DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tep4 and LOC101730404

DIOPT Version :9

Sequence 1:	NP_001260590.1	Gene:	Tep4 / 35248	FlyBaseID:	FBgn0041180	Length:	1498	Species:	Drosophila melanogaster
Sequence 2:	XP_031761602.1	Gene:	LOC101730404 / 101730404	-ID:	-	Length:	737	Species:	Xenopus tropicalis

Alignment Length:	740	Identity:	183/740 - (24%)
Similarity:	308/740 - (41%)	Gaps:	128/740 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   394 LNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELPTIEKKTFVFESHLNASGV 458
            :|....|..|...|....|...| .:.:|....:.....|..:..:..:          .:.:|:
Frog    62 VNLDTYYQKGIPFTGMMKVFNLK-KDPMRNEKVYLVVNVDEVDTNITLV----------TDENGM 115

  Fly   459 APFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTTYPYREPKQIENPSSEEEKEWFRAEVQRPK 523
            |.|.:...|..|:.:.|...|.| |.....|.|...:|:          ..|...:.:.:.....
Frog   116 ARFSLDTSDWNDMVSLTGRISFE-EGAGYFRALQWLFPF----------YSESNSFLKVQTVAED 169

  Fly   524 DVWNLK--IGQEYQVILNSSRP----LKYFVYNIVGRGNILETK--RVDL----AEP--QTTVNV 574
            .:.:.|  :..||.:..|...|    |.:| |.::.:|.|:..|  :||:    :.|  |.:.||
Frog   170 LLCSTKQSVSVEYTIDKNELDPESDHLSFF-YILMSKGTIITAKEHKVDVKNLPSGPILQGSFNV 233

  Fly   575 TIKPTFLTTPYGRVYFYYVDETGEFRYTEETFSVEVELQNQIEIK-APAEVKPGADVALEIKTSP 638
            |...|....|...:..|.:...||.......::|.:...|::::: ....|.||.:|.|::|...
Frog   234 TFLVTMNLVPVATLLVYAIFPDGEVAADRVRYNVPICFDNKVQLEFRENNVHPGGNVNLDVKADA 298

  Fly   639 KSFVGLLAVDQSVLLLGSNNDLNK----------ESFNWRLNGYD-------------------T 674
            .|...:.:||:. |||...:..||          ..|.:.:..::                   .
Frog   299 GSLCSVRSVDKG-LLLHQEHKTNKMGSDILRFYGRGFPYTIEDFEPYPCLEDVPVPPNRAKRSLK 362

  Fly   675 STPWQGG----YSYYPGERTGVVTMTNAYFFYNRTAPDYNILTEGFGGSSFAMRKTTVAHDSHVF 735
            ..||...    ||.:......|.|.|..........|:|.        ..|:::....|.|..:.
Frog   363 RAPWYQSEADVYSLFKSSSLKVFTNTRIRKPVTCELPEYT--------RRFSIKDGVGAADRKLD 419

  Fly   736 HSGAGGPTQAVGFSAESASASAAPVVRKNFAETWIFADIESTEEEVFKWVK-TIPDTITNWVVTG 799
            ..|             :|.||....|||.|.|||:: |:.|...:..|.:. |.|.:||.||...
Frog   420 SPG-------------TAPASKEHPVRKFFPETWLY-DLVSVGPQGKKSLNLTAPHSITEWVTDA 470

  Fly   800 FSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPK--TLDVELTLDNE 862
            |.: ...|.|..:| ..:|||||:|:.:.|||||.:.|...:.|||:|||..  .::|.||:..|
Frog   471 FCV-GNSGFGEVHD-IKMKTFQPYFIDLLLPYSVVQKEHFTLTALVYNYLNHCVLVEVALTIPPE 533

  Fly   863 --DQEYDFVDASNEVIGDQKRTQNIRVGANEAAGASFLIRPKVI------GNILL----KFKAIS 915
              :...| ::.|..:.|.:..:....:.|::.....|.:..:.:      .:::|    |||
Frog   534 FGEPRTD-IEKSACICGQETASFTWNITASKLGTIPFKVTSRALHVEGDCSDVVLDPETKFK--- 594

  Fly   916 PLAGDAIHKPLKVVPEGITQYQNRAFFINLKDTGE-FKNTFELEVPEDVVPDSERVEFGLVGDLL 979
               .||:.|.:.|.|.|:..::.....  |..||: .::...|.:|::||..|......::||:|
Frog   595 ---HDAVQKTILVKPSGVEVFKTHTSL--LCPTGDSVRDEVSLVLPDNVVEGSGHAHITVLGDVL 654

  Fly   980 GPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHMLHYRH 1044
            |..:.||.:||:||.|||||.|::..||..|.:||:|.|.|||.:..::...|..|||..|.::|
Frog   655 GNTISNLGDLLQLPYGCGEQNMAQFAPNVYVLEYLQSAKALTPEIKDKVLNYLTTGYQRQLMFKH 719

  Fly  1045 DDGSFSSFGPTKWRQEDPVRNGSTW 1069
            |:|::|:||     ::|  ..|:||
Frog   720 DNGAYSAFG-----KKD--EEGNTW 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081
		A2M_N_2	528..653	CDD:285005	34/139 (24%)
		A2M	768..859	CDD:278630	35/93 (38%)
		A2M_2	982..1279	CDD:239227	37/88 (42%)
		A2M_comp	1035..1281	CDD:284982	14/35 (40%)
		A2M_recep	1389..1479	CDD:284981
LOC101730404	XP_031761602.1	MG4	61..>134	CDD:407661	14/82 (17%)
		A2M_N_2	161..313	CDD:400170	35/153 (23%)
		A2M	439..528	CDD:395153	34/91 (37%)
		SVA	<490..571	CDD:398804	24/81 (30%)
		ISOPREN_C2_like	657..>737	CDD:415487	35/86 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010