Protein Alignment Tep4 and a2m2a

DIOPT Version :10

• Sequence 1: NP_001260590.1
• Gene: Tep4 / 35248
• FlyBaseID: FBgn0041180
• Length: 1498
• Species: Drosophila melanogaster
• Sequence 2: XP_001921519.4
• Gene: a2m2a / 100003785
• ZFINID: ZDB-GENE-131118-12
• Length: 1437
• Species: Danio rerio
• Alignment Length: 1600
• Identity: 411/1600 - (25%)
• Similarity: 661/1600 - (41%)
• Gaps: 298/1600 - (18%)

  Fly     7 FAVSLCVILA-LLQTMEPVKAEGKYTIVGPGTIHSHRDYNVAVAVHQTKEPVTLKVGITGPSYNK 70
            |.|...:||| :|.::....:...:.:..|..|.|..:..:..::....|.:.:.:.:...:.:.
Zfish     6 FCVWKGLILAIILLSVNGQMSTPSFMVTFPAVIRSGSEAKLCASLLNPNESLVMNIYLNQENQST 70

  Fly    71 TETVELATAGEFKQITFKLPPLEAGEYNLTAEGVKGLEFK--NSTKLNWENFKPYIKIQTDKGKY 133
            ....|.|.....:...|:.|.:||.........::|..||  ...|:....:.|...|||||..|
Zfish    71 LLLQEKAEQEFHRCFNFQAPLVEAESVQTMKVELQGKNFKMTEERKVMLRRYYPLTFIQTDKPIY 135

  Fly   134 KPGDTINYRVIFLDENLRP-DTAKDEVVVWFEDSKRNRIKQEKHIKTTGGVYTGKFELSEFATLG 197
            .||.|:.:|||.:|.|..| |...|.||:  |||:.|||.|..::.:|..:.....||:..|..|
Zfish   136 IPGQTVFFRVISMDANFVPLDQTYDTVVL--EDSQDNRIGQWTNVSSTRWILQLSHELNPEARQG 198

  Fly   198 SWSLHVQNGDQHHDGGIYFGGRKQFGGFGHRWHRSDELVNFEVEKYVLPKYSVKMDATQQVSVRD 262
            .:.|..           |.|.|....|             |||:.|||||:.|.:...:..|:.|
Zfish   199 LYKLKA-----------YIGERMISNG-------------FEVKNYVLPKFDVTIKQPETQSIGD 239

  Fly   263 GEFNVVLKANYTYGKPVNGKVLVNVHLDSTSSWENVDGKTVQTDYPGHSVVGTADMVG-GKAKLT 326
            .|..:.:...||||:|:.|...|.|..||.        |.|........:..||.|.. |.|...
Zfish   240 NEIKIEVCGKYTYGQPLPGNAWVEVCRDSF--------KYVSIPEVHLCLNKTAQMNELGCASFI 296

  Fly   327 MDLKDFASYLPHKTSSSYAQITATVEEDFTGVKLNETGGVQLYPYRYEMSCTDYSSCFSFKPDKE 391
            .:...|.:........:...:...|.|:.|.:.:.::..:.|   .||:.
Zfish   297 FNTSAFLNSTFENDLQNSLLVNTNVTEEGTDIVMTKSETISL---TYELG--------------- 343

  Fly   392 HELNFKITYVDGSLITDTKSVVKAKFTEGIRRNYAFYAFGTDHQEPELPTIEKKTFVFESH---- 452
                 |:|:.:...:.:..|:::.|..       ..:..||       |...|..::.|..
Zfish   344 -----KVTFAELPDLFEHGSIIEGKIK-------VAHFNGT-------PVYNKSVYLLEGRSWSS 389

  Fly   453 ---LN----ASGVAPFKVVLPDLPD-----IANFTR--YYSIELEF--VDEK--RDLYTTYPYRE 499
               ||    .:|:|.|......||.     :|:.|.  :|..:..:  .|||  |.|....||
Zfish   390 QLLLNLTTDRNGLAVFSFNTASLPSSDLHLMASLTSEVHYGYKTPYFTADEKTVRLLQPATPY-- 452

