DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep4 and cpamd8

DIOPT Version :9

Sequence 1:	NP_001260590.1	Gene:	Tep4 / 35248	FlyBaseID:	FBgn0041180	Length:	1498	Species:	Drosophila melanogaster
Sequence 2:	XP_003201105.2	Gene:	cpamd8 / 100151400	ZFINID:	ZDB-GENE-050208-428	Length:	1860	Species:	Danio rerio

Alignment Length:	1834	Identity:	451/1834 - (24%)
Similarity:	717/1834 - (39%)	Gaps:	505/1834 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FAVSLCVILALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVAVHQTKEP--VTLKVGITGPSYN 69
            :.|.:|.:::.:.:.|   .:| |.|..|....:..:..|:|.:....|.  |.|::.:.|....
Zfish    14 WTVFMCGVMSGVHSQE---RQG-YLIAAPSVFRAGVEEAVSVTLFNMVEDTRVQLQLSVKGEIVA 74

  Fly    70 KTETVELATAGEFKQITFKLPPLEAGEYNLTA-------EGVKGLEFKNSTKLNWENFKPYIKIQ 127
            .:.    .|..:...|..|:|....|:.:|..       ||  |..|:|.|.:..::....:.||
Zfish    75 HSH----GTVRDKGTIKIKVPSDLRGQAHLKVWGNCQLNEG--GYIFQNHTTVTIDSKGTTVFIQ 133

  Fly   128 TDKGKYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKT-TGGVYTGKFELS 191
            |||..|||...:...|..:..:|:|.:.|.|  .:..|.:.:.|...|.:|: ..|:....|.||
Zfish   134 TDKPVYKPQQKVLINVYAVTPDLKPTSEKLE--AYIVDPRGSHIVHWKDLKSICCGIVNMSFPLS 196

  Fly   192 EFATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSV------ 250
            :....|.|.:.|:..                   ||.:::|     |||:|||:|::.:
Zfish   197 DQPVFGEWLVFVEMQ-------------------GHTYNKS-----FEVQKYVMPRFELIIVPPP 237

  Fly   251 ---KMDATQQVSVRDGEFNVVLKANYTYGKPVNGKVLVNVHLDSTSSWENVDGKTVQTDYPGHSV 312
               .:::.:||:|         ||.||:||||:||:.||:         .|:|........||.|
Zfish   238 YIRDLNSCEQVTV---------KARYTFGKPVSGKLTVNM---------TVNGVGYYRHEVGHPV 284

  Fly   313 VGTADMVGGKAKLTMDLKDFASYLPHKTSSSYAQITATVEEDFTG-----VKLNET-GGVQLY-- 369
            |.:.: :.|.|..::.:||              .:...|.:.|.|     |.:|.. ||.|..
Zfish   285 VKSME-IKGSASFSLCVKD--------------MMPIEVTDHFRGAVNMWVTVNSVDGGQQTMFD 334

  Fly   370 ---PYRYEMSCTDYS--SCFSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYA 429
               |...::....||  :...|||...::...::||.|||........|||:.|
Zfish   335 DSTPVHKQLIDIKYSKDTRKQFKPGLPYKGMIEVTYPDGSPAEGVHVRVKAELT----------- 388

  Fly   430 FGTDHQEPELPTIEKKTFVFESHL-NASGVAPFKVVLPDLPDIANFTRYYSIELEFVDEK--RDL 491
                          .|..|:.|.| :.:|.|.|::  |.:|..|.:. :...::..:|.|  .|.
Zfish   389 --------------PKDNVYTSELVSKNGKATFEI--PSIPTAAQYV-WLESKVTAIDGKPAGDQ 436

  Fly   492 YTTYPYREPKQIENPSSEEEKEWF---RAEVQRPKDVWNLKIGQEYQVILNSSRPLKYFV-YNIV 552
            |.            |:......|:   :..:|.......|.||||.::.|.|:.|..:.: |.|.
Zfish   437 YL------------PNYLSITSWYSPSKCHIQLLSPSAPLMIGQEAEIFLKSTCPCNFTLHYEIA 489

