Protein Alignment Tep4 and c5

DIOPT Version :10

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: NP_001190988.1
• Gene: c5 / 100485433
• XenbaseID: XB-GENE-486371
• Length: 1688
• Species: Xenopus tropicalis
• Alignment Length: 1727
• Identity: 369/1727 - (21%)
• Similarity: 640/1727 - (37%)
• Gaps: 432/1727 - (25%)

  Fly    11 LCVILALLQTMEPVKA----EGKYTIVGPGTIHSHRDYNV----AVAVHQTKEPVTLKVGITGPS 67
            :|:..|||..:.....    |..|.:.||      |::.:    .|.|....:...|.:.|...|
 Frog     2 ICLKTALLLLLALCGCCRCQEKTYLVTGP------REWRIGALETVVVQAFGQEGDLAIRINALS 60

  Fly    68 Y------NKTETVELATAGEFK-QITFKLPPLEAGEYNLTAEGVKGLEF----KNSTKLNWENFK 121
            |      ..|:.:.|.....:: .:...:.|.:...|:.:    ..::|    ..|...|.|...
 Frog    61 YPDKKTTYATQHLVLNDQNNYQGLVKLMIQPKDFPTYSSS----DPMQFIYLQAQSNAFNKEEQV 121

  Fly   122 P------YIKIQTDKGKYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTT 180
            |      ::.|||||..|.|..::..||..:||.|:|...|  ||:.|:|.:..::...:....|
 Frog   122 PVSYRNGFLFIQTDKPFYTPDQSVKIRVYSMDEELKPGRRK--VVLTFKDPEEVKVDSIEEDDLT 184

  Fly   181 GGVYTGKFELSEFATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVL 245
            |.:....|::......|.|::....|             |.|...|        ...|||::|||
 Frog   185 GIISFPAFKIPANPKFGMWTIEAAYG-------------KDFTTSG--------TAKFEVKEYVL 228

  Fly   246 PKYSVKMDATQQVSVRD--GEFNVVLKANYTYGKPV-NGKVLVNVHL----DSTSSWENVDGKTV 303
            ||:.|.::..:.....|  .||.:.::|:|.:.|.| |.||.:...|    :.|...:::|   :
 Frog   229 PKFFVSIEPEKNFICYDKFTEFTITVRASYYFKKLVDNAKVYIRYGLIQDGERTMLPKSID---L 290

  Fly   304 QTDYPGHSVVGTADMVGGKAKLTMDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQ- 367
            |:.:.|.|:...      .::..::...::|.  .:.|.||..||.:|||.....:.:|...|:
 Frog   291 QSMFNGESIFQF------NSQKAVEELGYSSL--EEISGSYLYITVSVEESTGRTEESENVDVKF 347

  Fly   368 -LYPYRYEMSCT----------------------------------------------------- 378
             |.||.:::..|
 Frog   348 VLSPYTFKLVGTPLYVKPTLPYYIKVQLRDTMDKPVGNIPLVLSGDMVKEDGTSEPLTGGRLRMS 412

  Fly   379 ----DYSSCFSFK-PDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPE 438
                |.:..|... |.....|:||||..||||..|.::.|
 Frog   413 SDKRDGTGVFVLNIPSDISSLDFKITTDDGSLPEDNQATV------------------------- 452

  Fly   439 LPTIEKKTFVFESHLNASGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTTYPYREPKQI 503
                        :|:..|                    |.|:      .|..||..:
 Frog   453 ------------NHVAVS--------------------YQSL------TKSYLYINW-------- 471

  Fly   504 ENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQVILNSSRP----LKYFVYNIVGRGNILETKRVD 564
                            .|.|:|  |.:|....:.|..:.|    |:::.|.::.:|.||....|.
 Frog   472 ----------------AREKEV--LHVGSFLTIHLVPNSPYIAKLRHYSYLLISKGKILNFGTVQ 518

  Fly   565 LAEPQTTVNVTIKPTFLTTPYGRVYFYYV---DETGEFRYTEETFSVEVELQNQ--IEIKA-PAE 623
            ..|...:.::|:..|....|..|:..||:   |.|.|.........|.....|.  :|:.. ...
 Frog   519 RVEGSDSQSLTLPITSDMVPSVRLLVYYIVTGDATAELVADSIWLDVVESCVNHQTVELSTRETT 583

  Fly   624 VKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKESFNWRLNGYDTSTPWQGGYSYYPGE 688
            :|||....|::....||.|.|.|||.::..:|.......|:...::...|.......|.:.....
 Frog   584 LKPGQKFNLKVSGPSKSLVALSAVDTAIYDVGKRFQRPLETVFRKIEESDLGCGAGAGQNNADVF 648

  Fly   689 R-TGVVTMTNAYF------------------FYN---------RTAPDYNI-------------- 711
            | .|:..:|||..                  .:|         |...|.||
 Frog   649 RLAGLTFLTNANIQASQKYALKCNEVLRPKRSFNFKEEINKKARVYKDRNIRKCCYDGVKCFLEE 713

  Fly   712 -----------------LTEGFGGSSFAMRKTTVAHDSHVFHSGAGGPTQAVGFSAESASASAAP 759
                             .|:.|....|..:......|:.:...|.|........:.:.      |
 Frog   714 NDCTAGISRVSKRYGKSCTDTFQDCCFFAKSLKEKMDAEIQDVGMGRMYIRTVLNIDE------P 772

  Fly   760 VVRKNFAETWIFAD--IESTEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQP 822
            .:|..|.|:|::.:  ::...|:...  .|:||::|.|.:.|.|: ..|||.|. |:..:..::.
 Frog   773 QIRSYFPESWLWEEYLLDDRGEKTLS--VTLPDSLTTWEIQGVSM-SDKGLCVA-DRFKVTAYKD 833

