Protein Alignment Tep4 and c4a

DIOPT Version :10

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: NP_001107156.1
• Gene: c4a / 100135012
• XenbaseID: XB-GENE-478881
• Length: 1683
• Species: Xenopus tropicalis
• Alignment Length: 1545
• Identity: 351/1545 - (22%)
• Similarity: 617/1545 - (39%)
• Gaps: 325/1545 - (21%)

  Fly   123 YIKIQTDKGKYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGK 187
            |:.|||||..|.|.:.::.|:..||..|||  .::.|.:...:::..::::.:.| :.|.|....
 Frog   141 YLFIQTDKSIYTPKEAVHIRLFTLDHVLRP--TEELVTLSVFNAQGFQVRKVEMI-SKGSVVAEN 202

  Fly   188 FELSEFATLGSWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKM 252
            ..:.:.:|.|.|.:..:..|.                     ..::....|||:.||||.:.||:
 Frog   203 LRIPDISTPGVWKISARYRDA---------------------PETNFTAEFEVKPYVLPNFEVKI 246

  Fly   253 --DATQQVSVRDGEFNVVLKANYTYGKPVNGKVLVNVHLDSTSSWE-NVDGKTVQTDYPGHSVVG 314
              :....:..:| .|...::|.|.||:.|.|...|.|.:.:.:... .:.|...||.....:...
 Frog   247 IPEVPYFLMTKD-SFTFRVEARYVYGENVAGVAYVRVGITAQNGKRYMLRGLEKQTTLGDENTAI 310

  Fly   315 TADMVGGKAKLTMDLKDFASYLPHKTSSSYAQITATVEE-DFTGVKLNETGGVQLYPYRYEMSCT 378
            |..|...|.|:..|:.:......:..:|...:.:..:|| :.|.||...:      ||:.::|.|
 Frog   311 TIKMADIKEKIQQDMGNLLGASLYIAASVIEKASGVLEEKELTSVKFVSS------PYKLDLSRT 369

  Fly   379 D-YSSCFSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQ-----EP 437
            . |     |.|....::..:::.:|||..... ||..:|      .|...:.|.||.:     ..
 Frog   370 KRY-----FIPGAPAQIVVEVSLIDGSPAVGV-SVSLSK------SNVQLFEFKTDDKGVVTFHV 422

  Fly   438 ELPTIEKKTFVFESHLNASGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTTYPYREPKQ 502
            ...:.|||..:.......||....::.|......||...|.::                   |.|
 Frog   423 NTASNEKKCDITVKANADSGSETERITLLPYTSKANSYLYINV-------------------PNQ 468

  Fly   503 IENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQVILNSSRPLKYFVYNIVGRGNILETKRVDLAE 567
            :.||.| ..|...:|.:..     |..:|:.|.::||..:.|           ::...:|.::.|
 Frog   469 VLNPGS-SVKVSLKAIISN-----NQNVGKIYYMVLNKGQLL-----------SMASIQRAEVNE 516

  Fly   568 PQTTVNVTIKPTFLTTPYGRVYFYYVDETGEFRYTEETFSVEVELQNQIEIKAPAE-VKPGADVA 631
            ....|..|:.|:|      |:..:|..|: |.........|....:.::|:.|..: ::||....
 Frog   517 MSIAVTSTMIPSF------RIIAFYYHES-EIIANSVWVDVTDVCEGKLELHANKQIIEPGEAFK 574

  Fly   632 LEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKESFNWRLNGYDTSTPWQGGYSYYPGERTGVVTMT 696
            ||::...|:.|.|.|||.:|.:|...|.|..:.....:|.||......||..:       :..:|
 Frog   575 LEVRAEGKASVSLSAVDTAVYILNPKNKLTPQKMFKAMNAYDLGCSPGGGKDF-------INVLT 632

  Fly   697 NAYFFY-------------------NRTAPDYNILTE-----------------GFGGSSFAMRK 725
            :|...:                   .:.|.|:..||:                 |.......|.:
 Frog   633 DAGLAFVSSAGYSQINELGCRVHQRKKRAIDFQALTQQKAYSYPTTELQRCCQHGMMLPPRKMSR 697

  Fly   726 TTVAHDSHVFHSGAGG---------------------PTQAVG-------FSAESASASAAPVVR 762
            ......:.|..:...|                     .||..|       |..:.|..|... :|
 Frog   698 VCTQRAARVPDTSCRGVFLACCEYAENLRKQMTLEKRKTQGFGRTQNVDEFDEDFADESDIQ-MR 761

  Fly   763 KNFAETWIFADIE----STEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPF 823
            ..|.|:|::..::    ...|.|:     :||:||.|.:....:.|:||..:. :...:|.|:.|
 Frog   762 SFFPESWLWRTVKVYNGLISENVY-----VPDSITTWEIQAVGMSPEKGFCIA-EPLKVKVFKDF 820

  Fly   824 FVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVDASNEVIGDQK-RTQNIRV 887
            .:.:|:||||||.|.:.:..:::||..|.|:|::.::..:      |..:...|:.| ..:.:.|
 Frog   821 HIYLRVPYSVKRFEQMELRPILYNYNDKDLEVKVYMEQTE------DICSPGSGESKPHIKQVTV 879