  Fly   553 GRGNILET------------KRVDLAEPQTTVNVTIKPT------------------FLTT---- 583
            .||||:::            ||..:.. .|.::.|.||.                  |..|
Zfish   490 SRGNIVQSGQRHANSTTHREKRATITF-DTNIHTTAKPQQDSDSSQAEMDSCVSVLHFNVTPPMA 553

  Fly   584 PYGRVYFYYVDETGEFRYTEETFSVEVELQNQIEIK-APAEVKPGADVALEIKTSPKSFVGLLAV 647
            |..|:..|||.|.||.........|:...:|:|.:. :..|..||:.::|::|....|.|.:.:|
Zfish   554 PLSRLLVYYVRENGEGVTDSLQLPVQSRFENEISVSLSTNESMPGSPISLKVKAESGSCVCVASV 618

  Fly   648 DQSVLLLGSNNDLNKESFNWRLNGYDTS----TPWQGGYSYYPG--------------------- 687
            |:|:.||.....|..|.....|..:|.|    .|...|:.::||
Zfish   619 DKSMYLLKPGFQLTPEKVFKDLAEFDVSDAFGVPKDEGHFWWPGLSSRRRRSSVFPWHWDITKDA 683

  Fly   688 ----ERTGVVTMTNAYFFYNRTAPDYNILTEGFGGSSFAMRKTTVAHDSHVFHSGAGGPTQAVGF 748
                ..||:|.||:.....:|.:          ||  ....:...|...|         |..:..
Zfish   684 RFAFTETGLVVMTDMVSLNHRQS----------GG--MYTDEAVPAFQPH---------TSTLVA 727

  Fly   749 SAESASASAAPVVRKN-FAETWIF--ADIESTEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGV 810
            :..|.|.:.|...|:. |.||||:  .::.|...|. :....|||:||.||.....|..:||||:
Zfish   728 AMHSRSGTRAENRRRTFFPETWIWHCFNVSSLNGEA-ELHLDIPDSITTWVTEAIGLSAEKGLGL 791

  Fly   811 TNDQTNIKTFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDV-------------------- 855
            .. ...::||:|||:...||||:.|||...||..|:||||...:|
Zfish   792 AR-TAELRTFKPFFIDFTLPYSIVRGEQTKVPLTVYNYLPTCSEVHVKVSVPKGIKFVGHPGKHH 855

  Fly   856 ----------------------ELTLDN---------------------------EDQE------ 865
                                  ||...|                           |:||
Zfish   856 LTRKKCVAPGEATPTFIVLLFSELVSANITARAVAYSEPSCCSDGLQSSKASKAGEEQEDRSPVG 920

  Fly   866 YDFVDASNEVIGD---QKRTQNIRVGANEAAGAS--------FLIRPKVIGNILLKFK------- 912
            .|:|..|..|..:   ::.|.::....||....|        ::.:|..:.::.:..|
Zfish   921 MDYVRRSVLVEPEGLPREYTYSVFFCPNERIHISTPNKYEYQYVKKPAKVTHVQVAIKSHNDAHI 985

  Fly   913 AISPLAGDA----------------------IHKPLKVVP-EGITQYQN-RAFFINLK------- 946
            |:||.|.|:                      :.:|:...| .||..:.. |:|:|:.:
Zfish   986 ALSPSAHDSTEMVEIVLGGRQNSRSWISRGKMGEPVVSTPTPGILSWDEFRSFWISWRGGGVQVG 1050

  Fly   947 --------------------------------DTGEFK------------NTFELEVPEDVVPDS 967
                                            ..|||:            ..|.|.||.:|||.|
Zfish  1051 HGLEPSSETTILQLAGPLTSQVRHIGFSTGWGSIGEFRIWRKEDADENHNEAFTLGVPHNVVPGS 1115

  Fly   968 ERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSKLVPNYLVRDYLKSIKKLTPALDTRIKRNL 1032
            ||....::||::||.:.||:.|||||.|||||.|....||..|..||:...:|:..::......|
Zfish  1116 ERATAAMIGDVMGPTLNNLDKLLRLPFGCGEQNMIHFAPNVFVLKYLQKTHQLSLEVEAEATDYL 1180

  Fly  1033 QDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWLTAYVLRSFSKIKDIIDLDEQILAKGYE 1097
            ..|||..|.|:..|||:|:||     :.|  .:||.||||:||:||::.:..|.:|.:.|.....
Zfish  1181 LQGYQRQLTYKRQDGSYSAFG-----ERD--SSGSMWLTAFVLKSFAQSRGFIFIDPEELRAAKS 1238

