DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep4 and cpamd8

DIOPT Version :9

Sequence 1:	NP_001260590.1	Gene:	Tep4 / 35248	FlyBaseID:	FBgn0041180	Length:	1498	Species:	Drosophila melanogaster
Sequence 2:	XP_002934416.1	Gene:	cpamd8 / 100491045	XenbaseID:	XB-GENE-985023	Length:	1827	Species:	Xenopus tropicalis

Alignment Length:	1833	Identity:	433/1833 - (23%)
Similarity:	691/1833 - (37%)	Gaps:	546/1833 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KAEGK--YTIVGPGTIHSHRDYNVAVAVHQ--TKEPVTLKVGITGPSYNKTETVELATAGEFKQI 85
            :||.:  |.:..|....|..:..|:|.:..  |:..|.|::.:.|      |||.........:.
Frog    15 RAEDRQGYLVAAPSVFRSGVEEVVSVTIFNATTETKVQLQLVVKG------ETVAHGHGIVLDKG 73

  Fly    86 TFKL--PPLEAGEYNLTAEG-----VKGLEFKNSTKLNWENFKPYIKIQTDKGKYKPGDTINYRV 143
            |.|:  |....|:.||...|     .:|..|.|||.:..::....:.|||||..|||...:...:
Frog    74 TVKILVPSGLRGQANLKVWGNRHLTEEGFSFHNSTTVTVDSKGSSVFIQTDKPIYKPKQKVLINM 138

  Fly   144 IFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIK-TTGGVYTGKFELSEFATLGSWSLHVQNGD 207
            ..:..:|||.:.|.|..:.  |.:.:||.|...:: ...||....|.||:....|.|.:..:..
Frog   139 FMVTPDLRPTSEKIEAYIL--DPRGSRIIQWTDLRPICCGVVNMSFPLSDQPVFGEWLIFAETQ- 200

  Fly   208 QHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQQVSVRD------GEFN 266
                              ||.:::|     |.|:||||||:.:.:.....  :||      |
Frog   201 ------------------GHTYNKS-----FSVQKYVLPKFELVISPPSY--IRDIGTCEKG--- 237

  Fly   267 VVLKANYTYGKPVNGKVLVNVHLDSTSSWENVDG----KTVQ----------------TDYPGH- 310
             .:||.||:||||.|.:.:|:.:.....:::..|    ||::                .|:|.|
Frog   238 -TVKARYTFGKPVKGLLTINMTVTGVGYYKHEIGLQVLKTMEIYGSAVFDICAKDMMPVDFPEHF 301

  Fly   311 ----SVVGTADMVGGKAKLTMDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPY 371
                ::..|...|.|..::|.|                         |.|.|:      .||...
Frog   302 RGTVNIWATVISVDGSKQVTFD-------------------------DSTPVQ------KQLIDI 335

  Fly   372 RYEMSCTDYSSCFSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQE 436
            :|......     .|||...::...::||.|||........:||:.|
Frog   336 KYTKDTKK-----QFKPGLPYQGKVEVTYPDGSPADGVTVQIKAELT------------------ 377

  Fly   437 PELPTIEKKTFVFESHL-NASGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTTYPYREP 500
                   .|..|:.|.| :.:|:..|::  |.:|..|.:. :...::..:|.|
Frog   378 -------PKDNVYTSELVSRNGLVEFQI--PSIPTGAQYV-WLETKVMAIDGK------------ 420

  Fly   501 KQIENPSSEEE-------KEWFRAE-----VQRPKDVWNLKIGQEYQVILNSSRPLKYFV-YNIV 552
                 |:.|:.       ..|:...     :|.|::  .|.:|:|.::.|.|:.|....: |.:|
Frog   421 -----PAGEQYLPNYLSISSWYSPSKCHLLIQPPEE--PLLVGEEARIALKSTCPCNSTLHYELV 478

  Fly   553 GRGNIL------------ETKR--------------VDLAEPQ----------TTVNVTIKPTFL 581
            .||||:            .:||              .:.|..|          |.|:.|:  |..
Frog   479 ARGNIVLSGKQPGKVTLKRSKRDAFVTFDKDTHESVTNTASTQIPSEDSTVWLTYVHFTV--THN 541

