458..603	CDD:285005	36/150 (24%)
		ANATO	678..747	CDD:237984	14/82 (17%)
		A2M	770..866	CDD:278630	33/97 (34%)
		complement_C3_C4_C5	996..1282	CDD:239226	96/323 (30%)
		A2M_comp	1051..1282	CDD:284982	80/263 (30%)
		A2M_recep	1398..1493	CDD:284981	22/94 (23%)
		NTR_complement_C3	1513..1661	CDD:239638	2/6 (33%)
		Interaction with CFP/properdin. /evidence=ECO:0000250\|UniProtKB:P01024	1634..1659
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840026
Domainoid	1	1.000	49	1.000	Domainoid score	I11717
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.800