Protein Alignment Tep4 and Pzp

DIOPT Version :10

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: NP_031402.3
• Gene: Pzp / 11287
• MGIID: 87854
• Length: 1495
• Species: Mus musculus
• Alignment Length: 1657
• Identity: 424/1657 - (25%)
• Similarity: 694/1657 - (41%)
• Gaps: 351/1657 - (21%)

  Fly     1 MRR----ADAFAVSLCVILALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKV 61
            |||    ..||   |.:.|.|.:......|:.:|.::.|..::|.......|:::...|.|.|.:
Mouse     1 MRRNQLPTPAF---LLLFLLLPRDATTATAKPQYVVLVPSEVYSGVPEKACVSLNHVNETVMLSL 62

  Fly    62 GITGPSYNKTETVELATAGEFKQITFKLPPLEAGE---YNLTAEGVKG--LEFKNSTKLNWENFK 121
            .:   .|...:|..|......|...:..|...:|.   |......:||  ..|.....:.....:
Mouse    63 TL---EYAMQQTKLLTDQAVDKDSFYCSPFTISGSPLPYTFITVEIKGPTQRFIKKKSIQIIKAE 124

  Fly   122 PYIKIQTDKGKYKPGDTINYRVIFLDENLRP--DTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVY 184
            ..:.:||||..||||..:.:||:.:|.:.||  :|..   ||:.|..|||||.|.::|...||::
Mouse   125 SPVFVQTDKPIYKPGQIVKFRVVSVDISFRPLNETFP---VVYIETPKRNRIFQWQNIHLAGGLH 186

  Fly   185 TGKFELSEFATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYS 249
            ...|.||....||.:.:.||..          .|:|    ..|         :|||::|||||:.
Mouse   187 QLSFPLSVEPALGIYKVVVQKD----------SGKK----IEH---------SFEVKEYVLPKFE 228

  Fly   250 VKMDATQQVSVRDGEFNVVLKANYTYGKPVNGKVLVNV---HLDSTSSWENVDGKTVQTDYPGHS 311
            |.:...:.::..:.|..:.....|||||||.|.|.:.|   :....|:..|.:..::..::
Mouse   229 VIIKMQKTMAFLEEELPITACGVYTYGKPVPGLVTLRVCRKYSRYRSTCHNQNSMSICEEF---- 289

  Fly   312 VVGTADMVGGKAKLTMDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPYRYEMS 376
                :.....|......:|.....|..|......::.|.::|:.||::|...|..::
Mouse   290 ----SQQADDKGCFRQVVKTKVFQLRQKGHDMKIEVEAKIKEEGTGIELTGIGSCEI-------- 342

  Fly   377 CTDYSSCFSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELP- 440
                                            ..::.|.|||: :..||          .|.||
Mouse   343 --------------------------------ANALSKLKFTK-VNTNY----------RPGLPF 364

  Fly   441 -----TIEKK--------------------TFVFESHLNASGVAPFKVVLPDLPDIANFT----- 475
                 .:::|                    .|..:.|    |:|...:      |.:|||
Mouse   365 SGQVLLVDEKGKPIPNKNITSVVSPLGYLSIFTTDEH----GLANISI------DTSNFTAPFLR 419

  Fly   476 -------RYYSIELEFVDEKRDLYTTYPYREPKQIENPSSEEEKEWFRAEVQRPKDVWNLKIGQE 533
                   .:...:..::||    :.|........:.:||        ::.:|.......|..||.
Mouse   420 VVVTYKQNHVCYDNWWLDE----FHTQADHSATLVFSPS--------QSYIQLELVFGTLACGQT 472

  Fly   534 YQV---------ILNSSRPLKYFVYNIVGRGNILETKRVDLAEPQTTVN------VTIKPTFLTT 583
            .::         |:.:.:.|.:: |.|..||:|.......|:..|..:.      :.::|..  .
Mouse   473 QEIRIHYLLNEDIMKNEKDLTFY-YLIKARGSIFNLGSHVLSLEQGNMKGVFSLPIQVEPGM--A 534

  Fly   584 PYGRVYFYYVDETGEFRYTEETFSVEVELQNQIEIKAP-AEVKPGADVALEIKTSPKSFVGLLAV 647
            |..::..|.:....|.....:.|.:|....|::.:..| |:..|.:|..|::|.:|.|...|.||
Mouse   535 PEAQLLIYAILPNEELVADAQNFEIEKCFANKVNLSFPSAQSLPASDTHLKVKAAPLSLCALTAV 599

  Fly   648 DQSVLLLGSNNDLNKESFNWRLNGYDTSTPWQG-------------------GYSYYPG------ 687
            |||||||.....|:.:|....|.|......:.|                   |..|.|.
Mouse   600 DQSVLLLKPEAKLSPQSIYNLLPGKTVQGAFFGVPVYKDHENCISGEDITHNGIVYTPKHSLGDN 664

  Fly   688 ------ERTGVVTMTNAYFFYNRTAPDYN--------------ILTEGFGGSSFAMRKTTVAHDS 732
                  :..|:...||:.....|...::.              :...|.|.|..||
Mouse   665 DAHSIFQSVGINIFTNSKIHKPRFCQEFQHYPAMGGVAPQALAVAASGPGSSFRAM--------- 720

  Fly   733 HVFHSGAGGPTQAVGFSAE-SASASAAPVVRKNFAETWIF----ADIESTEEEVFKWVKTIPDTI 792
                   |.|...:.:|.| :........|||.|.||||:    .|:....|...|    :||||
Mouse   721 -------GVPMMGLDYSDEINQVVEVRETVRKYFPETWIWDLVPLDVSGDGELAVK----VPDTI 774

