Protein Alignment Tep4 and a2ml1

DIOPT Version :10

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: XP_031760638.1
• Gene: a2ml1 / 100127688
• XenbaseID: XB-GENE-5943821
• Length: 1486
• Species: Xenopus tropicalis
• Alignment Length: 1630
• Identity: 427/1630 - (26%)
• Similarity: 687/1630 - (42%)
• Gaps: 313/1630 - (19%)

  Fly    10 SLCVILALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGITGPSYNKTETV 74
            :|.:.|.||.....::|:..|.:|.|..:..|......|.:...:....::|.:.....|.| .:
 Frog     6 ALGLALVLLHLSGTLEAKLHYAVVFPSEMRCHSSEQACVHLSGAEGDSRIQVTLNMAERNST-VI 69

  Fly    75 E--LATAGEFKQITFKLPPLEAGEYNLTAEGV----KGLEFKNSTKLNWENFKPYIKIQTDKGKY 133
            |  |.....|..:||::||...|...:....:    .|....||:|:..:..:....|||||..|
 Frog    70 ERNLRQKSLFSCVTFQVPPPSEGNEEVATMEILIESAGETITNSSKVLVKRRRTSTFIQTDKAVY 134

  Fly   134 KPGDTINYRVIFLDENLRPDTAKDEV-VVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFATLG 197
            |||.|:.:||:.|.|||:|  .:::: |:..:|..:|||.|...:..|.|:......||...:||
 Frog   135 KPGQTVRFRVVSLKENLQP--GENQISVIQLQDPNKNRIAQWLDVTLTQGIAELSLPLSPEPSLG 197

  Fly   198 SWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQQVSVRD 262
            .:|:||  ||..|                          .|.||:|||||:.|.....:.|....
 Frog   198 EYSIHV--GDTVH--------------------------YFSVEEYVLPKFEVSFQFPKVVFFTS 234

  Fly   263 GEFNVVLKANYTYGKPVNGKVLVNVHLDSTSSW--ENVDGKTVQTDYPGHSVVGTADMVGGKAKL 325
            .:|.:.....|||||||.|.....|.......|  .|.|...:..|:.     |..|. .|.:.|
 Frog   235 EQFQLKTCGRYTYGKPVQGTYKATVCRKVIRYWWGHNDDRSDLCVDFS-----GKLDQ-SGCSTL 293

  Fly   326 TMDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPYRYEMSCTDYSSCFSFKPDK 390
            |...::|  .|.:.|.....:.|:|:.|..|||:.:.:|...:  .....||:...:..::||
 Frog   294 TATSENF--NLTYNTHEMGLEGTSTITEGGTGVEYSGSGKTII--SSVVTSCSFLDADSNYKP-- 352

  Fly   391 EHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELPTIEKKTFVFESHLNA 455
                        |...:.|..||.|                  :.:|    |..:.....||.|.
 Frog   353 ------------GIPYSGTVKVVDA------------------NDDP----IPNQIVYLTSHSNE 383

  Fly   456 SGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTT----YPYREPKQIE----------NP 506
            ..    |.::.|...:|:|....:.|.:.....|...||    :.:.:.:.|.          .|
 Frog   384 VN----KTLVSDENGLASFQLENTAEWKGQLSLRASTTTQDAGFDFLQGRLITPNDVSASLMLKP 444

  Fly   507 SSEEEKEWFRAEVQR-------PKDVWNLKIGQEYQVILNSSRPLKY----FVYNIVGRGNILET 560
            .....|.:.:...|:       .:||     ..|| :|.||:..::.    ..|.:..:|::.::
 Frog   445 FHSPSKSFLKLHSQQGALPCEGQRDV-----RVEY-IIPNSALGIEVKHMELHYLVASKGSVKDS 503

  Fly   561 KRVDLAEPQT-----------------TVNVTIKPT-----FLTTPYGRVYFYYVDETGEFRYTE 603
            ..|::  |.|                 |::..:.||     |::.|           .||.....
 Frog   504 GSVEV--PITSEGGGSSELRGEVSIKLTLSADVSPTLRALAFISLP-----------NGELVADS 555

  Fly   604 ETFSVEVELQNQIEIK-APAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKESFN- 666
            .||.::...:|::.:. :|.||.|||||:|:::.:..|..||..|||||:|:..:.:|..:..:
 Frog   556 ATFKLQRCFKNKVSVGFSPDEVLPGADVSLQVQAAAGSLCGLRVVDQSVVLMKPDKELTADQIHN 620

  Fly   667 ----WRLNGYDTST-------------------------PWQ-------GGYSYYPGERTGVVTM 695
                ....|||...                         ||.       ..||.:...|..:||.
 Frog   621 LFPFPDFGGYDARVQDSDDHCPFYPWFHRPMWKRSIVLPPWHMPHEDEVDVYSLFKDMRLKIVTS 685

  Fly   696 TNAYFFYNRTAPDYNILTEGFGGSSFAMRKTTVAHDSHVFHSGAG---GPTQAVGFSAESASASA 757
            ...........|:            ||::...:|| ..:..:|.|   ...:|||...| .:..|
 Frog   686 AEIKKPLRCREPE------------FALQYNVLAH-PRIADAGDGLVRAMPKAVGVGNE-LTEPA 736

  Fly   758 APVVRKNFAETWIFADIESTEE----EVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIK 818
            |.::|..|.||||: .:|...|    ||.   .:.|||||.|....|.:.| .|.|: :..|:::
 Frog   737 AEIIRAYFPETWIW-QLEPVGESGRAEVH---GSAPDTITEWNAGAFCMGP-SGFGI-SPPTSLR 795

