DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tep4 and a2ml

DIOPT Version :9

Sequence 1:NP_001260590.1 Gene:Tep4 / 35248 FlyBaseID:FBgn0041180 Length:1498 Species:Drosophila melanogaster
Sequence 2:XP_001345541.6 Gene:a2ml / 100006972 ZFINID:ZDB-GENE-090212-1 Length:1449 Species:Danio rerio


Alignment Length:1606 Identity:416/1606 - (25%)
Similarity:674/1606 - (41%) Gaps:292/1606 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 AFAVSLC-----VILALLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGITG 65
            |..||.|     :...|...::...||..:.:..|..|.|..:..:..::.:..|.:.:.:.:..
Zfish     9 ALNVSCCWKGLLLNFFLFVCVQGQAAEPSFMVTFPAVIESGSEAKLCASLLKPNESLVMNIYLVH 73

  Fly    66 PSYNKTETVELATAGEFKQITFKLPPLEAGEYNLTAEGVKGLEFK--NSTKLNWENFKPYIKIQT 128
            .:.:.....|.|.....:...||.|..||.........::|..||  ...|:.::::.|...|||
Zfish    74 GNQSTLLLQENAEQEFHRCFNFKAPLAEAESVQKIKVELQGESFKMTEERKVMFKSYDPLTFIQT 138

  Fly   129 DKGKYKPGDTINYRVIFLDENLRPDTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEF 193
            ||..|.||..:|:||:.:|.|..|...:..::| .|||:.|||.|..::.:|..:....:||:..
Zfish   139 DKPIYMPGQIVNFRVVTMDTNFAPVDQQYSIIV-LEDSQDNRIGQWTNVSSTRWILQRSYELNPE 202

  Fly   194 ATLGSWSLHVQNGDQH--HDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQ 256
            ...|::.|....|::.  ||                          |:|:||||||:.|.:...:
Zfish   203 CREGAYKLKAFIGERMILHD--------------------------FQVKKYVLPKFEVTLKKPK 241

  Fly   257 QVSVRDGEFNVVLKANYTYGKPVNGKVLVNVHLDSTSSWENVD--------------GKTVQTDY 307
            .|||.:.|..:.:.|.||||:||.||           ||..|.              |:|::...
Zfish   242 TVSVVEEELLIEVCAKYTYGQPVPGK-----------SWVKVCRDPLPYIFFFPLCLGETLEITK 295

  Fly   308 PGHSVVGTADMVGGKAKLTMDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPYR 372
            .|.::......:...:.|..:|||            ...:.|.|.|:.|.:...::..|.|   .
Zfish   296 TGCAIHNFGLSMILNSTLKNNLKD------------SLHVEAVVTEEGTEITRTKSESVHL---T 345

  Fly   373 YEMSCTDYSSCFSFKPDKEHELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEP 437
            ||:.             |...::...||..||:|   |..:|.                .|.::.
Zfish   346 YEIG-------------KATLIDLPKTYEHGSVI---KGKIKL----------------FDFKDA 378

  Fly   438 ELPTIEKKTFVFESH-------LN----ASGVAPFKV---------------VLPDLPDIANFTR 476
            .:|  .|:.::.|..       ||    :.|:|.|.:               |.||       ||
Zfish   379 PIP--NKEVYLLEGENWSSKLLLNLTTDSDGLASFSLNTSSLSKKDISLIASVYPD-------TR 434

  Fly   477 YYSIELEFVDEKRDLYTTYPYREPKQIENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQVILNSS 541
            ||..:..:....:.....:      ||....|....|....::::|     :|.|.|.      :
Zfish   435 YYGYKTPYFSTDKKTVQLF------QIATAYSPTLSELIIEDIEQP-----IKCGTEI------T 482

  Fly   542 RPLKYF-------------VYNIVGRGNI-------LETKRVDLAEPQTTVNVTIKPTFLTTPYG 586
            ..:||:             ||.::.||.|       :|.|.........|::..:......||..
Zfish   483 ATVKYYFVGETVEDFSTDIVYMVLSRGVIVHHGFEKVEVKSSSNGVASGTMSFKLSVGADLTPVV 547

  Fly   587 RVYFYYVDETGEFRYTEETFSVEVELQNQIEIK-APAEVKPGADVALEIKTSPKSFVGLLAVDQS 650
            ::..|.|..:.......:|...|....|::.:: :||:..||....|::...|.|..||.|||||
Zfish   548 QILAYCVLPSENVIAANKTLDTEKCFGNKVSLQFSPAKAVPGEKNTLQLSAQPGSLCGLSAVDQS 612

  Fly   651 VLLLGSNNDLNKES-FN----WRLNGYDTSTPWQGGYSYYPGERTGVVTMTNAYFFYNRT----- 705
            ||:|.|...|..:. ||    ..::.|..|.. .|....|...|..::| .|.|......     
Zfish   613 VLILESGKRLEADKIFNLLPVHSVSDYPYSVE-DGQACLYVRPRRSLLT-DNTYETLKSVGLKMA 675

  Fly   706 ------APDYNILTEGFG-GSSFAMRKTTVAHDSHVFHSGAGGPTQAVGFSAESASASAAPVVRK 763
                  .|:. :|.:|.. ..:|.|.:.. |....:|..|..|....||       .|.:..:|.
Zfish   676 TNLAVRVPEC-LLYKGLAYHKNFVMYRQN-APAPGMFAQGMAGVDGLVG-------NSPSVTIRT 731