  Fly   582 TTPYGRVYFYYVDETGEFRYTEETFSVEVELQNQIEIK-APAEVKPGADVALEIKTSPKSFVGLL 645
            ..|..|:..|||.|.||.........::...:||:.:. :....:||..|.:.:|.:..|.|.:.
Frog   542 MAPLSRILVYYVRENGEGVTDSAQIPIKPVFENQVSLTLSTNNSRPGDAVDINVKAAKGSCVCVA 606

  Fly   646 AVDQSVLLLGSNNDLNKESFNWRLNGYDTS--TPWQGGYSYYPG--------------------- 687
            .||:||.||.:...|..|.....|:.:|.|  |....|:.::||
Frog   607 TVDKSVYLLRNGFQLTPEQIFQELSEFDVSDGTGKDEGHFWWPGMGSQRRRRSSLFPWHWDITKD 671

  Fly   688 -----ERTGVVTMTNAY---------FFYNRTAPDYNILTEGFGGSSFAMRKTTVAHDSHVFHSG 738
                 ..||::.||:..         .:.:...|.:...|....|||:....|........|
Frog   672 ARFAFTETGLIVMTDIVSLNHRQSGGMYTDEAVPAFQPHTGTLVGSSYTRMATRTEKRKRTF--- 733

  Fly   739 AGGPTQAVGFSAESASASAAPVVRKNFAETWIF-----ADIESTEEEVFKWVKTIPDTITNWVVT 798
                                      |.|||::     :|:...::...:    :||:||.|:..
Frog   734 --------------------------FPETWVWHCFNVSDVTGEQQLHVE----VPDSITTWITE 768

  Fly   799 GFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNED 863
            ..::..:|||||.. |.::|.|:|||:...|||.|.|||.:.:|..|:||||..::|.:.: ...
Frog   769 AIAISSKKGLGVAG-QAHLKAFKPFFIDFTLPYHVIRGEQVKIPLTVYNYLPVGVEVHVKI-TIP 831

  Fly   864 QEYDFVDASNE---------VIGDQKRTQ-----------NIRVGANEAAGASFL-----IRPKV 903
            :...||....:         ..|:.|.|.           ||...|...||.|..     :|.|.
Frog   832 KGIKFVGYPGKQYLIRKLCVASGETKPTSAVFAFTDLGQANISARALAFAGMSCFPEGNTLRNKH 896

  Fly   904 IGNILLKFKAISPLAGDAIHKPLKVVPEGIT-------------------------QY------- 936
            ..:..|:.|.  |...|.:.:.|.|.|||:.                         ||
Frog   897 ADDAYLEKKV--PAGTDFVRRSLMVEPEGLAREYTYSVFFCPNEKIQISTPNKFEYQYVQKPQRM 959

  Fly   937 -----------------------------------QN---------------------------- 938
                                               ||
Frog   960 THFDLTVKAHNDAHIALSSGPHDMAEMIEIVIGGQQNSRTWISTSKMGDPVSSASTSSVLSWDEF 1024

  Fly   939 RAFFINLKD---------------------------------------TGEFK------------ 952
            |||:|:.|:                                       .||||
Frog  1025 RAFWISWKNGVIQVGYGIYSSNDSVIVEWTVDRQPDVKFIGFSTGWGSMGEFKIWRKEETDENHN 1089

  Fly   953 NTFELEVPEDVVPDSERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSI 1017
            ..|.|.||.:|:|.|||....::||::||.|.||:||||||.|||||.|....||..|..||:..
Frog  1090 EAFTLGVPHNVIPGSERATASIIGDVMGPTVSNLDNLLRLPFGCGEQNMIHFAPNVFVLKYLQKT 1154

  Fly  1018 KKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSFSKIK 1082
            ::|.|.:::.....|..|||..|.|:..|||:|:||     :.|  .:||.||||:||:||::.:
Frog  1155 RQLCPEVESEAVDYLVQGYQRQLTYKRLDGSYSAFG-----ERD--SSGSMWLTAFVLKSFAQSR 1212

