DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tep4 and WASHC1

DIOPT Version :9

Sequence 1:	NP_001260590.1	Gene:	Tep4 / 35248	FlyBaseID:	FBgn0041180	Length:	1498	Species:	Drosophila melanogaster
Sequence 2:	XP_011515961.1	Gene:	WASHC1 / 100287171	HGNCID:	24361	Length:	474	Species:	Homo sapiens

Alignment Length:	255	Identity:	59/255 - (23%)
Similarity:	83/255 - (32%)	Gaps:	82/255 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   379 DYSSCFSFKPDKEHELNFKITYVDG-----SLITDTKSVVKAKFTEGIRRNYAFY-----AFGTD 433
            |:..|.|.||:.|.:..      :|     |.|:...|::....||.:.:.|.|.     |....
Human   150 DFPVCVSTKPEPEDDAE------EGLGGLPSNISSVSSLLLFNTTENLYKKYVFLDPLAGAVTKT 208

  Fly   434 HQEPELPTIEKKTFVFESHLNAS-------------------GVAP---FKVVLPDLPDIANFTR 476
            |......|.||   :|::.|:.|                   |..|   ....|||||.||| ..
Human   209 HVMLGAETEEK---LFDAPLSISKREQLEQQVPENYFYVPDLGQVPEIHVPSYLPDLPGIAN-DL 269

  Fly   477 YYSIELEFVDEKRDLYTTYPYREPKQIENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQV----- 536
            .||.:|.            |...|..   |.:..|...|..||..|     ||:..:..|
Human   270 MYSADLG------------PGIAPSA---PGTIPELPTFHTEVAEP-----LKVDLQDGVLTPPP 314

  Fly   537 ----------ILNSSRPLKYFVYNIVGRGNILETKRVDLAEPQTTVNVTIKPTFLTTPYG 586
                      :|.|:.||.......||:|     .|.|.:....:.:|...|..:..|.|
Human   315 PPPPPPPAPEVLASAPPLPPSTAAPVGQG-----ARQDDSSSSASPSVQGAPREVVDPSG 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081
		A2M_N_2	528..653	CDD:285005	16/74 (22%)
		A2M	768..859	CDD:278630
		A2M_2	982..1279	CDD:239227
		A2M_comp	1035..1281	CDD:284982
		A2M_recep	1389..1479	CDD:284981
WASHC1	XP_011515961.1	WASH_WAHD	59..306	CDD:288773	45/185 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900