DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ref(2)P and nbr1b

DIOPT Version :9

Sequence 1:	NP_001014491.1	Gene:	ref(2)P / 35246	FlyBaseID:	FBgn0003231	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_001373572.1	Gene:	nbr1b / 555713	ZFINID:	ZDB-GENE-170215-1	Length:	992	Species:	Danio rerio

Alignment Length:	763	Identity:	152/763 - (19%)
Similarity:	244/763 - (31%)	Gaps:	281/763 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LKITYQGAGPQKKINAYLRMPSQNYTILRREIELYLFQERQLPKCDVRTFWIDADKDEIEIVNQN 70
            ||:|::|       ||...:.|.:.|.....:|..:  :|....|:::..:.|.:.:|:.:.:|.
Zfish     7 LKVTFRG-------NAKSFLLSGSETKSWESMEAMV--KRSFGLCNLQLTYFDEENEEVSVNSQL 62

  Fly    71 DYEIFLA-------KCESNMH-------------------VQVAPLAP--VEEPK---------- 97
            :||..|.       :.:.|::                   |.:|.:.|  |.|||
Zfish    63 EYEEALKSAARQGNRLQMNVYETRGSRATVPGPGPPPGSGVGIAQVKPGTVGEPKKGFRPPQHCP 127

  Fly    98 ------------ATKQEG-----SSANAEAPSVDDPSNFT----------IHDAVE--------- 126
                        |.::||     .....:|.....|:.||          :.:|||
Zfish   128 TLAQVVSRKVQAAVQEEGLVIVNELKGGKAEDKTPPAWFTSYMEKFKDQVVREAVEKICREFSGQ 192

  Fly   127 ------------------------------CDGCGLAPLIGFRYKCVQCSNYDLCQKCELAHKHP 161
                                          |..| .....|..|:|..|::..||:.|..:| .|
Zfish   193 CCIHKPVGAEAQVPEVTSSTLPGAPSSAPACSSC-RGQTAGGGYQCSVCTSCTLCEPCSFSH-DP 255

  Fly   162 EHLMLR------MPTNNGPGMVDAWFTGPGLGR--RSGRRSRGHCPFQETNQADPAGE------P 212
            .|.::|      :|.:..|        .|...|  |.|.||     |::..:.....|      .
Zfish   256 SHNLVRARTPLSIPEHGSP--------APDHSRFYRRGDRS-----FRKAEKQRLKAEKRQLKAE 307

  Fly   213 ARDSRRERRQARR-----HAG------VLTQFVEMMTNLPLNTTTATAPAEPQKPKAAEQTESPP 266
            .::.|::.|..||     .||      ||.|        | ..|.|.:|..|::|        .|
Zfish   308 VKEIRKQLRMERRGLQWSTAGEGNSSPVLLQ--------P-RATQANSPDRPKRP--------CP 355

  Fly   267 QAEPTVTAEKAAE-----SEAKP-------------------TEPK------KVNTDQSVPRTED 301
            .|.|.:||....|     |..:|                   :|.|      .:.........|.
Zfish   356 LAVPAMTALLLDENLPDGSRLRPGTKFIKYWKMKNSGRVCWDSETKLKFMWGNLAVGSGERWREV 420

  Fly   302 PVTTPRSTQPTTPVINLDNISQIVPPEYMSAGIEILNNFSEMF------SKIID----TTEGGDS 356
            ||.|.:..|  ..|:::...:..:...|.|..  .|.:..|.|      |.::|    |....|.
Zfish   421 PVPTLQPGQ--VGVVSVALCAPTIEGTYTSHW--RLAHRGEQFGPRVWCSIVVDPHAPTAICADG 481

  Fly   357 GIFAPSTTP---SAENKKPEEQGQSSGQSGASSANQSA-----VPSAAPSANQ------------ 401
            .:.:|..||   |:...:.||:.::||.....|.||..     :||......|
Zfish   482 LLVSPCVTPQEKSSRTLEREEKCRASGDQLLLSVNQDCDQEFYIPSVDLLTAQDLLSFELLDINI 546

  Fly   402 --------SNVPSANQSATPSISGSIPDAQLETEPLNPKPSETT------------TETE----Q 442
                    :|.|:   ..||.||....|..|:.:|......|.|            ||.|    |
Zfish   547 VQELESVPNNTPA---DTTPCISPLPHDGPLQEKPTLGLIQEETEAQGVSNIHDQGTELEGVPAQ 608

  Fly   443 ERRRSDSLDPEWQLIDNAYSANNSNLINLDTTNPTAA----PQEPVRDFGQ----LGELLRQHMN 499
            |:...:|:.|::      .|.:....:.|:.....|.    |.:.||...|    |.|...:.::
Zfish   609 EKGEENSIGPQF------VSPSVIRSLTLEVAERGALCGRYPAKVVRPAPQGSMSLCERQSKSVS 667

  Fly   500 EEARVEQASANTQTAQV--DTVSTSTSTTSVTTNSVGTSPA---APDD 542
            |...:...:.....|.:  |..|..|.||.:|...: |.||   :.||
Zfish   668 ETGLISAPAPLKVEAPLLSDPTSPQTETTEITVPLL-TLPAHLISTDD 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ref(2)P	NP_001014491.1	PB1	6..88	CDD:295447	19/107 (18%)
		ZZ	121..165	CDD:278966	15/82 (18%)
		UBA_SQSTM	555..593	CDD:270505
nbr1b	NP_001373572.1	PB1_NBR1	5..85	CDD:99718	18/86 (21%)
		ZZ	223..261	CDD:412288	12/39 (31%)
		NBR1_like	363..470	CDD:271343	18/110 (16%)
		UBA_NBR1	944..980	CDD:270504
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4582
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900