  Fly   500 PKQIENPSSEEEKEWFRAEVQRPKDVWNLKIGQEYQVILNSSRPLK-----------YF------ 547
                 :|:..|                        .:|.|..:|||           ||
Zfish   453 -----SPTLSE------------------------LIIENIEQPLKCDTEITATVKYYFVGETVK 488

  Fly   548 ------VYNIVGRGNIL-------ETKRVDLAEPQTTVNVTIKPTFLTTPYGRVYFYYVDETGEF 599
                  ||.::.||.|:       |.|.........|::..:.......|..::..|.|..:...
Zfish   489 DFNTDIVYMVLSRGVIIHHGYEKVEVKSSSNGVASGTMSFKLSVGADVAPVVQILAYCVLPSEIV 553

  Fly   600 RYTEETFSVEVELQNQIEIK-APAEVKPGADVALEIKTSPKSFVGLLAVDQSVLLLGSNNDLNKE 663
            ........||...:|::.:: :||:..||....|::.....|..||.|||||||:|.|...||.:
Zfish   554 IAGSRKLDVEKCFRNKVSLQFSPAKAVPGEKNTLQLSAQSGSLCGLSAVDQSVLILESGKRLNAD 618

  Fly   664 S-FNWRLNGYDTSTPWQGGYSY---------YPGERTGVVTMTNAY---------FFYNRTAPDY 709
            . ||.      ....:...|.|         :...|..|.| .:||         ...|....:.
Zfish   619 KIFNL------LPVQYMSDYLYSVEDEQECLHVRSRRAVHT-DSAYETLKSVGLKMATNLIVREP 676

  Fly   710 NILT-------EGFGGSSFAMRKTTVAHDSHVFHSGAGGPTQAVGFSAES-ASASAAPVVRKNFA 766
            ..||       ..||.|.:       :.|..|        ..|:.:..:| |..|....:|..|.
Zfish   677 QCLTYRGLNYHRSFGESDY-------SEDFVV--------KMAMNYEEDSFAVNSPDATIRTVFP 726

  Fly   767 ETWIF-----ADIESTEEEVFKWVKTIPDTITNWVVTGFSLHPQKGLGVTNDQTNIKTFQPFFVS 826
            ||||:     .|..|.|..|     |:|||||.|.:..|.| ...|||:. ....:..|||||:.
Zfish   727 ETWIWQLAEVGDSGSAEVPV-----TVPDTITTWEMDAFCL-SSTGLGLA-PPAQLTVFQPFFLE 784

  Fly   827 VRLPYSVKRGEVINVPALVFNYLPKTLDVELTLDNEDQEYDFVDASNEVIGDQKRTQNIRVGANE 891
            :.||||:.|||:..:.|.|||||.|.:.|::: .....:|....:|:    ||   .:..:.||.
Zfish   785 LSLPYSIIRGEIFELKATVFNYLSKCIMVKVS-PAPSSDYTLKASSD----DQ---YSSCLCANG 841

  Fly   892 AAGASFLIRPKVIG--NILLKFKAIS------------PLAG--DAIHKPLKVVPEGITQYQNRA 940
            .....:::.|.|.|  ||.:..:|.:            |..|  |.:.:.|:|..||:.:.:..:
Zfish   842 RQTFKWILTPSVFGVVNITVSAEAEASQTLCDNEIVSVPERGRIDTVTRSLRVQAEGVEKIKIYS 906

  Fly   941 FFINLKDTGEFKNTFELEVPEDVVPDSERVEFGLVGDLLGPVVKNLENLLRLPSGCGEQTMSKLV 1005
            :.: ........:...|.:|.||:..|.|....::||:||..::||..||::|.|||||.::.|.
Zfish   907 WLL-CPQGSRVSDEVTLTLPSDVIKGSVRSSVSVLGDILGRALQNLHGLLKMPYGCGEQNIAVLS 970