  Fly   819 TFQPFFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNE---------DQEYDFVDASNE 874
            .||||||.:.|||||.|||...:.|.|||||.:.:.|:.||...         |.:|     |:.
 Frog   796 AFQPFFVELTLPYSVVRGESFTLKASVFNYLKQCIKVQTTLQPSLELEQEPCADCQY-----SSC 855

  Fly   875 VIGDQKRTQNIRVGANEAAGASFLIRPKVIG--NILLKFKAISPLAG--DAIHKPLKVVPEGITQ 935
            :..|:.:|....:.|:.....:..:|.:.:.  ::......|.|..|  |.:.|||.|.|.|:..
 Frog   856 ICADESKTFYWNLKASNLGEVNITVRTEALNTQDMCNNEIPIVPKQGHSDTVIKPLLVQPGGVLI 920

  Fly   936 YQNRAFFINLKDTGEFKNT--FELEVPEDVVPDSERVEFGLVGDLLGPVVKNLENLLRLPSGCGE 998
            .::.:..|...:..:...|  ..|.|||:::..|||.....:|||:|..::||:.||.:|.||||
 Frog   921 EKSHSSLICSPEGEDHSKTEDISLNVPENILEGSERAYVTALGDLMGTAMQNLDRLLAMPYGCGE 985

  Fly   999 QTMSKLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPV 1063
            |.|....||..:..||::..:|:|.:.|:.|..|:.|||..|.|:.:|||:|:||     ..||
 Frog   986 QNMVLFAPNIFILQYLENTHQLSPEIQTKAKGFLESGYQRQLTYKRNDGSYSAFG-----SRDP- 1044

  Fly  1064 RNGSTWLTAYVLRSFSKIKDIIDLDEQILAKGYEFLLTRQAENGSFTEHGEYFYSSQR----SLL 1124
             .|:|||||:|::||||.:..|.:|...|...:.:|..::..:|.|...|:.|.::.:    ..:
 Frog  1045 -EGNTWLTAFVVKSFSKARPYIFIDGDHLNHSFSWLKDKRQRSGCFRSVGKLFNNAMKGGVDDEI 1108

  Fly  1125 TLTANSLLALLE----EEKP---------NQAAIDKAVAYLSANTAESIELLPKSIAIYALQKAK 1176
            :|:|...:||:|    :|.|         .:||...:.||..|..|.:..|           ...
 Frog  1109 SLSAYVTIALMEAGLSKEDPMVSDALSCLRKAARKVSSAYTQALLAYTFTL-----------SDD 1162

  Fly  1177 APEAAKQVASLKSLAKHEDDRTWWTEDLDKLRASKNCG-RWWCWIWSQDVEITSYALLSLLDSDQ 1240
            .....|.:|.|:..|..:|.:..|    ::..|||... .:|....|.:||:||||||:||....
 Frog  1163 TKHREKLLAKLEEKAVRKDGQLHW----ERKPASKASDLPYWYRAPSAEVELTSYALLALLSGPN 1223

  Fly  1241 ETADSVLNTVRWLIAQRNGFGGFASSQDTVVGLTALIKFAEKSGYEAAKWEVTVSNKGKREKTEK 1305
            :........|.||..|:|.:|||:|:|||||.|.||.::||.:..:  |.:|||:...|....::
 Frog  1224 KDLGKASEIVNWLSKQQNPYGGFSSTQDTVVALQALAEYAEATFSD--KGDVTVTVTSKTGFHQQ 1286

  Fly  1306 LNTSEENDLLLQTVEFPQGTKSLEFEAKGTGAAMVQISYQYNLVEKEPKPSFKIQTTVLPESSPA 1370
            .:..:.|.||||....|.........|.|:|...||...:||:.......:|.::....|:..|.
 Frog  1287 FHVDQTNRLLLQKASLPDIPGEYSLSATGSGCVYVQTVLRYNIPPPRSDATFSVRVETQPQQCPQ 1351

  Fly  1371 NLELSVCVD-YVE-EGESKESNMAILEVSLPSGYTADEDSFAD-IRNIERVRLVETKNGDSVVVI 1432
            .....:.:| |:: .|..::||||::||.:.||:|.|:.|... ||....:...||:.  ..|..
 Frog  1352 EPMKQMGIDIYIQYTGSREKSNMALVEVKMLSGFTPDKKSIDQVIRWNNFIMWSETQT--DKVTF 1414

  Fly  1433 YFENLAKN--------EEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKKA-TEYYSIKSKLCDI 1488
            |...|.::        |::.:         |.|.:|:.|.:||||:..:.| |||.|       .
 Frog  1415 YLSELGRHPVNFSFMVEQEVL---------VKNLRPAIVKVYDYYEPVEHAVTEYNS-------P 1463

  Fly  1489 CEGDD 1493
            |..|:
 Frog  1464 CSSDE 1468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	YfaS	<76..1411	CDD:441940	390/1468 (27%)
		A2M_2	982..1279	CDD:239227	104/314 (33%)
		A2M_recep	1387..1480	CDD:462226	31/102 (30%)
a2ml1	XP_031760638.1	YfaS	<126..1343	CDD:441940	363/1364 (27%)
		A2M_2	969..1262	CDD:239227	104/314 (33%)
		A2M_recep	1370..1461	CDD:462226	30/101 (30%)