DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tep4 and crebbp

DIOPT Version :9

Sequence 1:	NP_001260590.1	Gene:	Tep4 / 35248	FlyBaseID:	FBgn0041180	Length:	1498	Species:	Drosophila melanogaster
Sequence 2:	NP_001340300.1	Gene:	crebbp / 100101677	XenbaseID:	XB-GENE-6258723	Length:	2431	Species:	Xenopus tropicalis

Alignment Length:	932	Identity:	167/932 - (17%)
Similarity:	266/932 - (28%)	Gaps:	360/932 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 GKPVN-GKVLVNVHLDSTSSWENVDGKTVQTDYPGHS-----VVGTAD-------MVGGKAKLTM 327
            |.|:: ....|:.|:.:.:|..:.|.:..    |.||     |.|..|       .|..|.::..
Frog   960 GTPLSQAAASVDNHVRTPASVASTDNQPA----PDHSMTEVKVEGKTDEPEACENQVEPKTEVEP 1020

  Fly   328 D----LKDFASYLPHKTSSSYAQITATVEEDFTGVKL-----NETGGVQLYPYRYEMSCTDYSSC 383
            |    :|:     |...|:........|||..|.:|.     .|.||..             ||.
Frog  1021 DASSQVKE-----PVCESTEIKSEPMEVEEKKTEIKTENKEEEENGGTN-------------SSL 1067

  Fly   384 FSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPE-LPTIEKKTF 447
            .|..|.:..:..||...:..:|:...:::.:                    |:|| ||..:.
Frog  1068 QSTSPSQPRKKIFKPEELRQALMPTLEALYR--------------------QDPESLPFRQP--- 1109

  Fly   448 VFESHLNASGVAPFKVVLPDLPDIANFTRYYSIELEFVDEKRDLYTTYPYREPKQIENPSSEEEK 512
                      |.|..:.:||..||..    ..::|..:..|.|   |..|:||
Frog  1110 ----------VDPQLLGIPDYFDIVK----NPMDLSTIKRKLD---TGQYQEP------------ 1145

  Fly   513 EWFRAEVQRPKDVWNLKIGQEYQVILNSSRPLKYFVYNIVGRGNILETKRVDLAE---------- 567
             |     |...||| |.....:.....:||..||.            ||..::.|
Frog  1146 -W-----QYVDDVW-LMFNNAWLYNRKTSRVYKYC------------TKLAEVFEQEIDPVMQSL 1191

  Fly   568 -----------PQTTVNVTIKPTFLTTPYGRVYFYYVDETGEFRYTEETFSVEVELQNQIEIKAP 621
                       |||.  ........|.|....||.|   ...:.:.|:.|:   |:|
Frog  1192 GYCCGRKFEFSPQTL--CCYGKQLCTIPRDAAYFSY---QNRYHFCEKCFT---EIQ-------- 1240

  Fly   622 AEVKPGADVAL-EIKTSPKSFVGLLAVDQSVLLLGSNNDLNKESFNWRLNGYDTSTPWQGGYSYY 685
                 |.:|.| :..:.|::                  .::||.|..:.|  |...|
Frog  1241 -----GENVTLGDDPSQPQT------------------TISKEQFEKKKN--DMLDP-------- 1272

  Fly   686 PGERTGVVTMTNAYFFYNRTAPDYNILTEGFGGSSFAMRKTTVAHDSHVFHSGAGGPTQAVGFSA 750
                                        |.|.......||   .|...|.|.....|:   ||..
Frog  1273 ----------------------------EPFVDCKECGRK---MHQICVLHFDIIWPS---GFVC 1303

  Fly   751 ESASASAAPVVRKNFAETWIFADIEST------EEEVFKWVKTIPDTITNWVVTGFSLHPQKG-- 807
            ::.........::|   .:....:::|      |:.|.|:::.             ..||:.|
Frog  1304 DNCLKKTGRTRKEN---KFCAKRLQTTRLGNHLEDRVNKFLRR-------------QNHPEAGEV 1352

  Fly   808 -LGVTNDQTNIKTFQP-----FFVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNED--- 863
             :.|......|...:|     |..:..:|.|             |.|..|.|.....:|..|
Frog  1353 SVRVVASSDKIVEVRPGMKSKFVDTGEMPES-------------FPYRTKALFAFEEIDGVDVCF 1404

  Fly   864 -----QEY--------------DFVDASNEVIGDQKRTQNIRVGANEAAGASFLIRPKVIGNILL 909
                 |||              .::|:.:..     |.:::|..........:|...|.:|.:..
Frog  1405 FGMHVQEYGSDCPMPNTRRVYISYLDSIHFF-----RPRSLRTAVYHEILIGYLEYVKKLGYVTG 1464

  Fly   910 KFKAISPLAGD----AIHKPLKVVP------EGITQYQNRAF-------------------FINL 945
            ...|..|..||    ..|.|.:.:|      |...:..::||                   ..:.
Frog  1465 HIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSA 1529

  Fly   946 KDTGEFKNTFELEVPEDVVPDSERVE---------------FGLVGDLLGPVVKNLENLLR---- 991
            |:...|:..|...|.|:.:.:.|:.|               .|..||......||.:...:
Frog  1530 KELPYFEGDFWPNVLEESIKELEQEEEERKKEENTAACETTEGCQGDSKNAKKKNNKKTNKNKSS 1594

  Fly   992 ----------LPSGCGE------QTMSKLVPNYLVRDYLKS--IKKLTPAL--DTRIKRNLQDGY 1036
                      :|:.|.:      .||.|....:.|..:...  |..|.|..  |..:..:|.||.
Frog  1595 MSRANKKKASMPNVCNDLSQKLYATMEKHKEVFFVIHFYAGPVINSLPPIADPDPLLSCDLMDGR 1659

  Fly  1037 QHMLHYRHD-DGSFSSFGPTKW 1057
            ...|....| ...|||...:||
Frog  1660 DAFLTLARDKHWEFSSLRRSKW 1681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	A2M_N	126..219	CDD:280081
		A2M_N_2	528..653	CDD:285005	24/146 (16%)
		A2M	768..859	CDD:278630	17/104 (16%)
		A2M_2	982..1279	CDD:239227	22/101 (22%)
		A2M_comp	1035..1281	CDD:284982	8/24 (33%)
		A2M_recep	1389..1479	CDD:284981
crebbp	NP_001340300.1	zf-TAZ	362..429	CDD:307990
		KIX	578..658	CDD:280354
		Atrophin-1	<605..977	CDD:331285	4/16 (25%)
		Bromo_cbp_like	1082..1189	CDD:99927	32/177 (18%)
		RING_CBP-p300	1201..1273	CDD:276805	22/148 (15%)
		PHD_CBP_p300	1275..1306	CDD:277032	9/36 (25%)
		HAT_KAT11	1337..1645	CDD:311917	57/338 (17%)
		ZZ_CBP	1700..1740	CDD:239077
		zf-TAZ	1767..1835	CDD:307990
		Creb_binding	2039..2118	CDD:312539
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165169152
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930