  Fly   888 GANEAAGASFLIRPKVIGNILLKFKAI-SPLAGDAIHKPLKVVPEGITQYQNRAFFINLKDTGEF 951
            .||.|....|::.|....|.::...|: :.|..||:.|.:|:|.||.:..:.:::.|:..|....
 Frog   880 AANSALPVPFVVVPIGKSNPVVSVVALATSLVSDAVKKSMKIVKEGASVLEEKSYIIDPTDITRQ 944

  Fly   952 KNTFELEVPEDVVPDSE-----RV----EFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSKLVPN 1007
            ...||.|:|.:::||.:     :|    ....:.:.||  ...:..|:|:|.||.||||....|.
 Frog   945 SIDFEEELPSNIIPDGDFHSSIKVTMDSPMNTINNSLG--ADGISKLIRVPYGCAEQTMISTSPG 1007

  Fly  1008 YLVRDYLKSIKK---LTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTW 1069
            .....||...:|   |.|....:...|::.||..:|.::..|||:.:     |..    |..|||
 Frog  1008 VYALRYLDHTEKWNLLPPDRKDQGLENMRQGYLRILQFKKTDGSYGA-----WVS----RASSTW 1063

  Fly  1070 LTAYVLRSFSKIKDIIDLDEQILAKGYEFLLTRQAENGSFTE-----HGEYF--YSSQRSLLTLT 1127
            |||:|::..|..::.||::.:.:.:...:|.|.|.:.|:|.|     |.:..  .|:..:.:::|
 Frog  1064 LTAFVVKVLSLCRNYIDVNVEDIRRSVHYLTTMQTDKGAFQEKLTVIHQDMLGGASTIDAEVSIT 1128

  Fly  1128 A-------NSLLALLEEEKPNQAAIDKAVAYLSANTAESIELLPKSIAI--YALQKAKAPEAAKQ 1183
            |       :||.||.|:....:::|.|||.||  .|...|...|.|:|:  |||.........|.
 Frog  1129 AYVTVALYHSLDALSEDNVAVKSSISKAVDYL--RTKLDIVKHPYSLALTTYALTLTSKDSILKD 1191

  Fly  1184 VASLKSLAKHEDD----RTWWTEDLDKLRASKNCGRWWCWIWSQDVEITSYALL-SLLDSDQETA 1243
            .|:.|.:::.:.|    ..::......|.                ||.|||.|| :||..:...|
 Frog  1192 NANNKLMSQAQGDPNKKELYFGPPGTALA----------------VETTSYVLLITLLRGNIRDA 1240

  Fly  1244 DSVLNTVRWLIAQRNGFGGFASSQDTVVGLTALIKFAEKSGYEAAKW-----------EVTVSNK 1297
            :.:..   ||..|:|..|||.|:||||:.|.||.::          |           |:.| |.
 Frog  1241 EKMYT---WLSEQQNYGGGFRSTQDTVMALEALSEY----------WIRTFKQDDNTLEIEV-NS 1291

  Fly  1298 GKREKTEKLNTSEENDLLLQTVEFPQGTKSLEFEAKGTGAAMVQISYQYNLVEKEPKPSFKI--Q 1360
            .:::.::|....:|:.  ||......||| ...:..|.|..::.:...||:::.:.....::  .
 Frog  1292 LEKQHSQKFRLRKEDS--LQEELRSMGTK-FNVKVSGKGKGILTVMRMYNIIQMQNTSCTELGMD 1353

  Fly  1361 TTVLPESSPANLELSVCVDYVEE------------------------GESKE------------- 1388
            .||...|..|..:.....||.||                        .:.||
 Frog  1354 VTVTDASVDAGPDDQDDYDYDEEMADEPRDPIVWHDLRHRSRREVTFAKEKEVKLLYEVCLWKKS 1418

  Fly  1389 -----SNMAILEVSLPSGYTADEDSFADIRNIERVRLVETKNGDSVVVIYFENLAKNEEKCIRIE 1448
                 |.|||:::::.||.....|....:.......:...:.....:::||:.:....: |:..|
 Frog  1419 SKVHLSGMAIVDITMLSGIQPVIDDLKKLAESSEQYISHYEYQPGRLLLYFDKVPDTRD-CVTFE 1482

  Fly  1449 AYRTHAVANQKPSSVVLYDYYDTNKKATEYYSIKSK---LCDICEGDDCK 1495
            |.:|..|:..:|:|.||||:|:.|.|.|.:|...||   :..:|.||.|:
 Frog  1483 AVQTVKVSVLQPASAVLYDFYEPNIKCTVFYGAPSKPNFVSTLCSGDVCQ 1532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	YfaS	<76..1411	CDD:441940	327/1456 (22%)
		A2M_2	982..1279	CDD:239227	93/320 (29%)
		A2M_recep	1387..1480	CDD:462226	26/110 (24%)
c4a	NP_001107156.1	MG1	23..132	CDD:465508
		YfaS	<139..1331	CDD:441940	308/1341 (23%)
		complement_C3_C4_C5	983..1273	CDD:239226	93/319 (29%)
		A2M_recep	1424..1513	CDD:462226	24/89 (27%)
		NTR_like	1531..1681	CDD:470599	1/2 (50%)