Protein Alignment Tep4 and LOC110384692

DIOPT Version :10

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: NP_001338929.1
• Gene: LOC110384692 / 110384692
• -ID: -
• Length: 1744
• Species: Homo sapiens
• Alignment Length: 1740
• Identity: 392/1740 - (22%)
• Similarity: 647/1740 - (37%)
• Gaps: 442/1740 - (25%)

  Fly    32 IVGPGTIHSHRDYNVAVAVHQTKEPVTLK--VGITGPSYNKTE-----TVELATAGEFKQITFKL 89
            :..|..:|.....:|.|.:........:|  |.:..||.|...     ...|::..:|..::.::
Human    25 LFSPSVVHLGVPLSVGVQLQDVPRGQVVKGSVFLRNPSRNNVPCSPKVDFTLSSERDFALLSLQV 89

  Fly    90 P-----------PLEAGEYNLTAE------------GVKGLEFKNSTKLNWENFKPYIKIQTDKG 131
            |           .|...|..|.|.            .::|:....|::      :.::.:|||:.
Human    90 PLKDAKSCGLHQLLRGPEVQLVAHSPWLKDSLSRTTNIQGINLLFSSR------RGHLFLQTDQP 148

  Fly   132 KYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFATL 196
            .|.||..:.|||..||:.:||.|  |.:.|..|:|...|:: :|.:.....::...|.:.:.:..
Human   149 IYNPGQRVRYRVFALDQKMRPST--DTITVMVENSHGLRVR-KKEVYMPSSIFQDDFVIPDISEP 210

  Fly   197 GSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQ----Q 257
            |:|.:..:..|     |:                .|:....|||:|||||.:.||:...:    .
Human   211 GTWKISARFSD-----GL----------------ESNSSTQFEVKKYVLPNFEVKITPGKPYILT 254

  Fly   258 VSVRDGEFNVVLKANYTYGKPVNGKVLVNVHLDSTSSWENVDGKTVQTDYPGHSVVGTADMVGGK 322
            |.....|..:.::|.|.|||||.|...|...|      .:.|||  :|.:.|  :.....:|.|:
Human   255 VPGHLDEMQLDIQARYIYGKPVQGVAYVRFGL------LDEDGK--KTFFRG--LESQTKLVNGQ 309

  Fly   323 AKLTMDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYP--YRYEMSCTDY---SS 382
            :.:::...:|...|......    ||     |..|::|.....:..||  ...|...|.:   ||
Human   310 SHISLSKAEFQDALEKLNMG----IT-----DLQGLRLYVAAAIIEYPGGEMEEAELTSWYFVSS 365

  Fly   383 CFSFK---------PDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPE 438
            .||..         |.....|...:..:.||..:.....|.|             ...:....||
Human   366 PFSLDLSKTKRHLVPGAPFLLQALVREMSGSPASGIPVKVSA-------------TVSSPGSVPE 417

  Fly   439 LPTIEKKTFVFESHLNASGVAPFKVVLPDL--------------PDIANFTRYYSIELEFVDEKR 489
            :..|::.|       :.||.....:::|..              |.||..|
Human   418 VQDIQQNT-------DGSGQVSIPIIIPQTISELQLSVSAGSPHPAIARLT-------------- 461

  Fly   490 DLYTTYPYREP--KQIENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQVILNSSRPLKYFVYNIV 552
              ....|...|  ..||.|.|..         .|..|..||.:.     .:.|.....::.|.|:
Human   462 --VAAPPSGGPGFLSIERPDSRP---------PRVGDTLNLNLR-----AVGSGATFSHYYYMIL 510

  Fly   553 GRGNILETKRVDLAEPQ---TTVNVTIKPTFLTTPYGRVYFYYVDE--TGEFRYTEETFSVEVEL 612
            .||.|:...|    ||:   |:|:|.:......:.|...::|:.|.  ....|...:..:.|.:|
Human   511 SRGQIVFMNR----EPKRTLTSVSVFVDHHLAPSFYFVAFYYHGDHPVANSLRVDVQAGACEGKL 571

  Fly   613 QNQIEIKAPAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLLG--SNNDLNKESFNWRLNGYDTS 675
              ::.:....:.:.|..|.|.::|...:.|.|.|:|.::...|  |:..||.......:|.||..
Human   572 --ELSVDGAKQYRNGESVKLHLETDSLALVALGALDTALYAAGSKSHKPLNMGKVFEAMNSYDLG 634

  Fly   676 TPWQGGYSYY-------------------------PGERT------------------------- 690
            ....||.|..                         |.|:|
Human   635 CGPGGGDSALQVFQAAGLAFSDGDQWTLSRKRLSCPKEKTTRKKRNVNFQKAINEKLGQYASPTA 699

  Fly   691 ------GVVTMTNAYFFYNRTA----PDYNILTEGF-GGSSFAMRKTTVAHDSHVFHSGAGGPTQ 744
                  ||..:........|.|    ||   ..|.| ....||......:.|     .|..|..:
Human   700 KRCCQDGVTRLPMMRSCEQRAARVQQPD---CREPFLSCCQFAESLRKKSRD-----KGQAGLQR 756

  Fly   745 AVGFSAESASASAAPV-VRKNFAETWIFADIESTE--EEVFKWVKTIPDTITNWVVTGFSLHPQK 806
            |:....|........: ||..|.|.|::. :|:.:  :.:..|   :||::|.|.:.|.||...|
Human   757 ALEILQEEDLIDEDDIPVRSFFPENWLWR-VETVDRFQILTLW---LPDSLTTWEIHGLSLSKTK 817