  Fly   793 TNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVEL 857
            |.|..:.|.|....|||::: ..:::.|||||:.:.|||||.|||...:.|.|.||:...:.:.:
Mouse   775 TEWKASAFCLSGTTGLGLSS-TISLQAFQPFFLELTLPYSVVRGEAFTLKATVLNYMSHCIQIRV 838

  Fly   858 TLDNEDQEYDFV-------DASNEVIGDQKRTQNIRV------GANEAAGASFLIRPKVIGNILL 909
            .|:...   ||:       :.|:.:.|::::|.:..|      ..|..|.|..|..|::.||.|.
Mouse   839 DLEISP---DFLAVPVGGHENSHCICGNERKTVSWAVTPKSLGEVNFTATAEALQSPELCGNKLT 900

  Fly   910 KFKAISPLAGDAIHKPLKVVPEGITQYQNRAFFINLKDTGEFKNTFELEVPEDVVPDSERVEFGL 974
            :..|:  :..|.:.|.:.|.||||.:.|.....:..:|| |.::.:.||:|.:||..|.|....:
Mouse   901 EVPAL--VHKDTVVKSVIVEPEGIEKEQTYNTLLCPQDT-ELQDNWSLELPPNVVEGSARATHSV 962

  Fly   975 VGDLLGPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHM 1039
            :||:||..::||:|||::|.|||||.|...|||..|.:||...::||.|:.::....|..|||..
Mouse   963 LGDILGSAMQNLQNLLQMPYGCGEQNMVLFVPNIYVLNYLNETQQLTEAIKSKAINYLISGYQRQ 1027

  Fly  1040 LHYRHDDGSFSSFG-------PTKWRQEDPVRNGSTWLTAYVLRSFSKIKDIIDLDEQILAKGYE 1097
            |:|:|.|||:|:||       |           |:|||||:||::|::.:..|.:::..:...:.
Mouse  1028 LNYQHSDGSYSTFGNHGGGNTP-----------GNTWLTAFVLKAFAQAQSHIFIEKTHITNAFN 1081

  Fly  1098 FLLTRQAENGSFTEHGEYFYSSQR----SLLTLTANSLLALLEEEKP-NQAAIDKAV-----AYL 1152
            :|..:|.|||.|.:.|....::.:    ..:||:|...:||||...| ..:|:..|:     |:.
Mouse  1082 WLSMKQKENGCFQQSGYLLNNAMKGGVDDEVTLSAYITIALLEMPLPVTHSAVRNALFCLETAWA 1146

  Fly  1153 SANTAESIELLPKSIAIYALQKAKAPEAAKQVASLKSLAK---HEDDRTWWTE--DLDKLRASKN 1212
            |.:.::...:..|::..||.  |.|...||:...|:||.|   .|:|...|..  |:.|::|..
Mouse  1147 SISQSQESHVYTKALLAYAF--ALAGNKAKRSELLESLNKDAVKEEDSLHWQRPGDVQKVKALS- 1208

  Fly  1213 CGRWWCWIW-----SQDVEITSYALLSLLDSD-----QETADSVLNT----VRWLIAQRNGFGGF 1263
                   .:     |.:||:|:|.||:.|.|:     ::.:.|.|:|    |:|:..|:|..|||
Mouse  1209 -------FYQPRAPSAEVEMTAYVLLAYLTSESSRPTRDLSSSDLSTASKIVKWISKQQNSHGGF 1266

  Fly  1264 ASSQDTVVGLTALIKFAEKSGYEAAKWE-VTVSNKGKREKTEKLNTSEENDLLLQTVEFPQGTKS 1327
            :|:|||||.|.||.|:...:...:.|.. ||:.:.|...||..:|:.  |.||||.|..|....:
Mouse  1267 SSTQDTVVALQALSKYGAATFTRSQKEVLVTIESSGTFSKTFHVNSG--NRLLLQEVRLPDLPGN 1329

  Fly  1328 LEFEAKGTGAAMVQISYQYNLVE-KEPKPSFKIQTTVLP-----ESSPANLELSVCVDYVEEGES 1386
            ...:..|:|...:|.|.:||::. .:.|..|.:|...||     .......::.:.|.|.  ||.
Mouse  1330 YVTKGSGSGCVYLQTSLKYNILPVADGKAPFALQVNTLPLNFDKAGDHRTFQIRINVSYT--GER 1392

  Fly  1387 KESNMAILEVSLPSGYTADEDS---FADIRNIERVRLVETKNGDSVVVIYFENLAKNEEKCIRIE 1448
            ..|||.|::|.:.||:...:.|   ..|..||:|.. |.|.:    |:||.|.|. |:.......
Mouse  1393 PSSNMVIVDVKMVSGFIPMKPSVKKLQDQPNIQRTE-VNTNH----VLIYIEKLT-NQTLGFSFA 1451

  Fly  1449 AYRTHAVANQKPSSVVLYDYYDTNKKATEYYS 1480
            ..:...|.|.||:.:.:||||:|::...|.||
Mouse  1452 VEQDIPVKNLKPAPIKVYDYYETDEFTVEEYS 1483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	YfaS	<76..1411	CDD:441940	382/1507 (25%)
		A2M_2	982..1279	CDD:239227	109/332 (33%)
		A2M_recep	1387..1480	CDD:462226	30/95 (32%)
Pzp	NP_031402.3	YfaS	<127..1401	CDD:441940	370/1435 (26%)
		Bait region	686..744		10/73 (14%)
		A2M	750..840	CDD:459711	34/94 (36%)
		A2M_2	970..1282	CDD:239227	109/332 (33%)
		A2M_recep	1393..1483	CDD:462226	30/95 (32%)