  Fly  1006 PNYLVRDYLKSIKKLTPALDTRIKRNLQDGYQHMLHYRHDDGSFSSFGPTKWRQEDPVRNGSTWL 1070
            ||..:..||::.|:||.|:..:....|:.|||..|:|||.|||:|:||..:         |:|||
Zfish   971 PNIYILQYLENTKQLTSAIREKASGFLKSGYQRQLNYRHHDGSYSTFGNGE---------GNTWL 1026

  Fly  1071 TAYVLRSFSKIKDIIDLDEQILAKGYEFLLTRQAENGSFTEHGEYFYSSQR----SLLTLTANSL 1131
            ||:|||||.|.:..|.:|.||:....::|::|:..:|.|.:.|..|.|..:    ..:|:||...
Zfish  1027 TAFVLRSFDKAQRYIFVDPQIIQSAKDWLISRRDSDGCFIQQGRLFNSRMKGGVNDKVTMTAYIT 1091

  Fly  1132 LALLEEEKP-NQAAIDKAVAYLSANTAESIELLPKSIAIYALQKAKAPEAAKQVAS-LKSLAKHE 1194
            .:|||.|.| ....:.|.::.|.....:.......::..|....|:.....:|:.: |::||..:
Zfish  1092 ASLLELETPVTNPVVTKGLSCLRFVIEDVKNTYTTALLAYTFSLARDTNTRQQLFNKLENLAISD 1156

  Fly  1195 DDRTWWT-----EDLDKLRASKNCGRWWCWIWSQDVEITSYALLSLLDSDQ-ETAD--SVLNTVR 1251
            .....|:     :|.|.|                ||||:||.||::|.:|. .|||  .....|.
Zfish  1157 GPLVHWSQSASADDSDSL----------------DVEISSYVLLAVLTADSLTTADLGFANRIVS 1205

  Fly  1252 WLIAQRNGFGGFASSQDTVVGLTALIKFAEKSGYEAAKWEVTVSNKGKREKTEKLNTSEENDLLL 1316
            ||:.|:|.:|||:|:|||||.|.||..:|.|.........|||.:.|   .::..:.:::|.||.
Zfish  1206 WLVKQQNAYGGFSSTQDTVVALQALSLYATKVFSSDGSSTVTVQSAG---DSQHFDVNQDNKLLY 1267

  Fly  1317 QTVEFPQGTKSLEFEAKGTGAAMVQISYQYNLVEKEPKPSFK---IQTTVLPE---SSPANLELS 1375
            |..:..........|.||:....|||...||:  ..|.|:.|   ::.:|..:   |:..||.|:
Zfish  1268 QEKQLANVPGKYSIEVKGSACVSVQIPLFYNI--PTPPPTIKTLSVEASVTGDCLASTAKNLMLN 1330

  Fly  1376 VCVDYVEEGESKESNMAILEVSLPSGYTADEDSFADIRNIERVRLVETKNGDSVVVIYFENLAKN 1440
            ..:.|  .|....:||.|:::.|.||:|||....|...::..:.:....:.|..:::|.:.:.||
Zfish  1331 FTIKY--SGTQTRTNMVIVDIKLLSGFTADTSMLAIPPHMYALLVERVDSEDDHIMVYLKEVPKN 1393

  Fly  1441 EEKCIRIEAYRTHAVANQKPSSVVLYDYYDTNKKATEYYS 1480
            ..:...|:..:...|.:.:|:.:.:||||.|:.::...||
Zfish  1394 SPQLYTIQMKQAFPVRSLRPAVIKVYDYYQTSDQSETLYS 1433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tep4	NP_001260590.1	YfaS	<76..1411	CDD:441940	385/1459 (26%)
		A2M_2	982..1279	CDD:239227	106/310 (34%)
		A2M_recep	1387..1480	CDD:462226	22/92 (24%)
a2m2a	XP_001921519.4	YfaS	<127..1387	CDD:441940	377/1431 (26%)
		A2M	728..816	CDD:459711	39/94 (41%)
		A2M_2	947..1233	CDD:239227	106/310 (34%)