  Fly   807 GLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVDA 871
            ||.|.. ...::.|:.|.:.:|||.||:|.|.:.:..:::|||.|.|.|.:.:...:
Human   818 GLCVAT-PVQLRVFREFHLHLRLPMSVRRFEQLELRPVLYNYLDKNLTVSVHVSPVE-------- 873

  Fly   872 SNEVIGDQKRTQNIRVGANEAAGASFLIRPKVIGNILLKFKAISPL---AGDAIHKPLKVVPEGI 933
            ...:.|.....|.:.|.|..|...:|.:.|.....:.||..|....   .|||:.|.|::..||.
Human   874 GLCLAGGGGLAQQVLVPAGSARPVAFSVVPTAAAAVSLKVVARGSFEFPVGDAVSKVLQIEKEGA 938

  Fly   934 TQYQNRAFFIN-LKDTGEFKNTFELEVP----EDVVPDSE-----RVEFGLVGDLLG------PV 982
            ...:...:.:| |...|.     .||:|    .:::||.:     ||......|.||      |
Human   939 IHREELVYELNPLDHRGR-----TLEIPGNSDPNMIPDGDFNSYVRVTASDPLDTLGSEGALSP- 997

  Fly   983 VKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKK---LTPALDTRIKRNLQDGYQHMLHYRH 1044
             ..:.:|||||.|||||||..|.|......||...::   |.|.........:|.||..:..:|.
Human   998 -GGVASLLRLPRGCGEQTMIYLAPTLAASRYLDKTEQWSTLPPETKDHAVDLIQKGYMRIQQFRK 1061

  Fly  1045 DDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSFSKIKDIIDLDEQILAKGYEFLLTRQAENGSF 1109
            .|||:::     |..    |:.||||||:||:..|..::.:....:.|.:...:||::|..:|||
Human  1062 ADGSYAA-----WLS----RDSSTWLTAFVLKVLSLAQEQVGGSPEKLQETSNWLLSQQQADGSF 1117

  Fly  1110 TEHGEYFYSSQR-------------SLLTLTANSLLALLEEEKPN------QAAIDKAVAYLSAN 1155
            .:.......|.:             :.:|:..:..||:.::|...      :|:|.||.::|...
Human  1118 QDPCPVLDRSMQGGLVGNDETVALTAFVTIALHHGLAVFQDEGAEPLKQRVEASISKANSFLGEK 1182

  Fly  1156 TAESIELL---PKSIAIYALQKAKAPEAAKQVA--SLKSLAKHEDDRTWW-------TEDLDKLR 1208
            .  |..||   ..:|..|||...|||.....||  :|.::|:...|..:|       :..:....
Human  1183 A--SAGLLGAHAAAITAYALTLTKAPVDLLGVAHNNLMAMAQETGDNLYWGSVTGSQSNAVSPTP 1245

  Fly  1209 ASKN-------CGRWWCWIWSQDVEITSYALLSLL--DSDQETADSVLNTVRWLIAQRNGFGGFA 1264
            |.:|       ....|       :|.|:||||.||  :...|.||   ....||..|.:..|||.
Human  1246 APRNPSDPMPQAPALW-------IETTAYALLHLLLHEGKAEMAD---QAAAWLTRQGSFQGGFR 1300

  Fly  1265 SSQDTVVGLTALIKF------AEKSGYEAAKWEVTVSNKGK---REKTEKLNTSEENDLLLQTVE 1320
            |:||||:.|.||..:      .|:.|.     .||:|:.|:   :....:||..:... |.:.::
Human  1301 STQDTVIALDALSAYWIASHTTEERGL-----NVTLSSTGRNGFKSHALQLNNRQIRG-LEEELQ 1359

  Fly  1321 FPQGTKSLEFEAKGTGAAMVQISYQYNLVEKEPK--PSFKIQTTV-------------------- 1363
            |..|:| :..:..|.....:::...||:::.:..  ...:|:.||
Human  1360 FSLGSK-INVKVGGNSKGTLKVLRTYNVLDMKNTTCQDLQIEVTVKGHVEYTMEANEDYEDYEYD 1423

  Fly  1364 -LP---------------------------------ESSPANLELSVCVDYVEEGESKESNMAIL 1394
             ||                                 |...:.:..:||:  ...|:...|.|||.
Human  1424 ELPAKDDPDAPLQPVTPLQLFEGRRNRRRREAPKVVEEQESRVHYTVCI--WRNGKVGLSGMAIA 1486

  Fly  1395 EVSLPSGYTADEDSFADIRNIERV--RLV---ETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHA 1454
            :|:|.||:.|..   ||:..:..:  |.|   ||:...  |::||:::..:.| |:..||.:...
Human  1487 DVTLLSGFHALR---ADLEKLTSLSDRYVSHFETEGPH--VLLYFDSVPTSRE-CVGFEAVQEVP 1545

  Fly  1455 VANQKPSSVVLYDYYDTNKKATEYYSIKSK---LCDICEGDDC---KSKC 1498
            |...:|:|..|||||:..::.:.:|...||   |..:|..:.|   :.||
Human  1546 VGLVQPASATLYDYYNPERRCSVFYGAPSKSRLLATLCSAEVCQCAEGKC 1595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	YfaS	<76..1411	CDD:441940	354/1589 (22%)
		A2M_2	982..1279	CDD:239227	97/339 (29%)
		A2M_recep	1387..1480	CDD:462226	30/97 (31%)
LOC110384692	NP_001338929.1	YfaS	<138..1336	CDD:441940	317/1350 (23%)
		ANATO	686..750	CDD:237984	11/71 (15%)
		A2M	781..869	CDD:459711	29/92 (32%)
		TED_complement	982..1315	CDD:462227	101/355 (28%)
		A2M_recep	1481..1570	CDD:462226	30/94 (32%)
		NTR_complement_C4	1588..1742	CDD:239639	3/8 (38%)