  Fly  1083 DIIDLDEQILAKGYEFLLTRQAENGSFTEHGEY----FYSSQRSLLTLTANSLLALLE---EEKP 1140
            ..|.:|...|:...::::..|.::|||...|..    ........:.|||....||||   ..:.
Frog  1213 GFIFIDPGELSAAKDWIIQHQNKDGSFPAMGRILNKDIQGGNHGKIALTAYVAAALLETGVTSED 1277

  Fly  1141 NQAAIDKAVAYLSANTAESIELLPKSIAIYALQKAKAPEAAKQVASLKSLAKHEDDRTWWT---- 1201
            .:.|:.||..:|.::.....:....::..|||...::..|...:..|.::|...|..|.|:
Frog  1278 ERIAVSKAKLFLESHLFTVDDPYTTALTSYALTLLRSTYAPVALRKLNAMAITHDGFTHWSLTGS 1342

  Fly  1202 ----EDL-----DKLRASKNCGRWWCWIWSQDVEITSYALLS-LLDSDQETADSVLNTVRWLIAQ 1256
                ||.     |.|..|         :.|.:||:|:||||: .|..|   ..|.|..|:||..|
Frog  1343 AATEEDTFMGFNDGLSQS---------VISAEVEMTAYALLTYTLMGD---VASALPVVKWLSQQ 1395

  Fly  1257 RNGFGGFASSQDTVVGLTALIKFAEKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQTVEF 1321
            ||..|||:|:|||.|.|.||.::|..|........:::::. ..:..|.......|..:|||.:.
Frog  1396 RNSLGGFSSTQDTCVALQALAEYAILSYVGGVNLTISLAST-NLDYQETFELHRLNKKILQTAKI 1459

  Fly  1322 PQGTKSLEFEAKGTGAAMVQISYQYNLVEKEPKPSFKI------------------QTT-----V 1363
            |.....|...|||.|..::||...||:.:...||:|::                  |.|     .
Frog  1460 PSIPTGLFVSAKGEGCCLMQIDVHYNVPDPVAKPAFQLLIYLKEPKLSRKRRHVVHQETPLRDRA 1524

  Fly  1364 LP-ESSPAN--------LELSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSFADIRNIERVR 1419
            || :..|.:        :.|..|..::..|   .||||:||::|.||:.||.:|...:...:::.
Frog  1525 LPDDDDPGSHQDHQEYKITLEACTRWLHAG---ASNMAVLELALLSGFRADIESLEQLLLNKQIG 1586

  Fly  1420 LVETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKKATEYY--SIK 1482
            |...:.....|:.||:.:......|::::|:|.:.|....|..|.:||||:...:||.:|  |..
Frog  1587 LKRYEIDGRKVLFYFDEIPSQCLTCVKLQAFREYIVGKTAPVPVKIYDYYEPTFEATRFYNASES 1651

  Fly  1483 SKLC-DICEGDDC 1494
            |.|. ::|:|..|
Frog  1652 SPLSRELCDGTTC 1664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081	24/93 (26%)
		A2M_N_2	528..653	CDD:285005	40/162 (25%)
		A2M	768..859	CDD:278630	33/95 (35%)
		A2M_2	982..1279	CDD:239227	107/317 (34%)
		A2M_comp	1035..1281	CDD:284982	84/266 (32%)
		A2M_recep	1389..1479	CDD:284981	28/89 (31%)
cpamd8	XP_002934416.1	MG1	22..>83	CDD:375333	15/66 (23%)
		YfaS	<54..>257	CDD:225248	63/240 (26%)
		MG4	339..>398	CDD:375332	17/88 (19%)
		A2M_N_2	444..615	CDD:377903	42/174 (24%)
		A2M	737..828	CDD:365945	33/95 (35%)
		Methyltransf_FA	974..1075	CDD:371989	7/100 (7%)
		A2M_2	1119..1418	CDD:239227	107/317 (34%)
		A2M_recep	1556..1646	CDD:369460	28/89 (31%)
		KAZAL	1700..1744	CDD:197624
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9343
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	1	1.000	-	-		FOG0002157
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920