  Fly   764 NFAETWIF-----ADIESTEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPF 823
            .|.||||:     .|..|.|..|     .:|||||.|....|.| ...|||:. ....:..||||
Zfish   732 VFPETWIWELAEVGDSGSAEVPV-----KVPDTITTWETEAFCL-SSTGLGLA-PPAQLTVFQPF 789

  Fly   824 FVSVRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVDASNEVIGDQKRTQNIRVG 888
            |:.:.||||:.|||:..:.|.|||||.|.:.|::: .....:|....:|:    ||   .:..:.
Zfish   790 FLELSLPYSIIRGEIFELKATVFNYLSKCIMVKVS-PAPSSDYTLKASSD----DQ---YSSCLC 846

  Fly   889 ANEAAGASFLIRPKVIG--NILLKFKAIS------------PLAG--DAIHKPLKVVPEGITQYQ 937
            ||......:::.|.|:|  |:.:..:|.:            |..|  |.:.:.|.|..|||.:.:
Zfish   847 ANGRKTFKWILTPSVLGVVNVTVSAEAEASQTVCDNEIVSVPERGRIDIVTRSLLVQAEGIEKTE 911

  Fly   938 NRAFFINLKDTGEFKNTFELEVPEDVVPDSERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMS 1002
            ..::.:..|. .......:|.:|:||:..|.:....::||:||..::||..|||:|.|||||.|:
Zfish   912 TNSWLLCPKG-DSLSEKVDLTLPKDVIEGSAKSSVSVIGDILGRALQNLHGLLRMPYGCGEQNMA 975

  Fly  1003 KLVPNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGS 1067
            .|.||..:..||::.|:||.|:..:....|:.|||..|:|:|.||::|:||         ..:|:
Zfish   976 VLSPNIYILQYLENTKQLTSAIREKASSFLKSGYQRQLNYKHFDGAYSTFG---------YGDGN 1031

  Fly  1068 TWLTAYVLRSFSKIKDIIDLDEQILAKGYEFLLTRQAENGSFTEHGEYFYSSQR----SLLTLTA 1128
            |||||:|||||.|.:....:|.||:....::|::|:..:|.|.:.|..|.:..:    ..:|:||
Zfish  1032 TWLTAFVLRSFGKAQKYTFIDPQIIQSAKDWLISRRDSDGCFIQQGRLFNNRMKGGVNDNVTMTA 1096

  Fly  1129 NSLLALLEEEKP-NQAAIDKAVAYLSANTAESIELLPKSIAIYALQKAKAPEAAKQVAS-LKSLA 1191
            ....:|||.|.| ....|.|.::.|.:...|.......::..|....|:.....:|:.: |:.||
Zfish  1097 YITASLLELETPVTDPVITKGLSCLRSVIEEVKNTYTTALLAYTFSLARDTNTRQQLFNKLEDLA 1161

  Fly  1192 KHEDDRTWWTEDLDKLRASKNCGRWWCWIWSQDVEITSYALLSLLDSDQ-ETAD--SVLNTVRWL 1253
            ..:.....|::.     ||.:...      |.||||:||.||::|.:|. .|||  .....|.||
Zfish  1162 ISDGPLVHWSQS-----ASADDSA------SLDVEISSYVLLAVLTADSLTTADLGFANRIVSWL 1215

  Fly  1254 IAQRNGFGGFASSQDTVVGLTALIKFAEKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDLLLQT 1318
            :.|:|.:|||:|:|||||.|.||..:|.|.........|||.:.|   .:...:.:::|.||.|.
Zfish  1216 VKQQNAYGGFSSTQDTVVALQALSLYATKVFSSDGSSTVTVQSAG---DSHHFDVNQDNKLLYQE 1277

  Fly  1319 VEFPQGTKSLEFEAKGTGAAMVQISYQYNLVEKEPKPSFKIQTTVLP--ESSPANLELSVCVDYV 1381
            .:..........|.||:....|||:..||:.......:..|...:..  |:...|......|.| 
Zfish  1278 KQLANVPGKYSIEVKGSACVSVQIAQFYNIPTPTEAKTLSIDAKIEGDCEALGQNFIFDFTVKY- 1341

  Fly  1382 EEGESKESNMAILEVSLPSGYTADEDSFADIRN--IERVRLVETKNGDSVVVIYFENLAKNEEKC 1444
             :|..:::||||:::.|.||:|||..:......  :..|..|::|  |..|::|.:.:.||....
Zfish  1342 -DGPEEKTNMAIVDIKLLSGFTADTSALGTSSGTYVSLVERVDSK--DDHVIVYLKEIPKNVAMN 1403

  Fly  1445 IRIEAYRTHAVANQKPSSVVLYDYYDTNKKATEYYSIKSKLCDICE 1490
            .:|:..:...|.|.||:.|.:||||.|:.::...||..      ||
Zfish  1404 YQIQMKQVLPVKNLKPAVVKVYDYYQTSDQSEIEYSFH------CE 1443

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tep4NP_001260590.1 A2M_N 126..219 CDD:280081 30/94 (32%)
A2M_N_2 528..653 CDD:285005 35/145 (24%)
A2M 768..859 CDD:278630 38/95 (40%)
A2M_2 982..1279 CDD:239227 106/305 (35%)
A2M_comp 1035..1281 CDD:284982 84/254 (33%)
A2M_recep 1389..1479 CDD:284981 29/91 (32%)
a2mlXP_001345541.6 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170584163
Domainoid 1 1.000 217 1.000 Domainoid score I2610
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 517 1.000 Inparanoid score I1243
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - mtm6406
orthoMCL 1 0.900 - - OOG6_100452
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X292
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
109.700

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