Protein Alignment Tep4 and LOC100491968

DIOPT Version :10

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: XP_031755349.1
• Gene: LOC100491968 / 100491968
• XenbaseID: XB-GENE-29080963
• Length: 1653
• Species: Xenopus tropicalis
• Alignment Length: 1667
• Identity: 386/1667 - (23%)
• Similarity: 654/1667 - (39%)
• Gaps: 351/1667 - (21%)

  Fly    10 SLCVILALLQ-----------TMEPVKAEGKYTIVGPGTIH-SHRDYNVAV--------AVHQTK 54
            :||:.|.||.           |...::.|.:.|||.....| |..|.|:.:        ::...|
 Frog     5 TLCLSLLLLVAGSYAQQCTLITPSLLRVETEETIVVDAQGHNSAFDANILIQDFPQKKLSLASAK 69

  Fly    55 EPVTLKVGITGPSYNKTETVELATAGEFKQITFKLPPLEAGEYNLTAEGVKGLEFKNSTKLNWEN 119
            ..:....|..|....|..:.:|.......|..:    :.....:.|.|.|..|::.:.
 Frog    70 VSLNNSNGFLGSGTVKIPSDQLPKETRNNQFVY----VSVSSGSCTLEKVVLLQYSSG------- 123

  Fly   120 FKPYIKIQTDKGKYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVY 184
               ||.|||||..|.||..:.|||..::..:.| .||..|:.:........:::..|..:..|:.
 Frog   124 ---YIFIQTDKTIYTPGSKVMYRVFSMNYKMYP-VAKPMVIEFVNPDGIVVMRESIHPASKSGIL 184

  Fly   185 TGKFELSEFATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYS 249
            :...:|.|..:||.|::..:..|.                     .:.:...||||::||||...
 Frog   185 SETHDLPELVSLGVWTISAKYEDT---------------------PQQNYTTNFEVKEYVLPTIE 228

  Fly   250 VKMDATQQVSVRDGE-FNVVLKANYTYGKPVNGK--VLVNVHLDSTSSWENVDGKTVQTDYPGHS 311
            :.:.........|.: |:|.::|:|.:|:||.|.  ||..|..|...:........||.: .|.
 Frog   229 IILKPESSFFYTDAKTFSVNIEAHYLFGRPVEGHAFVLFGVQKDGRKTGIPESLARVQIN-EGE- 291

  Fly   312 VVGTADMVGGKAKLTMDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLY----PYR 372
              |..::.|...:.|::..:  ..|.:|...:.:.:||      ||..:.|....::|    ||:
 Frog   292 --GRVELEGEHIRKTLNTTE--EMLQYKLYLTVSVVTA------TGTDMVEAQLEEIYIVTSPYK 346

  Fly   373 YEMSCT-DYSSCFSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQE 436
            ...:.| .|     |||....::...:|..|||.......||:.....|:.:     ..||....
 Frog   347 VFFTKTPQY-----FKPGLSFDVMVFVTNPDGSPAKGIPVVVQPGGISGVTQ-----TDGTTRLP 401

  Fly   437 PELPTIEKKTFVFESHLNA----SGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTTYPY 497
            ...|....     |.|:..    .|:.|        ...||.|.              ..|.|..
 Frog   402 MNTPPDTN-----ELHVTVRTEQEGLPP--------QHQANATM--------------TATAYGS 439

  Fly   498 REPKQIENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQV--ILNSSRP-----LKYFVYNIVGRG 555
            .....:....:|.|                :.:|:...|  .:.:|.|     :::|.|.::.||
 Frog   440 ETGNYLHINIAESE----------------ITLGKGLSVNFFIKNSDPRFQEQIQHFTYLVLSRG 488

  Fly   556 NILETKRVDLAEPQTTVNVTIKPTFLTTPYGRVYFYYVDETGEFR-YTEETFSVEV--ELQNQIE 617
            .|::..|......|..|.:::..|....|..|:..||:..|.:.| ...::..|:|  .....:|
 Frog   489 QIIKVDRQARLSDQPVVAMSLLITEDYLPSFRIVAYYMVTTAKGRDIVSDSVWVDVVDSCMGTLE 553

  Fly   618 I-----KAPAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKESFNWRLNGYDTS-- 675
            :     |..|..|..|.|.|:::...|:.|||:.||:.|.:|.....|.:... |  :..:.|
 Frog   554 VTGLKDKDNAVQKLPATVQLKLRADHKANVGLVIVDKGVFVLNKKFKLTQSKI-W--DSVEKSDI 615

  Fly   676 --TPWQG---------------------------GYSYYPGER----TGVVTMTNAYFFYNRTAP 707
              ||..|                           .|...||:|    |..:....|     ..|.
 Frog   616 GCTPGSGVDSPGVFYDAGLTLHTSFAITTIQRIKPYCKVPGKRKRRSTAAIIEIKA-----GKAS 675

  Fly   708 DY---------NILTEGFGGSSFAMRKTTVA---------------HDSHVFHSGAGGPTQAVGF 748
            :|         :.:.|...|.|...|...:.               ::..............:..
 Frog   676 EYKDKVKQCCLDGMQENLMGHSCERRTRYILDGKECVDAFLDCCKYYEKRREDERKSKDEDTLAR 740

  Fly   749 SAESAS--ASAAPVVRKNFAETWIFADIESTEEEVFKWVKT------IPDTITNWVVTGFSLHPQ 805
            |.|.:.  ..:...||..|.|:|.:..:|..|....:.:.|      :.|:||.|.|...||...
 Frog   741 SDEDSDYILESEIDVRSEFPESWRWDVVEMRENPDKQNISTKIINLNLKDSITTWEVLAVSLSEN 805

