DRSC/TRiP Functional Genomics Resources

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Protein Alignment ref(2)P and Mib2

DIOPT Version :10

Sequence 1:NP_476700.1 Gene:ref(2)P / 35246 FlyBaseID:FBgn0003231 Length:599 Species:Drosophila melanogaster
Sequence 2:XP_017449042.1 Gene:Mib2 / 474147 RGDID:1359469 Length:982 Species:Rattus norvegicus


Alignment Length:584 Identity:109/584 - (18%)
Similarity:187/584 - (32%) Gaps:176/584 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   122 HDAVECDGCGLAPLIGFRYKCVQCSNYDLCQKCELAHKHP-EHLMLRMPTNNGPGMVDAWFTGP- 184
            |..:.||.|....|.|.|:||..|.:||||.:|.:.:||. .|...|..|::...:.    ..| 
  Rat    86 HPNIICDCCKKHGLRGMRWKCRVCFDYDLCTQCYMHNKHDLTHAFERYETSHSRPVT----LSPR 146

  Fly   185 -GLGR-------RSGRRSRGHCPFQETNQADPA-GEPAR--DSRRERRQARRHAGVLTQFVEMMT 238
             ||.|       :..:..||  |..|....|.. |:..|  |.|....:..|....:| :.:..|
  Rat   147 QGLPRIPLRGIFQGAKVVRG--PDWEWGSQDGGEGKTGRVVDIRGWDVETGRSVASVT-WADGTT 208

  Fly   239 N---------LPLNTTTATA--------------PAEPQKPKAAEQTESPPQAEPTVTAEKA--- 277
            |         :.|......|              |||.|:..:|:       .:|....:|.   
  Rat   209 NVYRVGHKGKVDLKCVGEAAGGFYYKEHLPKLGKPAELQRRVSAD-------GQPFQRGDKVKCL 266

  Fly   278 --------------------AESEAKPTEPKKVNTDQSVPRTEDPVTTPRSTQP----------- 311
                                ||...:.....:: ||:...|.:....|..:..|           
  Rat   267 LDTDVLRDMQEGHGGWNPRMAEFIGQMGTVHRI-TDRGDVRVQFNHETRWTFHPGALTKHNSFWV 330

  Fly   312 ---TTPVINLDNISQI----------VPPEYMSAGIEILNNFSEMFSKIIDTTEGGDSGIFAPST 363
               ...:.:||.:.::          :.|.....| :::..|.:...::   ..||....|:|:.
  Rat   331 GDVVRVIDDLDTVKRLQAGHGEWTDDMAPALGRVG-KVVKVFGDGNLRV---AVGGQRWTFSPAC 391

  Fly   364 TPSAENKKPEEQGQSSGQSGASSANQSAVPSAAPSANQSNVPSA---NQSATPSISGSIPDAQLE 425
            ..:.   :|||           .||......|..:.:.::||.|   .....|:::.::|...| 
  Rat   392 LVAC---RPEE-----------DANLGVAERARENKSAASVPVAGGRQGRPWPALTPTLPPGSL- 441

  Fly   426 TEPLNPKPSETTTETEQERRRSDSLDPE--WQLIDNAYSANNSNLINL--------DTTNPTAAP 480
                         ....::.|:...|||  .:|:..|...|.:..::|        ||.|.....
  Rat   442 -------------SVALDKLRTQKSDPEHPGRLVVEAALGNVARALDLLRRHPEQVDTKNQGRTA 493

  Fly   481 QEPVRDFGQLGELLRQHMNEEARVEQASANTQTAQVDTVSTSTSTTSVTTNSVGTSPAAPDDKRT 545
            .:.....||: ||:|..:...|.|:.......||...|...:....:....|.|....|.:..|:
  Rat   494 LQVAAYLGQV-ELVRLLLQARASVDLLDEEGNTALHYTAMGNQPEATRLLLSAGCGVDAQNGTRS 557

  Fly   546 --------------------------VPVYHTDESINKSIHAMMAMGFSNEGAWLTQLLESVQG 583
                                      :|..|.|..::.:|.|  ..|.|:    :.::|..|.|
  Rat   558 TALHVAVQRGFLEVVKILCEHGCDVNLPDAHADTPLHSAISA--GAGASS----IVEVLTEVPG 615

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ref(2)PNP_476700.1 PB1 6..88 CDD:413452
ZZ 121..165 CDD:395451 18/43 (42%)
UBA_SQSTM 555..593 CDD:270505 7/29 (24%)
Mib2XP_017449042.1 MIB_HERC2 12..78 CDD:461991
ZZ_Mind_bomb 89..133 CDD:239079 17/43 (40%)
MIB_HERC2 160..224 CDD:461991 14/66 (21%)
SH3_15 257..322 CDD:465720 8/65 (12%)
SH3_15 328..392 CDD:465720 9/67 (13%)
ANKYR 443..693 CDD:440430 35/180 (19%)
ANK repeat 490..520 CDD:293786 7/30 (23%)
ANK repeat 522..553 CDD:293786 6/30 (20%)
ANK repeat 555..586 CDD:293786 1/30 (3%)
ANK repeat 588..622 CDD:293786 9/34 (26%)
ANK repeat 625..656 CDD:293786
ANK repeat 658..690 CDD:293786
Ank_2 663..739 CDD:463710
ANK repeat 692..723 CDD:293786
RING-HC_MIB2_rpt1 857..894 CDD:438386
RING_Ubox 932..982 CDD:473075
Blue background indicates that the domain is not in the aligned region.

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