DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep4 and LOC100487578

DIOPT Version :9

Sequence 1:	NP_001260590.1	Gene:	Tep4 / 35248	FlyBaseID:	FBgn0041180	Length:	1498	Species:	Drosophila melanogaster
Sequence 2:	XP_012809164.2	Gene:	LOC100487578 / 100487578	-ID:	-	Length:	1437	Species:	Xenopus tropicalis

Alignment Length:	1574	Identity:	405/1574 - (25%)
Similarity:	688/1574 - (43%)	Gaps:	249/1574 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VSLCVILALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGITGPSYNKTET 73
            :|:|:.:......||.:|....|:... .||..:: ...|.:.|.|..|:|::.:....:::...
Frog     6 ISVCLSILDFGAAEPPQAHFMITVPAQ-LIHPSKE-EACVTLLQLKGAVSLRMELHRDDHHQVVA 68

  Fly    74 VELATAGEFKQ-ITFKLPPLEAGE----YNLTAEGVKGLEFKNSTKLNWENFKPYIK-IQTDKGK 132
            .:..|...|.. ..||:|..|...    ::::||| ..:.. |.||......:.|:. |||||..
Frog    69 DDKITTESFTHCYPFKVPAAEEDREVWLFHVSAEG-DNINI-NQTKKVLIMEQMYVTLIQTDKPM 131

  Fly   133 YKPGDTINYRVIFLDENLRPDTAKDE--VVVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFAT 195
            ||||..:|:||:.|.::..   |:|:  .:|...|...|||.|...:..|.|:....|.|:|...
Frog   132 YKPGQIVNFRVVTLGKDFH---AQDDKYPLVELLDPNDNRIGQWLDVAPTQGIADFSFRLAEEVE 193

  Fly   196 LGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQQVSV 260
            ||.:.:::.:.:                       ||.:  :|.|.:|||.::.|.:.|.:.||.
Frog   194 LGRYKINIPSTE-----------------------RSSQ--SFIVAEYVLKRFKVDIHAQEDVSP 233

  Fly   261 RDGEFNVVLKANYTYGKPVNGKVLVNVHLDSTSSWE----NVDGKTVQTDYPGHSVVGTADMVGG 321
            .|..|::.:..:|||||||.|.:.:.|...:.:.|.    :.|.:..:...|  ::.|..|..|.
Frog   234 TDDSFHLEVCGSYTYGKPVRGVMNITVFPLNIAWWRLYYGDFDREPTEELMP--TMQGRTDDRGC 296

  Fly   322 KAKLTMDLKDFASYLPHKTSSS---YAQITATVEEDFTGVKLNETGGVQLYPYRYEMSCTDYSSC 383
            ..| .:||.      |...|::   ...|.|.:.||.||  |.|:|.       :.:..||:.:.
Frog   297 FTK-DIDLH------PFNVSTNPRVKIVILALLTEDNTG--LEESGS-------HFIEFTDHQTV 345

  Fly   384 FSFKPDKEHELNFKITYVDGSLITDTKSVVKAK-FTEGIRRNYAFY-AFGTDHQEPELPTIEKKT 446
            .....|..::.....|           .::||: .....|:|...| ....|..:..: |:|
Frog   346 EFVNLDSYYQKGIPFT-----------GMLKARTLKREPRKNEKVYLVVNVDEVDTNI-TLE--- 395

  Fly   447 FVFESHLNASGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTTYPYREPKQIENPSSEEE 511
                  .:|:|:|.|.:...:..|:.:.|..:|:|     :..|::....:..|...|:.|
Frog   396 ------TDANGIARFTLDTSEWNDMVSLTGKFSLE-----DGDDMFVALNWLFPFYSESNS---- 445

  Fly   512 KEWFRAEVQRPKDVWNLK--IGQEYQVILNSSRP----LKYFVYNIVGRGNILETK--RVDL--- 565
              :.:.:......:.:.|  :..||.:..|...|    |.:| |.::.:|.|:..|  :||:
Frog   446 --FLKVQTVAEDLLCSTKQSVSVEYTIDKNELDPESDHLSFF-YILMSKGEIITNKEHKVDVPNL 507

  Fly   566 -AEP--QTTVNVTIKPTFLTTPYGRVYFYYVDETGEFRYTEETFSVEVELQNQIEIK-APAEVKP 626
             :.|  |.:.|:|........|...:..|.:...||.......:.|.|...|::::: ....|:|
Frog   508 PSGPILQGSFNITFSVNVNLVPVATLLVYAIFPDGEVAADRARYRVPVCFDNKVQLEFTENNVRP 572

  Fly   627 GADVALEIKTSPKSFVGLLAVDQSVLLLGSNN----------------DLNKESFNWRLNGYD-- 673
            |.:|.|::|....|...:.:||:.:|||..:.                ::|:..|.:.:..::
Frog   573 GGNVNLDVKADAGSLCSVRSVDKGLLLLQEHKTNEILSRVMGYYEYMFEINRRGFPYTIEDFEPY 637

  Fly   674 -----------------TSTPWQGG----YSYYPGERTGVVTMTNAYFFYNRTAPDYNILTEGFG 717
                             ...||...    ||.:......|.|.|..........|:|   |..|.
Frog   638 PCLEDAPVLPNRAKRSIKRAPWYQSEADVYSLFKSSNLKVFTNTRIRKPVTCELPEY---TRRFS 699

  Fly   718 GSSFAMRKTTVAHDSHVFHSGAGGPTQAVGFSAESASASAAPVVRKNFAETWIFADIESTEEEVF 782
                             ...|.|...:.:. |..:|.||....|||.|.|||:: |:.|...:..
Frog   700 -----------------IKDGVGAADRKLD-SPSTAPASKEHPVRKFFPETWLY-DLVSVGPQGK 745