  Fly   806 KGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLD--VELTLDNEDQEYDF 868
            |||.|.... .||..:.||:.::|||||.|.|.:.:.|:|.||....:.  ||.:.:.|     |
 Frog   806 KGLCVAPPH-EIKAMKDFFIDLKLPYSVVRNEQVEIRAVVHNYNSNRIKARVEFSYNPE-----F 864

  Fly   869 VDASNEVIGDQKRTQNIRVGANEAAGASFLIRPKVIG--NILLKFKAISPLAGDAIHKPLKVVPE 931
            ...|.   ..:|..|.:.|||..:|...|:|.|..||  ::.:|.........|.:.|.||||||
 Frog   865 CSLST---AKKKFRQEVWVGAESSAVVPFVIVPLTIGQHDVEVKASVYKHFFSDGVRKTLKVVPE 926

  Fly   932 GITQYQNRAFF-----INLKDTGEFKNTFELEVPEDVVPDSE-RVEFGLVGDLLGPVVK------ 984
            |:...:..:..     :..||..:..|...| ..|.:||.|: .::..|.|..:..:|:
 Frog   927 GVLLTKTLSSVTLEPEVKGKDGVQEVNIGAL-TAEHIVPRSDVDIKVILQGSPISQLVESAIDGI 990

  Fly   985 NLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKK-LTPALDTRIK--RNLQDGYQHMLHYRHDD 1046
            ||..|:::|:|||||.|.::..|.:...||.:..: ....:|.|:.  ||:..|||..|.||..|
 Frog   991 NLHPLIQIPTGCGEQNMMRMTTNVITTRYLDATAQWQRVGMDRRVAAIRNIAKGYQEELVYRKPD 1055

  Fly  1047 GSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSFSKIKDIIDLDEQILAKGYEFLLTRQAENGSFTE 1111
            |:|::|       :|  |..||||||||.:.|:...:...:::.:|....:: |.::.:||.|.|
 Frog  1056 GTFAAF-------KD--RPSSTWLTAYVAKVFAMSYEYTQIEDNVLCGAIKW-LEKKMQNGMFIE 1110

  Fly  1112 HGEYFY---------SSQRSLLTLTANSLLALLEEEK--PNQA-----AIDKAVAYLSANTAESI 1160
            .|...:         .:......|||..|:|:||..:  ..|.     :|::|..:|....::..
 Frog  1111 SGPVIHMEMVGGNKAGAAEPDAALTAFVLIAMLESRELCTQQLTSLGDSINRATDFLRGKYSQLR 1175

  Fly  1161 ELLPKSIAI--YALQKAKAPEAAKQVASLKSLAKHEDDRTWWTEDLDKLRASKNCGRWWCWIWSQ 1223
            :  |.||||  |||      ..|.::....:|.....|:|.|.|. |.|..|
 Frog  1176 K--PYSIAITSYAL------ALAGELQDTNTLMNAATDKTHWNEP-DSLFIS------------- 1218

  Fly  1224 DVEITSYALLSLLDSDQETADSVLNTVRWLIAQRNGFGGFASSQDTVVGLTALIKFAEKSGYEAA 1288
             :|.||||||:||...|......:  ||||..:|.....|.|:|.|::...||           |
 Frog  1219 -LEATSYALLTLLKMKQHDPTGAI--VRWLNEKRYYGAVFNSTQATIIMFQAL-----------A 1269

  Fly  1289 KWEVTVSNKGK---------REKTEKLNT--SEENDLLLQTVEFPQGTKSLEFEAKGTGAAMVQI 1342
            ::::.|.....         .||.:.:|.  ..||.:|.::.| .:..|....:|||.|.|::.:
 Frog  1270 QYQIDVPRIDDLDLDVSLYLPEKQDPINVRIDLENAILARSTE-TKINKDFVVKAKGKGQALLTV 1333

  Fly  1343 SYQYNLVEKEPK---PSFKIQTTV-------LPESSPANLELSVCVDYVEEGESKESNMAILEVS 1397
            ...::.:|.|.:   .:|.:...|       ||:...|.:.:.||..|:::   .::.|:|:::|
 Frog  1334 VSVFHSLETEKQMECNNFNLSVKVEEEKNMKLPDGVVAIVSVEVCARYLKD---SDATMSIMDIS 1395

  Fly  1398 LPSGYTADEDSF------ADIRNIERVRLVETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVA 1456
            :.:|::.|.||.      || :.|.:..:.:.......:::|.:.::..|.:|::..|::...|.
 Frog  1396 MMTGFSPDTDSVNKLMKGAD-KYISKYEINKGATERGTIILYLDKISHTEPECVKFYAHQYFVVG 1459

  Fly  1457 NQKPSSVVLYDYYDTNKKATEYYSIKSKLC---DICEGDDCK 1495
            ..:|:||.:||||....:.|::|..:....   .:|:||.|:
 Frog  1460 LVQPASVTVYDYYTPENRCTKFYHTEESSALFGKLCQGDVCR 1501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	YfaS	<76..1411	CDD:441940	347/1492 (23%)
		A2M_2	982..1279	CDD:239227	95/323 (29%)
		A2M_recep	1387..1480	CDD:462226	23/98 (23%)
LOC100491968	XP_031755349.1	MG1	20..118	CDD:465508	18/101 (18%)
		YfaS	<123..1333	CDD:441940	324/1371 (24%)
		MG4	349..437	CDD:465507	23/124 (19%)
		A2M	762..858	CDD:459711	31/96 (32%)
		complement_C3_C4_C5	991..1271	CDD:239226	95/325 (29%)
		A2M_recep	1385..1483	CDD:462226	23/98 (23%)
		NTR_complement_C3	1502..1651	CDD:239638	386/1667 (23%)