  Fly   823 FFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVDASNEVIGDQKRTQNIRV 887
            :|:.|:|||||.|||.|.:..:||||....:...:.:..|.:...|.:.|..  ...|...:..:
 Frog   834 YFLDVQLPYSVVRGEQIQIKVVVFNYRNNNVKGCVLMSAEKEICKFSETSTR--KGLKECFSHTL 896

  Fly   888 GANEAAGASFLIRPKVIGNILLKFKAISPLAGDAIHKPLKVVPEGITQYQNRAFFIN---LKDTG 949
            .|:.....:|.|.|..:|...|.|...:..:.|.:.|.|:||||||.:.:|..|.::   ::...
 Frog   897 SASSLTPFTFTILPLEVGLHPLTFTLSASGSSDIVKKTLRVVPEGIKKERNAGFTLDPQGIRGVA 961

  Fly   950 EFKNTFELEVPEDVVPDSE-----RVEFGLVGDLLGPVVKN--LENLLRLPSGCGEQTMSKLVPN 1007
            ..:.....::..::||.|:     .:...::|:::..|||:  |:.|:.||....|..:.::||.
 Frog   962 RRRQDISYKIHANIVPKSKVSRILSISGNILGEVINTVVKSEGLQYLISLPKASAETELMRVVPI 1026

  Fly  1008 YLVRDYLKSIKKL----TPALDTRI--KRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNG 1066
            :.|..||::.|:.    |..|..:|  :|.:::|...:|.:|..|.|:|.     |::..|
 Frog  1027 FYVYHYLETSKRWDLLGTNILAAQIEMQRKMREGVNSILSFRGSDYSYSI-----WKEGKP---- 1082

  Fly  1067 STWLTAYVLRSFSKIKDIIDLDEQILAKGYEFLLTR-QAENGSFTEHGEY----------FYSSQ 1120
            |.||||:.|:.|.:|:..:.:::..:.....:|:.: |..:|||.:...|          ..|.:
 Frog  1083 SAWLTAFALKIFGEIEKYVYVNKMSVCNSISWLIDQCQLRDGSFIDRSGYQPGKLQGTIPSESEE 1147

  Fly  1121 RSLLTLTANSLLAL--------LEEEKPNQAAIDKAVAYLSANTAESIELLPKSIAIYALQKAKA 1177
            |||. |||...:.:        |||.   .||:.:|..|||.|..::......:||.|||  |..
 Frog  1148 RSLY-LTAFVFIGIQKSFHMCPLEEV---NAAMRRAEEYLSNNIRKAKSTFTLAIAGYAL--ASW 1206

  Fly  1178 PEAAKQVASLKSLAKHE------DDR---TWWTEDLDKLRASKNCGRWWCWIWSQDVEITSYALL 1233
            ......|..:|...:.|      .|.   .:|.:.|.|:..:.....     .::.||.|:||||
 Frog  1207 DGTLASVRYVKGALEREAYVIESGDLPIVRYWKDSLKKVNPTAPGAE-----SARMVETTAYALL 1266

  Fly  1234 SLLDSDQETADSVLNTVRWLIAQRNGFGGFASSQDTVVGLTALIKFAEKSGYEAAKWEVTVSNKG 1298
            ..|...|:  |.....||||..|:...|||.|:|||.:.|.||.:.:...........|.||.|.
 Frog  1267 MYLKLAQK--DYYNPVVRWLKEQQRYGGGFYSTQDTAIALEALTEVSIVDKKLTLNMAVQVSYKK 1329

  Fly  1299 KRE-------KTEKLNTSEE----NDLLLQTVEFPQGTKSLEFEAKGTGAAMVQISYQYNLV--- 1349
            ..:       :|......||    .||::.|             ....|.|.|.:...||::
 Frog  1330 SGDFKNYRLTETSSFTRPEEVPLPEDLIVST-------------PTANGIATVHVQTVYNIISPP 1381

  Fly  1350 -EK-------EPKPSFKIQTTVLPESSPANLELSVCVDY-VEEGESKESNMAILEVSLPSGYTAD 1405
             ||       ..|.::|.:.::........:.:..|..| ..:.:...|..|::|:::.:|...|
 Frog  1382 QEKCQFHLKIGKKLNWKPRQSIFDSDKSGAIPIEACARYKAPDDDPYISGSAVMEITMVTGLVVD 1446

  Fly  1406 E----------DSFADIRNIERVRLVETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQKP 1460
            |          |.|....:||          |..|.::|:.:..:|..|:.:.|:....|:...|
 Frog  1447 ESELEELAQRVDQFVTAYDIE----------DGKVNLHFDGIPSDEYICVTLLAWEQFKVSMLSP 1501

  Fly  1461 SSVVLYDYYDTNKKATEYYS--IKSKLCDICEGDDCK 1495
            ....:|:::..:::.|..::  ....|.::|.|:.||
 Frog  1502 GVFRVYEFHAPDEECTTLFNPLASQDLVNVCTGNQCK 1538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	YfaS	<76..1411	CDD:441940	336/1560 (22%)
		A2M_2	982..1279	CDD:239227	95/332 (29%)
		A2M_recep	1387..1480	CDD:462226	20/102 (20%)
c5	NP_001190988.1	MG1	22..124	CDD:465508	20/111 (18%)
		YfaS	<128..1375	CDD:441940	312/1416 (22%)
		complement_C3_C4_C5	1001..1309	CDD:239226	93/329 (28%)
		A2M_recep	1430..1521	CDD:462226	20/100 (20%)
		NTR_like	1532..1688	CDD:470599	4/7 (57%)