Protein Alignment ref(2)P and sqstm1

DIOPT Version :9

• Sequence 1: NP_001014491.1
• Gene: ref(2)P / 35246
• FlyBaseID: FBgn0003231
• Length: 599
• Species: Drosophila melanogaster
• Sequence 2: NP_001299842.1
• Gene: sqstm1 / 406452
• ZFINID: ZDB-GENE-040426-2204
• Length: 452
• Species: Danio rerio
• Alignment Length: 633
• Identity: 130/633 - (20%)
• Similarity: 187/633 - (29%)
• Gaps: 264/633 - (41%)

  Fly    37 IELYLFQERQLPKCDVRTFWIDAD----------------------------KDE---------- 63
            ::.||..:....| ::|.|.:|.|                            |||
Zfish     5 VKAYLIGKEDCNK-EIRRFAVDQDVSTSFEYLQRKVLDVFVGLRTAPFQMYYKDEDGDMIAFSSD 68

  Fly    64 ------IEIVNQNDYEIFLAKCESN------------------------MHVQVAPLAPVEEPKA 98
                  :.:|..:.:.:|:.:.:.:                        .|:..:|:.|...|
Zfish    69 DELMMGLALVKDDTFRLFIKQRKEHKRDSSPHGIPGFPFTTPHFSPPGPCHMGPSPMGPPGPP-- 131

  Fly    99 TKQEGSSANAEAPSVDDPSNFTIHDAVECDGCGLAPLIGFRYKCVQCSNYDLCQKCELAHKHPEH 163
              ..|...:...|.|        |..|.||||. .|:.|.||||..|.:||||..|:....|.||
Zfish   132 --HMGGPPHHPHPMV--------HPGVTCDGCD-GPVAGTRYKCTVCPDYDLCPTCQSKGLHKEH 185

  Fly   164 LMLRMPTNNGPGMVDAWFTGPGLGRRSGRRSRGHCPFQETNQADPAGEPARDSRRERRQARRHAG 228
            .:|  |..:....|..|     |.|....|...||
Zfish   186 ALL--PIFHPMANVFEW-----LPRGKFWRKMRHC------------------------------ 213

  Fly   229 VLTQFVEMMTNLPLNTTTATAPAEPQK-PKAAEQTESPPQ--AEPTVTAEKAAESEAKPTEPKKV 290
                   |..|     ..|.|..:||. |..|:|.:..|:  .|...||...|..|
Zfish   214 -------MWAN-----AQAQAQNQPQPGPSGAQQNQDAPENPNENGATASSQANVE--------- 257

  Fly   291 NTDQSVPRTEDPVTTPRSTQPTTPVINLDNISQIVPPEYMSAGIEILNNFSEMFSKIIDTTEGGD 355
                                      .|.||.:.|.......||::          .||....|.
Zfish   258 --------------------------YLKNIGEEVAAMLSPLGIDV----------DIDVEHEGK 286

  Fly   356 SGIFAPSTTPSAENKKPEEQGQSSGQSGASSANQSAVPSAAPSANQSNVPSANQSATPSISGSIP 420
            .....|  ||      |...|.||.:|.:.|....:                        .||.|
Zfish   287 RTKVTP--TP------PASSGPSSARSDSGSVGLLS------------------------RGSGP 319

  Fly   421 DAQLETEPLNPKPSETTTETEQERRRSDSL-DPEWQLIDNAYSANNSNLINLDTTNPTAAPQEPV 484
            .            |:.|.|:..|..:.|.. |.||                   |:.:|...:|
Zfish   320 G------------SQATEESVSEGTKKDQCSDEEW-------------------THLSAKEVDP- 352

  Fly   485 RDFGQLGELLRQHMNEEARVEQASANTQTAQVDTVS-TSTSTTSVTTNSVGTSPAAPDDKRTVPV 548
                ..|||      :..|:||..|:. .|.::|.| |||.............|..|.|
Zfish   353 ----STGEL------QSLRLEQDGADL-PAPLNTASGTSTRDGPTGLREAALYPHLPQD------ 400

  Fly   549 YHTDESINKSIHAMMAMGFSNEGAWLTQLLESVQGNISAALDVMNVSQ 596
              .|..:.:|:..|::|||::||.|||:||.:...:|..|||.:..|:
Zfish   401 --ADPRLVESLSQMLSMGFTDEGGWLTRLLHTKNYDIGGALDTIQYSK 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ref(2)P	NP_001014491.1	PB1	6..88	CDD:295447	13/118 (11%)
		ZZ	121..165	CDD:278966	21/43 (49%)
		UBA_SQSTM	555..593	CDD:270505	16/37 (43%)
sqstm1	NP_001299842.1	PB1_p62	3..88	CDD:99723	12/83 (14%)
		ZZ_NBR1_like	148..190	CDD:239080	21/44 (48%)
		UBA_like_SF	390..448	CDD:304366	21/65 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576347
Domainoid	1	1.000	40	1.000	Domainoid score	I12535
eggNOG	1	0.900	-	-		E1_KOG4582
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1275680at2759
OrthoFinder	1	1.000	-	-		FOG0002104
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15090
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4736
SonicParanoid	1	1.000	-	-		X5995
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.970