  Fly   783 KWVK-TIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVF 846
            |.:. |.|.:||.||...|.: ...|.|..:| ..:|||||:|:.:.|||||.:.|...:.|||:
Frog   746 KSLNLTAPHSITEWVTDAFCV-GNSGFGEVHD-IRMKTFQPYFIDLLLPYSVVQKEHFTLTALVY 808

  Fly   847 NYLPKTLDVELTL----DNEDQEYDFVDASNEVIGDQKRTQNIRVGANEAAGASFLIRPKVI--- 904
            |||...:.||:.|    |..:...| ::.|..:.|.:..:....:.|.:.....|.:..:.:
Frog   809 NYLNHCVLVEVALTIPPDFGEPRTD-IEKSACICGQETASFTWNITATKLGTIPFKVTSRALHVE 872

  Fly   905 ---GNILL----KFKAISPLAGDAIHKPLKVVPEGITQYQNRAFFINLKDTGE-FKNTFELEVPE 961
               .:::|    |||      .||:.|.:.|.|.|:...:.....  |..||: .:....|.:|:
Frog   873 GDCSDVVLDPETKFK------HDAVQKTILVKPSGVEVDKTHTSL--LCPTGDSVRGEISLVLPD 929

  Fly   962 DVVPDSERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKKLTPALDT 1026
            :||..|......::||::|.::.||.|||:||:|||||.|:...||..|.:||:|.|.|||.:..
Frog   930 NVVEGSGHAHVTVLGDIMGNIISNLGNLLQLPTGCGEQNMALFAPNVYVLEYLESAKALTPEIKD 994

  Fly  1027 RIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSFSKIKDIIDLDEQI 1091
            ::...|..|||..|.::||:|::|:||     ::|  ..|:|||||.|:|.|||.:..:.:||:.
Frog   995 KVLNYLTTGYQRQLMFKHDNGAYSAFG-----KKD--EEGNTWLTAMVVRCFSKAQKTVFIDEKH 1052

  Fly  1092 LAKGYEFLLTRQAENGSFTEHGEYFYSSQRSL----LTLTANSLLALLEE-EKPNQAAIDKAVAY 1151
            :....::|.:.|.:||.|...|:.|.:..:..    :.::|...:||||. ...|.:.::.|:..
Frog  1053 IQDAIKWLGSHQLDNGCFRSVGKLFNNGLKGAVDDEMAISAYITVALLEHGTVHNSSLVENALRC 1117

  Fly  1152 L--SANTAESIELLPKSIAIYALQKAKAPEAAKQVASLKSLAKHEDDRTWWTEDLDKLRASKNCG 1214
            |  :|||..:  ...::|..||.                :|:..:|.|....::|:|....:...
Frog  1118 LKDAANTVNN--TYNEAILAYAF----------------TLSGDKDLRQHMLDELEKEVIEEGGS 1164

  Fly  1215 RWWCWIWSQDVEITSYALLSLLDSDQETADSV---LNTVRWLIAQRNGFGGFASSQDTVVGLTAL 1276
            :.|...||..|||:||.||:||..|:.|...:   .|.:.|:|.|:|.:|||.|:|||||.:.||
Frog  1165 KHWSEQWSGAVEISSYVLLALLSGDEVTKKDLELSSNIISWVIKQQNPWGGFYSTQDTVVAVHAL 1229

  Fly  1277 IKFAEKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQTVEFPQGTKSLEFEAKGTGAAMVQ 1341
            .|:|..:.:|.....:|| :.|......:.:..:.|.||||....|....:....|.|||...||
Frog  1230 SKYARATYHEKRDVALTV-HSGLIGYQNRFHVDDSNRLLLQRAPLPDELGTYIITATGTGCVYVQ 1293

  Fly  1342 ISYQYNLVEKEPKPSFKIQTTVLPESSPA----NLELSVCVDYVEEGESKESNMAILEVSLPSGY 1402
            ...:|:....|....|.::.|..|::..|    :.|:.:.|.|  .|....:||.|::|...||:
Frog  1294 GHLKYHTHPAESFQHFTLKVTTEPDNCTAEAERSFEIHMAVSY--SGNRATTNMGIIDVYHVSGF 1356

  Fly  1403 TADEDSFADIRNIERVRLVETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYD 1467
            .....|...:...|.|:..|..  |..|.||.|.|. :|.:...|...:...|:|.:|::|::||
Frog  1357 APVARSLKLLEKKENVKRTEVT--DEKVSIYLEELT-HETETFSIVVKQETPVSNLQPANVIVYD 1418

  Fly  1468 YYDTNKKA-TEYYS 1480
            |||..::| .||::
Frog  1419 YYDPRERAEAEYHA 1432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081	28/94 (30%)
		A2M_N_2	528..653	CDD:285005	33/139 (24%)
		A2M	768..859	CDD:278630	35/91 (38%)
		A2M_2	982..1279	CDD:239227	104/306 (34%)
		A2M_comp	1035..1281	CDD:284982	81/255 (32%)
		A2M_recep	1389..1479	CDD:284981	29/90 (32%)
LOC100487578	XP_012809164.2	YfaS	<125..>1043	CDD:225248	263/1036 (25%)
		A2M_N	125..223	CDD:396416	35/125 (28%)
		A2M_N_2	447..600	CDD:400170	34/153 (22%)
		A2M	732..821	CDD:395153	35/91 (38%)
		A2M_2	951..1232	CDD:239227	104/305 (34%)
		A2M_recep	1343..1430	CDD:400149	28/89 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I11799
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9328
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010