  Fly  1098 FLLTRQAENGSFTEHGEYFYSSQR----SLLTLTANSLLALLE-----EEKPNQAAIDKAVAYLS 1153
            :|::.|.:.|||...|.......:    ..::|||..::||:|     ||:  ..|:.||.|:|.
Zfish  1239 WLISNQKDEGSFPAMGRILNKDLQGGIHGKISLTAYVVVALMETGITTEEE--NVAVAKAKAFLE 1301

  Fly  1154 ANTAESIELLPKSIAIYALQKAKAPEAAKQVASLKSLAKHEDDRTWWT--------EDL-----D 1205
            :||..:.:....:::.|||...::|.|...:..|..:|..:|..|.|:        ||.     |
Zfish  1302 SNTYSADDPYTTALSAYALTLLRSPYAPLALRRLNHMAITQDGFTHWSLTGRTETDEDTFMGFSD 1366

  Fly  1206 KLRASKNCGRWWCWIWSQDVEITSYALL--SLLDSDQETADSVLNTVRWLIAQRNGFGGFASSQD 1268
            .|..|         :.|.:||:|:|.||  :||..    ..|.|..|:||..|||..|||:|:||
Zfish  1367 GLSQS---------VVSAEVEMTAYGLLTYTLLGD----VASALPVVKWLSQQRNALGGFSSTQD 1418

  Fly  1269 TVVGLTALIKFAEKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQTVEFPQGTKSLEFEAK 1333
            |.|.|.||.::|..|........:::::. ..:..|......:|..:||....|.....|...||
Zfish  1419 TCVALQALSEYAILSYVGGVNLTISLAST-NLDFQETFELQWDNKKILQKAVIPSIPTGLFVSAK 1482

  Fly  1334 GTGAAMVQISYQYNLVEKEPKPSFKIQTT---------VLPES---------------------- 1367
            |.|..::||...||:.:...||:|:::..         :||.|
Zfish  1483 GEGCCLMQIDVSYNVPDPVAKPAFQLKVDLKEPRQEQHILPSSRHISPRTRSRADNRSELTRKRR 1547

  Fly  1368 ------SPA--------NLELSVCVDYVEEGESKESNMAILEVSLPSGYTADEDSFADIRNIERV 1418
                  .||        .:.|.||..::..|   .||||:|||.|.||:.||.:|...:...:||
Zfish  1548 APVDDEDPAGHQDHLDYRVTLEVCTRWLHVG---SSNMAVLEVPLLSGFRADIESLERLLLDKRV 1609

  Fly  1419 RLVETKNGDSVVVIYFENLAKNEEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKKATEYYSI-- 1481
            .|...:.....|:.||:.:......|:...|.|.:.|....|..|.:||||:...:||.:|::
Zfish  1610 GLKRYEVDGRKVLFYFDEIPSQCMTCVAFNAVREYIVGKTAPVPVKVYDYYEPAFEATRFYNVSE 1674

  Fly  1482 KSKLC-DICEGDDC 1494
            .|.|. ::|:|..|
Zfish  1675 SSPLARELCDGTTC 1688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081	24/93 (26%)
		A2M_N_2	528..653	CDD:285005	43/160 (27%)
		A2M	768..859	CDD:278630	39/134 (29%)
		A2M_2	982..1279	CDD:239227	109/320 (34%)
		A2M_comp	1035..1281	CDD:284982	89/269 (33%)
		A2M_recep	1389..1479	CDD:284981	31/89 (35%)
cpamd8	XP_003201105.2	A2M_N	130..221	CDD:280081	28/116 (24%)
		A2M_N_2	460..624	CDD:285005	43/164 (26%)
		A2M	748..839	CDD:278630	37/92 (40%)
		Methyltransf_FA	985..1086	CDD:289052	12/100 (12%)
		A2M_2	1130..1429	CDD:239227	109/320 (34%)
		A2M_comp	1182..1431	CDD:284982	89/270 (33%)
		A2M_recep	1580..1670	CDD:284981	31/89 (35%)
		KAZAL	1724..1768	CDD:197624
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	1	1.000	-	-		FOG0002157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820